Search Results - "Thompson, Bonne M."

Niche-Specific Reprogramming of Epigenetic Landscapes Drives Myeloid Cell Diversity in Nonalcoholic Steatohepatitis by Seidman, Jason S., Troutman, Ty D., Sakai, Mashito, Gola, Anita, Spann, Nathanael J., Bennett, Hunter, Bruni, Cassi M., Ouyang, Zhengyu, Li, Rick Z., Sun, Xiaoli, Vu, BaoChau T., Pasillas, Martina P., Ego, Kaori M., Gosselin, David, Link, Verena M., Chong, Ling-Wa, Evans, Ronald M., Thompson, Bonne M., McDonald, Jeffrey G., Hosseini, Mojgan, Witztum, Joseph L., Germain, Ronald N., Glass, Christopher K.

“…Tissue-resident and recruited macrophages contribute to both host defense and pathology. Multiple macrophage phenotypes are represented in diseased tissues,…”
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Interleukins 4 and 13 drive lipid abnormalities in skin cells through regulation of sex steroid hormone synthesis by Zhang, Chenlu, Chinnappan, Mahendran, Prestwood, Courtney A., Edwards, Marshall, Artami, Methinee, Thompson, Bonne M., Eckert, Kaitlyn M., Vale, Goncalo, Zouboulis, Christos C., McDonald, Jeffrey G., Harris-Tryon, Tamia A.

“…Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by skin dryness, inflammation, and itch. A major hallmark of AD is an elevation of…”
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Structural basis for human sterol isomerase in cholesterol biosynthesis and multidrug recognition by Long, Tao, Hassan, Abdirahman, Thompson, Bonne M, McDonald, Jeffrey G, Wang, Jiawei, Li, Xiaochun

“…3-β-hydroxysteroid-Δ 8 , Δ 7 -isomerase, known as Emopamil-Binding Protein (EBP), is an endoplasmic reticulum membrane protein involved in cholesterol…”
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Desmosterol suppresses macrophage inflammasome activation and protects against vascular inflammation and atherosclerosis by Zhang, Xinbo, McDonald, Jeffrey G., Aryal, Binod, Canfrán-Duque, Alberto, Goldberg, Emily L., Araldi, Elisa, Ding, Wen, Fan, Yuhua, Thompson, Bonne M., Singh, Abhishek K., Li, Qian, Tellides, George, Ordovás-Montanes, Jose, Milian, Rolando García, Dixit, Vishwa Deep, Ikonen, Elina, Suárez, Yajaira, Fernández-Hernando, Carlos

“…Cholesterol biosynthetic intermediates, such as lanosterol and desmosterol, are emergent immune regulators of macrophages in response to inflammatory stimuli…”
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Cilia-Associated Oxysterols Activate Smoothened by Raleigh, David R., Sever, Navdar, Choksi, Pervinder K., Sigg, Monika Abedin, Hines, Kelly M., Thompson, Bonne M., Elnatan, Daniel, Jaishankar, Priyadarshini, Bisignano, Paola, Garcia-Gonzalo, Francesc R., Krup, Alexis Leigh, Eberl, Markus, Byrne, Eamon F.X., Siebold, Christian, Wong, Sunny Y., Renslo, Adam R., Grabe, Michael, McDonald, Jeffrey G., Xu, Libin, Beachy, Philip A., Reiter, Jeremy F.

“…Primary cilia are required for Smoothened to transduce vertebrate Hedgehog signals, but how Smoothened accumulates in cilia and is activated is incompletely…”
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Cell-specific discrimination of desmosterol and desmosterol mimetics confers selective regulation of LXR and SREBP in macrophages by Muse, Evan D., Yu, Shan, Edillor, Chantle R., Tao, Jenhan, Spann, Nathanael J., Troutman, Ty D., Seidman, Jason S., Henke, Adam, Roland, Jason T., Ozeki, Katherine A., Thompson, Bonne M., McDonald, Jeffrey G., Bahadorani, John, Tsimikas, Sotirios, Grossman, Tamar R., Tremblay, Matthew S., Glass, Christopher K.

