Search Results - "Thompson, Matthew D."

Role and Regulation of Pif1 Family Helicases at the Replication Fork by Malone, Emory G, Thompson, Matthew D, Byrd, Alicia K

“…Pif1 helicases are a multifunctional family of DNA helicases that are important for many aspects of genomic stability in the nucleus and mitochondria. Pif1…”
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Urinary Metabolite Risk Biomarkers of Lung Cancer: A Prospective Cohort Study by Haznadar, Majda, Cai, Qiuyin, Krausz, Kristopher W, Bowman, Elise D, Margono, Ezra, Noro, Rintaro, Thompson, Matthew D, Mathé, Ewy A, Munro, Heather M, Steinwandel, Mark D, Gonzalez, Frank J, Blot, William J, Harris, Curtis C

“…Lung cancer is a major health burden causing 160,000 and 1.6 million deaths annually in the United States and worldwide, respectively. While seeking to…”
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Unique and Novel Urinary Metabolomic Features in Malignant versus Benign Adrenal Neoplasms by Patel, Dhaval, Thompson, Matthew D, Manna, Soumen K, Krausz, Kristopher W, Zhang, Lisa, Nilubol, Naris, Gonzalez, Frank J, Kebebew, Electron

“…Adrenal incidentalomas must be differentiated from adrenocortical cancer (ACC). Currently, size, growth, and imaging characteristics determine the potential…”
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Physiological effects of bean (Phaseolus vulgaris L.) consumption on cellular signaling in cancer by Thompson, Matthew D., Thompson, Henry J.

“…Comment on: Thompson MD, et al. Carcinogenesis 2012; 33:226-32…”
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Lack of effect of metformin on mammary carcinogenesis in nondiabetic rat and mouse models by Thompson, Matthew D, Grubbs, Clinton J, Bode, Ann M, Reid, Joel M, McGovern, Renee, Bernard, Philip S, Stijleman, Inge J, Green, Jeffrey E, Bennett, Christina, Juliana, M Margaret, Moeinpour, Fariba, Steele, Vernon E, Lubet, Ronald A

“…Epidemiologic studies have shown that diabetics receiving the biguanide metformin, as compared with sulfonylureas or insulin, have a lower incidence of breast…”
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A systems pharmacokinetic and pharmacodynamic approach to identify opportunities and pitfalls in energy stress-mediated chemoprevention: the use of metformin and other biguanides by Thompson, Matthew D, Thompson, Henry J

“…Metformin, a widely used anti-hyperglycemic drug in the biguanide class, is currently under investigation for the prevention of cancer. Surprisingly however,…”
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Trends in the approval of cancer therapies by the FDA in the twenty-first century by Scott, Emma C., Baines, Andrea C., Gong, Yutao, Moore, Rodney, Pamuk, Gulsum E., Saber, Haleh, Subedee, Ashim, Thompson, Matthew D., Xiao, Wenming, Pazdur, Richard, Rao, V. Ashutosh, Schneider, Julie, Beaver, Julia A.

“…The cancer treatment landscape has changed dramatically since the turn of the century, resulting in substantial improvements in outcomes for patients. This…”
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Pharmacokinetic models for first-in-human dose selection of immune-activating products in oncology by Saber, Haleh, Thompson, Matthew D., Leighton, John K.

“…Pharmacokinetic (PK) models are increasingly submitted to the FDA to support first-in-human (FIH) dose selection of immune-oncology products. To examine…”
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Cognitive function and adaptive skills after a one-year trial of cannabidiol (CBD) in a pediatric sample with treatment-resistant epilepsy by Thompson, Matthew D., Martin, Roy C., Grayson, Leslie P., Ampah, Steve B., Cutter, Gary, Szaflarski, Jerzy P., Bebin, E. Martina

“…Cannabidiol (CBD) is a nonpsychoactive derivative of cannabis. Studies indicate that it is safe and effective in treating certain types of epilepsy. The…”
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Monitoring helicase-catalyzed unwinding of multiple duplexes simultaneously by Thompson, Matthew D, Malone, Emory G, Byrd, Alicia K

“…Helicases catalyze the unwinding of duplex nucleic acids to aid a variety of cellular processes. Although helicases unwind duplex DNA in the same direction…”
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FDA Approval Summary: Futibatinib for Unresectable Advanced or Metastatic, Chemotherapy Refractory Intrahepatic Cholangiocarcinoma with FGFR2 Fusions or Other Rearrangements by Gandhy, Shruti U, Casak, Sandra J, Mushti, Sirisha L, Cheng, Joyce, Subramaniam, Sriram, Zhao, Hong, Zhao, Miao, Bi, Youwei, Liu, Guansheng, Fan, Jianghong, Adeniyi, Oluseyi, Charlab, Rosane, Kufrin, Dubravka, Thompson, Matthew D, Jarrell, Kristin, Auth, Doris, Lemery, Steven J, Pazdur, Richard, Kluetz, Paul G, Fashoyin-Aje, Lola A

