Search Results - "Thomas Ried"

Genome-wide analysis of HPV integration in human cancers reveals recurrent, focal genomic instability by Akagi, Keiko, Li, Jingfeng, Broutian, Tatevik R, Padilla-Nash, Hesed, Xiao, Weihong, Jiang, Bo, Rocco, James W, Teknos, Theodoros N, Kumar, Bhavna, Wangsa, Danny, He, Dandan, Ried, Thomas, Symer, David E, Gillison, Maura L

“…Genomic instability is a hallmark of human cancers, including the 5% caused by human papillomavirus (HPV). Here we report a striking association between HPV…”
Get full text

A Novel MIF Signaling Pathway Drives the Malignant Character of Pancreatic Cancer by Targeting NR3C2 by Yang, Shouhui, He, Peijun, Wang, Jian, Schetter, Aaron, Tang, Wei, Funamizu, Naotake, Yanaga, Katsuhiko, Uwagawa, Tadashi, Satoskar, Abhay R, Gaedcke, Jochen, Bernhardt, Markus, Ghadimi, B Michael, Gaida, Matthias M, Bergmann, Frank, Werner, Jens, Ried, Thomas, Hanna, Nader, Alexander, H Richard, Hussain, S Perwez

“…Pancreatic cancers with aberrant expression of macrophage migration inhibitory factor (MIF) are particularly aggressive. To identify key signaling pathways…”
Get full text

Sex-chromosome dosage effects on gene expression in humans by Raznahan, Armin, Parikshak, Neelroop N., Chandran, Vijay, Blumenthal, Jonathan D., Clasen, Liv S., Alexander-Bloch, Aaron F., Zinn, Andrew R., Wangsa, Danny, Wise, Jasen, Murphy, Declan G. M., Bolton, Patrick F., Ried, Thomas, Ross, Judith, Giedd, Jay N., Geschwind, Daniel H.

“…A fundamental question in the biology of sex differences has eluded direct study in humans: How does sex-chromosome dosage (SCD) shape genome function? To…”
Get full text

Functional organization of the human 4D Nucleome by Chen, Haiming, Jie Chen, Lindsey A. Muir, Scott Ronquist, Walter Meixner, Mats Ljungman, Thomas Ried, Stephen Smale, Indika Rajapakse

“…The 4D organization of the interphase nucleus, or the 4D Nucleome (4DN), reflects a dynamical interaction between 3D genome structure and function and its…”
Get full text

Integration of Metabolomics and Transcriptomics Revealed a Fatty Acid Network Exerting Growth Inhibitory Effects in Human Pancreatic Cancer by GENG ZHANG, PEIJUN HE, HANNA, Nader, RICHARD ALEXANDER, H, PERWEZ HUSSAIN, S, HANSON TAN, BUDHU, Anuradha, GAEDCKE, Jochen, MICHAEL GHADIMI, B, RIED, Thomas, YFANTIS, Harris G, LEE, Dong H, MAITRA, Anirban

“…To identify metabolic pathways that are perturbed in pancreatic ductal adenocarcinoma (PDAC), we investigated gene-metabolite networks with integration of…”
Get full text

Positional stability of single double-strand breaks in mammalian cells by Soutoglou, Evi, Dorn, Jonas F, Sengupta, Kundan, Jasin, Maria, Nussenzweig, Andre, Ried, Thomas, Danuser, Gaudenz, Misteli, Tom

“…Formation of cancerous translocations requires the illegitimate joining of chromosomes containing double-strand breaks (DSBs). It is unknown how broken…”
Get full text

Colorectal cancer susceptibility loci as predictive markers of rectal cancer prognosis after surgery by Hu, Yue, Gaedcke, Jochen, Emons, Georg, Beissbarth, Tim, Grade, Marian, Jo, Peter, Yeager, Meredith, Chanock, Stephen J., Wolff, Hendrik, Camps, Jordi, Ghadimi, B. Michael, Ried, Thomas

“…To understand the molecular mechanism of rectal cancer and develop markers for disease prognostication, we generated and explored a dataset from 243 rectal…”
Get full text

Clonal selection of stable aneuploidies in progenitor cells drives high-prevalence tumorigenesis by Trakala, Marianna, Aggarwal, Muskaan, Sniffen, Courtney, Zasadil, Lauren, Carroll, Allison, Ma, Duanduan, Su, Xiaofeng A, Wangsa, Darawalee, Meyer, Ashleigh, Sieben, Cynthia J, Zhong, Jian, Hsu, Pei-Hsin, Paradis, Glenn, Ried, Thomas, Holland, Andrew, Van Deursen, Jan, Amon, Angelika

“…Chromosome gains and losses are a frequent feature of human cancers. However, how these aberrations can outweigh the detrimental effects of aneuploidy remains…”
Get full text

Near‐tetraploid cancer cells show chromosome instability triggered by replication stress and exhibit enhanced invasiveness by Wangsa, Darawalee, Quintanilla, Isabel, Torabi, Keyvan, Vila‐Casadesús, Maria, Ercilla, Amaia, Klus, Gregory, Yuce, Zeynep, Galofré, Claudia, Cuatrecasas, Miriam, José Lozano, Juan, Agell, Neus, Cimini, Daniela, Castells, Antoni, Ried, Thomas, Camps, Jordi

“…A considerable proportion of tumors exhibit aneuploid karyotypes, likely resulting from the progressive loss of chromosomes after whole‐genome duplication…”
Get full text

Chromothripsis and Focal Copy Number Alterations Determine Poor Outcome in Malignant Melanoma by HIRSCH, Daniela, KEMMERLING, Ralf, DAVIS, Sean, CAMPS, Jordi, MELTZER, Paul S, RIED, Thomas, GAISER, Timo

