Search Results - "Thompson, Keyata N."

Polarized NHE1 and SWELL1 regulate migration direction, efficiency and metastasis by Zhang, Yuqi, Li, Yizeng, Thompson, Keyata N., Stoletov, Konstantin, Yuan, Qinling, Bera, Kaustav, Lee, Se Jong, Zhao, Runchen, Kiepas, Alexander, Wang, Yao, Mistriotis, Panagiotis, Serra, Selma A., Lewis, John D., Valverde, Miguel A., Martin, Stuart S., Sun, Sean X., Konstantopoulos, Konstantinos

“…Cell migration regulates diverse (patho)physiological processes, including cancer metastasis. According to the Osmotic Engine Model, polarization of NHE1 at…”
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Microtubule disruption reduces metastasis more effectively than primary tumor growth by Thompson, Keyata N, Ju, Julia A, Ory, Eleanor C, Pratt, Stephen J P, Lee, Rachel M, Mathias, Trevor J, Chang, Katarina T, Lee, Cornell J, Goloubeva, Olga G, Bailey, Patrick C, Chakrabarti, Kristi R, Jewell, Christopher M, Vitolo, Michele I, Martin, Stuart S

“…Clinical cancer imaging focuses on tumor growth rather than metastatic phenotypes. The microtubule-depolymerizing drug, Vinorelbine, reduced the metastatic…”
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Lipid tethering of breast tumor cells reduces cell aggregation during mammosphere formation by Bhandary, Lekhana, Bailey, Patrick C., Chang, Katarina T., Underwood, Karen F., Lee, Cornell J., Whipple, Rebecca A., Jewell, Christopher M., Ory, Eleanor, Thompson, Keyata N., Ju, Julia A., Mathias, Trevor M., Pratt, Stephen J. P., Vitolo, Michele I., Martin, Stuart S.

“…Mammosphere assays are widely used in vitro to identify prospective cancer-initiating stem cells that can propagate clonally to form spheres in free-floating…”
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Hydrogen Peroxide Induces α-Tubulin Detyrosination and Acetylation and Impacts Breast Cancer Metastatic Phenotypes by Stemberger, Megan B, Ju, Julia A, Thompson, Keyata N, Mathias, Trevor J, Jerrett, Alexandra E, Chang, Katarina T, Ory, Eleanor C, Annis, David A, Mull, Makenzy L, Gilchrist, Darin E, Vitolo, Michele I, Martin, Stuart S

“…Levels of hydrogen peroxide are highly elevated in the breast tumor microenvironment compared to normal tissue. Production of hydrogen peroxide is implicated…”
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Single-Cell Tracking of Breast Cancer Cells Enables Prediction of Sphere Formation from Early Cell Divisions by Bailey, Patrick C, Lee, Rachel M, Vitolo, Michele I, Pratt, Stephen J P, Ory, Eleanor, Chakrabarti, Kristi, Lee, Cornell J, Thompson, Keyata N, Martin, Stuart S

“…The mammosphere assay has become widely employed to quantify stem-like cells in a population. However, the problem is there is no standard protocol employed by…”
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OBSCN restoration via OBSCN-AS1  long-noncoding RNA CRISPR-targeting suppresses metastasis in triple-negative breast cancer by Guardia, Talia, Zhang, Yuqi, Thompson, Keyata N, Lee, Se Jong, Martin, Stuart S, Konstantopoulos, Konstantinos, Kontrogianni-Konstantopoulos, Aikaterini

“…Mounting evidence implicates the giant, cytoskeletal protein obscurin (720 to 870 kDa), encoded by the gene, in the predisposition and development of breast…”
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Curcumin Targets Breast Cancer Stem-like Cells with Microtentacles That Persist in Mammospheres and Promote Reattachment by CHARPENTIER, Monica S, WHIPPLE, Rebecca A, VITOLO, Michele I, BOGGS, Amanda E, SLOVIC, Jana, THOMPSON, Keyata N, BHANDARY, Lekhana, MARTIN, Stuart S

“…Cancer stem-like cells (CSC) and circulating tumor cells (CTC) have related properties associated with distant metastasis, but the mechanisms through which…”
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Mechanoactivation of NOX2-generated ROS elicits persistent TRPM8 Ca2+ signals that are inhibited by oncogenic KRas by Pratt, Stephen J. P., Lee, Rachel M., Chang, Katarina T., Hernández-Ochoa, Erick O., Annis, David A., Ory, Eleanor C., Thompson, Keyata N., Bailey, Patrick C., Mathias, Trevor J., Ju, Julia A., Vitolo, Michele I., Schneider, Martin F., Stains, Joseph P., Ward, Christopher W., Martin, Stuart S.

