Search Results - "Thomas, Jean‐Yves"

Pharmacological characterisation of S 47445, a novel positive allosteric modulator of AMPA receptors by Bretin, Sylvie, Louis, Caroline, Seguin, Laure, Wagner, Stéphanie, Thomas, Jean-Yves, Challal, Sylvie, Rogez, Nathalie, Albinet, Karine, Iop, Fabrice, Villain, Nadège, Bertrand, Sonia, Krazem, Ali, Bérachochéa, Daniel, Billiald, Stéphanie, Tordjman, Charles, Cordi, Alex, Bertrand, Daniel, Lestage, Pierre, Danober, Laurence

“…S 47445 is a novel positive allosteric modulator of alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA) receptors (AMPA-PAM). S 47445 enhanced…”
Get full text

In vivo pharmacological profile of S 38093, a novel histamine H3 receptor inverse agonist by Panayi, Fany, Sors, Aurore, Bert, Lionel, Martin, Brigitte, Rollin-Jego, Gaelle, Billiras, Rodolphe, Carrié, Isabelle, Albinet, Karine, Danober, Laurence, Rogez, Nathalie, Thomas, Jean-Yves, Pira, Luigi, Bertaina-Anglade, Valérie, Lestage, Pierre

“…S 38093, a novel histamine H3 receptor inverse agonist, was tested in a series of neurochemical and behavioral paradigms designed to evaluate its procognitive…”
Get full text

Development of Thiochroman Dioxide Analogues of Benzothiadiazine Dioxides as New Positive Allosteric Modulators of α‑Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptors by Etsè, Koffi Sénam, Dorosz, Jerzy, McLain Christensen, Katrine, Thomas, Jean-Yves, Botez Pop, Iuliana, Goffin, Eric, Colson, Thomas, Lestage, Pierre, Danober, Laurence, Pirotte, Bernard, Kastrup, Jette Sandholm, Francotte, Pierre

“…On the basis of the activity of 1,2,4-benzothiadiazine 1,1-dioxides as positive allosteric modulators of AMPA receptors, thiochroman 1,1-dioxides were designed…”
Get full text

New Fluorinated 1,2,4-Benzothiadiazine 1,1-Dioxides: Discovery of an Orally Active Cognitive Enhancer Acting through Potentiation of the 2-Amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic Acid Receptors by Francotte, Pierre, Goffin, Eric, Fraikin, Pierre, Lestage, Pierre, Van Heugen, Jean-Claude, Gillotin, Florian, Danober, Laurence, Thomas, Jean-Yves, Chiap, Patrice, Caignard, Daniel-Henri, Pirotte, Bernard, de Tullio, Pascal

“…In the search of a potent cognitive enhancer, a series of 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxides have been synthesized and evaluated as positive…”
Get full text

Positive Allosteric Modulators of 2-Amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic Acid Receptors Belonging to 4-Cyclopropyl-3,4-dihydro-2 H -1,2,4-pyridothiadiazine Dioxides and Diversely Chloro-Substituted 4-Cyclopropyl-3,4-dihydro-2 H -1,2,4-benzothiadiazine 1,1-Dioxides by Francotte, Pierre, Nørholm, Ann-Beth, Deva, Taru, Olsen, Lars, Frydenvang, Karla, Goffin, Eric, Fraikin, Pierre, de Tullio, Pascal, Challal, Sylvie, Thomas, Jean-Yves, Iop, Fabrice, Louis, Caroline, Botez-Pop, Iuliana, Lestage, Pierre, Danober, Laurence, Kastrup, Jette S., Pirotte, Bernard

Get full text

Design, Synthesis, and Pharmacology of Novel 7-Substituted 3,4-Dihydro-2H-1,2,4-benzothiadiazine 1,1-Dioxides as Positive Allosteric Modulators of AMPA Receptors by Francotte, Pierre, de Tullio, Pascal, Goffin, Eric, Dintilhac, Gaëlle, Graindorge, Emmanuel, Fraikin, Pierre, Lestage, Pierre, Danober, Laurence, Thomas, Jean-Yves, Caignard, Daniel-Henri, Pirotte, Bernard

“…A series of 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxides have been synthesized and evaluated as potentiators of AMPA receptors. Attention was paid to the…”
Get full text

Synthesis and pharmacological evaluation of a second generation of pyridothiadiazine 1,1-dioxides acting as AMPA potentiators by Francotte, Pierre, Tullio, Pascal de, Podona, Tchao, Diouf, Ousmane, Fraikin, Pierre, Lestage, Pierre, Danober, Laurence, Thomas, Jean-Yves, Caignard, Daniel-Henri, Pirotte, Bernard

“…Taking into account structure-activity relationships obtained with our previous series, new diversely substituted 1,2,4-pyridothiadiazine 1,1-dioxides were…”
Get full text

