Search Results - "Thompson, Paul R"

Chemical Biology of Protein Arginine Modifications in Epigenetic Regulation by Fuhrmann, Jakob, Clancy, Kathleen W, Thompson, Paul R

“…Fuhrmann et al describe the chemical biology of protein arginine modifications in epigenetic regulation…”
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Emergence of SARM1 as a Potential Therapeutic Target for Wallerian-type Diseases by Loring, Heather S, Thompson, Paul R

“…Wallerian degeneration is a neuronal death pathway that is triggered in response to injury or disease. Death was thought to occur passively until the discovery…”
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Succination inactivates gasdermin D and blocks pyroptosis by Humphries, Fiachra, Shmuel-Galia, Liraz, Ketelut-Carneiro, Natalia, Li, Sheng, Wang, Bingwei, Nemmara, Venkatesh V, Wilson, Ruth, Jiang, Zhaozhao, Khalighinejad, Farnaz, Muneeruddin, Khaja, Shaffer, Scott A, Dutta, Ranjan, Ionete, Carolina, Pesiridis, Scott, Yang, Shuo, Thompson, Paul R, Fitzgerald, Katherine A

“…Activated macrophages undergo a metabolic switch to aerobic glycolysis, accumulating Krebs' cycle intermediates that alter transcription of immune response…”
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The protein arginine deiminases: Structure, function, inhibition, and disease by Bicker, Kevin L., Thompson, Paul R.

“…The post‐translational modification of histones has significant effects on overall chromatin function. One such modification is citrullination, which is…”
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Protein Arginine Methylation and Citrullination in Epigenetic Regulation by Fuhrmann, Jakob, Thompson, Paul R

“…The post-translational modification of arginine residues represents a key mechanism for the epigenetic control of gene expression. Aberrant levels of histone…”
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Diverse stimuli engage different neutrophil extracellular trap pathways by Kenny, Elaine F, Herzig, Alf, Krüger, Renate, Muth, Aaron, Mondal, Santanu, Thompson, Paul R, Brinkmann, Volker, Bernuth, Horst von, Zychlinsky, Arturo

“…Neutrophils release neutrophil extracellular traps (NETs) which ensnare pathogens and have pathogenic functions in diverse diseases. We examined the NETosis…”
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The Rheumatoid Arthritis-Associated Citrullinome by Tilvawala, Ronak, Nguyen, Son Hong, Maurais, Aaron J, Nemmara, Venkatesh V, Nagar, Mitesh, Salinger, Ari J, Nagpal, Sunil, Weerapana, Eranthie, Thompson, Paul R

“…Increased protein citrullination is linked to various diseases including rheumatoid arthritis (RA), lupus, and cancer. Citrullinated autoantigens, a hallmark…”
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Protein Arginine Deiminases and Associated Citrullination: Physiological Functions and Diseases Associated with Dysregulation by Witalison, Erin E, Thompson, Paul R, Hofseth, Lorne J

“…Human proteins are subjected to more than 200 known post-translational modifications (PTMs) (e.g., phosphorylation, glycosylation, ubiquitination,…”
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Nicotine induces neutrophil extracellular traps by Hosseinzadeh, Ava, Thompson, Paul R., Segal, Brahm H., Urban, Constantin F.

“…Nicotine induces neutrophils to release DNA traps via activation of Akt, but independently of NADPH oxidase. NETs serve to ensnare and kill microbial…”
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Site-specific incorporation of citrulline into proteins in mammalian cells by Mondal, Santanu, Wang, Shu, Zheng, Yunan, Sen, Sudeshna, Chatterjee, Abhishek, Thompson, Paul R.

“…Citrullination is a post-translational modification (PTM) of arginine that is crucial for several physiological processes, including gene regulation and…”
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Peptidylarginine Deiminase Inhibition Reduces Vascular Damage and Modulates Innate Immune Responses in Murine Models of Atherosclerosis by Knight, Jason S, Luo, Wei, O’Dell, Alexander A, Yalavarthi, Srilakshmi, Zhao, Wenpu, Subramanian, Venkataraman, Guo, Chiao, Grenn, Robert C, Thompson, Paul R, Eitzman, Daniel T, Kaplan, Mariana J

“…RATIONALE:Neutrophil extracellular trap (NET) formation promotes vascular damage, thrombosis, and activation of interferon-α–producing plasmacytoid dendritic…”
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Peptidylarginine deiminase inhibition is immunomodulatory and vasculoprotective in murine lupus by Knight, Jason S, Zhao, Wenpu, Luo, Wei, Subramanian, Venkataraman, O'Dell, Alexander A, Yalavarthi, Srilakshmi, Hodgin, Jeffrey B, Eitzman, Daniel T, Thompson, Paul R, Kaplan, Mariana J

