Search Results - "Thomas P. Blackburn"

Golexanolone reduces glial activation in the striatum and improves non-motor and some motor alterations in a rat model of Parkinson's disease by Izquierdo-Altarejos, Paula, Arenas, Yaiza M, Martínez-García, Mar, Vázquez, Lola, Mincheva, Gergana, Doverskog, Magnus, Blackburn, Thomas P, Bohnen, Nicolaas I, Llansola, Marta, Felipo, Vicente

“…Parkinson's disease (PD) affects more than 6 million people worldwide. Along with motor impairments, patients and animal models exhibiting PD symptoms also…”
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Depressive disorders: Treatment failures and poor prognosis over the last 50 years by Blackburn, Thomas P.

“…Depression like many diseases is pleiotropic but unlike cancer and Alzheimer's disease for example, is still largely stigmatized and falls into the dark…”
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Neurological drug development: A guide for a start-up biotech by Blackburn, Thomas P., Dr, Bezard, Erwan, Dr

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Antidepressant, anxiolytic and anorectic effects of a melanin-concentrating hormone-1 receptor antagonist by Forray, Carlos, Borowsky, Beth, Durkin, Margaret M, Ogozalek, Kristine, Marzabadi, Mohammad R, DeLeon, John, Heurich, Rainer, Lichtblau, Harvey, Shaposhnik, Zoya, Daniewska, Irena, Blackburn, Thomas P, Branchek, Theresa A, Gerald, Christophe, Vaysse, Pierre J

“…Melanin concentrating hormone (MCH) is an orexigenic hypothalamic neuropeptide, which plays an important role in the complex regulation of energy balance and…”
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The promise of molecular science in brain health. What breakthroughs are anticipated in the next 20 years? by Hainsworth, Atticus H, Blackburn, Thomas P, Bradshaw, Elizabeth M, Elahi, Fanny M, Gorelick, Philip B, Isaacs, Jeremy D, Wallin, Anders, Williams, Steven CR

“…•In the past twenty years molecular science has delivered progress in therapeutic antibodies, biochemical markers, gene therapy and drug re-purposing.•Areas of…”
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Anxiolytic- and Antidepressant-like Profiles of the Galanin-3 Receptor ($Gal_3$) Antagonists SNAP 37889 and SNAP 398299 by Chad J. Swanson, Thomas P. Blackburn, Xuexiang Zhang, Zheng, Kang, Xu, Zhi-Qing David, Hökfelt, Tomas, Toni D. Wolinsky, Michael J. Konkel, Heidi Chen, Huailing Zhong, Mary W. Walker, Craig, Douglas A., Christophe P. G. Gerald, Branchek, Theresa A.

“…The neuropeptide galanin mediates its effects through the receptor subtypes$Gal_1$,$Gal_2$, and$Gal_3$and has been implicated in anxiety-and depression-related…”
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The GABA system, a new target for medications against cognitive impairment—Associated with neuroactive steroids by Bäckström, Torbjörn, Turkmen, Sahruh, Das, Roshni, Doverskog, Magnus, Blackburn, Thomas P.

“…The prevalence of cognitive dysfunction, dementia, and neurodegenerative disorders such as Alzheimer's disease (AD) is increasing in parallel with an aging…”
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Allopregnanolone and its antagonist modulate neuroinflammation and neurological impairment by Bäckström, Torbjörn, Doverskog, Magnus, Blackburn, Thomas P., Scharschmidt, Bruce F., Felipo, Vicente

“…Neuroinflammation accompanies several brain disorders, either as a secondary consequence or as a primary cause and may contribute importantly to disease…”
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Selecting Double Bond Positions with a Single Cation-Responsive Iridium Olefin Isomerization Catalyst by Camp, Andrew M, Kita, Matthew R, Blackburn, P. Thomas, Dodge, Henry M, Chen, Chun-Hsing, Miller, Alexander J. M

“…The catalytic transposition of double bonds holds promise as an ideal route to alkenes of value as fragrances, commodity chemicals, and pharmaceuticals; yet,…”
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Effects of a triangular nanocage structure on the binding of neutral and anionic ligands to CoII and ZnII porphyrins by Blackburn, P. Thomas, Lipke, Mark C.

