Search Results - "Thomas G.P. Grünewald"

A single-sample workflow for joint metabolomic and proteomic analysis of clinical specimens by Gegner, Hagen M, Naake, Thomas, Aljakouch, Karim, Dugourd, Aurelien, Kliewer, Georg, Müller, Torsten, Schilling, Dustin, Schneider, Marc A, Kunze-Rohrbach, Nina, Grünewald, Thomas G P, Hell, Rüdiger, Saez-Rodriguez, Julio, Huber, Wolfgang, Poschet, Gernot, Krijgsveld, Jeroen

“…Understanding the interplay of the proteome and the metabolome helps to understand cellular regulation and response. To enable robust inferences from such…”
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Single-cell transcriptomic analyses provide insights into the developmental origins of neuroblastoma by Jansky, Selina, Sharma, Ashwini Kumar, Körber, Verena, Quintero, Andrés, Toprak, Umut H., Wecht, Elisa M., Gartlgruber, Moritz, Greco, Alessandro, Chomsky, Elad, Grünewald, Thomas G. P., Henrich, Kai-Oliver, Tanay, Amos, Herrmann, Carl, Höfer, Thomas, Westermann, Frank

“…Neuroblastoma is a pediatric tumor of the developing sympathetic nervous system. However, the cellular origin of neuroblastoma has yet to be defined. Here we…”
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Epithelial-to-Mesenchymal and Mesenchymal-to-Epithelial Transition in Mesenchymal Tumors: A Paradox in Sarcomas? by Sannino, Giuseppina, Marchetto, Aruna, Kirchner, Thomas, Grünewald, Thomas G P

“…The epithelial-to-mesenchymal transition (EMT) is a reversible process comprised of various subprograms via which epithelial cells reduce their intercellular…”
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Transcriptional Programs Define Intratumoral Heterogeneity of Ewing Sarcoma at Single-Cell Resolution by Aynaud, Marie-Ming, Mirabeau, Olivier, Gruel, Nadege, Grossetête, Sandrine, Boeva, Valentina, Durand, Simon, Surdez, Didier, Saulnier, Olivier, Zaïdi, Sakina, Gribkova, Svetlana, Fouché, Aziz, Kairov, Ulykbek, Raynal, Virginie, Tirode, Franck, Grünewald, Thomas G.P., Bohec, Mylene, Baulande, Sylvain, Janoueix-Lerosey, Isabelle, Vert, Jean-Philippe, Barillot, Emmanuel, Delattre, Olivier, Zinovyev, Andrei

“…EWSR1-FLI1, the chimeric oncogene specific for Ewing sarcoma (EwS), induces a cascade of signaling events leading to cell transformation. However, it remains…”
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Unraveling Ewing Sarcoma Tumorigenesis Originating from Patient-Derived Mesenchymal Stem Cells by Sole, Anna, Grossetête, Sandrine, Heintzé, Maxime, Babin, Loelia, Zaïdi, Sakina, Revy, Patrick, Renouf, Benjamin, De Cian, Anne, Giovannangeli, Carine, Pierre-Eugène, Cécile, Janoueix-Lerosey, Isabelle, Couronné, Lucile, Kaltenbach, Sophie, Tomishima, Mark, Jasin, Maria, Grünewald, Thomas G P, Delattre, Olivier, Surdez, Didier, Brunet, Erika

“…Ewing sarcoma is characterized by pathognomonic translocations, most frequently fusing with . An estimated 30% of Ewing sarcoma tumors also display genetic…”
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Tissue Preservation and FFPE Samples: Optimized Nucleic Acids Isolation in Ewing Sarcoma by Romero-Pérez, Laura, Grünewald, Thomas G P

“…Different methods have been described for the preservation of biopsy or resection samples. In the routine pathology, the cheapest and most commonly used is…”
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(Immuno)histological Analysis of Ewing Sarcoma by Marcilla, David, Machado, Isidro, Grünewald, Thomas G P, Llombart-Bosch, Antonio, de Álava, Enrique

“…The diagnosis of Ewing sarcoma requires the integration of the information generated from numerous techniques, some of them being very sophisticated. However,…”
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Focal adhesion kinase confers pro‐migratory and antiapoptotic properties and is a potential therapeutic target in Ewing sarcoma by Steinestel, Konrad, Trautmann, Marcel, Jansen, Esther‐Pia, Dirksen, Uta, Rehkämper, Jan, Mikesch, Jan‐Henrik, Gerke, Julia S., Orth, Martin F., Sannino, Giuseppina, Arteaga, Maria‐Francisca, Rossig, Claudia, Wardelmann, Eva, Grünewald, Thomas G. P., Hartmann, Wolfgang