“…Recent evidence suggests that enhanced neutrophil extracellular trap (NET) formation activates plasmacytoid dendritic cells and serves as a source of…”
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Chloramidine/Bisindolylmaleimide-I-Mediated Inhibition of Exosome and Microvesicle Release and Enhanced Efficacy of Cancer Chemotherapy by Kosgodage, Uchini S, Trindade, Rita P, Thompson, Paul R, Inal, Jameel M, Lange, Sigrun

“…Microvesicle (MV) release from tumour cells influences drug retention, contributing to cancer drug resistance. Strategically regulating MV release may increase…”
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Plasma Peptidylarginine Deiminase IV Promotes VWF-Platelet String Formation and Accelerates Thrombosis After Vessel Injury by Sorvillo, Nicoletta, Mizurini, Daniella M, Coxon, Carmen, Martinod, Kimberly, Tilvawala, Ronak, Cherpokova, Deya, Salinger, Ari J, Seward, Robert J, Staudinger, Caleb, Weerapana, Eranthie, Shapiro, Nathan I, Costello, Catherine E, Thompson, Paul R, Wagner, Denisa D

“…RATIONALE:PAD4 (peptidylarginine deiminase type IV), an enzyme essential for neutrophil extracellular trap formation (NETosis), is released together with…”
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Crystal Structure of SARS-CoV-2 Main Protease in Complex with the Non-Covalent Inhibitor ML188 by Lockbaum, Gordon J, Reyes, Archie C, Lee, Jeong Min, Tilvawala, Ronak, Nalivaika, Ellen A, Ali, Akbar, Kurt Yilmaz, Nese, Thompson, Paul R, Schiffer, Celia A

“…Viral proteases are critical enzymes for the maturation of many human pathogenic viruses and thus are key targets for direct acting antivirals (DAAs). The…”
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Peptidylarginine Deiminase Isozyme-Specific PAD2, PAD3 and PAD4 Inhibitors Differentially Modulate Extracellular Vesicle Signatures and Cell Invasion in Two Glioblastoma Multiforme Cell Lines by Uysal-Onganer, Pinar, MacLatchy, Amy, Mahmoud, Rayan, Kraev, Igor, Thompson, Paul R, Inal, Jameel M, Lange, Sigrun

“…Glioblastoma multiforme (GBM) is an aggressive adult brain tumour with poor prognosis. Roles for peptidylarginine deiminases (PADs) in GBM have recently been…”
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PAD1 promotes epithelial-mesenchymal transition and metastasis in triple-negative breast cancer cells by regulating MEK1-ERK1/2-MMP2 signaling by Qin, Hao, Liu, Xiaoqiu, Li, Fujun, Miao, Lixia, Li, Tingting, Xu, Boqun, An, Xiaofei, Muth, Aaron, Thompson, Paul R., Coonrod, Scott A., Zhang, Xuesen

“…Peptidylargininedeiminase 1 (PAD1) catalyzes protein for citrullination, and this activity has been linked to the epidermal cornification. However, a role for…”
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Activity-Based Profiling Reveals a Regulatory Link between Oxidative Stress and Protein Arginine Phosphorylation by Fuhrmann, Jakob, Subramanian, Venkataraman, Kojetin, Douglas J, Thompson, Paul R

“…Protein arginine phosphorylation is a recently discovered modification that affects multiple cellular pathways in Gram-positive bacteria. In particular, the…”
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Utilization of the Soft Agar Colony Formation Assay to Identify Inhibitors of Tumorigenicity in Breast Cancer Cells by Horibata, Sachi, Vo, Tommy V, Subramanian, Venkataraman, Thompson, Paul R, Coonrod, Scott A

“…Given the inherent difficulties in investigating the mechanisms of tumor progression in vivo, cell-based assays such as the soft agar colony formation assay…”
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Pathogen infection and cholesterol deficiency activate the C. elegans p38 immune pathway through a TIR-1/SARM1 phase transition by Peterson, Nicholas D, Icso, Janneke D, Salisbury, J Elizabeth, Rodríguez, Tomás, Thompson, Paul R, Pukkila-Worley, Read

“…Intracellular signaling regulators can be concentrated into membrane-free, higher ordered protein assemblies to initiate protective responses during stress - a…”
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