Search Results - "Thompson, Elizabeth A"

Identity by descent: variation in meiosis, across genomes, and in populations by Thompson, Elizabeth A

“…Gene identity by descent (IBD) is a fundamental concept that underlies genetically mediated similarities among relatives. Gene IBD is traced through ancestral…”
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Efficient Targeting and Activation of Antigen-Presenting Cells In Vivo after Modified mRNA Vaccine Administration in Rhesus Macaques by Liang, Frank, Lindgren, Gustaf, Lin, Ang, Thompson, Elizabeth A., Ols, Sebastian, Röhss, Josefine, John, Shinu, Hassett, Kimberly, Yuzhakov, Olga, Bahl, Kapil, Brito, Luis A., Salter, Hugh, Ciaramella, Giuseppe, Loré, Karin

“…mRNA vaccines are rapidly emerging as a powerful platform for infectious diseases because they are well tolerated, immunogenic, and scalable and are built on…”
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Route of Vaccine Administration Alters Antigen Trafficking but Not Innate or Adaptive Immunity by Ols, Sebastian, Yang, Lifei, Thompson, Elizabeth A., Pushparaj, Pradeepa, Tran, Karen, Liang, Frank, Lin, Ang, Eriksson, Bengt, Karlsson Hedestam, Gunilla B., Wyatt, Richard T., Loré, Karin

“…Although intramuscular (i.m.) administration is the most commonly used route for licensed vaccines, subcutaneous (s.c.) delivery is being explored for several…”
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Vaccine priming is restricted to draining lymph nodes and controlled by adjuvant-mediated antigen uptake by Liang, Frank, Lindgren, Gustaf, Sandgren, Kerrie J, Thompson, Elizabeth A, Francica, Joseph R, Seubert, Anja, De Gregorio, Ennio, Barnett, Susan, O'Hagan, Derek T, Sullivan, Nancy J, Koup, Richard A, Seder, Robert A, Loré, Karin

“…The innate immune mechanisms by which adjuvants enhance the potency and protection of vaccine-induced adaptive immunity are largely unknown. We introduce a…”
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Metabolic programs define dysfunctional immune responses in severe COVID-19 patients by Thompson, Elizabeth A., Cascino, Katherine, Ordonez, Alvaro A., Zhou, Weiqiang, Vaghasia, Ajay, Hamacher-Brady, Anne, Brady, Nathan R., Sun, Im-Hong, Wang, Rulin, Rosenberg, Avi Z., Delannoy, Michael, Rothman, Richard, Fenstermacher, Katherine, Sauer, Lauren, Shaw-Saliba, Kathyrn, Bloch, Evan M., Redd, Andrew D., Tobian, Aaron A.R., Horton, Maureen, Smith, Kellie, Pekosz, Andrew, D’Alessio, Franco R., Yegnasubramanian, Srinivasan, Ji, Hongkai, Cox, Andrea L., Powell, Jonathan D.

“…It is unclear why some SARS-CoV-2 patients readily resolve infection while others develop severe disease. By interrogating metabolic programs of immune cells…”
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Tissue Myeloid Cells in SIV-Infected Primates Acquire Viral DNA through Phagocytosis of Infected T Cells by Calantone, Nina, Wu, Fan, Klase, Zachary, Deleage, Claire, Perkins, Molly, Matsuda, Kenta, Thompson, Elizabeth A., Ortiz, Alexandra M., Vinton, Carol L., Ourmanov, Ilnour, Loré, Karin, Douek, Daniel C., Estes, Jacob D., Hirsch, Vanessa M., Brenchley, Jason M.