“…Oncogenesis of Ewing sarcoma (EwS), the second most common malignant bone tumor of childhood and adolescence, is dependent on the expression of chimeric…”
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Are EWSR1-NFATc2-positive sarcomas really Ewing sarcomas? by Baldauf, Michaela C., Gerke, Julia S., Orth, Martin F., Dallmayer, Marlene, Baumhoer, Daniel, de Alava, Enrique, Hartmann, Wolfgang, Kirchner, Thomas, Grünewald, Thomas G.P.

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YB-1 regulates stress granule formation and tumor progression by translationally activating G3BP1 by Somasekharan, Syam Prakash, El-Naggar, Amal, Leprivier, Gabriel, Cheng, Hongwei, Hajee, Shamil, Grunewald, Thomas G P, Zhang, Fan, Ng, Tony, Delattre, Olivier, Evdokimova, Valentina, Wang, Yuzhuo, Gleave, Martin, Sorensen, Poul H

“…Under cell stress, global protein synthesis is inhibited to preserve energy. One mechanism is to sequester and silence mRNAs in ribonucleoprotein complexes…”
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Translational Activation of HIF1α by YB-1 Promotes Sarcoma Metastasis by El-Naggar, Amal M., Veinotte, Chansey J., Cheng, Hongwei, Grunewald, Thomas G.P., Negri, Gian Luca, Somasekharan, Syam Prakash, Corkery, Dale P., Tirode, Franck, Mathers, Joan, Khan, Debjit, Kyle, Alastair H., Baker, Jennifer H., LePard, Nancy E., McKinney, Steven, Hajee, Shamil, Bosiljcic, Momir, Leprivier, Gabriel, Tognon, Cristina E., Minchinton, Andrew I., Bennewith, Kevin L., Delattre, Olivier, Wang, Yuzhuo, Dellaire, Graham, Berman, Jason N., Sorensen, Poul H.

“…Metastatic dissemination is the leading cause of death in cancer patients, which is particularly evident for high-risk sarcomas such as Ewing sarcoma,…”
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PBX3 Is Part of an EMT Regulatory Network and Indicates Poor Outcome in Colorectal Cancer by Lamprecht, Sebastian, Kaller, Markus, Schmidt, Eva Marina, Blaj, Cristina, Schiergens, Tobias S, Engel, Jutta, Jung, Andreas, Hermeking, Heiko, Grünewald, Thomas G P, Kirchner, Thomas, Horst, David

“…Colorectal cancers are composed of phenotypically different tumor cell subpopulations within the same core genetic background. Here, we identify high…”
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Proline metabolism supports metastasis formation and could be inhibited to selectively target metastasizing cancer cells by Elia, Ilaria, Broekaert, Dorien, Christen, Stefan, Boon, Ruben, Radaelli, Enrico, Orth, Martin F., Verfaillie, Catherine, Grünewald, Thomas G. P., Fendt, Sarah-Maria

“…Metastases are the leading cause of mortality in patients with cancer. Metastasis formation requires cancer cells to adapt their cellular phenotype. However,…”
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MYBL2 (B-Myb): a central regulator of cell proliferation, cell survival and differentiation involved in tumorigenesis by Musa, Julian, Aynaud, Marie-Ming, Mirabeau, Olivier, Delattre, Olivier, Grünewald, Thomas GP

“…Limitless cell proliferation, evasion from apoptosis, dedifferentiation, metastatic spread and therapy resistance: all these properties of a cancer cell…”
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DKK2 Mediates Osteolysis, Invasiveness, and Metastatic Spread in Ewing Sarcoma by HAUER, Kristina, CALZADA-WACK, Julia, RICHTER, Günther H. S, STEIGER, Katja, GRUNEWALD, Thomas G. P, BAUMHOER, Daniel, PLEHM, Stephanie, BUCH, Thorsten, DA COSTA, Olivia Prazeres, ESPOSITO, Irene, BURDACH, Stefan

