Search Results - "Thomas, Michael G"

Analyses of MbtB, MbtE, and MbtF Suggest Revisions to the Mycobactin Biosynthesis Pathway in Mycobacterium tuberculosis by McMahon, Matthew D, Rush, Jason S, Thomas, Michael G

“…The production of mycobactin (MBT) by Mycobacterium tuberculosis is essential for this bacterium to access iron when it is in an infected host. Due to this…”
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Characterization of the Complete Zwittermicin A Biosynthesis Gene Cluster from Bacillus cereus by Kevany, Brian M, Rasko, David A, Thomas, Michael G

“…Bacillus cereus UW85 produces the linear aminopolyol antibiotic zwittermicin A (ZmA). This antibiotic has diverse biological activities, such as suppression of…”
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Core Outcomes for Colorectal Cancer Surgery: A Consensus Study by McNair, Angus G K, Whistance, Robert N, Forsythe, Rachael O, Macefield, Rhiannon, Rees, Jonathan, Pullyblank, Anne M, Avery, Kerry N L, Brookes, Sara T, Thomas, Michael G, Sylvester, Paul A, Russell, Ann, Oliver, Alfred, Morton, Dion, Kennedy, Robin, Jayne, David G, Huxtable, Richard, Hackett, Roland, Dutton, Susan J, Coleman, Mark G, Card, Mia, Brown, Julia, Blazeby, Jane M

“…Colorectal cancer (CRC) is a major cause of worldwide morbidity and mortality. Surgical treatment is common, and there is a great need to improve the delivery…”
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MbtH-Like Proteins as Integral Components of Bacterial Nonribosomal Peptide Synthetases by Felnagle, Elizabeth A, Barkei, John J, Park, Hyunjun, Podevels, Angela M, McMahon, Matthew D, Drott, Donald W, Thomas, Michael G

“…The biosynthesis of many natural products of clinical interest involves large, multidomain enzymes called nonribosomal peptide synthetases (NRPSs). In…”
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Identification of a Biosynthetic Gene Cluster and the Six Associated Lipopeptides Involved in Swarming Motility of Pseudomonas syringae pv. tomato DC3000 by BERTI, Andrew D, GREVE, Nathan J, CHRISTENSEN, Quin H, THOMAS, Michael G

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Colorectal cancer incidence trends by tumour location among adults of screening-age in England: a population-based study by Granger, Sam P, Preece, Ryan A D, Thomas, Michael G, Dixon, Steven W, Chambers, Adam C, Messenger, David E

“…Proximal and distal colorectal cancers (CRCs) exhibit different clinical, molecular and biological patterns. The aim of this study was to determine temporal…”
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Analysis of Achromobactin Biosynthesis by Pseudomonas syringae pv. syringae B728a by BERTI, Andrew D, THOMAS, Michael G

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Metagenomic Analysis of Streptomyces lividans Reveals Host-Dependent Functional Expression by MCMAHON, Matthew D, CHANGHUI GUAN, HANDELSMAN, Jo, THOMAS, Michael G

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A polyketide synthase acyltransferase domain structure suggests a recognition mechanism for its hydroxymalonyl-acyl carrier protein substrate by Park, Hyunjun, Kevany, Brian M, Dyer, David H, Thomas, Michael G, Forest, Katrina T

“…We have previously shown that the acyl transferase domain of ZmaA (ZmaA-AT) is involved in the biosynthesis of the aminopolyol polyketide/nonribosomal peptide…”
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Recognition of (2S)-Aminomalonyl-Acyl Carrier Protein (ACP) and (2R)-Hydroxymalonyl-ACP by Acyltransferases in Zwittermicin A Biosynthesis by Chan, Yolande A, Thomas, Michael G

“…Polyketide synthases elongate a polyketide backbone by condensing carboxylic acid precursors that are thioesterified to either coenzyme A or an acyl carrier…”
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Identification of the Biosynthetic Gene Cluster and an Additional Gene for Resistance to the Antituberculosis Drug Capreomycin by Felnagle, Elizabeth A, Rondon, Michelle R, Berti, Andrew D, Crosby, Heidi A, Thomas, Michael G

