Search Results - "Thomas, Susan N."

Thermosensitive hydrogel releasing nitric oxide donor and anti-CTLA-4 micelles for anti-tumor immunotherapy by Kim, Jihoon, Francis, David M., Sestito, Lauren F., Archer, Paul A., Manspeaker, Margaret P., O’Melia, Meghan J., Thomas, Susan N.

“…Due to their autosynchronous roles in shaping the anti-tumor immune response, complex immune regulatory networks acting both locally within the tumor…”
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Drugging the lymphatic system: An emerging opportunity for cancer immunotherapy by Nakamura, Takashi, Thomas, Susan N.

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Cancer cells in transit: the vascular interactions of tumor cells by Konstantopoulos, Konstantinos, Thomas, Susan N

“…Metastasis is a highly regulated, multistep process in which cancerous cells shed from the primary tumor and enter the circulatory system, where they interact…”
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Implications of Lymphatic Transport to Lymph Nodes in Immunity and Immunotherapy by Thomas, Susan N, Rohner, Nathan A, Edwards, Erin E

“…Adaptive immune response consists of many highly regulated, multistep cascades that protect against infection while preserving the health of autologous tissue…”
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VEGF-C Promotes Immune Tolerance in B16 Melanomas and Cross-Presentation of Tumor Antigen by Lymph Node Lymphatics by Lund, Amanda W., Duraes, Fernanda V., Hirosue, Sachiko, Raghavan, Vidya R., Nembrini, Chiara, Thomas, Susan N., Issa, Amine, Hugues, Stéphanie, Swartz, Melody A.

“…Tumor expression of the lymphangiogenic factor VEGF-C is correlated with metastasis and poor prognosis, and although VEGF-C enhances transport to the draining…”
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Overcoming transport barriers for interstitial-, lymphatic-, and lymph node-targeted drug delivery by Thomas, Susan N, Schudel, Alex

“…Despite drug formulation improving circulation times and targeting, efficacy is stymied by inadequate penetration into and retention within target tissues…”
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Phosphoinositide 3-Kinase Signaling Can Modulate MHC Class I and II Expression by Chandrasekaran, Sanjay, Sasaki, Maiko, Scharer, Christopher D, Kissick, Haydn T, Patterson, Dillon G, Magliocca, Kelly R, Seykora, John T, Sapkota, Bishu, Gutman, David A, Cooper, Lee A, Lesinski, Gregory B, Waller, Edmund K, Thomas, Susan N, Kotenko, Sergei V, Boss, Jeremy M, Moreno, Carlos S, Swerlick, Robert A, Pollack, Brian P

“…Molecular events activating the PI3K pathway are frequently detected in human tumors and the activation of PI3K signaling alters numerous cellular processes…”
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Targeting vasoactive intestinal peptide-mediated signaling enhances response to immune checkpoint therapy in pancreatic ductal adenocarcinoma by Ravindranathan, Sruthi, Passang, Tenzin, Li, Jian-Ming, Wang, Shuhua, Dhamsania, Rohan, Ware, Michael Brandon, Zaidi, Mohammad Y., Zhu, Jingru, Cardenas, Maria, Liu, Yuan, Gumber, Sanjeev, Robinson, Brian, Sen-Majumdar, Anish, Zhang, Hanwen, Chandrakasan, Shanmuganathan, Kissick, Haydn, Frey, Alan B., Thomas, Susan N., El-Rayes, Bassel F., Lesinski, Gregory B., Waller, Edmund K.

“…A paucity of effector T cells within tumors renders pancreatic ductal adenocarcinoma (PDAC) resistant to immune checkpoint therapies. While several…”
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Carcinoembryonic Antigen and CD44 Variant Isoforms Cooperate to Mediate Colon Carcinoma Cell Adhesion to E- and L-selectin in Shear Flow by Thomas, Susan N., Zhu, Fei, Schnaar, Ronald L., Alves, Christina S., Konstantopoulos, Konstantinos

“…Selectin-mediated adhesion of tumor cells to platelets, leukocytes, and endothelial cells may regulate their hematogenous dissemination in the…”
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The Biophysics of Lymphatic Transport: Engineering Tools and Immunological Consequences by O'Melia, Meghan J., Lund, Amanda W., Thomas, Susan N.

