Search Results - "Thomas, Jean O"

H1 and HMGB1: modulators of chromatin structure by Thomas, Jean O, Stott, Katherine

“…Histone H1 and HMGB1 (high-mobility group protein B1) are the most abundant chromosomal proteins apart from the core histones (on average, one copy per…”
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HMGB1-Facilitated p53 DNA Binding Occurs via HMG-Box/p53 Transactivation Domain Interaction, Regulated by the Acidic Tail by Rowell, John P., Simpson, Kathryn L., Stott, Katherine, Watson, Matthew, Thomas, Jean O.

“…Facilitated binding of p53 to DNA by high mobility group B1 (HMGB1) may involve interaction between the N-terminal region of p53 and the high mobility group…”
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Tail-Mediated Collapse of HMGB1 Is Dynamic and Occurs via Differential Binding of the Acidic Tail to the A and B Domains by Stott, Katherine, Watson, Matthew, Howe, Françoise S., Grossmann, J. Günter, Thomas, Jean O.

“…The architectural DNA-binding protein HMGB1 consists of two tandem HMG-box domains joined by a basic linker to a C-terminal acidic tail, which negatively…”
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HMG1 and 2, and related ‘architectural’ DNA-binding proteins by Thomas, Jean O, Travers, Andrew A

“…The HMG-box proteins, one of the three classes of high mobility group (HMG) chromosomal proteins 1 1 The recent revisions of the nomenclature for the HMG…”
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Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domain by Kouzarides, Tony, Bannister, Andrew J, Zegerman, Philip, Partridge, Janet F, Miska, Eric A, Thomas, Jean O, Allshire, Robin C

“…Heterochromatin protein 1 (HP1) is localized at heterochromatin sites where it mediates gene silencing. The chromo domain of HP1 is necessary for both…”
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Mapping Intramolecular Interactions between Domains in HMGB1 using a Tail-truncation Approach by Watson, Matthew, Stott, Katherine, Thomas, Jean O.

“…The mechanism underlying negative regulation of HMGB1-DNA interaction by the acidic C-terminal tail is ill defined. To address this issue, we have devised a…”
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Structure of a Complex of Tandem HMG Boxes and DNA by Stott, Katherine, Tang, George S.F., Lee, Keng-Boon, Thomas, Jean O.

“…The high-mobility group protein HMGB1 contains two tandem DNA-binding HMG box domains, A and B, linked by a short flexible linker that allows the two domains…”
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Highly disordered histone H1−DNA model complexes and their condensates by Turner, Abigail L., Watson, Matthew, Wilkins, Oscar G., Cato, Laura, Travers, Andrew, Thomas, Jean O., Stott, Katherine

“…Disordered proteins play an essential role in a wide variety of biological processes, and are often posttranslationally modified. One such protein is histone…”
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A critical role in structure-specific DNA binding for the acetylatable lysine residues in HMGB1 by Assenberg, René, Webb, Michelle, Connolly, Edward, Stott, Katherine, Watson, Matthew, Hobbs, Josie, Thomas, Jean O

“…The structure-specific DNA-binding protein HMGB1 (high-mobility group protein B1) which comprises two tandem HMG boxes (A and B) and an acidic C-terminal tail,…”
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Structure-specific binding of the two tandem HMG boxes of HMG1 to four-way junction DNA is mediated by the A domain by Webb, Michelle, Thomas, Jean O

“…We have investigated the nature of the “structure-specific” binding of the tandem A and B HMG boxes of high mobility group protein 1 (HMG1) to four-way…”
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Characterization of the interaction between HMGB1 and H3-a possible means of positioning HMGB1 in chromatin by Watson, Matthew, Stott, Katherine, Fischl, Harry, Cato, Laura, Thomas, Jean O

“…High mobility group protein B1 (HMGB1) binds to the internucleosomal linker DNA in chromatin and abuts the nucleosome. Bending and untwisting of the linker DNA…”
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The Interaction of HMGB1 and Linker Histones Occurs Through their Acidic and Basic Tails by Cato, Laura, Stott, Katherine, Watson, Matthew, Thomas, Jean O.

“…H1 and HMGB1 bind to linker DNA in chromatin, in the vicinity of the nucleosome dyad. They appear to have opposing effects on the nucleosome, H1 stabilising it…”
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Two Homologous Domains of Similar Structure but Different Stability in the Yeast Linker Histone, Hho1p by Ali, Tariq, Coles, Patrick, Stevens, Timothy J., Stott, Katherine, Thomas, Jean O.

“…The Saccharomyces cerevisiae homologue of the linker histone H1, Hho1p, has two domains that are similar in sequence to the globular domain of H1 (and variants…”
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Structural Insights into the Mechanism of Negative Regulation of Single-box High Mobility Group Proteins by the Acidic Tail Domain by Stott, Katherine, Watson, Matthew, Bostock, Mark J., Mortensen, Simon A., Travers, Andrew, Grasser, Klaus D., Thomas, Jean O.

“…The Drosophila and plant (maize) functional counterparts of the abundant vertebrate chromosomal protein HMGB1 (HMG-D and ZmHMGB1, respectively) differ from…”
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Characterization of Chromoshadow Domain-mediated Binding of Heterochromatin Protein 1α (HP1α) to Histone H3 by Richart, Alexandria N., Brunner, Clair I.W., Stott, Katherine, Murzina, Natalia V., Thomas, Jean O.

“…The chromoshadow domain (CSD) of heterochromatin protein 1 (HP1) was recently shown to contribute to chromatin binding and transcriptional regulation through…”
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Histone H1: location and role by Thomas, Jean O

“…Recent experiments have shown directly that, in bulk chromatin, the globular domain of histone H1 is positioned close to the dyad axis and is asymmetrically…”
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Structure-specific binding of MeCP2 to four-way junction DNA through its methyl CpG-binding domain by Galvão, Teca Calcagno, Thomas, Jean O.

“…MeCP2, whose methylated DNA-binding domain (MBD) binds preferentially to DNA containing 5Me-CpG relative to linear unmethylated DNA, also binds preferentially,…”
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The effect of the acidic tail on the DNA-binding properties of the HMG1,2 class of proteins: insights from tail switching and tail removal by Lee, Keng-Boon, Thomas, Jean O

“…The high-mobility group (HMG) proteins HMG1, HMG2 and HMG2a are relatively abundant vertebrate DNA-binding and bending proteins that bind with structure…”
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Distinct Properties of the Two Putative “Globular Domains” of the Yeast Linker Histone, Hho1p by Ali, Tariq, Thomas, Jean O

“…The putative linker histone in Saccharomyces cerevisiae, Hho1p, has two regions of sequence (GI and GII) that are homologous to the single globular domains of…”
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Methylation-dependent silencing at the H19 imprinting control region by MeCP2 by Drewell, Robert A, Goddard, Carolyn J, Thomas, Jean O, Surani, M Azim

“…Methylation of CpG dinucleotides is correlated with transcriptional repression of genes, including imprinted genes. In the case of the imprinted H19 gene, a 2…”
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