Search Results - "Thomas, Martin G"

Under construction: The dynamic assembly, maintenance, and degradation of the cardiac sarcomere by Martin, Thomas G., Kirk, Jonathan A.

“…The sarcomere is the basic contractile unit of striated muscle and is a highly ordered protein complex with the actin and myosin filaments at its core…”
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Facile and Scalable Preparation of Pure and Dense DNA Origami Solutions by Stahl, Evi, Martin, Thomas G., Praetorius, Florian, Dietz, Hendrik

“…DNA has become a prime material for assembling complex three‐dimensional objects that promise utility in various areas of application. However, achieving…”
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Synthetic Lipid Membrane Channels Formed by Designed DNA Nanostructures by Langecker, Martin, Arnaut, Vera, Martin, Thomas G., List, Jonathan, Renner, Stephan, Mayer, Michael, Dietz, Hendrik, Simmel, Friedrich C.

“…We created nanometer-scale transmembrane channels in lipid bilayers by means of self-assembled DNA-based nanostructures. Scaffolded DNA origami was used to…”
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Kidney Injury and Repair Biomarkers in Marathon Runners by Mansour, Sherry G., DO, Verma, Gagan, MPH, Pata, Rachel W., DPT, CCS, Martin, Thomas G., PhD, Perazella, Mark A., MD, Parikh, Chirag R., MD, PhD

“…Background Investigation into strenuous activity and kidney function has gained interest given increasing marathon participation. Study Design Prospective…”
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Cryo-EM structure of a 3D DNA-origami object by Bai, Xiao-chen, Martin, Thomas G, Scheres, Sjors H. W, Dietz, Hendrik

“…A key goal for nanotechnology is to design synthetic objects that may ultimately achieve functionalities known today only from natural macromolecular…”
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Molecular transport through large-diameter DNA nanopores by Krishnan, Swati, Ziegler, Daniela, Arnaut, Vera, Martin, Thomas G., Kapsner, Korbinian, Henneberg, Katharina, Bausch, Andreas R., Dietz, Hendrik, Simmel, Friedrich C.

“…DNA-based nanopores are synthetic biomolecular membrane pores, whose geometry and chemical functionality can be tuned using the tools of DNA nanotechnology,…”
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Cardiomyocyte contractile impairment in heart failure results from reduced BAG3-mediated sarcomeric protein turnover by Martin, Thomas G., Myers, Valerie D., Dubey, Praveen, Dubey, Shubham, Perez, Edith, Moravec, Christine S., Willis, Monte S., Feldman, Arthur M., Kirk, Jonathan A.

“…The association between reduced myofilament force-generating capacity (F max ) and heart failure (HF) is clear, however the underlying molecular mechanisms are…”
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Randomized multicenter phase 2 study of pomalidomide, cyclophosphamide, and dexamethasone in relapsed refractory myeloma by Baz, Rachid C., Martin, Thomas G., Lin, Hui-Yi, Zhao, Xiuhua, Shain, Kenneth H., Cho, Hearn J., Wolf, Jeffrey L., Mahindra, Anuj, Chari, Ajai, Sullivan, Daniel M., Nardelli, Lisa A., Lau, Kenneth, Alsina, Melissa, Jagannath, Sundar

“…Pomalidomide and low-dose dexamethasone (PomDex) is standard treatment of lenalidomide refractory myeloma patients who have received >2 prior therapies. We…”
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The surfaceome of multiple myeloma cells suggests potential immunotherapeutic strategies and protein markers of drug resistance by Ferguson, Ian D., Patiño-Escobar, Bonell, Tuomivaara, Sami T., Lin, Yu-Hsiu T., Nix, Matthew A., Leung, Kevin K., Kasap, Corynn, Ramos, Emilio, Nieves Vasquez, Wilson, Talbot, Alexis, Hale, Martina, Naik, Akul, Kishishita, Audrey, Choudhry, Priya, Lopez-Girona, Antonia, Miao, Weili, Wong, Sandy W., Wolf, Jeffrey L., Martin, Thomas G., Shah, Nina, Vandenberg, Scott, Prakash, Sonam, Besse, Lenka, Driessen, Christoph, Posey, Avery D., Mullins, R. Dyche, Eyquem, Justin, Wells, James A., Wiita, Arun P.

“…The myeloma surface proteome (surfaceome) determines tumor interaction with the microenvironment and serves as an emerging arena for therapeutic development…”
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Cryo-EM structure of lysenin pore elucidates membrane insertion by an aerolysin family protein by Bokori-Brown, Monika, Martin, Thomas G., Naylor, Claire E., Basak, Ajit K., Titball, Richard W., Savva, Christos G.

