Search Results - "Thomas, Sherine E."

RNA structure mediated thermoregulation: What can we learn from plants? by Thomas, Sherine E, Balcerowicz, Martin, Chung, Betty Y-W

“…RNA molecules have the capacity to form a multitude of distinct secondary and tertiary structures, but only the most energetically favorable conformations are…”
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Development of Inhibitors against Mycobacterium abscessus tRNA (m1G37) Methyltransferase (TrmD) Using Fragment-Based Approaches by Whitehouse, Andrew J, Thomas, Sherine E, Brown, Karen P, Fanourakis, Alexander, Chan, Daniel S.-H, Libardo, M. Daben J, Mendes, Vitor, Boshoff, Helena I. M, Floto, R. Andres, Abell, Chris, Blundell, Tom L, Coyne, Anthony G

“…Mycobacterium abscessus (Mab) is a rapidly growing species of multidrug-resistant nontuberculous mycobacteria that has emerged as a growing threat to…”
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Fragment-based discovery of a new class of inhibitors targeting mycobacterial tRNA modification by Thomas, Sherine E, Whitehouse, Andrew J, Brown, Karen, Burbaud, Sophie, Belardinelli, Juan M, Sangen, Jasper, Lahiri, Ramanuj, Libardo, Mark Daben J, Gupta, Pooja, Malhotra, Sony, Boshoff, Helena I M, Jackson, Mary, Abell, Chris, Coyne, Anthony G, Blundell, Tom L, Floto, Rodrigo Andres, Mendes, Vítor

“…Abstract Translational frameshift errors are often deleterious to the synthesis of functional proteins and could therefore be promoted therapeutically to kill…”
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Predicted structural mimicry of spike receptor-binding motifs from highly pathogenic human coronaviruses by Beaudoin, Christopher A., Jamasb, Arian R., Alsulami, Ali F., Copoiu, Liviu, van Tonder, Andries J., Hala, Sharif, Bannerman, Bridget P., Thomas, Sherine E., Vedithi, Sundeep Chaitanya, Torres, Pedro H.M., Blundell, Tom L.

“…[Display omitted] •Potential coronavirus spike protein mimicry revealed by structural comparison.•Human and non-human protein potential interactions with virus…”
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Mycobacterial genomics and structural bioinformatics: opportunities and challenges in drug discovery by Waman, Vaishali P., Vedithi, Sundeep Chaitanya, Thomas, Sherine E., Bannerman, Bridget P., Munir, Asma, Skwark, Marcin J., Malhotra, Sony, Blundell, Tom L.

“…Of the more than 190 distinct species of Mycobacterium genus, many are economically and clinically important pathogens of humans or animals. Among those…”
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A fragment-based approach to assess the ligandability of ArgB, ArgC, ArgD and ArgF in the L-arginine biosynthetic pathway of Mycobacterium tuberculosis by Gupta, Pooja, Thomas, Sherine E., Zaidan, Shaymaa A., Pasillas, Maria A., Cory-Wright, James, Sebastián-Pérez, Víctor, Burgess, Ailidh, Cattermole, Emma, Meghir, Clio, Abell, Chris, Coyne, Anthony G., Jacobs, William R., Blundell, Tom L., Tiwari, Sangeeta, Mendes, Vítor

“…[Display omitted] The L-arginine biosynthesis pathway consists of eight enzymes that catalyse the conversion of L-glutamate to L-arginine. Arginine auxotrophs…”
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Structural Characterization of Mycobacterium abscessus Phosphopantetheine Adenylyl Transferase Ligand Interactions: Implications for Fragment-Based Drug Design by Thomas, Sherine E, McCarthy, William J, El Bakali, Jamal, Brown, Karen P, Kim, So Yeon, Blaszczyk, Michal, Mendes, Vítor, Abell, Chris, Floto, R Andres, Coyne, Anthony G, Blundell, Tom L

“…Anti-microbial resistance is a rising global healthcare concern that needs urgent attention as growing number of infections become difficult to treat with the…”
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Structural insights into inhibitor regulation of the DNA repair protein DNA-PKcs by Liang, Shikang, Thomas, Sherine E., Chaplin, Amanda K., Hardwick, Steven W., Chirgadze, Dimitri Y., Blundell, Tom L.

“…The DNA-dependent protein kinase catalytic subunit (DNA-PKcs) has a central role in non-homologous end joining, one of the two main pathways that detect and…”
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Structure-guided, target-based drug discovery - exploiting genome information from HIV to mycobacterial infections by Malhotra, Sony, Thomas, Sherine E, Ochoa Montano, Bernardo, Blundell, Tom L

“…The use of protein crystallography in structure-guided drug discovery allows identification of potential inhibitor-binding sites and optimisation of…”
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Arginine-deprivation–induced oxidative damage sterilizes Mycobacterium tuberculosis by Tiwari, Sangeeta, van Tonder, Andries J., Vilchèze, Catherine, Mendes, Vitor, Thomas, Sherine E., Malek, Adel, Chen, Bing, Chen, Mei, Kim, John, Blundell, Tom L., Parkhill, Julian, Weinrick, Brian, Berney, Michael, Jacobs, William R.

