Search Results - "Thomases, Daniel R"
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Downregulation of parvalbumin expression in the prefrontal cortex during adolescence causes enduring prefrontal disinhibition in adulthood
Published in Neuropsychopharmacology (New York, N.Y.) (01-08-2020)“…The expression of the calcium binding protein parvalbumin (PV) has been observed in several cortical regions during development in a temporal pattern…”
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MK-801 Exposure during Adolescence Elicits Enduring Disruption of Prefrontal E-I Balance and Its Control of Fear Extinction Behavior
Published in The Journal of neuroscience (17-06-2020)“…Understanding how disruption of prefrontal cortex (PFC) maturation during adolescence is crucial to reveal which neural processes could contribute to the onset…”
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Journal Article -
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Periadolescent exposure to the NMDA receptor antagonist MK-801 impairs the functional maturation of local GABAergic circuits in the adult prefrontal cortex
Published in The Journal of neuroscience (02-01-2013)“…A developmental disruption of prefrontal cortical inhibitory circuits is thought to contribute to the adolescent onset of cognitive deficits observed in…”
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Journal Article -
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Developmental Disruption of Gamma-Aminobutyric Acid Function in the Medial Prefrontal Cortex by Noncontingent Cocaine Exposure During Early Adolescence
Published in Biological psychiatry (1969) (01-10-2013)“…Background Drug experimentation during adolescence is associated with increased risk of drug addiction relative to any other age group. To further understand…”
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Emergence of GABAergic-dependent regulation of input-specific plasticity in the adult rat prefrontal cortex during adolescence
Published in Psychopharmacology (01-04-2014)“…Objective The prefrontal cortex (PFC) receives multiple cortical and subcortical afferents that regulate higher order cognitive functions, many of which emerge…”
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Late Adolescent Expression of GluN2B Transmission in the Prefrontal Cortex Is Input-Specific and Requires Postsynaptic Protein Kinase A and D1 Dopamine Receptor Signaling
Published in Biological psychiatry (1969) (15-03-2014)“…Background Refinement of mature cognitive functions, such as working memory and decision making, typically takes place during adolescence. The acquisition of…”
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Preferential Disruption of Prefrontal GABAergic Function by Nanomolar Concentrations of the α7nACh Negative Modulator Kynurenic Acid
Published in The Journal of neuroscience (16-08-2017)“…Increased concentrations of kynurenic acid (KYNA) in the prefrontal cortex (PFC) are thought to contribute to the development of cognitive deficits observed in…”
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Prefrontal α7nAChR Signaling Differentially Modulates Afferent Drive and Trace Fear Conditioning Behavior in Adolescent and Adult Rats
Published in The Journal of neuroscience (03-03-2021)“…Increased level of kynurenic acid is thought to contribute to the development of cognitive deficits in schizophrenia through an α7nAChR-mediated mechanism in…”
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Inhibitory Control of Basolateral Amygdalar Transmission to the Prefrontal Cortex by Local Corticotrophin Type 2 Receptor
Published in The international journal of neuropsychopharmacology (01-02-2020)“…Basolateral amygdalar projections to the prefrontal cortex play a key role in modulating behavioral responses to stress stimuli. Among the different…”
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Journal Article -
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Early adolescent MK-801 exposure impairs the maturation of ventral hippocampal control of basolateral amygdala drive in the adult prefrontal cortex
Published in The Journal of neuroscience (02-07-2014)“…The adolescent susceptibility to the onset of psychiatric disorders is only beginning to be understood when factoring in the development of the prefrontal…”
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Journal Article -
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CB1 cannabinoid receptor stimulation during adolescence impairs the maturation of GABA function in the adult rat prefrontal cortex
Published in Molecular psychiatry (01-05-2014)“…Converging epidemiological studies indicate that cannabis abuse during adolescence increases the risk of developing psychosis and prefrontal cortex…”
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Developmental disruption of medial prefrontal cortical GABAergic function by non-contingent cocaine exposure during early adolescence
Published in Biological psychiatry (1969) (01-04-2013)Get full text
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Maturation of the prefrontal cortical GABAergic system during adolescence: Role of NMDA receptors
Published 01-01-2015“…Functional disruptions of the prefrontal cortex (PFC) and its maturation are thought to contribute to the adolescent onset of cognitive deficits observed in…”
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Dissertation -
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Maturation of the prefrontal cortical GABAergic system during adolescence: Role of NMDA receptors
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Dissertation