Search Results - "Thomas, Rajan"

Development of a Sensing System for a Wireless Charging Pad Array Suitable for Electric Personal Transporters by Rajan, Thomas P., George, Boby

“…A sensing system is proposed for a wireless charging pad or pad array suitable for electric personal transporters (EPTs). Most of the existing sensing…”
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Mapping effector genes at lupus GWAS loci using promoter Capture-C in follicular helper T cells by Su, Chun, Johnson, Matthew E., Torres, Annabel, Thomas, Rajan M., Manduchi, Elisabetta, Sharma, Prabhat, Mehra, Parul, Le Coz, Carole, Leonard, Michelle E., Lu, Sumei, Hodge, Kenyaita M., Chesi, Alessandra, Pippin, James, Romberg, Neil, Grant, Struan F. A., Wells, Andrew D.

“…Systemic lupus erythematosus (SLE) is mediated by autoreactive antibodies that damage multiple tissues. Genome-wide association studies (GWAS) link >60 loci…”
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Implicating effector genes at COVID-19 GWAS loci using promoter-focused Capture-C in disease-relevant immune cell types by Pahl, Matthew C, Le Coz, Carole, Su, Chun, Sharma, Prabhat, Thomas, Rajan M, Pippin, James A, Cruz Cabrera, Emylette, Johnson, Matthew E, Leonard, Michelle E, Lu, Sumei, Chesi, Alessandra, Sullivan, Kathleen E, Romberg, Neil, Grant, Struan F A, Wells, Andrew D

“…SARS-CoV-2 infection results in a broad spectrum of COVID-19 disease, from mild or no symptoms to hospitalization and death. COVID-19 disease severity has been…”
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Mbd2 Promotes Foxp3 Demethylation and T-Regulatory-Cell Function by Wang, Liqing, Liu, Yujie, Han, Rongxiang, Beier, Ulf H., Thomas, Rajan M., Wells, Andrew D., Hancock, Wayne W.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Conserved Intergenic Elements and DNA Methylation Cooperate to Regulate Transcription at the il17 Locus by Thomas, Rajan M., Sai, Hong, Wells, Andrew D.

“…Background: IL-17 is an inflammatory cytokine that mediates immunopathology in autoimmune disease. Results: DNA methylation at the il17 locus is…”
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Foxp3 depends on Ikaros for control of regulatory T cell gene expression and function by Thomas, Rajan M, Pahl, Matthew C, Wang, Liqing, Grant, Struan F A, Hancock, Wayne W, Wells, Andrew D

“…Ikaros is a transcriptional factor required for conventional T cell development, differentiation, and anergy. While the related factors Helios and Eos have…”
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Ndfip1 restricts mTORC1 signalling and glycolysis in regulatory T cells to prevent autoinflammatory disease by Layman, Awo Akosua Kesewa, Deng, Guoping, O’Leary, Claire E., Tadros, Samuel, Thomas, Rajan M., Dybas, Joseph M., Moser, Emily K., Wells, Andrew D., Doliba, Nicolai M., Oliver, Paula M.

“…Foxp3 + T regulatory (T reg ) cells suppress immune cell activation and establish normal immune homeostasis. How T reg cells maintain their identity is not…”
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Epigenetic remodeling of the IL-2 and IFN-gamma loci in memory CD8 T cells is influenced by CD4 T cells by Northrop, John K, Thomas, Rajan M, Wells, Andrew D, Shen, Hao

“…Memory T cells (T(M)) are able to rapidly exert effector functions, including immediate effector cytokine production upon re-encounter with Ag, which is…”
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Dynamic chromatin architecture identifies new autoimmune-associated enhancers for IL2 and novel genes regulating CD4+ T cell activation by Pahl, Matthew C, Sharma, Prabhat, Thomas, Rajan M, Thompson, Zachary, Mount, Zachary, Pippin, James A, Morawski, Peter A, Sun, Peng, Su, Chun, Campbell, Daniel, Grant, Struan F A, Wells, Andrew D

“…Genome-wide association studies (GWAS) have identified hundreds of genetic signals associated with autoimmune disease. The majority of these signals are…”
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Transcriptional Regulation by Foxp3 Is Associated with Direct Promoter Occupancy and Modulation of Histone Acetylation by Chen, Chunxia, Rowell, Emily A., Thomas, Rajan M., Hancock, Wayne W., Wells, Andrew D.