“…Genetic changes during tumorigenesis are usually acquired sequentially. However, a recent study showed that in 2% to 3% of all cancers a single catastrophic…”
Get full text

The Rectal Cancer microRNAome ― microRNA Expression in Rectal Cancer and Matched Normal Mucosa by GAEDCKE, Jochen, GRADE, Marian, BEISSBARTH, Tim, RIED, Thomas, LITMAN, Thomas, CAMPS, Jordi, SØKILDE, Rolf, KACZKOWSKI, Bogumil, SCHETTER, Aaron J, DIFILIPPANTONIO, Michael J, HARRIS, Curtis C, MICHAEL GHADIMI, B, MØLLER, Soren

“…miRNAs play a prominent role in a variety of physiologic and pathologic biologic processes, including cancer. For rectal cancers, only limited data are…”
Get full text

Molecular characterization of ulcerative colitis-associated colorectal carcinomas by Hirsch, Daniela, Hardt, Julia, Sauer, Christian, Heselmeyer-Hadded, Kerstin, Witt, Stephanie H., Kienle, Peter, Ried, Thomas, Gaiser, Timo

“…Patients with ulcerative colitis (UC) are at increased risk for developing colorectal cancer (CRC). In contrast to sporadic colorectal tumorigenesis, TP53…”
Get full text

The role of lamin B1 for the maintenance of nuclear structure and function by Camps, Jordi, Erdos, Michael R, Ried, Thomas

“…Lamins constitute an integral structural component of the nuclear lamina. However, their impact on the structure and stability of chromosome territories, and…”
Get full text

Mutated KRAS results in overexpression of DUSP4, a MAP-kinase phosphatase, and SMYD3, a histone methyltransferase, in rectal carcinomas by Gaedcke, Jochen, Grade, Marian, Jung, Klaus, Camps, Jordi, Jo, Peter, Emons, Georg, Gehoff, Anastasia, Sax, Ulrich, Schirmer, Markus, Becker, Heinz, Beissbarth, Tim, Ried, Thomas, Ghadimi, B. Michael

“…Mutations of the KRAS oncogene are predictive for resistance to treatment with antibodies against the epithelial growth factor receptor in patients with…”
Get full text

Actin-dependent intranuclear repositioning of an active gene locus in vivo by Dundr, Miroslav, Ospina, Jason K, Sung, Myong-Hee, John, Sam, Upender, Madhvi, Ried, Thomas, Hager, Gordon L, Matera, A. Gregory

“…Although bulk chromatin is thought to have limited mobility within the interphase eukaryotic nucleus, directed long-distance chromosome movements are not…”
Get full text

TCF7L2 silencing results in altered gene expression patterns accompanied by local genomic reorganization by Brown, Markus A., Dotson, Gabrielle A., Ronquist, Scott, Emons, Georg, Rajapakse, Indika, Ried, Thomas

“…Canonical Wnt signaling is crucial for intestinal homeostasis as TCF4, the major Wnt signaling effector in the intestines, is required for stem cell…”
Get full text

Tumor heterogeneity assessed by sequencing and fluorescence in situ hybridization (FISH) data by Lei, Haoyun, Gertz, E Michael, Schäffer, Alejandro A, Fu, Xuecong, Tao, Yifeng, Heselmeyer-Haddad, Kerstin, Torres, Irianna, Li, Guibo, Xu, Liqin, Hou, Yong, Wu, Kui, Shi, Xulian, Dean, Michael, Ried, Thomas, Schwartz, Russell

“…Abstract Motivation Computational reconstruction of clonal evolution in cancers has become a crucial tool for understanding how tumors initiate and progress…”
Get full text

Single-cell resolved ploidy and chromosomal aberrations in nonalcoholic steatohepatitis-(NASH) induced hepatocellular carcinoma and its precursor lesions by Friemel, Juliane, Torres, Irianna, Brauneis, Elizabeth, Thörner, Tim, Schäffer, Alejandro A., Gertz, E. Michael, Grob, Tobias, Seidl, Kati, Weber, Achim, Ried, Thomas, Heselmeyer-Haddad, Kerstin

“…Nonalcoholic steatohepatitis (NASH)-induced hepatocellular carcinoma (HCC) and its precursor, nonalcoholic fatty liver disease (NAFLD) are an unmet health…”
Get full text

Single Chromosome Aneuploidy Induces Genome-Wide Perturbation of Nuclear Organization and Gene Expression by Braun, Rüdiger, Ronquist, Scott, Wangsa, Darawalee, Chen, Haiming, Anthuber, Lena, Gemoll, Timo, Wangsa, Danny, Koparde, Vishal, Hunn, Cynthia, Habermann, Jens K., Heselmeyer-Haddad, Kerstin, Rajapakse, Indika, Ried, Thomas

“…Chromosomal aneuploidy is a defining feature of carcinomas and results in tumor-entity specific genomic imbalances. For instance, most sporadic colorectal…”
Get full text

Suppressing proteasome mediated processing of topoisomerase II DNA-protein complexes preserves genome integrity by Sciascia, Nicholas, Wu, Wei, Zong, Dali, Sun, Yilun, Wong, Nancy, John, Sam, Wangsa, Darawalee, Ried, Thomas, Bunting, Samuel F, Pommier, Yves, Nussenzweig, André

“…Topoisomerase II (TOP2) relieves topological stress in DNA by introducing double-strand breaks (DSBs) via a transient, covalently linked TOP2 DNA-protein…”
Get full text