“…Activation of liver X receptors (LXRs) with synthetic agonists promotes reverse cholesterol transport and protects against atherosclerosis in mouse models…”
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Three-phase liquid extraction: a simple and fast method for lipidomic workflows[S] by Vale, Gonçalo, Martin, Sarah A., Mitsche, Matthew A., Thompson, Bonne M., Eckert, Kaitlyn M., McDonald, Jeffrey G.

“…An unbiased sample preparation free of interferents (i.e., competing analytes, detergents, plastics) is critical to any lipid MS workflow. Here we present a…”
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25-Hydroxycholesterol secreted by macrophages in response to Toll-like receptor activation suppresses immunoglobulin A production by Bauman, David R, Bitmansour, Andrew D, McDonald, Jeffrey G, Thompson, Bonne M, Liang, Guosheng, Russell, David W

“…25-Hydroxycholesterol is produced in mammalian tissues. The function of this oxysterol is unknown. Here we describe a central role for 25-hydroxycholesterol in…”
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Genetic, anatomic, and clinical determinants of human serum sterol and vitamin D levels by Stiles, Ashlee R., Kozlitina, Julia, Thompson, Bonne M., McDonald, Jeffrey G., King, Kevin S., Russell, David W.

“…An unknown fraction of the genome participates in the metabolism of sterols and vitamin D, two classes of lipids with diverse physiological and…”
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MMAB promotes negative feedback control of cholesterol homeostasis by Goedeke, Leigh, Canfrán-Duque, Alberto, Rotllan, Noemi, Chaube, Balkrishna, Thompson, Bonne M., Lee, Richard G., Cline, Gary W., McDonald, Jeffrey G., Shulman, Gerald I., Lasunción, Miguel A., Suárez, Yajaira, Fernández-Hernando, Carlos

“…Intricate regulatory networks govern the net balance of cholesterol biosynthesis, uptake and efflux; however, the mechanisms surrounding cholesterol…”
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Desmosterol and 7-dehydrocholesterol concentrations in post mortem brains of depressed people: The role of trazodone by Cenik, Basar, Palka, Jayme M., Thompson, Bonne M., McDonald, Jeffrey G., Tamminga, Carol A., Cenik, Can, Brown, E. Sherwood

“…Major depressive disorder (MDD) is a common, disabling, and heterogeneous condition that responds unpredictably to current treatments. We previously showed an…”
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Schnyder corneal dystrophy-associated UBIAD1 inhibits ER-associated degradation of HMG CoA reductase in mice by Jo, Youngah, Hamilton, Jason S, Hwang, Seonghwan, Garland, Kristina, Smith, Gennipher A, Su, Shan, Fuentes, Iris, Neelam, Sudha, Thompson, Bonne M, McDonald, Jeffrey G, DeBose-Boyd, Russell A

“…Autosomal-dominant Schnyder corneal dystrophy (SCD) is characterized by corneal opacification owing to overaccumulation of cholesterol. SCD is caused by…”
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25-Hydroxycholesterol exacerbates vascular leak during acute lung injury by Madenspacher, Jennifer H, Morrell, Eric D, McDonald, Jeffrey G, Thompson, Bonne M, Li, Yue, Birukov, Konstantin G, Birukova, Anna A, Stapleton, Renee D, Alejo, Aidin, Karmaus, Peer W, Meacham, Julie M, Rai, Prashant, Mikacenic, Carmen, Wurfel, Mark M, Fessler, Michael B

“…Cholesterol-25-hydroxylase (CH25H), the biosynthetic enzyme for 25-hydroxycholesterol (25HC), is most highly expressed in the lung, but its role in lung…”
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Extraction and analysis of sterols in biological matrices by high performance liquid chromatography electrospray ionization mass spectrometry by McDonald, Jeffrey G, Thompson, Bonne M, McCrum, Erin C, Russell, David W

