Search Results - "Thomes, Paul"

Acute and Chronic Ethanol Administration Differentially Modulate Hepatic Autophagy and Transcription Factor EB by Thomes, Paul G., Trambly, Casey S., Fox, Howard S., Tuma, Dean J., Donohue Jr, Terrence M.

“…Background Chronic ethanol (EtOH) consumption decelerates the catabolism of long‐lived proteins, indicating that it slows hepatic macroautophagy (hereafter…”
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Ethanol withdrawal mitigates fatty liver by normalizing lipid catabolism by Thomes, Paul G, Rasineni, Karuna, Yang, Li, Donohue, Jr, Terrence M, Kubik, Jacy L, McNiven, Mark A, Casey, Carol A

“…We are investigating the changes in hepatic lipid catabolism that contribute to alcohol-induced fatty liver. Following chronic ethanol (EtOH) exposure,…”
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Crohn's Disease Patients Uniquely Contain Inflammatory Responses to Flagellin in a CD4 Effector Memory Subset by Morgan, Nadine N, Duck, Lennard W, Wu, Jiongru, Rujani, Mahmud, Thomes, Paul G, Elson, Charles O, Mannon, Peter J

“…Specific microbial antigens stimulate production of antibodies indicative of the aberrant immune response in Crohn's disease (CD). We tested for T cell…”
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Lipophagy and Alcohol-Induced Fatty Liver by Yang, Li, Yang, Changqing, Thomes, Paul G, Kharbanda, Kusum K, Casey, Carol A, McNiven, Mark A, Donohue, Jr, Terrence M

“…This review describes the influence of ethanol consumption on hepatic lipophagy, a selective form of autophagy during which fat-storing organelles known as…”
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Chronic alcohol exposure alters circulating insulin and ghrelin levels: role of ghrelin in hepatic steatosis by Rasineni, Karuna, Thomes, Paul G, Kubik, Jacy L, Harris, Edward N, Kharbanda, Kusum K, Casey, Carol A

“…Fatty liver is the earliest response of the liver to excessive ethanol consumption. Central in the development of alcoholic steatosis is increased mobilization…”
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Lipid droplet membrane proteome remodeling parallels ethanol-induced hepatic steatosis and its resolution by Casey, Carol A., Donohue, Terrence M., Kubik, Jacy L., Kumar, Vikas, Naldrett, Michael J., Woods, Nicholas T., Frisbie, Cole P., McNiven, Mark A., Thomes, Paul G.

“…Lipid droplets (LDs) are composed of neutral lipids enclosed in a phospholipid monolayer, which harbors membrane-associated proteins that regulate LD…”
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Autophagy in Alcohol-Induced Liver Diseases by Dolganiuc, Angela, Thomes, Paul G., Ding, Wen-Xing, Lemasters, John J., Donohue Jr, Terrence M.

“…Alcohol is the most abused substance worldwide and a significant source of liver injury; the mechanisms of alcohol‐induced liver disease are not fully…”
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Emerging mechanistic insights of selective autophagy in hepatic diseases by Alim Al-Bari, Abdul, Ito, Yuko, Thomes, Paul G, Menon, Manoj B, García-Macia, Marina, Fadel, Raouf, Stadlin, Alfreda, Peake, Nicholas, Faris, MoezAlIslam Ezzat, Eid, Nabil, Klionsky, Daniel J

“…Macroautophagy (hereafter referred to as autophagy), a highly conserved metabolic process, regulates cellular homeostasis by degrading dysfunctional cytosolic…”
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Hydroxysteroid 17β-dehydrogenase 11 accumulation on lipid droplets promotes ethanol-induced cellular steatosis by Thomes, Paul G., Strupp, Michael S., Donohue, Terence M., Kubik, Jacy L., Sweeney, Sarah, Mahmud, R., Schott, Micah B., Schulze, Ryan J., McNiven, Mark A., Casey, Carol A.

“…Lipid droplets (LDs) are fat-storing organelles enclosed by a phospholipid monolayer, which harbors membrane-associated proteins that regulate distinct LD…”
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Rev-erb agonist and TGF-β similarly affect autophagy but differentially regulate hepatic stellate cell fibrogenic phenotype by Thomes, Paul G., Brandon-Warner, Elizabeth, Li, Ting, Donohue, Terrence M., Schrum, Laura W.

