Search Results - "Thomaston, Jessica L"

Packing of apolar side chains enables accurate design of highly stable membrane proteins by Mravic, Marco, Thomaston, Jessica L, Tucker, Maxwell, Solomon, Paige E, Liu, Lijun, DeGrado, William F

“…The features that stabilize the structures of membrane proteins remain poorly understood. Polar interactions contribute modestly, and the hydrophobic effect…”
Get full text

Inhibitors of the M2 Proton Channel Engage and Disrupt Transmembrane Networks of Hydrogen-Bonded Waters by Thomaston, Jessica L, Polizzi, Nicholas F, Konstantinidi, Athina, Wang, Jun, Kolocouris, Antonios, DeGrado, William F

“…Water-mediated interactions play key roles in drug binding. In protein sites with sparse polar functionality, a small-molecule approach is often viewed as…”
Get full text

Crystal structure of the drug‐resistant S31N influenza M2 proton channel by Thomaston, Jessica L., DeGrado, William F.

“…The M2 protein is a small proton channel found in the influenza A virus that is necessary for viral replication. The M2 channel is the target of a class of…”
Get full text

High-resolution structures of the M2 channel from influenza A virus reveal dynamic pathways for proton stabilization and transduction by Thomaston, Jessica L., Alfonso-Prieto, Mercedes, Woldeyes, Rahel A., Fraser, James S., Klein, Michael L., Fiorin, Giacomo, DeGrado, William F.

“…The matrix 2 (M2) protein from influenza A virus is a proton channel that uses His37 as a selectivity filter. Here we report high-resolution (1.10 Å) cryogenic…”
Get full text

X‑ray Crystal Structure of the Influenza A M2 Proton Channel S31N Mutant in Two Conformational States: An Open and Shut Case by Thomaston, Jessica L, Wu, Yibing, Polizzi, Nicholas, Liu, Lijun, Wang, Jun, DeGrado, William F

“…The amantadine-resistant S31N mutant of the influenza A M2 proton channel has become prevalent in currently circulating viruses. Here, we have solved an X-ray…”
Get full text

X‑ray Crystal Structures of the Influenza M2 Proton Channel Drug-Resistant V27A Mutant Bound to a Spiro-Adamantyl Amine Inhibitor Reveal the Mechanism of Adamantane Resistance by Thomaston, Jessica L, Konstantinidi, Athina, Liu, Lijun, Lambrinidis, George, Tan, Jingquan, Caffrey, Martin, Wang, Jun, Degrado, William F, Kolocouris, Antonios

“…The V27A mutation confers adamantane resistance on the influenza A matrix 2 (M2) proton channel and is becoming more prevalent in circulating populations of…”
Get full text

Transient water wires mediate selective proton transport in designed channel proteins by Kratochvil, Huong T., Watkins, Laura C., Mravic, Marco, Thomaston, Jessica L., Nicoludis, John M., Somberg, Noah H., Liu, Lijun, Hong, Mei, Voth, Gregory A., DeGrado, William F.

“…Selective proton transport through proteins is essential for forming and using proton gradients in cells. Protons are conducted along hydrogen-bonded ‘wires’…”
Get full text

XFEL structures of the influenza M2 proton channel: Room temperature water networks and insights into proton conduction by Thomaston, Jessica L., Woldeyes, Rahel A., Nakane (中根崇智), Takanori, Yamashita, Ayumi, Tanaka, Tomoyuki, Koiwai, Kotaro, Brewster, Aaron S., Barad, Benjamin A., Chen, Yujie, Lemmin, Thomas, Uervirojnangkoorn, Monarin, Arima, Toshi, Kobayashi, Jun, Masuda, Tetsuya, Suzuki, Mamoru, Sugahara, Michihiro, Sauter, Nicholas K., Tanaka, Rie, Nureki, Osamu, Tono, Kensuke, Joti, Yasumasa, Nango, Eriko, Iwata, So, Yumoto, Fumiaki, Fraser, James S., DeGrado, William F.

“…The M2 proton channel of influenza A is a drug target that is essential for the reproduction of the flu virus. It is also a model system for the study of…”
Get full text

Rimantadine Binds to and Inhibits the Influenza A M2 Proton Channel without Enantiomeric Specificity by Thomaston, Jessica L, Samways, Marley L, Konstantinidi, Athina, Ma, Chunlong, Hu, Yanmei, Bruce Macdonald, Hannah E, Wang, Jun, Essex, Jonathan W, DeGrado, William F, Kolocouris, Antonios

“…The influenza A M2 wild-type (WT) proton channel is the target of the anti-influenza drug rimantadine. Rimantadine has two enantiomers, though most…”
Get full text

Detection of drug-induced conformational change of a transmembrane protein in lipid bilayers using site-directed spin labeling by Thomaston, Jessica L, Nguyen, Phuong A, Brown, Emily C, Upshur, Mary Alice, Wang, Jun, DeGrado, William F, Howard, Kathleen P

“…As a target of antiviral drugs, the influenza A M2 protein has been the focus of numerous structural studies and has been extensively explored as a model ion…”
Get full text

X-Ray Crystal Structures of the Influenza a M2 Proton Channel Bound to Amantadine, Rimantadine, and Inhibiting Compounds by Thomaston, Jessica L., DeGrado, William F.

Get full text

Structural characterization of adamantane-resistant mutants of the influenza M2 proton channel by Thomaston, Jessica L., DeGrado, William F.

“…Abstract only…”
Get full text

Crystal structure of the drug-resistant S31N influenza M2 proton channel: Crystal Structure of M2 S31N Proton Channel by Thomaston, Jessica L., DeGrado, William F.

Get full text

X-ray crystal structures of the influenza A M2 proton channel bound to amantadine, rimantadine and inhibiting compounds by Thomaston, Jessica L., DeGrado, William F.

“…Abstract only…”
Get full text

Proton Stabilization and Conduction Pathway in the Matrix Protein M2 by Kratochvil, Huong T., Thomaston, Jessica L., Gai, Feng, DeGrado, William F.

Get full text

XFEL structures of the influenza M2 proton channel: Room temperature water networks and insights into proton conduction by Thomaston, Jessica L., Woldeyes, Rahel A., Nakane, Takanori, Yamashita, Ayumi, Tanaka, Tomoyuki, Koiwai, Kotaro, Brewster, Aaron S., Barad, Benjamin A., Chen, Yujie, Lemmin, Thomas, Uervirojnangkoorn, Monarin, Arima, Toshi, Kobayashi, Jun, Masuda, Tetsuya, Suzuki, Mamoru, Sugahara, Michihiro, Sauter, Nicholas K., Tanaka, Rie, Nureki, Osamu, Tono, Kensuke, Joti, Yasumasa, Nango, Eriko, Iwata, So, Yumoto, Fumiaki, Fraser, James S., DeGrado, William F.

“…TheM2 proton channel of influenza A is a drug target that is essential for the reproduction of the flu virus. It is also a model system for the study of…”
Get full text

XFEL structures of the influenza M2 proton channel at 1.4 Å: room-temperature water networks and insights into proton conduction by Thomaston, Jessica L., Woldeyes, Rahel A., Nakane, Takanori, Koiwai, Kotaro, Yamashita, Ayumi, Tanaka, Tomoyuki, Arima, Toshi, Kobayashi, Jun, Masuda, Tetsuya, Suzuki, Mamoru, Sugahara, Michihiro, Tanaka, Rie, Nango, Eriko, Iwata, So, Yumoto, Fumiaki, Fraser, James S., DeGrado, William F.

“…Abstract only…”
Get full text