“…Interactions of neutral pyridine ligands and anionic benzoate ligands with the metalloporphyrin walls of M 6 L 3 nanocages (M = [(tmeda)Pt] 2+ , L =…”
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Golexanolone, a GABAA receptor modulating steroid antagonist, restores motor coordination and cognitive function in hyperammonemic rats by dual effects on peripheral inflammation and neuroinflammation by Mincheva, Gergana, Gimenez‐Garzo, Carla, Izquierdo‐Altarejos, Paula, Martinez‐Garcia, Mar, Doverskog, Magnus, Blackburn, Thomas P., Hällgren, Anneli, Bäckström, Torbjörn, Llansola, Marta, Felipo, Vicente

“…Aims Hyperammonemic rats show peripheral inflammation, increased GABAergic neurotransmission and neuroinflammation in cerebellum and hippocampus which induce…”
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Editorial overview: Preface to ‘a tribute to professor Norman Bowery’ by Blackburn, Thomas P, Trist, David G

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In memory of Norman Bowery (1944–2016) by Trist, David G, Kenakin, Terry P, Blackburn, Thomas P

“…•An article in memory of Professor Norman Bowery.•Norman Bowery discovered the GABAB receptor.•He identified the mechanism of action of Baclofen as a GABAB…”
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The medical benefit of 5-HT research by Jones, Brian J, Blackburn, Thomas P

“…5-HT research is now more than 50 years old, and it has generated a wealth of therapeutic agents, some of which have had a major impact on disease management…”
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Trace amine receptors as targets for novel therapeutics: legend, myth and fact by Branchek, Theresa A, Blackburn, Thomas P

“…Trace amines are attracting attention as neurotransmitters because they are believed to play a role in human disorders such as schizophrenia, depression,…”
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Acute and repeated administration of fluoxetine, citalopram, and paroxetine significantly alters the activity of midbrain dopamine neurons in rats: An in vivo electrophysiological study by Sekine, Yoshimoto, Suzuki, Katsuaki, Ramachandran, P. Veeraraghavan, Blackburn, Thomas P., Ashby JR, Charles R.

“…We examined the effect of the administration of the selective serotonin reuptake inhibitors (SSRIs) fluoxetine, citalopram, and paroxetine on the activity of…”
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3-Arylimino-2-indolones Are Potent and Selective Galanin GAL3 Receptor Antagonists by Konkel, Michael J, Lagu, Bharat, Boteju, Lakmal W, Jimenez, Hermogenes, Noble, Stewart, Walker, Mary W, Chandrasena, Gamini, Blackburn, Thomas P, Nikam, Sham S, Wright, Jon L, Kornberg, Brian E, Gregory, Tracy, Pugsley, Thomas A, Akunne, Hyacinth, Zoski, Kim, Wise, Lawrence D

“…A series of 3-imino-2-indolones are the first published, high-affinity antagonists of the galanin GAL3 receptor. One example,…”
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5-ht6 receptors as emerging targets for drug discovery by Branchek, T A, Blackburn, T P

“…5-ht6 receptors are the latest serotonin receptors to be identified by molecular cloning. Their high affinity for a wide range of drugs used in psychiatry,…”
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6-Chloro-5-methyl-1-[[2-[(2-methyl-3- pyridyl)oxy]-5-pyridyl]carbamoyl]indoline (SB-242084):  The First Selective and Brain Penetrant 5-HT2C Receptor Antagonist by Bromidge, Steven M, Duckworth, Malcolm, Forbes, Ian T, Ham, Peter, King, Frank D, Thewlis, Kevin M, Blaney, Frank E, Naylor, Christopher B, Blackburn, Thomas P, Kennett, Guy A, Wood, Martyn D, Clarke, Stephen E

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The acute and chronic administration of the 5-HT2B/2C receptor antagonist SB-200646A significantly alters the activity of spontaneously active midbrain dopamine neurons in the rat: An in vivo extracellular single cell study by Blackburn, Thomas P., Suzuki, Katsuaki, Ashby Jr, Charles R.

“…This study examined the effect of the acute and chronic administration of the 5‐HT2B/2C receptor antagonist N‐(1‐methyl‐5‐indolyl)‐N′‐(3‐pyridyl) urea…”
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