Search Results - "Thompson, LaDora"

Skeletal muscle denervation investigations: selecting an experimental control wisely by Liu, Haiming, Thompson, LaDora V

“…Unilateral denervation is widely used for studies investigating mechanisms of muscle atrophy. The "contralateral-innervated muscle" is a commonly used…”
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Age-induced oxidative stress: how does it influence skeletal muscle quantity and quality? by Baumann, Cory W, Kwak, Dongmin, Liu, Haiming M, Thompson, LaDora V

“…With advancing age, skeletal muscle function declines as a result of strength loss. These strength deficits are largely due to reductions in muscle size (i.e.,…”
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Sex-specific components of frailty in C57BL/6 mice by Baumann, Cory W, Kwak, Dongmin, Thompson, LaDora V

“…Many age-related biochemical, physiological and behavioral changes are known to be sex-specific. However, how sex influences frailty status and mortality risk…”
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Phenotypic Frailty Assessment in Mice: Development, Discoveries, and Experimental Considerations by Baumann, Cory W, Kwak, Dongmin, Thompson, LaDora V

“…The underlying mechanisms contributing to the onset of frailty, its progression, and its mortality risk remain unknown. Recently, the two most common human…”
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Age-related muscle dysfunction by Thompson, LaDora V.

“…Aging is associated with a progressive decline of muscle mass, strength, and quality, a condition described as sarcopenia of aging. Despite the significance of…”
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Clinically relevant frailty index for mice by Liu, Haiming, Graber, Ted G, Ferguson-Stegall, Lisa, Thompson, LaDora V

“…Frailty is a clinical syndrome associated with the aging process and adverse outcomes. The purpose of this short report was to initiate the development of a…”
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Identifying Characteristics of Frailty in Female Mice Using a Phenotype Assessment Tool by Kwak, Dongmin, Baumann, Cory W, Thompson, LaDora V

“…Abstract Preclinical studies are important in identifying the underlying mechanisms contributing to frailty. Frailty studies have mainly focused on male…”
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Assessing onset, prevalence and survival in mice using a frailty phenotype by Baumann, Cory W, Kwak, Dongmin, Thompson, LaDora V

“…Little is known whether frailty assessments in mice are capable of distinguishing important characteristics of the frailty syndrome. The goals of this study…”
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Frailty: Past, present, and future? by Kwak, Dongmin, Thompson, LaDora V.

“…The prevalence of frailty across the world in older adults is increasing dramatically and having frailty places a person at increased risk for many adverse…”
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Denervation-Induced Activation of the Ubiquitin-Proteasome System Reduces Skeletal Muscle Quantity Not Quality by Baumann, Cory W, Liu, Haiming M, Thompson, LaDora V

“…It is well known that the ubiquitin-proteasome system is activated in response to skeletal muscle wasting and functions to degrade contractile proteins. The…”
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Denervation-Induced Activation of the Standard Proteasome and Immunoproteasome by Liu, Haiming M, Ferrington, Deborah A, Baumann, Cory W, Thompson, LaDora V

“…The standard 26S proteasome is responsible for the majority of myofibrillar protein degradation leading to muscle atrophy. The immunoproteasome is an inducible…”
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Murine models of atrophy, cachexia, and sarcopenia in skeletal muscle by Romanick, Mark, Thompson, LaDora V., Brown-Borg, Holly M.

“…With the extension of life span over the past several decades, the age-related loss of muscle mass and strength that characterizes sarcopenia is becoming more…”
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Voluntary Aerobic Exercise Reverses Frailty in Old Mice by Graber, Ted G, Ferguson-Stegall, Lisa, Liu, Haiming, Thompson, LaDora V

“…Frailty is a major cause of disability and loss of independence in the elderly. Using clinically relevant criteria from our previously established mouse…”
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Increasing myosin light chain 3f (MLC3f) protects against a decline in contractile velocity by Kim, Jong-Hee, Graber, Ted G, Liu, Haiming, Asakura, Atsushi, Thompson, LaDora V

“…Disuse induces adaptations in skeletal muscle, which lead to muscle deterioration. Hindlimb-unloading (HU) is a well-established model to investigate cellular…”
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Short-Term ONX-0914 Administration: Performance and Muscle Phenotype in Mdx Mice by Kwak, Dongmin, Wei, Guoxian, Thompson, LaDora V., Kim, Jong-Hee

“…Duchenne muscular dystrophy (DMD) is a severe muscle-wasting disease. Although the lack of dystrophin protein is the primary defect responsible for the…”
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Age-dependent effects of caloric restriction on mTOR and ubiquitin-proteasome pathways in skeletal muscles by Chen, Chiao-Nan, Liao, Yi-Hung, Tsai, Shiow-Chwen, Thompson, LaDora V.

“…In skeletal muscles, calorie restriction (CR) preserves muscle mass in middle-aged rats but not younger rats. The underlying mechanisms for this age-specific…”
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C57BL/6 neuromuscular healthspan scoring system by Graber, Ted G, Ferguson-Stegall, Lisa, Kim, Jong-Hee, Thompson, LaDora V

“…Developing a scoring system based on physiological and functional measurements is critical to test the efficacy of potential interventions for sarcopenia and…”
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Lipotoxicity, aging, and muscle contractility: does fiber type matter? by Carter, Christy S., Justice, Jamie N., Thompson, LaDora

“…Sarcopenia is a universal characteristic of the aging process and is often accompanied by increases in whole-body adiposity. These changes in body composition…”
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Contribution of oxidative stress to pathology in diaphragm and limb muscles with Duchenne muscular dystrophy by Kim, Jong-Hee, Kwak, Hyo-Bum, Thompson, LaDora V., Lawler, John M.

“…Duchenne muscular dystrophy (DMD) is a degenerative skeletal muscle disease that makes walking and breathing difficult. DMD is caused by an X-linked (Xp21)…”
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Altered proteasome structure, function, and oxidation in aged muscle by Ferrington, Deborah A, Husom, Aimee D, Thompson, LaDora V

“…ABSTRACT The proteasome is the main protease for degrading oxidized proteins. We asked whether altered proteasome function contributes to the accumulation of…”
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