Search Results - "Thomas Hoyler"

Two distinct immunopathological profiles in autopsy lungs of COVID-19 by Nienhold, Ronny, Ciani, Yari, Koelzer, Viktor H., Tzankov, Alexandar, Haslbauer, Jasmin D., Menter, Thomas, Schwab, Nathalie, Henkel, Maurice, Frank, Angela, Zsikla, Veronika, Willi, Niels, Kempf, Werner, Hoyler, Thomas, Barbareschi, Mattia, Moch, Holger, Tolnay, Markus, Cathomas, Gieri, Demichelis, Francesca, Junt, Tobias, Mertz, Kirsten D.

“…Coronavirus Disease 19 (COVID-19) is a respiratory disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which has grown to a…”
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Differentiation of type 1 ILCs from a common progenitor to all helper-like innate lymphoid cell lineages by Klose, Christoph S N, Flach, Melanie, Möhle, Luisa, Rogell, Leif, Hoyler, Thomas, Ebert, Karolina, Fabiunke, Carola, Pfeifer, Dietmar, Sexl, Veronika, Fonseca-Pereira, Diogo, Domingues, Rita G, Veiga-Fernandes, Henrique, Arnold, Sebastian J, Busslinger, Meinrad, Dunay, Ildiko R, Tanriver, Yakup, Diefenbach, Andreas

“…Innate lymphoid cells (ILCs) are a recently recognized group of lymphocytes that have important functions in protecting epithelial barriers against infections…”
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The Transcription Factor GATA-3 Controls Cell Fate and Maintenance of Type 2 Innate Lymphoid Cells by Hoyler, Thomas, Klose, Christoph S.N., Souabni, Abdallah, Turqueti-Neves, Adriana, Pfeifer, Dietmar, Rawlins, Emma L., Voehringer, David, Busslinger, Meinrad, Diefenbach, Andreas

“…Innate lymphoid cells (ILCs) reside at mucosal surfaces and control immunity to intestinal infections. Type 2 innate lymphoid cells (ILC2s) produce cytokines…”
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Transcription factor EBF1 is essential for the maintenance of B cell identity and prevention of alternative fates in committed cells by Nechanitzky, Robert, Akbas, Duygu, Scherer, Stefanie, Györy, Ildiko, Hoyler, Thomas, Ramamoorthy, Senthilkumar, Diefenbach, Andreas, Grosschedl, Rudolf

“…Lineage-commitment factors enforce irreversible loss of alternative lineage potentials during development. Grosschedl and colleagues show that EBF1 expression…”
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Opposing functions of thymic stromal lymphopoietin–responsive basophils and dendritic cells in a mouse model of atopic dermatitis by Schwartz, Christian, PhD, Eberle, Joerg U., MSc, Hoyler, Thomas, PhD, Diefenbach, Andreas, MD, Lechmann, Matthias, PhD, Voehringer, David, PhD

“…[...]increased ear swelling was also observed in basophil-deficient Mcpt8Cre mice (see Fig E2 in this article's Online Repository at www.jacionline.org)…”
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CARD10 cleavage by MALT1 restricts lung carcinoma growth in vivo by Israël, Laura, Glück, Anton, Berger, Marjorie, Coral, Marine, Ceci, Melanie, Unterreiner, Adeline, Rubert, Joëlle, Bardet, Maureen, Ginster, Stefanie, Golding-Ochsenbein, Alexandra M., Martin, Kea, Hoyler, Thomas, Calzascia, Thomas, Wieczorek, Grazyna, Hillenbrand, Rainer, Ferretti, Stéphane, Ferrero, Enrico, Bornancin, Frédéric

“…CARD-CC complexes involving BCL10 and MALT1 are major cellular signaling hubs. They govern NF-κB activation through their scaffolding properties as well as…”
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Distinct pathogenic roles for resident and monocyte-derived macrophages in lupus nephritis by Richoz, Nathan, Tuong, Zewen K., Loudon, Kevin W., Patiño-Martínez, Eduardo, Ferdinand, John R., Portet, Anaïs, Bashant, Kathleen R., Thevenon, Emeline, Rucci, Francesca, Hoyler, Thomas, Junt, Tobias, Kaplan, Mariana J., Siegel, Richard M., Clatworthy, Menna R.

