Search Results - "Thompson, Kary E"

Success and failure in human spermatogenesis as revealed by teratozoospermic RNAs by Platts, Adrian E., Dix, David J., Chemes, Hector E., Thompson, Kary E., Goodrich, Robert, Rockett, John C., Rawe, Vanesa Y., Quintana, Silvina, Diamond, Michael P., Strader, Lillian F., Krawetz, Stephen A.

“…We are coming to appreciate that at fertilization human spermatozoa deliver the paternal genome alongside a suite of structures, proteins and RNAs. Although…”
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Comparing rat and rabbit embryo-fetal developmental toxicity data for 379 pharmaceuticals: on systemic dose and developmental effects by Theunissen, Peter T., Beken, Sonia, Beyer, Bruce, Breslin, William J., Cappon, Gregg D., Chen, Connie L., Chmielewski, Gary, de Schaepdrijver, Luc, Enright, Brian, Foreman, Jennifer E., Harrouk, Wafa, Hew, Kok-Wah, Hoberman, Alan M., Y. Hui, Julia, Knudsen, Thomas B., Laffan, Susan B., Makris, Susan L., Martin, Matthew, McNerney, Mary Ellen, Siezen, Christine L., Stanislaus, Dinesh J., Stewart, Jane, Thompson, Kary E., Tornesi, Belen, Van der Laan, Jan Willem, Weinbauer, Gerhard F., Wood, Sandra, Piersma, Aldert H.

“…A database of embryo-fetal developmental toxicity (EFDT) studies of 379 pharmaceutical compounds in rat and rabbit was analyzed for species differences based…”
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Pegbelfermin, a PEGylated FGF21 analogue, has pharmacology without bone toxicity after 1-year dosing in skeletally-mature monkeys by Thompson, Kary E., Guillot, Martin, Graziano, Michael J., Mangipudy, Raja S., Chadwick, Kristina D.

“…Pegbelfermin (PGBF) is a PEGylated fibroblast growth factor 21 (FGF21) analogue in development for treatment of nonalcoholic steatohepatitis (NASH). Mouse…”
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Science‐Based Approach to Harmonize Contraception Recommendations in Clinical Trials and Pharmaceutical Labels by Bowman, Christopher J., Becourt‐Lhote, Nathalie, Boulifard, Virginie, Cordts, Rüdiger, Corriol‐Rohou, Solange, Enright, Brian, Erkman, Linda, Harris, Jayne, Hartmann, Andreas, Hilpert, Jan, Kervyn, Sophie, Mattson, Britta, Morford, LaRonda, Muller, Mireille, Powell, Marcy, Sobol, Zhanna, Srinivasan, Rajamuthu, Stark, Claudia, Thompson, Kary E., Turner, Katie J., Barrow, Paul

“…This review presents a European Federation of Pharmaceutical Industries and Association/PreClinical Development Expert Group (EFPIA‐PDEG) topic group consensus…”
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Differences between rats and mice in the involvement of the aryl hydrocarbon receptor in 4-vinylcyclohexene diepoxide-induced ovarian follicle loss by Thompson, Kary E., Bourguet, Shannon M., Christian, Patricia J., Benedict, Jamie C., Sipes, I. Glenn, Flaws, Jodi A., Hoyer, Patricia B.

“…Repeated dosing with the occupational chemical 4-vinylcyclohexene diepoxide (VCD) selectively depletes small pre-antral follicles in the ovaries of rats and…”
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Assessment of cervical passage of vital dyes in pregnant, nonpregnant, and mated rats and mice by Thompson, Kary E., Rayhon, Stephanie L., Bailey, Graham, Delille, Peter, McNerney, Mary Ellen

“…•Vital dyes do not cross the cervix following vaginal administration.•Rat semen does not move vital dyes into uterus following natural mating.•Traditional…”
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Scientific and Regulatory Policy Committee Points to Consider Review: Inclusion of Reproductive and Pathology End Points for Assessment of Reproductive and Developmental Toxicity in Pharmaceutical Drug Development by Halpern, Wendy G., Ameri, Mehrdad, Bowman, Christopher J., Elwell, Michael R., Mirsky, Michael L., Oliver, Julian, Regan, Karen S., Remick, Amera K., Sutherland, Vicki L., Thompson, Kary E., Tremblay, Claudine, Yoshida, Midori, Tomlinson, Lindsay

“…Standard components of nonclinical toxicity testing for novel pharmaceuticals include clinical and anatomic pathology, as well as separate evaluation of…”
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Comparison of rat and rabbit embryo-fetal developmental toxicity data for 379 pharmaceuticals: on the nature and severity of developmental effects by Theunissen, Peter T., Beken, Sonja, Beyer, Bruce K., Breslin, William J., Cappon, Gregg D., Chen, Connie L., Chmielewski, Gary, De Schaepdrijver, Luc, Enright, Brian, Foreman, Jennifer E., Harrouk, Wafa, Hew, Kok-Wah, Hoberman, Alan M., Hui, Julia Y., Knudsen, Thomas B., Laffan, Susan B., Makris, Susan L., Martin, Matt, McNerney, Mary Ellen, Siezen, Christine L., Stanislaus, Dinesh J., Stewart, Jane, Thompson, Kary E., Tornesi, Belen, Van der Laan, Jan Willem, Weinbauer, Gerhard F., Wood, Sandra, Piersma, Aldert H.