“…Ewing sarcoma, an osteolytic malignancy that mainly affects children and young adults, is characterized by early metastasis to lung and bone. In this study, we…”
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Endogenous TCR promotes in vivo persistence of CD19-CAR-T cells compared to a CRISPR/Cas9-mediated TCR knockout CAR by Stenger, Dana, Stief, Tanja A., Kaeuferle, Theresa, Willier, Semjon, Rataj, Felicitas, Schober, Kilian, Vick, Binje, Lotfi, Ramin, Wagner, Beate, Grünewald, Thomas G.P., Kobold, Sebastian, Busch, Dirk H., Jeremias, Irmela, Blaeschke, Franziska, Feuchtinger, Tobias

“…Anti-CD19 chimeric antigen receptor (CAR) T cells showed significant antileukemic activity in B-precursor acute lymphoblastic leukemia (ALL). Allogeneic,…”
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Heterogeneity of neuroblastoma cell identity defined by transcriptional circuitries by Boeva, Valentina, Louis-Brennetot, Caroline, Peltier, Agathe, Durand, Simon, Pierre-Eugène, Cécile, Raynal, Virginie, Etchevers, Heather C, Thomas, Sophie, Lermine, Alban, Daudigeos-Dubus, Estelle, Geoerger, Birgit, Orth, Martin F, Grünewald, Thomas G P, Diaz, Elise, Ducos, Bertrand, Surdez, Didier, Carcaboso, Angel M, Medvedeva, Irina, Deller, Thomas, Combaret, Valérie, Lapouble, Eve, Pierron, Gaelle, Grossetête-Lalami, Sandrine, Baulande, Sylvain, Schleiermacher, Gudrun, Barillot, Emmanuel, Rohrer, Hermann, Delattre, Olivier, Janoueix-Lerosey, Isabelle

“…Isabelle Janoueix-Lerosey, Valentina Boeva and colleagues analyze the super-enhancer landscape of 25 neuroblastoma cell lines to define core regulatory…”
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Evidence for an alternative fatty acid desaturation pathway increasing cancer plasticity by Vriens, Kim, Christen, Stefan, Parik, Sweta, Broekaert, Dorien, Yoshinaga, Kazuaki, Talebi, Ali, Dehairs, Jonas, Escalona-Noguero, Carmen, Schmieder, Roberta, Cornfield, Thomas, Charlton, Catriona, Romero-Pérez, Laura, Rossi, Matteo, Rinaldi, Gianmarco, Orth, Martin F., Boon, Ruben, Kerstens, Axelle, Kwan, Suet Ying, Faubert, Brandon, Méndez-Lucas, Andrés, Kopitz, Charlotte C., Chen, Ting, Fernandez-Garcia, Juan, Duarte, João A. G., Schmitz, Arndt A., Steigemann, Patrick, Najimi, Mustapha, Hägebarth, Andrea, Van Ginderachter, Jo A., Sokal, Etienne, Gotoh, Naohiro, Wong, Kwok-Kin, Verfaillie, Catherine, Derua, Rita, Munck, Sebastian, Yuneva, Mariia, Beretta, Laura, DeBerardinis, Ralph J., Swinnen, Johannes V., Hodson, Leanne, Cassiman, David, Verslype, Chris, Christian, Sven, Grünewald, Sylvia, Grünewald, Thomas G. P., Fendt, Sarah-Maria

“…Most tumours have an aberrantly activated lipid metabolism 1 , 2 that enables them to synthesize, elongate and desaturate fatty acids to support proliferation…”
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Ewing sarcoma by Grünewald, Thomas G. P., Cidre-Aranaz, Florencia, Surdez, Didier, Tomazou, Eleni M., de Álava, Enrique, Kovar, Heinrich, Sorensen, Poul H., Delattre, Olivier, Dirksen, Uta

“…Ewing sarcoma is the second most frequent bone tumour of childhood and adolescence that can also arise in soft tissue. Ewing sarcoma is a highly aggressive…”
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In Vivo Evidence for Serine Biosynthesis-Defined Sensitivity of Lung Metastasis, but Not of Primary Breast Tumors, to mTORC1 Inhibition by Rinaldi, Gianmarco, Pranzini, Erica, Van Elsen, Joke, Broekaert, Dorien, Funk, Cornelius M., Planque, Mélanie, Doglioni, Ginevra, Altea-Manzano, Patricia, Rossi, Matteo, Geldhof, Vincent, Teoh, Shao Thing, Ross, Christina, Hunter, Kent W., Lunt, Sophia Y., Grünewald, Thomas G.P., Fendt, Sarah-Maria

“…In tumors, nutrient availability and metabolism are known to be important modulators of growth signaling. However, it remains elusive whether cancer cells that…”
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