Search Results - "Thomas, Reeby"

Obesity Is a Positive Modulator of IL-6R and IL-6 Expression in the Subcutaneous Adipose Tissue: Significance for Metabolic Inflammation by Sindhu, Sardar, Thomas, Reeby, Shihab, Puthiyaveetil, Sriraman, Devarajan, Behbehani, Kazem, Ahmad, Rasheed

“…The role of IL-6R/IL-6 axis in metabolic inflammation remains controversial. We determined the changes in adipose tissue expression of IL-6R and IL-6 in obese,…”
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ROS/TNF-α Crosstalk Triggers the Expression of IL-8 and MCP-1 in Human Monocytic THP-1 Cells via the NF-κB and ERK1/2 Mediated Signaling by Akhter, Nadeem, Wilson, Ajit, Thomas, Reeby, Al-Rashed, Fatema, Kochumon, Shihab, Al-Roub, Areej, Arefanian, Hossein, Al-Madhoun, Ashraf, Al-Mulla, Fahd, Ahmad, Rasheed, Sindhu, Sardar

“…IL-8/MCP-1 act as neutrophil/monocyte chemoattractants, respectively. Oxidative stress emerges as a key player in the pathophysiology of obesity. However, it…”
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Increased Expression of the Innate Immune Receptor TLR10 in Obesity and Type-2 Diabetes: Association with ROS-Mediated Oxidative Stress by Sindhu, Sardar, Akhter, Nadeem, Kochumon, Shihab, Thomas, Reeby, Wilson, Ajit, Shenouda, Steve, Tuomilehto, Jaakko, Ahmad, Rasheed

“…Background/Aims: Metabolic diseases such as obesity and type-2 diabetes (T2D) are known to be associated with chronic low-grade inflammation called metabolic…”
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LPS Induces GM-CSF Production by Breast Cancer MDA-MB-231 Cells via Long-Chain Acyl-CoA Synthetase 1 by Al-Rashed, Fatema, Thomas, Reeby, Al-Roub, Areej, Al-Mulla, Fahd, Ahmad, Rasheed

“…Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a monomeric glycoprotein that has been implicated in the tumor growth and progression of different…”
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Endoplasmic Reticulum Stress Promotes the Expression of TNF-α in THP-1 Cells by Mechanisms Involving ROS/CHOP/HIF-1α and MAPK/NF-κB Pathways by Akhter, Nadeem, Wilson, Ajit, Arefanian, Hossein, Thomas, Reeby, Kochumon, Shihab, Al-Rashed, Fatema, Abu-Farha, Mohamed, Al-Madhoun, Ashraf, Al-Mulla, Fahd, Ahmad, Rasheed, Sindhu, Sardar

“…Obesity and metabolic syndrome involve chronic low-grade inflammation called metabolic inflammation as well as metabolic derangements from increased endotoxin…”
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Ceramide kinase regulates TNF-α-induced immune responses in human monocytic cells by Al-Rashed, Fatema, Ahmad, Zunair, Snider, Ashley J., Thomas, Reeby, Kochumon, Shihab, Melhem, Motasem, Sindhu, Sardar, Obeid, Lina M., Al-Mulla, Fahd, Hannun, Yusuf A., Ahmad, Rasheed

“…Ceramide kinase (CERK) phosphorylates ceramide to produce ceramide-1-phosphate (C1P), which is involved in the development of metabolic inflammation. TNF-α…”
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Elevated adipose tissue associated IL-2 expression in obesity correlates with metabolic inflammation and insulin resistance by Kochumon, Shihab, Al Madhoun, Ashraf, Al-Rashed, Fatema, Thomas, Reeby, Sindhu, Sardar, Al-Ozairi, Ebaa, Al-Mulla, Fahd, Ahmad, Rasheed