“…Capreomycin (CMN) belongs to the tuberactinomycin family of nonribosomal peptide antibiotics that are essential components of the drug arsenal for the…”
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Structural basis for the erythro-stereospecificity of the l-arginine oxygenase VioC in viomycin biosynthesis by Helmetag, Verena, Samel, Stefan A, Thomas, Michael G, Marahiel, Mohamed A, Essen, Lars-Oliver

“…The nonheme iron oxygenase VioC from Streptomyces vinaceus catalyzes Fe(II)-dependent and α-ketoglutarate-dependent Cβ-hydroxylation of l-arginine during the…”
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Hydroxymalonyl-Acyl Carrier Protein (ACP) and Aminomalonyl-ACP Are Two Additional Type I Polyketide Synthase Extender Units by Chan, Yolande A., Boyne, Michael T., Podevels, Angela M., Klimowicz, Amy K., Handelsman, Jo, Kelleher, Neil L., Thomas, Michael G.

“…Combinatorial biosynthesis of type I polyketide synthases is a promising approach for the generation of new structural derivatives of polyketide-containing…”
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Utilization of lignocellulosic biofuel conversion residue by diverse microorganisms by Wadler, Caryn S, Wolters, John F, Fortney, Nathaniel W, Throckmorton, Kurt O, Zhang, Yaoping, Miller, Caroline R, Schneider, Rachel M, Wendt-Pienkowski, Evelyn, Currie, Cameron R, Donohue, Timothy J, Noguera, Daniel R, Hittinger, Chris Todd, Thomas, Michael G

“…Abstract Background Lignocellulosic conversion residue (LCR) is the material remaining after deconstructed lignocellulosic biomass is subjected to microbial…”
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Genomic and Secondary Metabolite Analyses of Streptomyces sp. 2AW Provide Insight into the Evolution of the Cycloheximide Pathway by Stulberg, Elizabeth R, Lozano, Gabriel L, Morin, Jesse B, Park, Hyunjun, Baraban, Ezra G, Mlot, Christine, Heffelfinger, Christopher, Phillips, Gillian M, Rush, Jason S, Phillips, Andrew J, Broderick, Nichole A, Thomas, Michael G, Stabb, Eric V, Handelsman, Jo

“…The dearth of new antibiotics in the face of widespread antimicrobial resistance makes developing innovative strategies for discovering new antibiotics…”
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Alterations in the Composition of the Supramucosal Defense Barrier in Relation to Disease Severity of Ulcerative Colitis by Longman, Rob J, Poulsom, Richard, Corfield, Anthony P, Warren, Bryan F, Wright, Nicholas A, Thomas, Michael G

“…Mucin glycoproteins and trefoil peptides play an important role in protection and repair of the gastrointestinal epithelium. This study investigates…”
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Deciphering Tuberactinomycin Biosynthesis: Isolation, Sequencing, and Annotation of the Viomycin Biosynthetic Gene Cluster by THOMAS, Michael G, CHAN, Yolande A, OZANICK, Sarah G

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Genetics of Zwittermicin A Production by Bacillus cereus by EMMERT, Elizabeth A. B, KLIMOWICZ, Amy K, THOMAS, Michael G, HANDELSMAN, Jo

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A Systematic Review of Local Excision After Neoadjuvant Therapy for Rectal Cancer: Are ypT0 Tumors the Limit? by Hallam, Sally, Messenger, David E, Thomas, Michael G

“…BACKGROUND:Neoadjuvant therapy reduces local recurrence after radical surgery for rectal cancer with complete pathological response in 15% to 25% of patients…”
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Characterization of the Functional Variance in MbtH-like Protein Interactions with a Nonribosomal Peptide Synthetase by Schomer, Rebecca A, Thomas, Michael G

“…Many nonribosomal peptide synthetases (NRPSs) require MbtH-like proteins (MLPs) for solubility or for activation of amino acid substrate by the adenylation…”
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