Search Results - "Thompson, Jeremy G"
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Metabolic co-dependence of the oocyte and cumulus cells: essential role in determining oocyte developmental competence
Published in Human reproduction update (04-01-2021)“…Abstract BACKGROUND Within the antral follicle, the oocyte is reliant on metabolic support from its surrounding somatic cells. Metabolism plays a critical role…”
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Bidirectional communication between cumulus cells and the oocyte: Old hands and new players?
Published in Theriogenology (01-07-2016)“…Cumulus cell–oocyte communication is an essential feature of mammalian reproduction. Established mechanisms involve the bidirectional transfer of ions and…”
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HYPOXIA AND REPRODUCTIVE HEALTH: Hypoxia and ovarian function: follicle development, ovulation, oocyte maturation
Published in Reproduction (Cambridge, England) (01-01-2021)“…The ovarian follicle provides the oocyte with the ideal environment for growth and development in preparation for ovulation and fertilisation. The follicle…”
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Oocyte-secreted factors: regulators of cumulus cell function and oocyte quality
Published in Human reproduction update (01-03-2008)“…Oocyte quality is a key limiting factor in female fertility, yet we have a poor understanding of what constitutes oocyte quality or the mechanisms governing…”
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The definition of IVM is clear—variations need defining
Published in Human reproduction (Oxford) (01-11-2016)“…Abstract Oocyte in vitro maturation (IVM) is currently defined as the maturation in vitro of immature cumulus–oocyte complexes collected from antral follicles…”
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The pivotal role of glucose metabolism in determining oocyte developmental competence
Published in Reproduction (Cambridge, England) (01-04-2010)“…The environment that the cumulus oocyte complex (COC) is exposed to during either in vivo or in vitro maturation (IVM) can have profound effects on the success…”
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Oocyte-secreted factors enhance oocyte developmental competence
Published in Developmental biology (15-08-2006)“…The capacity of fully grown oocytes to regulate their own microenvironment by paracrine factors secreted by the oocyte (oocyte-secreted factors, OSFs) may in…”
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Nano-liter perfusion microfluidic device made entirely by two-photon polymerization for dynamic cell culture with easy cell recovery
Published in Scientific reports (11-01-2023)“…Polydimethylsiloxane (PDMS) has been the material of choice for microfluidic applications in cell biology for many years, with recent advances encompassing…”
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Oocyte maturation: Emerging concepts and technologies to improve developmental potential in vitro
Published in Theriogenology (2007)“…Oocyte in vitro maturation (IVM) is an important reproductive technology that generates mature oocytes that are capable of supporting preimplantation embryo…”
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Biphasic in vitro maturation with C-type natriuretic peptide enhances the developmental competence of juvenile-goat oocytes
Published in PloS one (23-08-2019)“…In vitro embryo production success in juvenile animals is compromised due to their intrinsic lower oocyte quality. Conventional in vitro maturation (IVM)…”
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Promotion of EGF receptor signaling improves the quality of low developmental competence oocytes
Published in Developmental biology (15-07-2015)“…Oocytes acquire developmental competence with progressive folliculogenesis. Cumulus oocyte complexes (COCs) from small antral follicles have inherent low…”
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Bone morphogenetic protein 15 in the pro-mature complex form enhances bovine oocyte developmental competence
Published in PloS one (24-07-2014)“…Developmental competence of in vitro matured (IVM) oocytes needs to be improved and this can potentially be achieved by adding recombinant bone morphogenetic…”
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Utilization of endogenous fatty acid stores for energy production in bovine preimplantation embryos
Published in Theriogenology (01-05-2012)“…Although current embryo culture media are based on carbohydrate metabolism of embryos, little is known about metabolism of endogenous lipids. L-carnitine is a…”
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Boronate probes for the detection of hydrogen peroxide release from human spermatozoa
Published in Free radical biology & medicine (01-04-2015)“…Human spermatozoa are compromised by production of reactive oxygen species (ROS), and detection of ROS in spermatozoa is important for the diagnosis of male…”
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Fibroblast growth factor 17 and bone morphogenetic protein 15 enhance cumulus expansion and improve quality of in vitro–produced embryos in cattle
Published in Theriogenology (01-08-2015)“…Bone morphogenetic protein 15 (BMP15) and members of the fibroblast growth factor (FGF) family are expressed by the oocyte and are involved in the control of…”
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A Dual Sensor for pH and Hydrogen Peroxide Using Polymer-Coated Optical Fibre Tips
Published in Sensors (Basel, Switzerland) (17-12-2015)“…This paper demonstrates the first single optical fibre tip probe for concurrent detection of both hydrogen peroxide (H₂O₂) concentration and pH of a solution…”
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Oocytes prevent cumulus cell apoptosis by maintaining a morphogenic paracrine gradient of bone morphogenetic proteins
Published in Journal of cell science (15-11-2005)“…Paracrine factors secreted by the oocyte regulate a broad range of cumulus cell functions. Characteristically, cumulus cells have a low incidence of apoptosis…”
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Bone morphogenetic protein 15 and fibroblast growth factor 10 enhance cumulus expansion, glucose uptake, and expression of genes in the ovulatory cascade during in vitro maturation of bovine cumulus–oocyte complexes
Published in Reproduction (Cambridge, England) (01-07-2013)“…Oocyte-secreted factors (OSFs) regulate differentiation of cumulus cells and are of pivotal relevance for fertility. Bone morphogenetic protein 15 (BMP15) and…”
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Regulation of sheep oocyte maturation using cAMP modulators
Published in Theriogenology (2013)“…Physical removal of mammalian cumulus-oocyte complexes (COCs) from ovarian follicles results in spontaneous resumption of meiosis, largely because of a…”
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The effect of streptozotocin-induced hyperglycemia on N-and O-linked protein glycosylation in mouse ovary
Published in Glycobiology (Oxford) (01-11-2018)“…Post-translational modification of proteins namely glycosylation influences cellular behavior, structural properties and interactions including during ovarian…”
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