“…Changes in the mechanical microenvironment and mechanical signals are observed during tumor progression, malignant transformation, and metastasis. In this…”
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A microfluidic assay for the quantification of the metastatic propensity of breast cancer specimens by Yankaskas, Christopher L., Thompson, Keyata N., Paul, Colin D., Vitolo, Michele I., Mistriotis, Panagiotis, Mahendra, Ankit, Bajpai, Vivek K., Shea, Daniel J., Manto, Kristen M., Chai, Andreas C., Varadarajan, Navin, Kontrogianni-Konstantopoulos, Aikaterini, Martin, Stuart S., Konstantopoulos, Konstantinos

“…The challenge of predicting which patients with breast cancer will develop metastases leads to the overtreatment of patients with benign disease and to the…”
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Mechanoactivation of NOX2-generated ROS elicits persistent TRPM8 Ca 2+ signals that are inhibited by oncogenic KRas by Pratt, Stephen J P, Lee, Rachel M, Chang, Katarina T, Hernández-Ochoa, Erick O, Annis, David A, Ory, Eleanor C, Thompson, Keyata N, Bailey, Patrick C, Mathias, Trevor J, Ju, Julia A, Vitolo, Michele I, Schneider, Martin F, Stains, Joseph P, Ward, Christopher W, Martin, Stuart S

“…Changes in the mechanical microenvironment and mechanical signals are observed during tumor progression, malignant transformation, and metastasis. In this…”
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Elevation of Cytoplasmic Calcium Suppresses Microtentacle Formation and Function in Breast Tumor Cells by Chang, Katarina T, Thompson, Keyata N, Pratt, Stephen J P, Ju, Julia A, Lee, Rachel M, Mathias, Trevor J, Mull, Makenzy L, Annis, David A, Ory, Eleanor C, Stemberger, Megan B, Vitolo, Michele I, Martin, Stuart S

“…Cytoskeletal remodeling in circulating tumor cells (CTCs) facilitates metastatic spread. Previous oncology studies examine sustained aberrant calcium (Ca )…”
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Tubulin Carboxypeptidase Activity Promotes Focal Gelatin Degradation in Breast Tumor Cells and Induces Apoptosis in Breast Epithelial Cells That Is Overcome by Oncogenic Signaling by Mathias, Trevor J, Ju, Julia A, Lee, Rachel M, Thompson, Keyata N, Mull, Makenzy L, Annis, David A, Chang, Katarina T, Ory, Eleanor C, Stemberger, Megan B, Hotta, Takashi, Ohi, Ryoma, Vitolo, Michele I, Moutin, Marie-Jo, Martin, Stuart S

“…Post-translational modifications (PTMs) of the microtubule network impart differential functions across normal cell types and their cancerous counterparts. The…”
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ROCK inhibition promotes microtentacles that enhance reattachment of breast cancer cells by Bhandary, Lekhana, Whipple, Rebecca A, Vitolo, Michele I, Charpentier, Monica S, Boggs, Amanda E, Chakrabarti, Kristi R, Thompson, Keyata N, Martin, Stuart S

“…The presence of circulating tumor cells (CTCs) in blood predicts poor patient outcome and CTC frequency is correlated with higher risk of metastasis. Recently…”
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The combinatorial activation of the PI3K and Ras/MAPK pathways is sufficient for aggressive tumor formation, while individual pathway activation supports cell persistence by Thompson, Keyata N, Whipple, Rebecca A, Yoon, Jennifer R, Lipsky, Michael, Charpentier, Monica S, Boggs, Amanda E, Chakrabarti, Kristi R, Bhandary, Lekhana, Hessler, Lindsay K, Martin, Stuart S, Vitolo, Michele I

“…A high proportion of human tumors maintain activation of both the PI3K and Ras/MAPK pathways. In basal-like breast cancer (BBC), PTEN expression is…”
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Successful rederivation of contaminated immunocompetent mice using neonatal transfer with iodine immersion by Watson, J, Thompson, K.N, Feldman, S.H

“…There is an ongoing need to eradicate intercurrent disease from research mouse colonies. Commonly used surgical methods, however, are expensive and…”
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Abstract 2575: Mechanoactivation of NOX2-generated ROS elicits persistent TRPM8 Ca2+ signals that are inhibited by oncogenic KRas by Pratt, Stephen JP, Lee, Rachel M., Hernandez-Ochoa, Erick O., Ory, Eleanor C., Thompson, Keyata N., Bailey, Patrick C., Mathias, Trevor J., Ju, Julia A., Vitolo, Michele I., Schneider, Martin F., Stains, Joseph P., Ward, Christopher W., Martin, Stuart S.

“…Changes in the mechanical microenvironment and mechanical signals are observed during tumor progression, malignant transformation, and metastasis. In this…”
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Abstract LB-342: HDAC inhibition promotes tubulin-independent cancer cell migration by Hessler, Lindsay K., Boggs, Amanda E., Whipple, Rebecca A., Vitolo, Michele I., Chakrabarti, Kristi R., Bhandary, Lekhana, Thompson, Keyata N., Martin, Stuart S.

“…Breast cancer remains the most common cancer and second-leading cause of cancer-related death in women, with metastatic disease carrying a particularly poor…”
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Abstract 2161: Activation of the MAPK pathway in combination with PTEN loss leads to aggressive primary tumor formation by Thompson, Keyata N., Whipple, Rebecca A., Yoon, Jennifer R., Charpentier, Monica S., Boggs, Amanda E., Bhandary, Lekhana, Chakrabarti, Kristi R., Martin, Stuart S., Vitolo, Michele I.

“…Breast cancer is the most frequent malignancy in women, and although many breast cancers are curable via surgery, approximately one quarter maintain a latent…”
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Abstract A32: Cell dormancy and tumorigenicity due to PTEN loss by Thompson, Keyata N., Whipple, Rebecca A., Charpentier, Monica S., Boggs, Amanda E., Bhandray, Lekhana, Chakrabarti, Kristi R., Martin, Stuart S., Vitolo, Michele I.

“…Breast cancer is the most frequent malignancy in women, and although many breast cancers are curable via surgery, approximately one quarter maintain a latent…”
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