“…Lymphatic vessels mediate fluid flows that affect antigen distribution and delivery, lymph node stromal remodeling, and cell-cell interactions, to thus…”
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The Kinetics of Lymphatic Dysfunction and Leukocyte Expansion in the Draining Lymph Node during LTB4 Antagonism in a Mouse Model of Lymphedema by Cribb, Matthew T., Sestito, Lauren F., Rockson, Stanley G., Nicolls, Mark R., Thomas, Susan N., Dixon, J. Brandon

“…The mechanisms of lymphedema development are not well understood, but emerging evidence highlights the crucial role the immune system plays in driving its…”
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Elicitation of stem-like CD8+ T cell responses via lymph node-targeted chemoimmunotherapy evokes systemic tumor control by Manspeaker, Margaret P, O'Melia, Meghan J, Thomas, Susan N

“…BackgroundTumor-draining lymph nodes (TdLNs) are critical in the regulation of local and systemic antitumor T cell immunity and are implicated in coordinating…”
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In Situ Crosslinked Hydrogel Depot for Sustained Antibody Release Improves Immune Checkpoint Blockade Cancer Immunotherapy by Kim, Jihoon, Francis, David M, Thomas, Susan N

“…The therapeutic inhibition of immune checkpoints, including cytotoxic T lymphocyte-associated protein (CTLA)-4 and programmed cell death 1 (PD-1), through the…”
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Lymph Node Subcapsular Sinus Microenvironment-On-A-Chip Modeling Shear Flow Relevant to Lymphatic Metastasis and Immune Cell Homing by Birmingham, Katherine G., O'Melia, Meghan J., Bordy, Samantha, Reyes Aguilar, David, El-Reyas, Bassel, Lesinski, Gregory, Thomas, Susan N.

“…A lymph node sinus-on-a-chip adhesion microfluidic platform that recapitulates the hydrodynamic microenvironment of the lymph node subcapsular sinus was…”
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Podocalyxin-like protein is an E-/L-selectin ligand on colon carcinoma cells: comparative biochemical properties of selectin ligands in host and tumor cells by Thomas, Susan N, Schnaar, Ronald L, Konstantopoulos, Konstantinos

“…Selectins facilitate metastasis and tumor cell arrest in the microvasculature by mediating binding of selectin-expressing host cells to ligands on tumor cells…”
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A rapid method for determining protein diffusion through hydrogels for regenerative medicine applications by Hettiaratchi, Marian H., Schudel, Alex, Rouse, Tel, García, Andrés J., Thomas, Susan N., Guldberg, Robert E., McDevitt, Todd C.

“…Hydrogels present versatile platforms for the encapsulation and delivery of proteins and cells for regenerative medicine applications. However, differences in…”
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The dual role of CD44 as a functional P-selectin ligand and fibrin receptor in colon carcinoma cell adhesion by Alves, Christina S, Burdick, Monica M, Thomas, Susan N, Pawar, Parag, Konstantopoulos, Konstantinos

“…Selectins and fibrin(ogen) play key roles in the hematogenous dissemination of tumor cells, and especially of colon carcinomas. However, the fibrin(ogen)…”
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Opportunities for Nitric Oxide in Potentiating Cancer Immunotherapy by Kim, Jihoon, Thomas, Susan N.

“…Despite nearly 30 years of development and recent highlights of nitric oxide (NO) donors and NO delivery systems in anticancer therapy, the limited…”
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Material design for lymph node drug delivery by Schudel, Alex, Francis, David M., Thomas, Susan N.

“…A significant fraction of the total immune cells in the body are located in several hundred lymph nodes, in which lymphocyte accumulation, activation and…”
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Progress and opportunities for enhancing the delivery and efficacy of checkpoint inhibitors for cancer immunotherapy by Francis, David M., Thomas, Susan N.

“…Despite the advent of immune checkpoint blockade for effective treatment of advanced malignancies, only a minority of patients responds to therapy and…”
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