Search Results - "Thompson, Katherine H"

Vanadium treatment of type 2 diabetes: A view to the future by Thompson, Katherine H., Lichter, Jay, LeBel, Carl, Scaife, Michael C., McNeill, John H., Orvig, Chris

“…3-Hydroxy-2-methyl-4-pyrone and 2-ethyl-3-hydroxy-4-pyrone (maltol and ethyl maltol, respectively) have proven especially suitable as ligands for vanadyl ions,…”
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Boon and Bane of Metal Ions in Medicine by Thompson, Katherine H., Orvig, Chris

“…In biological systems metal ions promote responses that range from deficiency to toxicity. Some, such as iron and zinc, have a known optimal intake range for…”
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Synthesis, Characterization, and Metal Coordinating Ability of Multifunctional Carbohydrate-Containing Compounds for Alzheimer's Therapy by Storr, Tim, Merkel, Michael, Song-Zhao, George X, Scott, Lauren E, Green, David E, Bowen, Meryn L, Thompson, Katherine H, Patrick, Brian O, Schugar, Harvey J, Orvig, Chris

“…Dysfunctional interactions of metal ions, especially Cu, Zn, and Fe, with the amyloid-β (Aβ) peptide are hypothesized to play an important role in the etiology…”
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Combating Alzheimer's Disease With Multifunctional Molecules Designed for Metal Passivation by Schugar, Harvey, Green, David E., Bowen, Meryn L., Scott, Lauren E., Storr, Tim, Böhmerle, Karin, Thomas, Fancy, Allen, David D., Lockman, Paul R., Merkel, Michael, Thompson, Katherine H., Orvig, Chris

“…A trifunctional approach: 3‐hydroxy‐4‐pyridinones that contain phenol groups for antioxidant functionality are further elaborated with pendant glucosyl…”
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Design of targeting ligands in medicinal inorganic chemistry by Storr, Tim, Thompson, Katherine H, Orvig, Chris

“…This tutorial review will highlight recent advances in medicinal inorganic chemistry pertaining to the use of multifunctional ligands for enhanced effect…”
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Metal complexes in medicinal chemistry: new vistas and challenges in drug design by Thompson, Katherine H, Orvig, Chris

“…An overview is presented of selected metal-based pharmaceuticals, either diagnostic or therapeutic, with emphasis on specific attributes and in vivo…”
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Vanadium in diabetes: 100 years from Phase 0 to Phase I by Thompson, Katherine H., Orvig, Chris

“…A little over one hundred years ago, a vanadium-containing compound was assessed clinically for use in treatment of human diabetic patients. The results were…”
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Metal complexes of maltol and close analogues in medicinal inorganic chemistry by Thompson, Katherine H, Barta, Cheri A, Orvig, Chris

“…The family of hydroxypyrones and close congeners, the hydroxypyridinones, is a particularly versatile class of ligands. The most widely investigated for…”
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Vanadium Complexes as Insulin Mimetic Agents:  Coordination Chemistry and in Vivo Studies of Oxovanadium(IV) and Dioxovanadate(V) Complexes Formed from Naturally Occurring Chelating Oxazolinate, Thiazolinate, or Picolinate Units by Melchior, Marco, Thompson, Katherine H, Jong, Janet M, Rettig, Steven J, Shuter, Ed, Yuen, Violet G, Zhou, Ying, McNeill, John H, Orvig, Chris

“…The synthesis and characterization of four complexes containing naturally occurring binding groups are reported:  VO(pic)2·H2O (Hpic = picolinic or…”
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Coordination chemistry of vanadium in metallopharmaceutical candidate compounds by Thompson, Katherine H, Orvig, Chris

“…The discovery of vanadium's insulin-like behaviour in vitro, and later of the orally available glucose- and lipid-lowering capability of these same compounds…”
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Vanadium Compounds as Insulin Mimics by Thompson, Katherine H., McNeill, John H., Orvig, Chris

“…Thompson et al discuss the chemistry of the vanadium and peroxovanadium complexes deemed to have potential as insulin-mimetic agents in the treatment of human…”
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Lanthanide containing compounds for therapeutic care in bone resorption disorders by Barta, Cheri A, Sachs-Barrable, Kristina, Jia, Jessica, Thompson, Katherine H, Wasan, Kishor M, Orvig, Chris

