Search Results - "Thome, Ulrich H"

Albumin Stimulates Epithelial Na+ Transport and Barrier Integrity by Activating the PI3K/AKT/SGK1 Pathway by Laube, Mandy, Thome, Ulrich H.

“…Albumin is a major serum protein and is frequently used as a cell culture supplement. It is crucially involved in the regulation of osmotic pressure and…”
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Glucocorticoids Equally Stimulate Epithelial Na + Transport in Male and Female Fetal Alveolar Cells by Laube, Mandy, Riedel, Diana, Ackermann, Benjamin, Haase, Melanie, H Thome, Ulrich

“…Preterm infants frequently suffer from respiratory distress syndrome (RDS), possibly due to lower expression of epithelial Na channels (ENaC). RDS incidence is…”
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Epidermal growth factor strongly affects epithelial Na+ transport and barrier function in fetal alveolar cells, with minor sex-specific effects by Laube, Mandy, Dornis, Diana, Wenzel, Fine, Thome, Ulrich H.

“…Male sex remains an independent risk factor for respiratory distress syndrome (RDS) in preterm infants. Insufficient Na + transport-mediated alveolar fluid…”
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Y It Matters-Sex Differences in Fetal Lung Development by Laube, Mandy, Thome, Ulrich H

“…Within this review, sex-specific differences in alveolar epithelial functions are discussed with special focus on preterm infants and the respiratory disorders…”
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Male Sex is Associated with a Reduced Alveolar Epithelial Sodium Transport by Kaltofen, Till, Haase, Melanie, Thome, Ulrich H, Laube, Mandy

“…Respiratory distress syndrome (RDS) is the most frequent pulmonary complication in preterm infants. RDS incidence differs between genders, which has been…”
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Paracrine stimulation of perinatal lung functional and structural maturation by mesenchymal stem cells by Obendorf, Janine, Fabian, Claire, Thome, Ulrich H, Laube, Mandy

“…Mesenchymal stem cells (MSCs) were shown to harbor therapeutic potential in models of respiratory diseases, such as bronchopulmonary dysplasia (BPD), the most…”
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The role of early-onset-sepsis in the neurodevelopment of very low birth weight infants by Ortgies, Tjark, Rullmann, Michael, Ziegelhöfer, Dorothée, Bläser, Annett, Thome, Ulrich H

“…Abstract Aims The study investigated a putative association between early-onset-sepsis (EOS) and poor neurodevelopmental outcomes at 2 years corrected age in…”
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Glucocorticoids Distinctively Modulate the CFTR Channel with Possible Implications in Lung Development and Transition into Extrauterine Life by Laube, Mandy, Bossmann, Miriam, Thome, Ulrich H

“…During fetal development, the lung is filled with fluid that is secreted by an active Cl- transport promoting lung growth. The basolateral Na+,K+,2Cl-…”
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Imbalanced Inflammatory Responses in Preterm and Term Cord Blood Monocytes and Expansion of the CD14 + CD16 + Subset upon Toll-like Receptor Stimulation by Glaser, Kirsten, Kern, David, Speer, Christian P, Schlegel, Nicolas, Schwab, Michael, Thome, Ulrich H, Härtel, Christoph, Wright, Clyde J

“…Developmentally regulated features of innate immunity are thought to place preterm and term infants at risk of infection and inflammation-related morbidity…”
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Development and Functional Characterization of Fetal Lung Organoids by Laube, Mandy, Pietsch, Soeren, Pannicke, Thomas, Thome, Ulrich H., Fabian, Claire

“…Preterm infants frequently suffer from pulmonary complications due to a physiological and structural lung immaturity resulting in significant morbidity and…”
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The association of different types of human milk with bronchopulmonary dysplasia in preterm infants by Pütz, Elisabeth, Ascherl, Rudolf, Wendt, Thomas, Thome, Ulrich H, Gebauer, Corinna, Genuneit, Jon, Siziba, Linda P

“…To evaluate the association between different types of human milk feeds and bronchopulmonary dysplasia (BPD) in preterm infants. Data on dispensed mother's own…”
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Mechanical properties of the premature lung: From tissue deformation under load to mechanosensitivity of alveolar cells by Naumann, Jonas, Koppe, Nicklas, Thome, Ulrich H., Laube, Mandy, Zink, Mareike