“…The viral accessory protein Vpx, expressed by certain simian and human immunodeficiency viruses (SIVs and HIVs), is thought to improve viral infectivity of…”
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Induction of Robust B Cell Responses after Influenza mRNA Vaccination Is Accompanied by Circulating Hemagglutinin-Specific ICOS+ PD-1+ CXCR3+ T Follicular Helper Cells by Lindgren, Gustaf, Ols, Sebastian, Liang, Frank, Thompson, Elizabeth A, Lin, Ang, Hellgren, Fredrika, Bahl, Kapil, John, Shinu, Yuzhakov, Olga, Hassett, Kimberly J, Brito, Luis A, Salter, Hugh, Ciaramella, Giuseppe, Loré, Karin

“…Modified mRNA vaccines have developed into an effective and well-tolerated vaccine platform that offers scalable and precise antigen production. Nevertheless,…”
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Androgen receptor activity in prostate cancer dictates efficacy of bipolar androgen therapy through MYC by Sena, Laura A, Kumar, Rajendra, Sanin, David E, Thompson, Elizabeth A, Rosen, D Marc, Dalrymple, Susan L, Antony, Lizamma, Yang, Yuhan, Gomes-Alexandre, Carolina, Hicks, Jessica L, Jones, Tracy, Bowers, Kiara A, Eskra, Jillian N, Meyers, Jennifer, Gupta, Anuj, Skaist, Alyza, Yegnasubramanian, Srinivasan, Luo, Jun, Brennen, W Nathaniel, Kachhap, Sushant K, Antonarakis, Emmanuel S, De Marzo, Angelo M, Isaacs, John T, Markowski, Mark C, Denmeade, Samuel R

“…Testosterone is the canonical growth factor of prostate cancer but can paradoxically suppress its growth when present at supraphysiological levels. We have…”
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Monocytes Acquire the Ability to Prime Tissue-Resident T Cells via IL-10-Mediated TGF-β Release by Thompson, Elizabeth A., Darrah, Patricia A., Foulds, Kathryn E., Hoffer, Elena, Caffrey-Carr, Alayna, Norenstedt, Sophie, Perbeck, Leif, Seder, Robert A., Kedl, Ross M., Loré, Karin

“…Using non-human primates (NHPs), mice, and human primary cells, we found a role for interleukin-10 (IL-10) in the upregulation of the tissue-resident memory…”
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GIGI: An Approach to Effective Imputation of Dense Genotypes on Large Pedigrees by Cheung, Charles Y.K., Thompson, Elizabeth A., Wijsman, Ellen M.

“…Recent emergence of the common-disease-rare-variant hypothesis has renewed interest in the use of large pedigrees for identifying rare causal variants…”
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Atomic layer deposition coating of carbon nanotubes with aluminum oxide alters pro-fibrogenic cytokine expression by human mononuclear phagocytes in vitro and reduces lung fibrosis in mice in vivo by Taylor, Alexia J, McClure, Christina D, Shipkowski, Kelly A, Thompson, Elizabeth A, Hussain, Salik, Garantziotis, Stavros, Parsons, Gregory N, Bonner, James C

“…Multi-walled carbon nanotubes (MWCNTs) pose a possible human health risk for lung disease as a result of inhalation exposure. Mice exposed to MWCNTs develop…”
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STAT1-dependent and -independent pulmonary allergic and fibrogenic responses in mice after exposure to tangled versus rod-like multi-walled carbon nanotubes by Duke, Katherine S, Taylor-Just, Alexia J, Ihrie, Mark D, Shipkowski, Kelly A, Thompson, Elizabeth A, Dandley, Erinn C, Parsons, Gregory N, Bonner, James C

“…Pulmonary toxicity of multi-walled carbon nanotubes (MWCNTs) is influenced by physicochemical characteristics and genetic susceptibility. We hypothesized that…”
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Sulforaphane exhibits antiviral activity against pandemic SARS-CoV-2 and seasonal HCoV-OC43 coronaviruses in vitro and in mice by Ordonez, Alvaro A., Bullen, C. Korin, Villabona-Rueda, Andres F., Thompson, Elizabeth A., Turner, Mitchell L., Merino, Vanessa F., Yan, Yu, Kim, John, Davis, Stephanie L., Komm, Oliver, Powell, Jonathan D., D’Alessio, Franco R., Yolken, Robert H., Jain, Sanjay K., Jones-Brando, Lorraine