“…Adipose tissue (AT) associated cytokines are involved in the development of chronic low-grade inflammation in obese individuals. IL-2, a pleiotropic cytokine,…”
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TNF-α in Combination with Palmitate Enhances IL-8 Production via The MyD88- Independent TLR4 Signaling Pathway: Potential Relevance to Metabolic Inflammation by Hasan, Amal, Akhter, Nadeem, Al-Roub, Areej, Thomas, Reeby, Kochumon, Shihab, Wilson, Ajit, Koshy, Merin, Al-Ozairi, Ebaa, Al-Mulla, Fahd, Ahmad, Rasheed

“…Elevated levels of IL-8 (CXCL8) in obesity have been linked with insulin resistance and type 2 diabetes (T2D). The mechanisms that lead to the profound…”
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Short Chain Fatty Acid Acetate Increases TNFα-Induced MCP-1 Production in Monocytic Cells via ACSL1/MAPK/NF-κB Axis by Al-Roub, Areej, Akhter, Nadeem, Al-Sayyar, Amnah, Wilson, Ajit, Thomas, Reeby, Kochumon, Shihab, Al-Rashed, Fatema, Al-Mulla, Fahd, Sindhu, Sardar, Ahmad, Rasheed

“…Short-chain fatty acid (SCFA) acetate, a byproduct of dietary fiber metabolism by gut bacteria, has multiple immunomodulatory functions. The anti-inflammatory…”
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The Synergy between Palmitate and TNF-α for CCL2 Production Is Dependent on the TRIF/IRF3 Pathway: Implications for Metabolic Inflammation by Ahmad, Rasheed, Al-Roub, Areej, Kochumon, Shihab, Akther, Nadeem, Thomas, Reeby, Kumari, Manju, Koshy, Merin S, Tiss, Ali, Hannun, Yusuf A, Tuomilehto, Jaakko, Sindhu, Sardar, Rosen, Evan D

“…The chemokine CCL2 (also known as MCP-1) is a key regulator of monocyte infiltration into adipose tissue, which plays a central role in the pathophysiology of…”
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1491-P: ER Stress Drives the VEGF Expression in Monocytic Cells by Mechanisms Involving CHOP/ROS/HIF-1alpha/NRF2 and NF-kappaB/p38 MAPK Pathways by SINDHU, SARDAR A.K., AKHTER, NADEEM, WILSON, AJIT, AREFANIAN, HOSSEIN, AL MADHOUN, ASHRAF, THOMAS, REEBY S., KOCHUMON, SHIHAB P., ALRASHED, FATEMA, BAHMAN, FATEMAH, ALZAID, FAWAZ, ALMULLA, FAHD, AHMAD, RASHEED

“…Obesity is marked by metabolic inflammation and by metabolic impairment caused by increased endotoxin, free fatty acids, and vascular endothelial growth factor…”
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1690-P: Adipose Tissue Dectin-1 Upregulation in Hyperglycemic Obesity Involves TNF-α/NF-kB Mediated Signaling by AL MADHOUN, ASHRAF, HADDAD, DANIA, KOCHUMON, SHIHAB P., ALRASHED, FATEMA, THOMAS, REEBY S., MIRANDA, LAVINA P., SINDHU, SARDAR T.A.K., AHMAD, RASHEED, ALMULLA, FAHD

“…Dectin-1 is a pathogen recognition receptor as well as an innate immune response modulator; its function in metabolic disorders is yet unclear. Previously, we…”
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Palmitate-Induced MMP-9 Expression in the Human Monocytic Cells is Mediated through the TLR4-MyD88 Dependent Mechanism by Sindhu, Sardar, Al-Roub, Areej, Koshy, Merin, Thomas, Reeby, Ahmad, Rasheed

“…Background/Aims: Obese individuals are known to have increased Matrix metalloproteinase (MMP)-9 plasma levels and MMP-9 is reported to play an important role…”
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Gut Dysbiosis Shaped by Cocoa Butter-Based Sucrose-Free HFD Leads to Steatohepatitis, and Insulin Resistance in Mice by Kochumon, Shihab, Malik, Md Zubbair, Sindhu, Sardar, Arefanian, Hossein, Jacob, Texy, Bahman, Fatemah, Nizam, Rasheeba, Hasan, Amal, Thomas, Reeby, Al-Rashed, Fatema, Shenouda, Steve, Wilson, Ajit, Albeloushi, Shaima, Almansour, Nourah, Alhamar, Ghadeer, Al Madhoun, Ashraf, Alzaid, Fawaz, Thanaraj, Thangavel Alphonse, Koistinen, Heikki A, Tuomilehto, Jaakko, Al-Mulla, Fahd, Ahmad, Rasheed

