Search Results - "Thommen, Michael"
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Co-translational protein folding: progress and methods
Published in Current opinion in structural biology (01-02-2017)“…•Proteins begin to fold within the polypeptide exit tunnel of the ribosome.•Ribosomes change the landscape of protein folding.•Ribosomes can stabilize…”
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Synonymous Codons Direct Cotranslational Folding toward Different Protein Conformations
Published in Molecular cell (04-02-2016)“…In all genomes, most amino acids are encoded by more than one codon. Synonymous codons can modulate protein production and folding, but the mechanism…”
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3
Ribosome selectivity and nascent chain context in modulating the incorporation of fluorescent non-canonical amino acid into proteins
Published in Scientific reports (27-07-2022)“…Fluorescence reporter groups are important tools to study the structure and dynamics of proteins. Genetic code reprogramming allows for cotranslational…”
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Deducing the kinetics of protein synthesis in vivo from the transition rates measured in vitro
Published in PLoS computational biology (01-10-2014)“…The molecular machinery of life relies on complex multistep processes that involve numerous individual transitions, such as molecular association and…”
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5
Mycobacterial Ubiquitin-like Protein Ligase PafA Follows a Two-step Reaction Pathway with a Phosphorylated Pup Intermediate
Published in The Journal of biological chemistry (11-02-2011)“…In Mycobacterium tuberculosis, the enzyme PafA is responsible for the activation and conjugation of the proteasome-targeting molecule Pup to protein…”
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Deducing the Kinetics of Protein Synthesis In Vivo from the Transition Rates Measured In Vitro: e1003909
Published in PLoS computational biology (01-10-2014)“…The molecular machinery of life relies on complex multistep processes that involve numerous individual transitions, such as molecular association and…”
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7
Protein Synthesis by Ribosomes: Mapping In Vitro onto In Vivo Rates
Published in Biophysical journal (28-01-2014)Get full text
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8
SYNONYMOUS CODONS DIRECT CO-TRANSLATIONAL FOLDING TOWARDS DIFFERENT PROTEIN CONFORMATIONS
Published in Molecular cell (04-02-2016)“…In all genomes, most amino acids are encoded by more than one codon. Synonymous codons can modulate protein production and folding, but the mechanism…”
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Journal Article