“…Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), the cause of coronavirus disease 2019 (COVID-19), has incited a global health crisis. Currently,…”
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Measurement of the Heterocyclic Amines 2‑Amino‑9H‑pyrido[2,3‑b]indole and 2‑Amino-1-methyl-6-phenylimidazo[4,5‑b]pyridine in Urine: Effects of Cigarette Smoking by Konorev, Dmitri, Koopmeiners, Joseph S, Tang, Yijin, Franck Thompson, Elizabeth A, Jensen, Joni A, Hatsukami, Dorothy K, Turesky, Robert J

“…2-Amino-9H-pyrido­[2,3-b]­indole (AαC) and 2-amino-1-methyl-6-phenylimidazo­[4,5-b]­pyridine (PhIP) are carcinogenic heterocyclic aromatic amines (HAAs) formed…”
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Three doses of COVID-19 mRNA vaccine induce class-switched antibody responses in inflammatory arthritis patients on immunomodulatory therapies by Lee, Jenny M, Figueroa, Alexis, Sachithanandham, Jaiprasath, Li, Maggie, Connolly, Caoilfhionn M, Shapiro, Janna R, Chen, Yiqun, Jones, Michelle, Dhara, Venkata Gayatri, Towns, Marilyn, Lee, John S, Peralta, Stephanie R, Milstone, Aaron M, Betenbaugh, Michael, Debes, Amanda K, Blankson, Joel, Sitaras, Ioannis, Yoon, Steve, Thompson, Elizabeth A, Bingham, 3rd, Clifton O, Klein, Sabra L, Pekosz, Andrew, Bailey, Justin R

“…Patients with inflammatory arthritis (IA) are at increased risk of severe COVID-19 due to medication-induced immunosuppression that impairs host defenses. The…”
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T cell metabolic reprogramming in acute kidney injury and protection by glutamine blockade by Lee, Kyungho, Thompson, Elizabeth A, Gharaie, Sepideh, Patel, Chirag H, Kurzhagen, Johanna T, Pierorazio, Phillip M, Arend, Lois J, Thomas, Ajit G, Noel, Sanjeev, Slusher, Barbara S, Rabb, Hamid

“…T cells play an important role in acute kidney injury (AKI). Metabolic programming of T cells regulates their function, is a rapidly emerging field, and is…”
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Activated iNKT cells promote memory CD8+ T cell differentiation during viral infection by Reilly, Emma C, Thompson, Elizabeth A, Aspeslagh, Sandrine, Wands, Jack R, Elewaut, Dirk, Brossay, Laurent

“…α-Galactosylceramide (α-GalCer) is the prototypical lipid ligand for invariant NKT cells. Recent studies have proposed that α-GalCer is an effective adjuvant…”
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Estimation of the Inbreeding Coefficient through Use of Genomic Data by Leutenegger, Anne-Louise, Prum, Bernard, Génin, Emmanuelle, Verny, Christophe, Lemainque, Arnaud, Clerget-Darpoux, Françoise, Thompson, Elizabeth A.

“…Many linkage studies are performed in inbred populations, either small isolated populations or large populations with a long tradition of marriages between…”
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COVID-19 vaccination induces distinct T-cell responses in pediatric solid organ transplant recipients and immunocompetent children by Roznik, Katerina, Xue, Jiashu, Stavrakis, Georgia, Johnston, T. Scott, Kalluri, Divya, Ohsie, Rivka, Qin, Caroline X., McAteer, John, Segev, Dorry L., Mogul, Douglas, Werbel, William A., Karaba, Andrew H., Thompson, Elizabeth A., Cox, Andrea L.

“…Immune responses to COVID-19 vaccination are attenuated in adult solid organ transplant recipients (SOTRs) and additional vaccine doses are recommended for…”
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Inhibition of the Adenosine Pathway to Potentiate Cancer Immunotherapy: Potential for Combinatorial Approaches by Thompson, Elizabeth A, Powell, Jonathan D

“…Cancer immunotherapy has revolutionized the way that we think about treating cancer. Although checkpoint blockade therapy, including anti-PD-1 PD-L1 and…”
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