“…Regulatory T cells (Treg) express Foxp3, a forkhead family member that is necessary and sufficient for Treg lineage choice and function. Ectopic expression of…”
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Ikaros imposes a barrier to CD8+ T cell differentiation by restricting autocrine IL-2 production by O'Brien, Shaun, Thomas, Rajan M, Wertheim, Gerald B, Zhang, Fuqin, Shen, Hao, Wells, Andrew D

“…Naive CD4(+) T cells require signals from the TCR and CD28 to produce IL-2, expand, and differentiate. However, these same signals are not sufficient to induce…”
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De Novo DNA Methylation Is Required to Restrict T Helper Lineage Plasticity by Thomas, Rajan M., Gamper, Christopher J., Ladle, Brian H., Powell, Jonathan D., Wells, Andrew D.

“…Naïve CD4+ T cells are highly plastic and can differentiate into discrete lineages with unique functions during an immune response. Once differentiated, helper…”
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Regulatory T cells suppress CD4+ T cells through NFAT-dependent transcriptional mechanisms by Shin, Daniel S, Jordan, Ayana, Basu, Samik, Thomas, Rajan M, Bandyopadhyay, Sanmay, de Zoeten, Edwin F, Wells, Andrew D, Macian, Fernando

“…Regulatory T cells (Tregs) control autoreactive T cells by inhibiting activation‐induced proliferation and cytokine expression. The molecular mechanisms…”
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Ikaros Silences T-bet Expression and Interferon-γ Production during T Helper 2 Differentiation by Thomas, Rajan M., Chen, Chunxia, Chunder, Neelanjana, Ma, Lingzhi, Taylor, Justin, Pearce, Edward J., Wells, Andrew D.

“…CD4+ T cells can be instructed by nonantigen-specific signals to differentiate into functionally distinct lineages with mutually exclusive patterns of cytokine…”
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Ikaros Enforces the Costimulatory Requirement for IL2 Gene Expression and Is Required for Anergy Induction in CD4+ T Lymphocytes by Thomas, Rajan M, Chunder, Neelanjana, Chen, Chunxia, Umetsu, Sarah E, Winandy, Susan, Wells, Andrew D

“…T cell activation results in dynamic remodeling of the chromatin at the IL2 promoter and induction of IL2 gene transcription. These processes are each…”
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Signals from CD28 Induce Stable Epigenetic Modification of the IL-2 Promoter by Thomas, Rajan M, Gao, Ling, Wells, Andrew D

“…CD28 costimulation controls multiple aspects of T cell function, including the expression of proinflammatory cytokine genes. One of these genes encodes IL-2, a…”
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Defective Activation of Protein Kinase C and Ras-ERK Pathways Limits IL-2 Production and Proliferation by CD4+CD25+ Regulatory T Cells by Hickman, Somia P, Yang, Jaeseok, Thomas, Rajan M, Wells, Andrew D, Turka, Laurence A

“…Naturally occurring CD4+CD25+ regulatory T cells (Tregs), which play an important role in the maintenance of self-tolerance, proliferate poorly and fail to…”
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Atypical mycobacterial infection masquerading as an endobronchial growth in an immunocompromised host by Thomas, Arun Rajan, Prasad, Virender Pratibh, Sethi, Shweta, Maturu, Venkata Nagarjuna

“…Non-tuberculous mycobacteria (NTM) are ubiquitous organisms. Endobronchial growth as a presenting feature of NTM disease is uncommon. Here we present a case of…”
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Drug abuse and bipolar disorder: comorbidity or misdiagnosis? by Sherwood Brown, E, Suppes, Trisha, Adinoff, Bryon, Rajan Thomas, Nancy

“…Bipolar disorder is a common, severe and cyclic psychiatric illness. A strong association between alcohol dependence and bipolar disorder has been reported in…”
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Poly(vinylidene fluoride‐co‐hexafluoropropylene) additive in perovskite for stable performance of carbon‐based perovskite solar cells by Narendhiran, Santhosh, Kunka Ravindran, Acchutharaman, Rajan Thomas, Isaac Daniel, Muthu, Senthil Pandian, Perumalsamy, Ramasamy

“…Summary The efficiency of perovskite devices is depending on the crystallization process with a controlled microstructure. Perovskite precursors with polymer…”
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