DRUG FOCUS: S 18986: A Positive Allosteric Modulator of AMPA‐Type Glutamate Receptors Pharmacological Profile of a Novel Cognitive Enhancer by Bernard, Katy, Danober, Laurence, Thomas, Jean‐Yves, Lebrun, Cécile, Muñoz, Carmen, Cordi, Alex, Desos, Patrice, Lestage, Pierre, Morain, Philippe

“…Alpha‐amino‐3‐hydroxy‐5‐methyl‐4‐isoxazole‐propionic acid (AMPA) type glutamate receptors are critical for synaptic plasticity and induction of long‐term…”
Get full text

Positive Allosteric Modulators of 2‑Amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic Acid Receptors Belonging to 4‑Cyclopropyl-3,4-dihydro‑2H‑1,2,4-pyridothiadiazine Dioxides and Diversely Chloro-Substituted 4‑Cyclopropyl-3,4-dihydro‑2H‑1,2,4-benzothiadiazine 1,1-Dioxides by Francotte, Pierre, Nørholm, Ann-Beth, Deva, Taru, Olsen, Lars, Frydenvang, Karla, Goffin, Eric, Fraikin, Pierre, de Tullio, Pascal, Challal, Sylvie, Thomas, Jean-Yves, Iop, Fabrice, Louis, Caroline, Botez-Pop, Iuliana, Lestage, Pierre, Danober, Laurence, Kastrup, Jette S, Pirotte, Bernard

“…Two 4-ethyl-substituted pyridothiadiazine dioxides belonging to α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor positive allosteric…”
Get full text

Novel quinolinone-phosphonic acid AMPA antagonists devoid of nephrotoxicity by Cordi, Alex A., Desos, Patrice, Ruano, Elisabeth, Al-Badri, Hashim, Fugier, Claude, Chapman, Astrid G., Meldrum, Brian S., Thomas, Jean-Yves, Roger, Anita, Lestage, Pierre

“…We reported previously the synthesis and structure–activity relationships (SAR) in a series of 2-(1 H)-oxoquinolines bearing different acidic functions in the…”
Get full text

In vitro characterization of s44858: A positive allosteric modulator of ampa receptors and GluN2B selective non-competitive nmda receptors antagonist by Danober, Laurence, Thomas, Jean-Yves, Challal, Sylvie, Rogez, Nathalie, Albinet, Karine, Villain, Nadège, Mony, Laétitia, Paoletti, Pierre, Bertrand, Daniel, Wagner, Stéphanie, Desos, Patrice, Cordi, Alex, Lestage, Pierre

Get full text

P2‐311: In vitro characterization of s44858: A positive allosteric modulator of ampa receptors and GluN2B selective non‐competitive nmda receptors antagonist by Danober, Laurence, Thomas, Jean-Yves, Challal, Sylvie, Rogez, Nathalie, Albinet, Karine, Villain, Nadège, Mony, Laétitia, Paoletti, Pierre, Bertrand, Daniel, Wagner, Stéphanie, Desos, Patrice, Cordi, Alex, Lestage, Pierre

Get full text

In vivo characterization of s44858, a positive allosteric modulator of ampa receptors and GluN2B selective non-competitive nmda antagonist by Lestage, Pierre, Danober, Laurence, Thomas, Jean-Yves, Krentner, Martine, Roger, Anita, Albinet, Karine, Louis, Caroline, Bertaina-Anglade, Valérie, Kazem, Ali, Béracochéa, Daniel, Bordet, Regis, Papp, Mariusz, Junges, Céline, Bertrand, Marc, Desos, Patrice, Cordi, Alex

Get full text

P2‐312: In vivo characterization of s44858, a positive allosteric modulator of ampa receptors and GluN2B selective non‐competitive nmda antagonist by Lestage, Pierre, Danober, Laurence, Thomas, Jean-Yves, Krentner, Martine, Roger, Anita, Albinet, Karine, Louis, Caroline, Bertaina-Anglade, Valérie, Kazem, Ali, Béracochéa, Daniel, Bordet, Regis, Papp, Mariusz, Junges, Céline, Bertrand, Marc, Desos, Patrice, Cordi, Alex

Get full text

Design, Synthesis, and Pharmacology of Novel 7-Substituted 3,4-Dihydro-2 H -1,2,4-benzothiadiazine 1,1-Dioxides as Positive Allosteric Modulators of AMPA Receptors by Francotte, Pierre, de Tullio, Pascal, Goffin, Eric, Dintilhac, Gaëlle, Graindorge, Emmanuel, Fraikin, Pierre, Lestage, Pierre, Danober, Laurence, Thomas, Jean-Yves, Caignard, Daniel-Henri, Pirotte, Bernard

Get full text

线性化行为模型的迭代统计公差分析 by Antoine DUMAS Jean-Yves DANTAN Nicolas GAYTON Thomas BLES Robin LOEBL

Get full text