Search Results - "Thomford, P. J."

Pharmacokinetics of Perfluorooctanoate in Cynomolgus Monkeys by Butenhoff, J. L., Kennedy, G. L., Hinderliter, P. M., Lieder, P. H., Jung, R., Hansen, K. J., Gorman, G. S., Noker, P. E., Thomford, P. J.

“…The pharmacokinetics of perfluorooctanoate (PFOA) in cynomolgus monkeys were studied in a six-month oral capsule dosing study of ammonium perfluorooctanoate…”
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Preclinical Safety Evaluation of rhuMAbVEGF, an Antiangiogenic Humanized Monoclonal Antibody by Ryan, Anne M., Eppler, Dorothy Bates, Hagler, Kelly E., Bruner, Richard H., Thomford, Peter J., Hall, Robert L., Shopp, George M., O'Neill, Charles A.

“…Recombinant humanized antivascular endothelial growth factor (rhuMAbVEGF) is a monoclonal IgG, antibody that is being developed as an antiangiogenic agent for…”
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Subchronic Toxicity Studies on Perfluorooctanesulfonate Potassium Salt in Cynomolgus Monkeys by Seacat, Andrew M., Thomford, Peter J., Hansen, Kris J., Olsen, Geary W., Case, Marvin T., Butenhoff, John L.

“…This study was conducted to determine the earliest measurable response of primates to low-level perfluorooctanesulfonate (PFOS) exposure and to provide…”
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Sub-chronic dietary toxicity of potassium perfluorooctanesulfonate in rats by Seacat, Andrew M, Thomford, Peter J, Hansen, Kris J, Clemen, Lisa A, Eldridge, Sandra R, Elcombe, Cliff R, Butenhoff, John L

“…Perfluorooctanesulfonate (PFOS) is a widely disseminated persistent compound found at low (part-per-billion) concentrations in serum and liver samples from…”
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Maternal recognition of pregnancy in swine. I. Minimal requirement for exogenous estradiol-17 beta to induce either short or long pseudopregnancy in cycling gilts by A E Pusateri, J M Smith, J W Smith, 2nd, P J Thomford, M A Diekman

“…Five experiments were conducted to determine the minimal requirement for estradiol-17 beta (E2) injections to induce either short pseudopregnancy (SPP) or long…”
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The Influence of Dose of Phenobarbital and Interval to Measurement on Concentration of Liver Enzymes in Barrows and Gilts by Thomford, P. J, Dziuk, P. J

“…The administration of xenobiotics such as phenobarbital (PB) and chlorinated hydrocarbons to rats, mice and several other species has been shown to increase…”
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Effect of oocyte number and rate of atresia on the age of menopause by Thomford, P J, Jelovsek, F R, Mattison, D R

“…Menopause occurs when oocyte number falls below the threshold required for ovarian function. The age of menopause is decreased by some drugs, some occupational…”
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Influence of porcine somatotropin on endocrine and histological variables in gilts by Andres, C.J, Green, M.L, Clapper, J.A, Cline, T.R, Diekman, M.A, Thomford, P.J

“…Thirty-six crossbred gilts (71.7 +/- 0.9 kg and 140.1 +/- 0.9 d) were assigned to one of three doses (0, 35, or 70 micrograms.kg BW-1.d-1) of recombinant…”
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The mechanisms of action of reproductive toxicants by Mattison, D R, Thomford, P J

“…Successful human reproduction is a complex process which requires normal function of 2 individuals. Reproductive toxicants can impair reproduction by acting in…”
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Effects of plane of nutrition and phenobarbital during the pre-mating period on reproduction in ewes fed differentially during the summer and mated in the fall by Thomas, D.L, Thomford, P.J, Crickman, J.G, Cobb, A.R, Dziuk, P.J

“…An increased plane of nutrition of ewes before mating (flushing) has been associated with an increased number of lambs per ewe. The following study was done to…”
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TOXICOKINETIC EVALUATION OF A SELEGILINE TRANSDERMAL SYSTEM IN THE DOG by BARRETT, JEFFREY S., DISANTO, ANTHONY R., THOMFORD, PETER J., LARSEN, ERIC M., PALAZZOLO, MATTHEW J., MORALES, RICHARD J.

“…The toxicology and toxicokinetics of a selegiline transdermal system (STS) were evaluated in a 3 month dog study of daily 24 h applications of placebo 4, 8, or…”
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Influence of phenobarbital dosage, dietary crude protein level and interval to measurement on hepatic monoxygenase activity in ewes by Thomford, P.J, Dziuk, P.J

“…Hepatic monoxygenases metabolize steroids that in turn influence reproduction. Experiments were conducted to establish the effect of dose of phenobarbital and…”
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Twenty-four-hour progesterone and luteinizing hormone profiles in the midluteal phase of the infertile patient: correlation with other indicators of luteal phase insufficiency by Olive, D L, Thomford, P J, Torres, S E, Lambert, T S, Rosen, G F

“…The authors have further analyzed women diagnosed as having luteal phase insufficiency in hope of determining the value of specific screening tests as well as…”
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Maintenance of pregnancy and levels of progesterone and relaxin in the serum of gilts following a stepwise reduction in the number of corpora lutea by Thomford, P J, Sander, H K, Kendall, J Z, Sherwood, O D, Dziuk, P J

“…The number of corpora lutea (CL) was reduced in pregnant gilts in a stepwise fashion. Eleven pregnant gilts were unilaterally ovariectomized at Day 30, leaving…”
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Effects of manganese (Mn++) and iron (Fe+++) on magnetic resonance imaging (MRI) characteristics of human placenta and amniotic fluid by Plowchalk, D R, Jordan, J P, Thomford, P J, Mattison, D R

“…The contrast and intensity of a magnetic resonance image (MRI) is affected in part by the spin-lattice relaxation time (T1) and spin-spin relaxation time (T2)…”
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Perinatal cannabinoid exposure: effects on hepatic cytochrome P-450 and plasma protein levels in male mice by Dalterio, S, Thomford, P J, Michael, S D, DeAngelo, L, Mayfield, D

“…Maternal exposure to the major psychoactive delta 9-tetrahydrocannabinol (THC), or to the nonpsychoactive cannabinol (CBN) or cannabidiol (CBD) on day 12 of…”
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Effect of manganese on human placental spin-lattice (T1) and spin-spin (T2) relaxation times by ANGTUACO, T. L, MATTISON, D. R, THOMFORD, F. J, JORDAN, J

“…Human placentas were obtained immediately following delivery and incubated with manganese chloride (MnCl2) in concentrations ranging from 0.002 to 2.0 mM…”
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Perinatal cannabinoid exposure: demasculinization in male mice by Dalterio, S L, Michael, S D, Thomford, P J

“…Maternal exposure to psychoactive or non-psychoactive cannabinoids produces long-term changes in body weight regulation, pituitary-gonadal feedback, testicular…”
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Ovarian toxicity of benzo(a)pyrene and metabolites in mice by Mattison, D R, Singh, H, Takizawa, K, Thomford, P J

“…The effect of intraovarian injection of benzo(a)pyrene (BP) or one of three metabolites: +7,8-oxide (7,8-O), (-)-dihydrodiol (DHD), and (+)-diol-epoxide-2…”
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Effect of estrogen, testosterone, and phenobarbital on uterine weight and liver microsomal enzymes in prepuberal mice by Robl, J M, Thomford, P J, Wu, M C, Dziuk, P J

“…Prepuberal female mice were treated with estradiol benzoate (EB), testosterone (T), or phenobarbital (PB), or were untreated. At 8 days after treatment treated…”
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