“…Reactive oxygen species (ROS)-mediated oxidative stress and DNA damage have recently been recognized as contributing to the efficacy of most bactericidal…”
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Structural Biology and the Design of New Therapeutics: From HIV and Cancer to Mycobacterial Infections: A Paper Dedicated to John Kendrew by Thomas, Sherine E, Mendes, Vitor, Kim, So Yeon, Malhotra, Sony, Ochoa-Montaño, Bernardo, Blaszczyk, Michal, Blundell, Tom L

“…Interest in applications of protein crystallography to medicine was evident, as the first high-resolution structures emerged in the 50s and 60s. In Cambridge,…”
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Structure-guided fragment-based drug discovery at the synchrotron: screening binding sites and correlations with hotspot mapping by Thomas, Sherine E, Collins, Patrick, James, Rory Hennell, Mendes, Vitor, Charoensutthivarakul, Sitthivut, Radoux, Chris, Abell, Chris, Coyne, Anthony G, Floto, R Andres, von Delft, Frank, Blundell, Tom L

“…Structure-guided drug discovery emerged in the 1970s and 1980s, stimulated by the three-dimensional structures of protein targets that became available, mainly…”
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A Fragment-Based Competitive 19 F LB-NMR Platform For Hotspot-Directed Ligand Profiling by McCarthy, William J, Thomas, Sherine E, Olaleye, Tayo, Boland, Jennifer A, Floto, R Andres, Williams, Glyn, Blundell, Tom L, Coyne, Anthony G, Abell, Chris

“…Ligand binding hotspots are regions of protein surfaces that form particularly favourable interactions with small molecule pharmacophores. Targeting…”
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A Fragment‐Based Competitive 19F LB‐NMR Platform For Hotspot‐Directed Ligand Profiling by McCarthy, William J., Thomas, Sherine E., Olaleye, Tayo, Boland, Jennifer A., Floto, R. Andres, Williams, Glyn, Blundell, Tom L., Coyne, Anthony G., Abell, Chris

“…Ligand binding hotspots are regions of protein surfaces that form particularly favourable interactions with small molecule pharmacophores. Targeting…”
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Genomes, structural biology and drug discovery: combating the impacts of mutations in genetic disease and antibiotic resistance by Pandurangan, Arun Prasad, Ascher, David B, Thomas, Sherine E, Blundell, Tom L

“…For over four decades structural biology has been used to understand the mechanisms of disease, and structure-guided approaches have demonstrated clearly that…”
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SARS-CoV-2 3D database: understanding the coronavirus proteome and evaluating possible drug targets by Alsulami, Ali F, Thomas, Sherine E, Jamasb, Arian R, Beaudoin, Christopher A, Moghul, Ismail, Bannerman, Bridget, Copoiu, Liviu, Vedithi, Sundeep Chaitanya, Torres, Pedro, Blundell, Tom L

“…Abstract The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a rapidly growing infectious disease, widely spread with high mortality rates…”
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Structural insights into the EthR-DNA interaction using native mass spectrometry by Shiu-Hin Chan, Daniel, Seetoh, Wei-Guang, McConnell, Brendan N, Matak-Vinković, Dijana, Thomas, Sherine E, Mendes, Vitor, Blaszczyk, Michal, Coyne, Anthony G, Blundell, Tom L, Abell, Chris

“…EthR is a transcriptional repressor that increases Mycobacterium tuberculosis resistance to ethionamide. In this study, the EthR-DNA interaction has been…”
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Fragment Screening against the EthR–DNA Interaction by Native Mass Spectrometry by Chan, Daniel Shiu‐Hin, Mendes, Vitor, Thomas, Sherine E., McConnell, Brendan N., Matak‐Vinković, Dijana, Coyne, Anthony G., Blundell, Tom L., Abell, Chris

“…Native nanoelectrospray ionization mass spectrometry is an underutilized technique for fragment screening. In this study, the first demonstration is provided…”
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A Fragment‐Based Competitive 19F LB‐NMR Platform For Hotspot‐Directed Ligand Profiling by McCarthy, William J., Thomas, Sherine E., Olaleye, Tayo, Boland, Jennifer A., Floto, R. Andres, Williams, Glyn, Blundell, Tom L., Coyne, Anthony G., Abell, Chris

“…Ligand binding hotspots are regions of protein surfaces that form particularly favourable interactions with small molecule pharmacophores. Targeting…”
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Development of Inhibitors of SAICAR Synthetase (PurC) from Mycobacterium abscessus Using a Fragment-Based Approach by Charoensutthivarakul, Sitthivut, Thomas, Sherine E, Curran, Amy, Brown, Karen P, Belardinelli, Juan M, Whitehouse, Andrew J, Acebrón-García-de-Eulate, Marta, Sangan, Jaspar, Gramani, Subramanian G, Jackson, Mary, Mendes, Vitor, Floto, R. Andres, Blundell, Tom L, Coyne, Anthony G, Abell, Chris

“…Mycobacterium abscessus (Mab) has emerged as a challenging threat to individuals with cystic fibrosis. Infections caused by this pathogen are often impossible…”
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