“…We demonstrated that ligand-activated nuclear receptor Rev-erbα mitigates CCl4-induced liver fibrosis. Rev-erbα is also a novel regulator of autophagy, a…”
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Ethanol Exposure to Ethanol-Oxidizing HEPG2 Cells Induces Intracellular Protein Aggregation by Thomes, Paul G, Rensch, Gage, Casey, Carol A, Donohue, Jr, Terrence M

“…Aggresomes are collections of intracellular protein aggregates. In liver cells of patients with alcoholic hepatitis, aggresomes appear histologically as…”
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Multilevel regulation of autophagosome content by ethanol oxidation in HepG2 cells by Thomes, Paul G., Ehlers, Rebecca A., Trambly, Casey S., Clemens, Dahn L., Fox, Howard S., Tuma, Dean J., Donohue, Jr, Terrence M.

“…Acute and chronic ethanol administration increase autophagic vacuole (i.e., autophagosome; AV) content in liver cells. This enhancement depends on ethanol…”
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Ethanol-induced oxidant stress modulates hepatic autophagy and proteasome activity by Donohue, Jr, Terrence M, Thomes, Paul G

“…In this review, we describe research findings on the effects of alcohol exposure on two major catabolic systems in liver cells: the ubiquitin-proteasome system…”
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Proteasome activity and autophagosome content in liver are reciprocally regulated by ethanol treatment by Thomes, Paul G., Trambly, Casey S., Thiele, Geoffrey M., Duryee, Michael J., Fox, Howard S., Haorah, James, Donohue, Terrence M.

“…► We used three ethanol exposure models that cause low to moderate oxidant stress in liver. ► We related oxidant stress to proteasome activity and…”
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Contrasting Effects of Fasting on Liver-Adipose Axis in Alcohol-Associated and Non-alcoholic Fatty Liver by Rasineni, Karuna, Jordan, Clayton W, Thomes, Paul G, Kubik, Jacy L, Staab, Elizabeth M, Sweeney, Sarah A, Talmon, Geoffrey A, Donohue, Terrence M, McNiven, Mark A, Kharbanda, Kusum K, Casey, Carol A

“…Fatty liver, a major health problem worldwide, is the earliest pathological change in the progression of alcohol-associated (AFL) and non-alcoholic fatty liver…”
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Alcohol-Induced Lysosomal Damage and Suppression of Lysosome Biogenesis Contribute to Hepatotoxicity in HIV-Exposed Liver Cells by New-Aaron, Moses, Thomes, Paul G, Ganesan, Murali, Dagur, Raghubendra Singh, Donohue, Jr, Terrence M, Kusum, Kharbanda K, Poluektova, Larisa Y, Osna, Natalia A

“…Although the causes of hepatotoxicity among alcohol-abusing HIV patients are multifactorial, alcohol remains the least explored "second hit" for HIV-related…”
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Multiomics Approach Captures Hepatic Metabolic Network Altered by Chronic Ethanol Administration by Sakallioglu, Isin Tuna, Tripp, Bridget, Kubik, Jacy, Casey, Carol A, Thomes, Paul, Powers, Robert

“…Using a multiplatform and multiomics approach, we identified metabolites, lipids, proteins, and metabolic pathways that were altered in the liver after chronic…”
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Role of defective methylation reactions in ethanol-induced dysregulation of intestinal barrier integrity by Thomes, Paul G., Osna, Natalia A., Bligh, Sarah M., Tuma, Dean J., Kharbanda, Kusum K.

“…Alcoholic liver disease (ALD) is a major healthcare challenge worldwide. Emerging evidence reveals that ethanol administration disrupts the intestinal…”
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Creatine Supplementation Does Not Prevent the Development of Alcoholic Steatosis by Ganesan, Murali, Feng, Dan, Barton, Ryan W., Thomes, Paul G., McVicker, Benita L., Tuma, Dean J., Osna, Natalia A., Kharbanda, Kusum K.

“…Background Alcohol‐induced reduction in the hepatocellular S‐adenosylmethionine (SAM):S‐adenosylhomocysteine (SAH) ratio impairs the activities of many…”
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Role of Early Growth Response-1 in the Development of Alcohol-Induced Steatosis by Thomes, Paul G, Donohue, Terrence M

“…Here, we describe research on the involvement of the transcription factor, Early Growth Response- 1 (Egr-1) in alcohol-induced liver injury, specifically,…”
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