“…Lysenin from the coelomic fluid of the earthworm Eisenia fetida belongs to the aerolysin family of small β-pore-forming toxins (β-PFTs), some members of which…”
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DNA methyltransferase inhibitors upregulate CD38 protein expression and enhance daratumumab efficacy in multiple myeloma by Choudhry, Priya, Mariano, Margarette C., Geng, Huimin, Martin, Thomas G., Wolf, Jeffrey L., Wong, Sandy W., Shah, Nina, Wiita, Arun P.

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BCMA Directed Bispecific Antibody Induced Tumor Flare in Multiple Myeloma by Nagarajan, Chandramouli, Eu Jo, Martin Wong, Martin, Thomas G

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Design of a molecular support for cryo-EM structure determination by Martin, Thomas G., Bharat, Tanmay A. M., Joerger, Andreas C., Bai, Xiao-chen, Praetorius, Florian, Fersht, Alan R., Dietz, Hendrik, Scheres, Sjors H. W.

“…Despite the recent rapid progress in cryo-electron microscopy (cryo-EM), there still exist ample opportunities for improvement in sample preparation…”
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Revealing the structures of megadalton-scale DNA complexes with nucleotide resolution by Kube, Massimo, Kohler, Fabian, Feigl, Elija, Nagel-Yüksel, Baki, Willner, Elena M., Funke, Jonas J., Gerling, Thomas, Stömmer, Pierre, Honemann, Maximilian N., Martin, Thomas G., Scheres, Sjors H. W., Dietz, Hendrik

“…The methods of DNA nanotechnology enable the rational design of custom shapes that self-assemble in solution from sets of DNA molecules. DNA origami, in which…”
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Proteasome inhibitor-induced modulation reveals the spliceosome as a specific therapeutic vulnerability in multiple myeloma by Huang, Hector H., Ferguson, Ian D., Thornton, Alexis M., Bastola, Prabhakar, Lam, Christine, Lin, Yu-Hsiu T., Choudhry, Priya, Mariano, Margarette C., Marcoulis, Makeba D., Teo, Chin Fen, Malato, Julia, Phojanakong, Paul J., Martin, Thomas G., Wolf, Jeffrey L., Wong, Sandy W., Shah, Nina, Hann, Byron, Brooks, Angela N., Wiita, Arun P.

“…Enhancing the efficacy of proteasome inhibitors (PI) is a central goal in myeloma therapy. We proposed that signaling-level responses after PI may reveal new…”
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Cryo-EM structure of a metazoan separase–securin complex at near-atomic resolution by Boland, Andreas, Martin, Thomas G, Zhang, Ziguo, Yang, Jing, Bai, Xiao-chen, Chang, Leifu, Scheres, Sjors H W, Barford, David

“…Cryo-EM analyses provide a near-atomic view of the C. elegans securin–separase complex, with insights into the mechanism by which securin inhibits separase's…”
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Phase Ib Dose-Escalation Study (PX-171-006) of Carfilzomib, Lenalidomide, and Low-Dose Dexamethasone in Relapsed or Progressive Multiple Myeloma by NIESVIZKY, Ruben, MARTIN, Thomas G, BENSINGER, William I, ALSINA, Melissa, SIEGEL, David S, KUNKEL, Lori A, WONG, Alvin F, LEE, Susan, ORLOWSKI, Robert Z, WANG, Michael

“…Carfilzomib, a selective proteasome inhibitor, has shown safety and efficacy in relapsed and/or refractory multiple myeloma. This phase I study in patients…”
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A phase 2 study of isatuximab monotherapy in patients with multiple myeloma who are refractory to daratumumab by Mikhael, Joseph, Belhadj-Merzoug, Karim, Hulin, Cyrille, Vincent, Laure, Moreau, Philippe, Gasparetto, Cristina, Pour, Ludek, Spicka, Ivan, Vij, Ravi, Zonder, Jeffrey, Atanackovic, Djordje, Gabrail, Nashat, Martin, Thomas G., Perrot, Aurore, Bensfia, Samira, Weng, Qilong, Brillac, Claire, Semiond, Dorothée, Macé, Sandrine, Corzo, Kathryn P., Leleu, Xavier

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Isatuximab, carfilzomib and dexamethasone (Isa-Kd) for the management of relapsed multiple myeloma by Banerjee, Rahul, Lo, Mimi, Martin, 3rd, Thomas G

“…The treatment of relapsed multiple myeloma remains challenging. Based on interim data from the randomized Phase III IKEMA study demonstrating a…”
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Dysregulated Autophagy and Sarcomere Dysfunction in Patients With Heart Failure With Co-Occurrence of P63A and P380S BAG3 Variants by Martin, Thomas G, Pak, Hana, Gerhard, Glenn S, Merali, Salim, Merali, Carmen, Lemster, Bonnie, Dubey, Praveen, McTiernan, Charles F, Bristow, Michael R, Feldman, Arthur M, Kirk, Jonathan A

“…Mutations to the co-chaperone protein BAG3 (B-cell lymphoma-2-associated athanogene-3) are a leading cause of dilated cardiomyopathy (DCM). These mutations…”
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