Search Results - "Thomas Rozario"

Whole chromosome loss and associated breakage–fusion–bridge cycles transform mouse tetraploid cells by Thomas, Rozario, Marks, Daniel Henry, Chin, Yvette, Benezra, Robert

“…Whole chromosome gains or losses (aneuploidy) are a hallmark of ~70% of human tumors. Modeling the consequences of aneuploidy has relied on perturbing spindle…”
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Integrated analysis of patient samples identifies biomarkers for venetoclax efficacy and combination strategies in acute myeloid leukemia by Zhang, Haijiao, Nakauchi, Yusuke, Köhnke, Thomas, Stafford, Melissa, Bottomly, Daniel, Thomas, Rozario, Wilmot, Beth, McWeeney, Shannon K, Majeti, Ravindra, Tyner, Jeffrey W

“…Deregulation of the gene family plays an important role in the pathogenesis of acute myeloid leukemia (AML). The BCL2 inhibitor, venetoclax, has received FDA…”
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Somatic chromosomal engineering identifies BCAN-NTRK1 as a potent glioma driver and therapeutic target by Cook, Peter J., Thomas, Rozario, Kannan, Ram, de Leon, Esther Sanchez, Drilon, Alexander, Rosenblum, Marc K., Scaltriti, Maurizio, Benezra, Robert, Ventura, Andrea

“…The widespread application of high-throughput sequencing methods is resulting in the identification of a rapidly growing number of novel gene fusions caused by…”
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Mad2 Overexpression Uncovers a Critical Role for TRIP13 in Mitotic Exit by Marks, Daniel Henry, Thomas, Rozario, Chin, Yvette, Shah, Riddhi, Khoo, Christine, Benezra, Robert

“…The mitotic checkpoint ensures proper segregation of chromosomes by delaying anaphase until all kinetochores are bound to microtubules. This inhibitory signal…”
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Correction: Author Correction: Somatic chromosomal engineering identifies BCAN-NTRK1 as a potent glioma driver and therapeutic target by Cook, Peter J., Thomas, Rozario, Kannan, Ram, de Leon, Esther Sanchez, Drilon, Alexander, Rosenblum, Marc K., Scaltriti, Maurizio, Benezra, Robert, Ventura, Andrea

“…Nature Communications 8: Article number: 15987 (2017); Published: 11 July 2017; Updated: 13 March 2018 In the original version of this Article, financial…”
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Integrated Hydrological Model-Based Assessment of Stormwater Management Scenarios in Copenhagen’s First Climate Resilient Neighbourhood Using the Three Point Approach by Sara Maria Lerer, Francesco Righetti, Thomas Rozario, Peter Steen Mikkelsen

“…The city of Copenhagen currently pursues a very ambitious plan to make the city ‘cloudburst proof’ within the next 30 years. The cloudburst management plan has…”
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No Matter How You Splice It, RBM39 Inhibition Targets Spliceosome Mutant AML by Thomas, Rozario, Majeti, Ravindra

“…A report in this issue of Cancer Cell identifies the RNA-binding protein RBM39 as a potential target in spliceosome mutant AML that can be targeted by existing…”
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Cox-2-derived PGE2 induces Id1-dependent radiation resistance and self-renewal in experimental glioblastoma by Cook, Peter J, Thomas, Rozario, Kingsley, Philip J, Shimizu, Fumiko, Montrose, David C, Marnett, Lawrence J, Tabar, Viviane S, Dannenberg, Andrew J, Benezra, Robert

“…In glioblastoma (GBM), Id1 serves as a functional marker for self-renewing cancer stem-like cells. We investigated the mechanism by which cyclooxygenase-2…”
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Whole Chromosome Loss Events in a Tetraploid Background Confer Tumorigenic Potential in a Mouse Allograft Model by Thomas, Rozario

“…Aneuploidy is a hallmark of most human tumors and is a poor prognostic marker. Mouse models of aneuploidy rely on altering the levels of proteins involved in…”
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Cox-2-derived PGE 2 induces Id1-dependent radiation resistance and self-renewal in experimental glioblastoma by Cook, Peter J., Thomas, Rozario, Kingsley, Philip J., Shimizu, Fumiko, Montrose, David C., Marnett, Lawrence J., Tabar, Viviane S., Dannenberg, Andrew J., Benezra, Robert

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Author Correction: Somatic chromosomal engineering identifies BCAN-NTRK1 as a potent glioma driver and therapeutic target by Cook, Peter J, Thomas, Rozario, Kannan, Ram, de Leon, Esther Sanchez, Drilon, Alexander, Rosenblum, Marc K, Scaltriti, Maurizio, Benezra, Robert, Ventura, Andrea

“…This corrects the article DOI: 10.1038/ncomms15987…”
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