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Nonhematopoietic IRAK1 drives arthritis via neutrophil chemoattractants by Hoyler, Thomas, Bannert, Bettina, André, Cédric, Beck, Damian, Boulay, Thomas, Buffet, David, Caesar, Nadja, Calzascia, Thomas, Dawson, Janet, Kyburz, Diego, Hennze, Robert, Huppertz, Christine, Littlewood-Evans, Amanda, Loetscher, Pius, Mertz, Kirsten D., Niwa, Satoru, Robert, Gautier, Rush, James S., Ruzzante, Giulia, Sarret, Sophie, Stein, Thomas, Touil, Ismahane, Wieczorek, Grazyna, Zipfel, Geraldine, Hawtin, Stuart, Junt, Tobias

“…IL-1 receptor-activated kinase 1 (IRAK1) is involved in signal transduction downstream of many TLRs and the IL-1R. Its potential as a drug target for chronic…”
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Transcriptional control of innate lymphocyte fate decisions by Klose, Christoph SN, Hoyler, Thomas, Kiss, Elina A, Tanriver, Yakup, Diefenbach, Andreas

“…Highlights ► Differential roles of T-bet and Eomes for NK cell development. ► Lineage specification of type 2 ILC. ► The aryl hydrocarbon receptor controls the…”
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LO-016 The multifaceted immunomodulatory properties of cenerimod, a selective S1P1 receptor modulator, target three key aspects of SLE pathogenesis by Hoyler, Thomas F, Strasser, Daniel S, Ouali Berkani, Cahuzac, Clelia, Cornelisse, Peter, Murphy, Mark J, Martinic, Marianne M

“…BackgroundSystemic lupus erythematosus (SLE) is a complex autoimmune disorder characterized by aberrant lymphocyte activation and autoantibodies. Formation and…”
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The transcription factor GATA3 controls cell fate and maintenance of type 2 innate lymphoid cells by Hoyler, Thomas, Klose, Christoph S.N., Souabni, Abdallah, Turqueti-Neves, Adriana, Pfeifer, Dietmar, Rawlins, Emma L., Voehringer, David, Busslinger, Meinrad, Diefenbach, Andreas

“…Innate lymphoid cells (ILCs) reside at mucosal surfaces and control immunity to intestinal infections. Type 2 innate lymphoid cells (ILC2) produce cytokines…”
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Specific subfamilies of transposable elements contribute to different domains of T lymphocyte enhancers by Ye, Mengliang, Goudot, Christel, Hoyler, Thomas, Lemoine, Benjamin, Amigorena, Sebastian, Zueva, Elina

“…Transposable elements (TEs) compose nearly half of mammalian genomes and provide building blocks for cis-regulatory elements. Using high-throughput sequencing,…”
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A T-bet gradient controls the fate and function of CCR6−RORγt+ innate lymphoid cells by Klose, Christoph S. N., Kiss, Elina A., Schwierzeck, Vera, Ebert, Karolina, Hoyler, Thomas, d’Hargues, Yannick, Göppert, Nathalie, Croxford, Andrew L., Waisman, Ari, Tanriver, Yakup, Diefenbach, Andreas

“…The graded expression of the transcription factor T-bet in CCR6 − RORγt + innate lymphoid cells is found to be involved in the control of interferon-γ…”
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TNF leads to mtDNA release and cGAS/STING-dependent interferon responses that support inflammatory arthritis by Willemsen, Joschka, Neuhoff, Marie-Therese, Hoyler, Thomas, Noir, Emma, Tessier, Clemence, Sarret, Sophie, Thorsen, Tara N., Littlewood-Evans, Amanda, Zhang, Juan, Hasan, Maroof, Rush, James S., Guerini, Danilo, Siegel, Richard M.