“…On September 30, 2022, the FDA granted accelerated approval to futibatinib for the treatment of adult patients with previously treated, unresectable, locally…”
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FDA Approval Summary: Ripretinib for Advanced Gastrointestinal Stromal Tumor by Kumar, Vaibhav, Doros, Leslie, Thompson, Margaret, Mushti, Sirisha L, Charlab, Rosane, Spehalski, Elizabeth I, Zhao, Hong, Thompson, Matthew D, Tang, Shenghui, Pazdur, Richard, Lemery, Steven J, Theoret, Marc R, Fashoyin-Aje, Lola A

“…On May 15, 2020, the FDA approved ripretinib for adult patients with advanced gastrointestinal stromal tumor who have received prior treatment with three or…”
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FDA Approval Summary: Fruquintinib for the Treatment of Refractory Metastatic Colorectal Cancer by Fusco, Michael J, Casak, Sandra J, Mushti, Sirisha L, Cheng, Joyce, Christmas, Brian J, Thompson, Matthew D, Fu, Wentao, Wang, Hezhen, Yoon, Miyoung, Yang, Yuching, Moore, Jason N, Bi, Youwei, Nan, Yang, Long, Craig E, Auth, Doris, Rahman, Nam A, Tang, Shenghui, Pazdur, Richard, Fashoyin-Aje, Lola A, Kluetz, Paul G, Lemery, Steven J

“…On November 8, 2023, the FDA approved fruquintinib, an inhibitor of vascular endothelial growth factor receptor (VEGFR)-1, -2, and -3, for the treatment of…”
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A structural feature of Dda helicase which enhances displacement of streptavidin and trp repressor from DNA by Byrd, Alicia K., Malone, Emory G., Hazeslip, Lindsey, Zafar, Maroof Khan, Harrison, David K., Thompson, Matthew D., Gao, Jun, Perumal, Senthil K., Marecki, John C., Raney, Kevin D.

“…Helicases are molecular motors with many activities. They use the energy from ATP hydrolysis to unwind double‐stranded nucleic acids while translocating on the…”
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A method for serial tissue processing and parallel analysis of aberrant crypt morphology, mucin depletion, and Beta-catenin staining in an experimental model of colon carcinogenesis by McGinley, John N, Thompson, Matthew D, Thompson, Henry J

“…The use of architectural and morphological characteristics of cells for establishing prognostic indicators by which individual pathologies are assigned grade…”
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An FDA analysis of clinical hold deficiencies affecting investigational new drug applications for oncology products by Manning, Michael L., Thompson, Matthew D., Saber, Haleh, Maher, Virginia E., Crich, Joyce Z., Leighton, John K.

“…A systematic analysis of new commercial investigational new drug applications (IND) submitted to the FDA's Office of Hematology and Oncology Products (OHOP) in…”
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Caregiver-reported religious beliefs and complementary and alternative medicine use among children admitted to an epilepsy monitoring unit by Beattie, Julia Fleming, Thompson, Matthew D, Parks, Pamela H, Jacobs, Ruth Q, Goyal, Monisha

“…Abstract Complementary and alternative medicine (CAM) includes a wide range of practices and products that are generally outside the use of conventional…”
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Effects of metformin, buformin, and phenformin on the post-initiation stage of chemically induced mammary carcinogenesis in the rat by Zhu, Zongjian, Jiang, Weiqin, Thompson, Matthew D, Echeverria, Dimas, McGinley, John N, Thompson, Henry J

“…Metformin is a widely prescribed drug for the treatment of type II diabetes. Although epidemiologic data have provided a strong rationale for investigating the…”
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Physiologically based pharmacokinetic tissue compartment model selection in drug development and risk assessment by Thompson, Matthew D, Beard, Daniel A

“…A well-stirred tank (WST) has been the predominant flow-limited tissue compartment model in physiologically based pharmacokinetic (PBPK) modeling. Recently, we…”
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Development of appropriate equations for physiologically based pharmacokinetic modeling of permeability-limited and flow-limited transport by Thompson, Matthew D., Beard, Daniel A.

“…Although the implementation of a flow-limited, well-stirred tank (WST) single-compartment tissue model in pharmacokinetics and toxicokinetics is widespread,…”
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