Search Results - "Thomas, Joanna R"

Adhesion and growth factor receptor crosstalk mechanisms controlling cell migration by Thomas, Joanna R, Paul, Nikki R, Morgan, Mark R

“…Cell migration requires cells to sense and interpret an array of extracellular signals to precisely co-ordinate adhesion dynamics, local application of…”
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Abcg2a is the functional homolog of human ABCG2 expressed at the zebrafish blood-brain barrier by Thomas, Joanna R, Frye, William J E, Robey, Robert W, Warner, Andrew C, Butcher, Donna, Matta, Jennifer L, Morgan, Tamara C, Edmondson, Elijah F, Salazar, Paula B, Ambudkar, Suresh V, Gottesman, Michael M

“…A principal protective component of the mammalian blood-brain barrier (BBB) is the high expression of the multidrug efflux transporters P-glycoprotein (P-gp,…”
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Progress in characterizing ABC multidrug transporters in zebrafish by Thomas, Joanna R, Frye, William J E, Robey, Robert W, Gottesman, Michael M

“…Zebrafish have proved to be invaluable for modeling complex physiological processes shared by all vertebrate animals. Resistance of cancers and other diseases…”
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Dual Inhibition of Histone Deacetylases and the Mechanistic Target of Rapamycin Promotes Apoptosis in Cell Line Models of Uveal Melanoma by Patel, Ruchi P., Thomas, Joanna R., Curt, Katherine M., Fitzsimmons, Christina M., Batista, Pedro J., Bates, Susan E., Gottesman, Michael M., Robey, Robert W.

“…PurposeOver 90% of uveal melanomas harbor pathogenic variants of the GNAQ or GNA11 genes that activate survival pathways. As previous studies found that…”
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ATP-binding cassette transporters at the zebrafish blood-brain barrier and the potential utility of the zebrafish as an in vivo model by Hotz, Jordan M, Thomas, Joanna R, Katz, Emily N, Robey, Robert W, Horibata, Sachi, Gottesman, Michael M

“…The brain is protected from toxins by a tightly regulated network of specialized cells, including endothelial cells, pericytes, astrocyes, and neurons, known…”
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Exploring integrin and growth factor receptor crosstalk mechanisms by Thomas, Joanna R

“…The pro-invasive integrin αvβ6 is upregulated in a range of carcinomas, from normally very low levels, and is associated with poor prognosis. Therapeutic…”
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