Search Results - "Thompson, Gilbert R"

Use of apheresis in the age of new therapies for familial hypercholesterolaemia by Thompson, Gilbert R.

“…Purpose of review Lipoprotein apheresis has been first line therapy for homozygous familial hypercholesterolaemia (FH) and other severe and refractory forms of…”
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The scientific basis and future of lipoprotein apheresis by Thompson, Gilbert R.

“…Lipoprotein apheresis plays a vital role in the management of the severe hyperlipidemias that predispose to atherosclerosis. Determinants of efficacy are the…”
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FH through the retrospectoscope by Thompson, Gilbert R.

“…After training as a gastroenterologist in the UK, the author became interested in lipidology while he was a research fellow in the USA and switched careers…”
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International Atherosclerosis Society guidance for implementing best practice in the care of familial hypercholesterolaemia by Watts, Gerald F., Gidding, Samuel S., Hegele, Robert A., Raal, Frederick J., Sturm, Amy C., Jones, Laney K., Sarkies, Mitchell N., Al-Rasadi, Khalid, Blom, Dirk J., Daccord, Magdalena, de Ferranti, Sarah D., Folco, Emanuela, Libby, Peter, Mata, Pedro, Nawawi, Hapizah M., Ramaswami, Uma, Ray, Kausik K., Stefanutti, Claudia, Yamashita, Shizuya, Pang, Jing, Thompson, Gilbert R., Santos, Raul D.

“…This contemporary, international, evidence-informed guidance aims to achieve the greatest good for the greatest number of people with familial…”
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Efficacy criteria and cholesterol targets for LDL apheresis by Thompson, Gilbert R, Barbir, M, Davies, D, Dobral, P, Gesinde, M, Livingston, M, Mandry, P, Marais, A.D, Matthews, S, Neuwirth, C, Pottle, A, le Roux, C, Scullard, D, Tyler, C, Watkins, S

“…Abstract Low density lipoprotein (LDL) apheresis is now accepted as the treatment of choice for patients with homozygous familial hypercholesterolaemia and for…”
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History and Development of Plant Sterol and Stanol Esters for Cholesterol-Lowering Purposes by Thompson, Gilbert R., Grundy, Scott M.

“…Plant stanol esters provide a novel approach to lowering plasma low-density lipoprotein (LDL) cholesterol by dietary means. Their development was preceded by a…”
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PCSK9 Inhibitors for Homozygous Familial Hypercholesterolemia: Useful But Seldom Sufficient by Thompson, Gilbert R.

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Atherosclerosis in cholesterol-fed rabbits and in homozygous and heterozygous LDL receptor-deficient humans by Thompson, Gilbert R.

“…A phenocopy is an environmentally-defined phenotype that mimics another, genetically-determined phenotype. The severity of hypercholesterolaemia, extent of…”
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Additive Effects of Plant Sterol and Stanol Esters to Statin Therapy by Thompson, Gilbert R.

“…Plant sterol and stanol esters each have similar additive effects in lowering low-density lipoprotein cholesterol when combined with statins. They differ in…”
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Survival in homozygous familial hypercholesterolaemia is determined by the on-treatment level of serum cholesterol by Thompson, Gilbert R, Blom, Dirk J, Marais, A David, Seed, Mary, Pilcher, Gillian J, Raal, Frederick J

“…Abstract Aims Homozygous familial hypercholesterolaemia (FH) is a rare inherited disorder characterized by extreme hypercholesterolaemia from birth,…”
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Comparison of Efficacy of Plant Stanol Ester and Sterol Ester: Short-Term and Longer-Term Studies by O’Neill, Frans H., Sanders, Tom A.B., Thompson, Gilbert R.

“…Published data suggest that the cholesterol-lowering effect of dietary plant sterol esters is less marked in longer-term than in short-term studies, whereas…”
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Lipoprotein Apheresis in the Management of Familial Hypercholesterolaemia: Historical Perspective and Recent Advances by Stefanutti, Claudia, Thompson, Gilbert R.

“…At present, lipoprotein apheresis, combined with high-dose statin and ezetimibe therapy, is the best available means of treating patients with homozygous and…”
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Lipoprotein apheresis by Thompson, Gilbert R

“…Lipoprotein apheresis is being performed with increasing frequency, but better data collection and recording of clinical outcomes are needed. Setting up…”
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Obituary of Dr N.B. Myant by Thompson, Gilbert R

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Lipoprotein Apheresis: Utility, Outcomes, and Implementation in Clinical Practice: A Scientific Statement From the American Heart Association by Gianos, Eugenia, Duell, P Barton, Toth, Peter P, Moriarty, Patrick M, Thompson, Gilbert R, Brinton, Eliot A, Hudgins, Lisa C, Nametka, Mary, Byrne, Kathleen H, Raghuveer, Geetha, Nedungadi, Prashant, Sperling, Laurence S

“…Despite the availability of multiple classes of lipoprotein-lowering medications, some high-risk patients have persistent hypercholesterolemia and may require…”
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Lipoprotein(a): the underestimated cardiovascular risk factor by Thompson, Gilbert R, Seed, Mary

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Improved cardiovascular outcomes following temporal advances in lipid-lowering therapy in a genetically-characterised cohort of familial hypercholesterolaemia homozygotes by Thompson, Gilbert R, Seed, Mary, Naoumova, Rossi P, Neuwirth, Clare, Walji, Shahenaz, Aitman, Timothy J, Scott, James, Myant, Nicolas B, Soutar, Anne K

“…Abstract Background and aims There is a paucity of data concerning the influence of lipid-lowering therapy on cardiovascular (CV) outcomes in patients with…”
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LDL apheresis by Thompson, Gilbert R

“…Low density lipoprotein (LDL) apheresis provides a safe and effective means of treating patients with homozygous familial hypercholesterolaemia (FH). It also…”
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Severe hypercholesterolaemia: therapeutic goals and eligibility criteria for LDL apheresis in Europe by Thompson, Gilbert R, Catapano, Alberico, Saheb, Samir, Atassi-Dumont, Marielle, Barbir, Mahmoud, Eriksson, Mats, Paulweber, Bernhard, Sijbrands, Eric, Stalenhoef, Anton F, Parhofer, Klaus G

“…Despite the use of currently available lipid-lowering therapies, a significant proportion of patients with severe hypercholesterolaemia do not reach treatment…”
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Measurement of the Reflectivity of the Intima-Medial Layer of the Common Carotid Artery Improves the Discriminatory Value of Intima-Medial Thickness Measurement as a Predictor of Risk of Atherosclerotic Disease by Ellis, Stephen M, Naoumova, Rossi P, Neuwirth, Clare K, Eckersley, Robert, Cosgrove, David O, Thompson, Gilbert R, Sidhu, Paul S

“…Abstract Our aim was to assess the predictive value of a measurement of intima-medial layer (IML) reflectivity in the differentiation of pathological from…”
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