“…Many preterm infants require mechanical ventilation as life-saving therapy. However, ventilation-induced overpressure can result in lung diseases. Considering…”
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Permissive hypercapnia in extremely low birthweight infants (PHELBI): a randomised controlled multicentre trial by Thome, Ulrich H, Prof, Genzel-Boroviczeny, Orsolya, Prof, Bohnhorst, Bettina, Prof, Schmid, Manuel, MD, Fuchs, Hans, MD, Rohde, Oliver, MD, Avenarius, Stefan, MD, Topf, Hans-Georg, MD, Zimmermann, Andrea, MD, Faas, Dirk, MD, Timme, Katharina, MD, Kleinlein, Barbara, MD, Buxmann, Horst, MD, Schenk, Wilfried, MD, Segerer, Hugo, Prof, Teig, Norbert, MD, Gebauer, Corinna, MD, Hentschel, Roland, Prof, Heckmann, Matthias, Prof, Schlösser, Rolf, Prof, Peters, Jochen, Prof, Rossi, Rainer, Prof, Rascher, Wolfgang, MD, Böttger, Ralf, MD, Seidenberg, Jürgen, MD, Hansen, Gesine, Prof, Zernickel, Maria, MSc, Alzen, Gerhard, Prof, Dreyhaupt, Jens, PhD, Muche, Rainer, PhD, Hummler, Helmut D, Prof

“…Summary Background Tolerating higher partial pressure of carbon dioxide (pCO2 ) in mechanically ventilated, extremely low birthweight infants might reduce…”
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Inflammatory Mediators in Tracheal Aspirates of Preterm Infants Participating in a Randomized Trial of Inhaled Nitric Oxide by Laube, Mandy, Amann, Elena, Uhlig, Ulrike, Yang, Yang, Fuchs, Hans W, Zemlin, Michael, Mercier, Jean-Christophe, Maier, Rolf F, Hummler, Helmut D, Uhlig, Stefan, Thome, Ulrich H

“…Ventilated preterm infants frequently develop bronchopulmonary dysplasia (BPD) which is associated with elevated inflammatory mediators in their tracheal…”
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Elective high-frequency oscillatory versus conventional ventilation in preterm infants: a systematic review and meta-analysis of individual patients' data by Cools, Filip, Dr, Askie, Lisa M, PhD, Offringa, Martin, MD, Asselin, Jeanette M, RRT, Calvert, Sandra A, MB, Courtney, Sherry E, MD, Dani, Carlo, MD, Durand, David J, MD, Gerstmann, Dale R, MD, Henderson-Smart, David J, Prof, Marlow, Neil, DM, Peacock, Janet L, Prof, Pillow, J Jane, FRACP, Soll, Roger F, Prof, Thome, Ulrich H, MD, Truffert, Patrick, MD, Schreiber, Michael D, MD, Van Reempts, Patrick, MD, Vendettuoli, Valentina, MD, Vento, Giovanni, MD

“…Summary Background Population and study design heterogeneity has confounded previous meta-analyses, leading to uncertainty about effectiveness and safety of…”
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Evaluation of a diluted lipid emulsion solution as a lubricant for improved peripherally inserted central catheter guidewire removal in a neonatal population by van Rens, Matheus F P T, Paramban, Ratheesh, Francia, Airene L V, Chandra, Prem, Mahmah, Mohamad Adnan, Thome, Ulrich H, Bayoumi, Mohammad A A, Spencer, Timothy R

“…Medical management of neonates is often established upon safe and reliable vascular access, frequently utilized to provide physiological monitoring, parenteral…”
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Signaling Cascade Involved in Rapid Stimulation of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) by Dexamethasone by Bossmann, Miriam, Ackermann, Benjamin W, Thome, Ulrich H, Laube, Mandy

“…Impairment of mucociliary clearance with reduced airway fluid secretion leads to chronically inflamed airways. Cystic fibrosis transmembrane conductance…”
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A descriptive analysis of human milk dispensed by the Leipzig Donor Human Milk Bank for neonates between 2012 and 2019 by Siziba, Linda P., Baier, Caroline, Pütz, Elisabeth, Ascherl, Rudolf, Wendt, Thomas, Thome, Ulrich H., Gebauer, Corinna, Genuneit, Jon

“…Background Human milk banking has become an important aspect of Nutritional medicine. It is not just about the provision of mother’s own milk (MOM) or donor…”
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Similar adverse outcome rates with high or low oxygen saturation targets in an area with low background mortality by Willgerodt, Nina, Bührer, Christoph, Rossi, Rainer, Kühn, Thomas, Rüdiger, Mario, Avenarius, Stefan, Böttger, Ralf, Olbertz, Dirk M., Proquitte, Hans, Bittrich, Hans-Jörg, Haase, Roland, Fröhlich, Matthias, Höhne, Sybille, Thome, Ulrich H.

“…Background Randomized controlled trials have indicated reduced mortality rates in very preterm infants assigned to high compared to low oxygen saturation (SpO…”
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Permissive Hypercapnia Results in Decreased Functional Vessel Density in the Skin of Extremely Low Birth Weight Infants by Puchwein-Schwepcke, Alexandra Francoise, Schottmayer, Kristina, Mormanová, Zuzana, Dreyhaupt, Jens, Genzel-Boroviczeny, Orsolya, Thome, Ulrich H

“…Ventilator-induced lung injury with subsequent bronchopulmonary dysplasia remains an important issue in the care of extremely low-birth-weight infants…”
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