“…High-fat diets cause gut dysbiosis and promote triglyceride accumulation, obesity, gut permeability changes, inflammation, and insulin resistance. Both cocoa…”
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MIP-1α Expression Induced by Co-Stimulation of Human Monocytic Cells with Palmitate and TNF-α Involves the TLR4-IRF3 Pathway and Is Amplified by Oxidative Stress by Sindhu, Sardar, Akhter, Nadeem, Wilson, Ajit, Thomas, Reeby, Arefanian, Hossein, Al Madhoun, Ashraf, Al-Mulla, Fahd, Ahmad, Rasheed

“…Metabolic inflammation is associated with increased expression of saturated free fatty acids, proinflammatory cytokines, chemokines, and adipose oxidative…”
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1603-P: Differential Effects of Cocoa Butter, Sunflower, Soybean, and Fish Oil Based Sucrose-Free HFDs on Hepatic Steatosis, Lipogenesis, Inflammation, and Insulin Resistance in Mice by AHMAD, RASHEED, JACOB, TEXY K., KOCHUMON, SHIHAB P., THOMAS, REEBY S., SHENOUDA, STEVE, AKHTER, NADEEM, WILSON, AJIT, BAHMAN, FATEMAH, HASAN, AMAL, ALRASHED, FATEMA, AREFANIAN, HOSSEIN, AL MADHOUN, ASHRAF, ALMULLA, FAHD, SINDHU, SARDAR T.A.K.

“…Nonalcoholic fatty liver disease (NAFLD) is a risk factor of type-2 diabetes and cardiovascular disease. Obesity induced by various high-fat diets from…”
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Increased adipose tissue expression of TLR8 in obese individuals with or without type-2 diabetes: significance in metabolic inflammation by Ahmad, Rasheed, Kochumon, Shihab, Thomas, Reeby, Atizado, Valerie, Sindhu, Sardar

“…The innate immune Toll-like receptors (TLRs) 2/4 are important players in chronic low-grade inflammation called metabolic inflammation in obesity and type-2…”
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Repetitive Intermittent Hyperglycemia Drives the M1 Polarization and Inflammatory Responses in THP-1 Macrophages Through the Mechanism Involving the TLR4-IRF5 Pathway by Al-Rashed, Fatema, Sindhu, Sardar, Arefanian, Hossein, Al Madhoun, Ashraf, Kochumon, Shihab, Thomas, Reeby, Al-Kandari, Sarah, Alghaith, Abdulwahab, Jacob, Texy, Al-Mulla, Fahd, Ahmad, Rasheed

“…Repetitive intermittent hyperglycemia (RIH) is an independent risk factor for complications associated with type-2 diabetes (T2D). Glucose fluctuations…”
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Dectin-1 as a Potential Inflammatory Biomarker for Metabolic Inflammation in Adipose Tissue of Individuals with Obesity by Al Madhoun, Ashraf, Kochumon, Shihab, Al-Rashed, Fatema, Sindhu, Sardar, Thomas, Reeby, Miranda, Lavina, Al-Mulla, Fahd, Ahmad, Rasheed

“…In obesity, macrophage activation and infiltration in adipose tissue (AT) underlie chronic low-grade inflammation-induced insulin resistance. Although dectin-1…”
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Increased adipose tissue expression of IL‐18R and its ligand IL‐18 associates with inflammation and insulin resistance in obesity by Ahmad, Rasheed, Thomas, Reeby, Kochumon, Shihab, Sindhu, Sardar

“…Introduction The proinflammatory cytokine IL‐18 is involved in the pathogenesis of metabolic syndrome. While the changes in IL‐18 are known, IL‐18R expression…”
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