Search Results - "Thompson, Jeffrey F"

Matrix metalloproteinase-mediated disruption of tight junction proteins in cerebral vessels is reversed by synthetic matrix metalloproteinase inhibitor in focal ischemia in rat by Yang, Yi, Estrada, Eduardo Y, Thompson, Jeffrey F, Liu, Wenlan, Rosenberg, Gary A

“…Matrix metalloproteinases (MMPs) disrupt the blood—brain barrier (BBB) during reperfusion. Occludin and claudins are recently described tight junction proteins…”
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Attenuation of acute stroke injury in rat brain by minocycline promotes blood-brain barrier remodeling and alternative microglia/macrophage activation during recovery by Yang, Yirong, Salayandia, Victor M, Thompson, Jeffrey F, Yang, Lisa Y, Estrada, Eduardo Y, Yang, Yi

“…Minocycline reduces reperfusion injury by inhibiting matrix metalloproteinases (MMPs) and microglia activity after cerebral ischemia. Prior studies of…”
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Vascular tight junction disruption and angiogenesis in spontaneously hypertensive rat with neuroinflammatory white matter injury by Yang, Yi, Kimura-Ohba, Shihoko, Thompson, Jeffrey F., Salayandia, Victor M., Cossé, Melissa, Raz, Limor, Jalal, Fakhreya Y., Rosenberg, Gary A.

“…Vascular cognitive impairment is a major cause of dementia caused by chronic hypoxia, producing progressive damage to white matter (WM) secondary to…”
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Hypoxia-Induced Neuroinflammatory White-Matter Injury Reduced by Minocycline in SHR/SP by Jalal, Fakhreya Y, Yang, Yi, Thompson, Jeffrey F, Roitbak, Tamara, Rosenberg, Gary A

“…Hypertensive small vessel disease is a major cause of vascular cognitive impairment (VCI). Spontaneously hypertensive/stroke prone rats (SHR/SP) with…”
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Early Inhibition of MMP Activity in Ischemic Rat Brain Promotes Expression of Tight Junction Proteins and Angiogenesis During Recovery by Yang, Yi, Thompson, Jeffrey F, Taheri, Saeid, Salayandia, Victor M, McAvoy, Thera A, Hill, Jeff W, Yang, Yirong, Estrada, Eduardo Y, Rosenberg, Gary A

“…In cerebral ischemia, matrix metalloproteinases (MMPs) have a dual role by acutely disrupting tight junction proteins (TJPs) in the blood-brain barrier (BBB)…”
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Multi-vendor and multisite evaluation of cerebrovascular reactivity mapping using hypercapnia challenge by Liu, Peiying, Jiang, Dengrong, Albert, Marilyn, Bauer, Christopher E., Caprihan, Arvind, Gold, Brian T., Greenberg, Steven M., Helmer, Karl G., Jann, Kay, Jicha, Gregory, Rodriguez, Pavel, Satizabal, Claudia L., Seshadri, Sudha, Singh, Herpreet, Thompson, Jeffrey F., Wang, Danny J.J., Lu, Hanzhang

“…Cerebrovascular reactivity (CVR), which measures the ability of cerebral blood vessels to dilate or constrict in response to vasoactive stimuli such as CO2…”
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Tissue inhibitor of metalloproteinases-3 mediates the death of immature oligodendrocytes via TNF-α/TACE in focal cerebral ischemia in mice by Yang, Yi, Jalal, Fakhreya Y, Thompson, Jeffrey F, Walker, Espen J, Candelario-Jalil, Eduardo, Li, Lu, Reichard, Ross R, Ben, Chi, Sang, Qing-Xiang, Cunningham, Lee Anna, Rosenberg, Gary A

“…Oligodendrocyte (OL) death is important in focal cerebral ischemia. TIMP-3 promotes apoptosis in ischemic neurons by inhibiting proteolysis of TNF-α…”
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Identification of isoxsuprine hydrochloride as a neuroprotectant in ischemic stroke through cell-based high-throughput screening by Hill, Jeff W, Thompson, Jeffrey F, Carter, Mark B, Edwards, Bruce S, Sklar, Larry A, Rosenberg, Gary A

“…Stroke is a leading cause of death and disability and treatment options are limited. A promising approach to accelerate the development of new therapeutics is…”
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Placental growth factor as a sensitive biomarker for vascular cognitive impairment by Hinman, Jason D., Elahi, Fanny, Chong, Davis, Radabaugh, Hannah, Ferguson, Adam, Maillard, Pauline, Thompson, Jeffrey F, Rosenberg, Gary A., Sagare, Abhay, Moghekar, Abhay, Lu, Hanzhang, Lee, Tiffany, Wilcock, Donna, Satizabal, Claudia L., Tracy, Russell, Seshadri, Sudha, Schwab, Kristin, Helmer, Karl, Singh, Herpreet, Kivisäkk, Pia, Greenberg, Steve, DeCarli, Charlie, Kramer, Joel