“…We describe the development of a high performance liquid chromatography mass spectrometry (HPLC-MS) method that allows the identification and quantitation of…”
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Subcellular organelle lipidomics in TLR-4-activated macrophages by Andreyev, Alexander Y., Fahy, Eoin, Guan, Ziqiang, Kelly, Samuel, Li, Xiang, McDonald, Jeffrey G., Milne, Stephen, Myers, David, Park, Hyejung, Ryan, Andrea, Thompson, Bonne M., Wang, Elaine, Zhao, Yihua, Brown, H. Alex, Merrill, Alfred H., Raetz, Christian R.H., Russell, David W., Subramaniam, Shankar, Dennis, Edward A.

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Liver-Derived Signals Sequentially Reprogram Myeloid Enhancers to Initiate and Maintain Kupffer Cell Identity by Sakai, Mashito, Troutman, Ty D., Seidman, Jason S., Ouyang, Zhengyu, Spann, Nathanael J., Abe, Yohei, Ego, Kaori M., Bruni, Cassi M., Deng, Zihou, Schlachetzki, Johannes C.M., Nott, Alexi, Bennett, Hunter, Chang, Jonathan, Vu, BaoChau T., Pasillas, Martina P., Link, Verena M., Texari, Lorane, Heinz, Sven, Thompson, Bonne M., McDonald, Jeffrey G., Geissmann, Frederic, Glass, Christopher K.

“…Tissue environment plays a powerful role in establishing and maintaining the distinct phenotypes of resident macrophages, but the underlying molecular…”
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High-Throughput Lipidomic and Metabolomic Profiling for Brain Tissue and Biofluid Samples in Neurodegenerative Disorders by Thompson, Bonne M, Astarita, Giuseppe

“…Recent research has revealed the potential of lipidomics and metabolomics in identifying new biomarkers and mechanistic insights for neurodegenerative…”
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Macrophage-Derived 25-Hydroxycholesterol Promotes Vascular Inflammation, Atherogenesis, and Lesion Remodeling by Canfrán-Duque, Alberto, Rotllan, Noemi, Zhang, Xinbo, Andrés-Blasco, Irene, Thompson, Bonne M., Sun, Jonathan, Price, Nathan L., Fernández-Fuertes, Marta, Fowler, Joseph W., Gómez-Coronado, Diego, Sessa, William C., Giannarelli, Chiara, Schneider, Robert J., Tellides, George, McDonald, Jeffrey G., Fernández-Hernando, Carlos, Suárez, Yajaira

“…Cross-talk between sterol metabolism and inflammatory pathways has been demonstrated to significantly affect the development of atherosclerosis. Cholesterol…”
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A Medicinal Chemistry-Driven Approach Identified the Sterol Isomerase EBP as the Molecular Target of TASIN Colorectal Cancer Toxins by Theodoropoulos, Panayotis C, Wang, Wentian, Budhipramono, Albert, Thompson, Bonne M, Madhusudhan, Nikhil, Mitsche, Matthew A, McDonald, Jeffrey G, De Brabander, Jef K, Nijhawan, Deepak

“…TASIN (Truncated APC-Selective Inhibitors) compounds are selectively toxic to colorectal cancer cells with APC mutations, although their mechanism of action…”
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Target identification reveals lanosterol synthase as a vulnerability in glioma by Phillips, Richard E., Yang, Yanhong, Smith, Ryan C., Thompson, Bonne M., Yamasaki, Tomoko, Soto-Feliciano, Yadira M., Funato, Kosuke, Liang, Yupu, Garcia-Bermudez, Javier, Wang, Xiaoshi, Garcia, Benjamin A., Yamasaki, Kazuhiko, McDonald, Jeffrey G., Birsoy, Kivanç, Tabar, Viviane, Allis, C. David

“…Diffuse intrinsic pontine glioma (DIPG) remains an incurable childhood brain tumor for which novel therapeutic approaches are desperately needed. Previous…”
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