“…Tumor necrosis factor (TNF) is a key driver of several inflammatory diseases, such as rheumatoid arthritis, inflammatory bowel disease, and psoriasis, in which…”
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Regulated Expression of Nuclear Receptor RORγt Confers Distinct Functional Fates to NK Cell Receptor-Expressing RORγt + Innate Lymphocytes by Vonarbourg, Cedric, Mortha, Arthur, Bui, Viet L., Hernandez, Pedro P., Kiss, Elina A., Hoyler, Thomas, Flach, Melanie, Bengsch, Bertram, Thimme, Robert, Hölscher, Christoph, Hönig, Manfred, Pannicke, Ulrich, Schwarz, Klaus, Ware, Carl F., Finke, Daniela, Diefenbach, Andreas

“…Whether the recently identified innate lymphocyte population coexpressing natural killer cell receptors (NKRs) and the nuclear receptor RORγt is part of the NK…”
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82 Using the C3 gain-of-function mouse model of aHUS as a complement therapeutic testbed to enable precision medicine for complement mediated atypical haemolytic uraemic syndrome by Smith-Jackson, Kate, Pappworth, Isabel, Gibson, Beth, Kamala, Ola, Walsh, Patrick, Yang, Yi, Johnson, Krista, Denton, Harriet, Bertram, Paula, Hoyler, Thomas, Martinic, Marianne, Kim, Sung-Kwon, Zelek, Wioleta, Hourcade, Dennis, Tomlinson, Stephen, Murphy, Mark, Kavanagh, David, Marchbank, Kevin

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T-bet and Gata3 in controlling type 1 and type 2 immunity mediated by innate lymphoid cells by Hoyler, Thomas, Connor, Catherine A, Kiss, Elina A, Diefenbach, Andreas

“…Highlights ► A T-bet gradient controls fate and function of CCR6− ILC3s. ► T-bet and the control of ILC-mediated immunity to infections. ► Gata3 and ILC2 cell…”
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Critical role for TRIM28 and HP1β/γ in the epigenetic control of T cell metabolic reprograming and effector differentiation by Gehrmann, Ulf, Burbage, Marianne, Zueva, Elina, Goudot, Christel, Esnault, Cyril, Ye, Mengliang, Carpier, Jean-Marie, Burgdorf, Nina, Hoyler, Thomas, Suarez, Guadalupe, Joannas, Leonel, Heurtebise-Chrétien, Sandrine, Durand, Sylvère, Panes, Rébecca, Bellemare-Pelletier, Angélique, Sáez, Pablo J., Aprahamian, Fanny, Lefevre, Deborah, Adoue, Veronique, El Aabidine, Amal Zine, Ahmad, Maqbool Muhammad, Hivroz, Claire, Joffre, Olivier, Cammas, Florence, Kroemer, Guido, Gagnon, Etienne, Andrau, Jean-Christophe, Amigorena, Sebastian

“…Naive CD4⁺ T lymphocytes differentiate into different effector types, including helper and regulatory cells (Th and Treg, respectively). Heritable gene…”
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Distinct pathogenic roles for resident and monocyte-derived macrophages in lupus nephritis by Richoz, Nathan, Tuong, Zewen K, Loudon, Kevin W, Patiño-Martínez, Eduardo, Ferdinand, John R, Portet, Anaïs, Bashant, Kathleen R, Thevenon, Emeline, Rucci, Francesca, Hoyler, Thomas, Junt, Tobias, Kaplan, Mariana J, Siegel, Richard M, Clatworthy, Menna R

“…Lupus nephritis is a serious complication of systemic lupus erythematosus, mediated by IgG immune complex (IC) deposition in kidneys, with limited treatment…”
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Distinct pathogenic roles for resident and monocyte-derived macrophages in lupus nephritis by Nathan Richoz, Zewen K. Tuong, Kevin W. Loudon, Eduardo Patiño-Martínez, John R. Ferdinand, Jorge Romo-Tena, Anaïs Portet, Kathleen R. Bashant, Emeline Thevenon, Francesca Rucci, Thomas Hoyler, Tobias Junt, Mariana J. Kaplan, Richard M. Siegel, Menna R. Clatworthy

“…Lupus nephritis is a serious complication of systemic lupus erythematosus, mediated by IgG immune complex (IC) deposition in kidneys, with limited treatment…”
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