“…Lanthanide ions, Ln(III), are known functional mimics of Ca(II) ions and have been shown to affect the bone remodeling cycle. Exploiting this disruption to the…”
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New Insights into the Interactions of Serum Proteins with Bis(maltolato)oxovanadium(IV):  Transport and Biotransformation of Insulin-Enhancing Vanadium Pharmaceuticals by Liboiron, Barry D, Thompson, Katherine H, Hanson, Graeme R, Lam, Edmond, Aebischer, Nicolas, Orvig, Chris

“…Significant new insights into the interactions of the potent insulin-enhancing compound bis(maltolato)oxovanadium(IV) (BMOV) with the serum proteins,…”
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Editorial: lanthanide compounds for therapeutic and diagnostic applications by Thompson, Katherine H, Orvig, Chris

“…The medical applications of lanthanides are diverse: MRI contrast agents, hypophosphatemic agents for kidney dialysis patients, luminescent probes in cell…”
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Synthesis and characterization of dual function vanadyl, gallium and indium curcumin complexes for medicinal applications by Mohammadi, Khosro, Thompson, Katherine H., Patrick, Brian O., Storr, Tim, Martins, Candice, Polishchuk, Elena, Yuen, Violet G., McNeill, John H., Orvig, Chris

“…Novel bis[4-hydroxy-3-methoxyphenyl]-1,6-heptadiene-3,5-dione (curcumin) complexes with the formula, ML 3, where M is Ga(III) or In(III), or of the formula, ML…”
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In vitro studies of 3-hydroxy-4-pyridinones and their glycosylated derivatives as potential agents for Alzheimer's disease by Green, David E, Bowen, Meryn L, Scott, Lauren E, Storr, Tim, Merkel, Michael, Böhmerle, Karin, Thompson, Katherine H, Patrick, Brian O, Schugar, Harvey J, Orvig, Chris

“…Glycosides of 3-hydroxy-4-pyridinones were synthesized and characterized by mass spectrometry, elemental analysis, (1)H and (13)C NMR spectroscopy, and in one…”
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Glycosylated tetrahydrosalens as multifunctional molecules for Alzheimer's therapy by Storr, Tim, Scott, Lauren E, Bowen, Meryn L, Green, David E, Thompson, Katherine H, Schugar, Harvey J, Orvig, Chris

“…The tetrahydrosalens N,N'-bis(2-hydroxybenzyl)-ethane-1,2-diamine ((2)(1)), N,N'-bis(2-hydroxybenzyl)-(-)-1,2-cyclohexane-(1R,2R)-diamine ((2)(2)),…”
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Vanadium Complexes with Mixed O,S Anionic Ligands Derived from Maltol:  Synthesis, Characterization, and Biological Studies by Monga, Vishakha, Thompson, Katherine H, Yuen, Violet G, Sharma, Vijay, Patrick, Brian O, McNeill, John H, Orvig, Chris

“…Four mixed O,S binding bidentate ligand precursors derived from maltol (3-hydroxy-2-methyl-4-pyrone) have been chelated to vanadium to yield new…”
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Complementary inhibition of synoviocyte, smooth muscle cell or mouse lymphoma cell proliferation by a vanadyl curcumin complex compared to curcumin alone by Thompson, Katherine H., Böhmerle, Karin, Polishchuk, Elena, Martins, Candice, Toleikis, Philip, Tse, Jeremy, Yuen, Violet, McNeill, John H., Orvig, Chris

“…A novel vanadyl curcumin complex (VO(cur) 2) has been synthesized and and its physicochemical properties characterized. Biological characterization included in…”
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Comparison of anti-hyperglycemic effect amongst vanadium, molybdenum and other metal maltol complexes by Thompson, Katherine H, Chiles, Jessica, Yuen, Violet G, Tse, Jeremy, McNeill, John H, Orvig, Chris

“…A wide variety of vanadium-containing complexes have been tested, both in vivo and in vitro, as possible therapeutic agents for the oral treatment of type 2…”
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