“…INTRODUCTION High‐performing biomarkers measuring the vascular contributions to cognitive impairment and dementia are lacking. METHODS Using a multi‐site…”
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Treatment with Atorvastatin During Vascular Remodeling Promotes Pericyte-Mediated Blood-Brain Barrier Maturation Following Ischemic Stroke by Yang, Yirong, Yang, Lisa Y., Salayandia, Victor M., Thompson, Jeffrey F., Torbey, Michel, Yang, Yi

“…We previously showed that newly formed vessels in ischemic rat brain have high blood-brain barrier (BBB) permeability at 3 weeks after stroke due to a lack of…”
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Increased intranuclear matrix metalloproteinase activity in neurons interferes with oxidative DNA repair in focal cerebral ischemia by Yang, Yi, Candelario-Jalil, Eduardo, Thompson, Jeffrey F, Cuadrado, Eloy, Estrada, Eduardo Y, Rosell, Anna, Montaner, Joan, Rosenberg, Gary A

“…Increased matrix metalloproteinase (MMP) activity is implicated in proteolysis of extracellular matrix in ischemic stroke. We recently observed intranuclear…”
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Substantia nigra pars reticulata neurons code initiation of a serial pattern: implications for natural action sequences and sequential disorders by Meyer-Luehmann, Melanie, Thompson, Jeffrey F., Berridge, Kent C., Aldridge, J. Wayne

“…Sequences of movements are initiated abnormally in neurological disorders involving basal ganglia dysfunction, such as Parkinson's disease or Tourette's…”
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Multi-Site Cross-Site Inter-Rater and Test-Retest Reliability and Construct Validity of the MarkVCID White Matter Hyperintensity Growth and Regression Protocol by Bahrani, Ahmed A, Abner, Erin L, DeCarli, Charles S, Barber, Justin M, Sutton, Abigail C, Maillard, Pauline, Sandoval, Francisco, Arfanakis, Konstantinos, Yang, Yung-Chuan, Evia, Arnold M, Schneider, Julie A, Habes, Mohamad, Franklin, Crystal G, Seshadri, Sudha, Satizabal, Claudia L, Caprihan, Arvind, Thompson, Jeffrey F, Rosenberg, Gary A, Wang, Danny J J, Jann, Kay, Zhao, Chenyang, Lu, Hanzhang, Rosenberg, Paul B, Albert, Marilyn S, Ali, Doaa G, Singh, Herpreet, Schwab, Kristin, Greenberg, Steven M, Helmer, Karl G, Powel, David K, Gold, Brian T, Goldstein, Larry B, Wilcock, Donna M, Jicha, Gregory A

“…White matter hyperintensities (WMH) that occur in the setting of vascular cognitive impairment and dementia (VCID) may be dynamic increasing or decreasing…”
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Abstract T MP21: Administration Of Atorvastatin During Angiogenesis After Stroke Promotes Long-term Restoration Of BBB In Peri-infarct Regions Of Rat Brains by Salayandia, Victor M, Yang, Yi R, Yang, Lisa, Thompson, Jeffrey F, Yang, Yi

“…Abstract only Our previous study shows that the newly formed vessels in peri-infarct regions of ischemic hemispheres have hyperperfusion and high blood-brain…”
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Abstract TMP110: Minocycline Reduces Hypoxia-mediated BBB Disruption by Protecting TJP Degradation and Promoting Angiogenesis in SHR/SP With Chronic White-matter Injury by Yang, Yi, Kimura-Ohba, Shihoko, Thompson, Jeffrey F, Salayandia, Victor M, Cosse, Millie, Raz, Limor, Jalal, Fakhreya Y, Rosenberg, Gary A

“…Abstract only Introduction: Our previous study indicated that blood-brain barrier (BBB) disruption occurred secondary to hypoxia-induced and MMP-mediated…”
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Abstract W MP42: Early Treatment With Minocycline Promotes Neurovascular Remodeling of Tight Junctions Facilitating Recovery After Stroke in Rat Brain by Yang, Yi R, Salayandia, Victor M, Estrata, Eduardo Y, Thompson, Jeffrey F, Rosenberg, Gary A, Yang, Yi

“…Abstract only Minocycline (Mino) reduces reperfusion injury and inflammation after stroke in animals and humans, but the late effects on remodeling of the…”
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Tissue inhibitor of metalloproteinases-3 mediates the death of immature oligodendrocytes via TNF-[alpha]/TACE in focal cerebral ischemia in mice by Yang, Yi, Jalal, Fakhreya Y, Thompson, Jeffrey F, Walker, Espen J, Candelario-Jalil, Eduardo, Li, Lu, Reichard, Ross R, Ben, Chi, Sang, Qing-Xiang, Cunningham, Lee Anna, Rosenberg, Gary A

“…Background and Purpose Oligodendrocyte (OL) death is important in focal cerebral ischemia. TIMP-3 promotes apoptosis in ischemic neurons by inhibiting…”
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