“…Regulatory non-clinical safety testing of human pharmaceuticals typically requires embryo-fetal developmental toxicity (EFDT) testing in two species (one…”
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Rethinking developmental toxicity testing: Evolution or revolution? by Scialli, Anthony R., Daston, George, Chen, Connie, Coder, Prägati S., Euling, Susan Y., Foreman, Jennifer, Hoberman, Alan M., Hui, Julia, Knudsen, Thomas, Makris, Susan L., Morford, LaRonda, Piersma, Aldert H., Stanislaus, Dinesh, Thompson, Kary E.

“…Background Current developmental toxicity testing adheres largely to protocols suggested in 1966 involving the administration of test compound to pregnant…”
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Evaluation of early fetal exposure to vaginally-administered metronidazole in pregnant cynomolgus monkeys by Thompson, Kary E., Newcomb, Deanna L., Moffat, Graeme J., Zalikowski, Julie, Chellman, Gary J., McNerney, Mary Ellen

“…•Maternal and fetal exposure are comparable after intravaginal dosing.•Metronidazole does not accumulate in the fetus after maternal intravaginal dosing.•Fetal…”
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Potential seminal transport of pharmaceuticals to the conceptus by Scialli, Anthony R., Bailey, Graham, Beyer, Bruce K., Bøgh, Ingrid Brück, Breslin, William J., Chen, Connie L., DeLise, Anthony M., Hui, Julia Y., Moffat, Graeme J., Stewart, Jane, Thompson, Kary E.

“…•Exposure of the conceptus to pharmaceuticals in semen can be modeled using conservative assumptions.•Modeling for small molecules predicts large multiples of…”
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Reprint of “Potential seminal transport of pharmaceuticals to the conceptus” by Scialli, Anthony R., Bailey, Graham, Beyer, Bruce K., Bøgh, Ingrid Brück, Breslin, William J., Chen, Connie L., DeLise, Anthony M., Hui, Julia Y., Moffat, Graeme J., Stewart, Jane, Thompson, Kary E.

“…•Exposure of the conceptus to pharmaceuticals in semen can be modeled using conservative assumptions.•Modeling for small molecules predicts large multiples of…”
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Allogeneic murine pregnancy models for assessing the developmental effects of immune‐stimulating antibodies: Challenges in reproducibility by Thompson, Kary E., Danberry, Tracy L., Bunch, Roderick T., Graziano, Michael J., McNerney, Mary E.

“…Literature suggests that murine allogeneic pregnancy models are an alternative approach for evaluating the developmental toxicity of immune‐stimulating agents…”
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Introduction to the HESI DART Drugs in Semen Consortium by Chen, Connie L., Beyer, Bruce K., Breslin, William J., DeLise, Anthony M., Hui, Julia Y., Moffat, Graeme J., Thompson, Kary E.

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Effects of Storage, RNA Extraction, Genechip Type, and Donor Sex on Gene Expression Profiling of Human Whole Blood by Kim, Sung Jae, Dix, David J, Thompson, Kary E, Murrell, Rachel N, Schmid, Judith E, Gallagher, Jane E, Rockett, John C

“…Gene expression profiling of whole blood may be useful for monitoring toxicological exposure and for diagnosis and monitoring of various diseases. Several…”
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Effect of conazole fungicides on reproductive development in the female rat by Rockett, John C., Narotsky, Michael G., Thompson, Kary E., Thillainadarajah, Inthirany, Blystone, Chad R., Goetz, Amber K., Ren, Hongzu, Best, Deborah S., Murrell, Rachel N., Nichols, Harriette P., Schmid, Judith E., Wolf, Douglas C., Dix, David J.

“…Three triazole fungicides were evaluated for effects on female rat reproductive development. Rats were exposed via feed to propiconazole (P) (100, 500, or 2500…”
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Apoptosis Induced in Rats by 4-Vinylcyclohexene Diepoxide Is Associated with Activation of the Caspase Cascades by XIAOMING HU, CHRISTIAN, Patricia J, THOMPSON, Kary E, SIPES, I. Glenn, HOYER, Patricia B

“…Previous studies have shown that ovotoxicity induced in rats by dosing with 4-vinylcyclohexene diepoxide (VCD) is likely via acceleration of the normal rate of…”
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Ovarian Toxicity of 4-Vinylcyclohexene Diepoxide: A Mechanistic Model by Hoyer, Patricia B., Devine, Patrick J., Xiaoming Hu, Thompson, Kary E., Sipes, I. Glenn

“…Female mammals are born with a fi nite number of ovarian primordial follicles that cannot be regenerated; thus, chemicals that destroy oocytes contained in…”
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17β-Estradiol Affords Protection against 4-Vinylcyclohexene Diepoxide-Induced Ovarian Follicle Loss in Fischer-344 Rats by Thompson, Kary E, Sipes, I. Glenn, Greenstein, Ben D, Hoyer, Patricia B

“…Repeated dosing with 4-vinylcyclohexene diepoxide (VCD) accelerates atresia via apoptosis in primordial and primary follicles in ovaries of rats. The…”
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17beta-estradiol affords protection against 4-vinylcyclohexene diepoxide-induced ovarian follicle loss in Fischer-344 rats by Thompson, Kary E, Sipes, I Glenn, Greenstein, Ben D, Hoyer, Patricia B

“…Repeated dosing with 4-vinylcyclohexene diepoxide (VCD) accelerates atresia via apoptosis in primordial and primary follicles in ovaries of rats. The…”
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