Search Results - "Thomas, James A"

IRAK-1 bypasses priming and directly links TLRs to rapid NLRP3 inflammasome activation by Lin, Keng-Mean, Hu, Wei, Troutman, Ty Dale, Jennings, Michelle, Brewer, Travis, Li, Xiaoxia, Nanda, Sambit, Cohen, Philip, Thomas, James A., Pasare, Chandrashekhar

“…Pathogenic infections and tissue injuries trigger the assembly of inflammasomes, cytosolic protein complexes that activate caspase-1, leading to cleavage of…”
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Development and Application of a Simple Plaque Assay for the Human Malaria Parasite Plasmodium falciparum by Thomas, James A, Collins, Christine R, Das, Sujaan, Hackett, Fiona, Graindorge, Arnault, Bell, Donald, Deu, Edgar, Blackman, Michael J

“…Malaria is caused by an obligate intracellular protozoan parasite that replicates within and destroys erythrocytes. Asexual blood stages of the causative agent…”
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Use of a highly specific kinase inhibitor for rapid, simple and precise synchronization of Plasmodium falciparum and Plasmodium knowlesi asexual blood-stage parasites by Ressurreição, Margarida, Thomas, James A, Nofal, Stephanie D, Flueck, Christian, Moon, Robert W, Baker, David A, van Ooij, Christiaan

“…During the course of the asexual erythrocytic stage of development, Plasmodium spp. parasites undergo a series of morphological changes and induce alterations…”
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Insights into antitrypanosomal drug mode-of-action from cytology-based profiling by Thomas, James A, Baker, Nicola, Hutchinson, Sebastian, Dominicus, Caia, Trenaman, Anna, Glover, Lucy, Alsford, Sam, Horn, David

“…Chemotherapy continues to have a major impact on reducing the burden of disease caused by trypanosomatids. Unfortunately though, the mode-of-action (MoA) of…”
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Macrophage therapy for murine liver fibrosis recruits host effector cells improving fibrosis, regeneration, and function by Thomas, James A., Pope, Caroline, Wojtacha, Davina, Robson, Andrew J., Gordon‐Walker, Timothy T., Hartland, Stephen, Ramachandran, Prakash, Van Deemter, Marielle, Hume, David A., Iredale, John P., Forbes, Stuart J.

“…Clinical studies of bone marrow (BM) cell therapy for liver cirrhosis are under way but the mechanisms of benefit remain undefined. Cells of the…”
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Sequential roles for red blood cell binding proteins enable phased commitment to invasion for malaria parasites by Hart, Melissa N., Mohring, Franziska, DonVito, Sophia M., Thomas, James A., Muller-Sienerth, Nicole, Wright, Gavin J., Knuepfer, Ellen, Saibil, Helen R., Moon, Robert W.

“…Invasion of red blood cells (RBCs) by Plasmodium merozoites is critical to their continued survival within the host. Two major protein families, the Duffy…”
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Bone marrow injection stimulates hepatic ductular reactions in the absence of injury via macrophage-mediated TWEAK signaling by Bird, Thomas G., Lu, Wei-Yu, Boulter, Luke, Gordon-Keylock, Sabrina, Ridgway, Rachel A., Williams, Michael J., Taube, Jessica, Thomas, James A., Wojtacha, Davina, Gambardella, Adriana, Sansom, Owen J., Iredale, John P., Forbes, Stuart J.

“…Tissue progenitor cells are an attractive target for regenerative therapy. In various organs, bone marrow cell (BMC) therapy has shown promising preliminary…”
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Lys63-Linked Polyubiquitination of IRAK-1 Is Required for Interleukin-1 Receptor- and Toll-Like Receptor-Mediated NF-κB Activation by Conze, Dietrich B., Wu, Chuan-Jin, Thomas, James A., Landstrom, Allison, Ashwell, Jonathan D.

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A malaria parasite phospholipase facilitates efficient asexual blood stage egress by Ramaprasad, Abhinay, Burda, Paul-Christian, Koussis, Konstantinos, Thomas, James A, Pietsch, Emma, Calvani, Enrica, Howell, Steven A, MacRae, James I, Snijders, Ambrosius P, Gilberger, Tim-Wolf, Blackman, Michael J

“…Malaria parasite release (egress) from host red blood cells involves parasite-mediated membrane poration and rupture, thought to involve membrane-lytic…”
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Oxidized Phospholipids Induce Phenotypic Switching of Vascular Smooth Muscle Cells In Vivo and In Vitro by Pidkovka, Nataliya A, Cherepanova, Olga A, Yoshida, Tadashi, Alexander, Matthew R, Deaton, Rebecca A, Thomas, James A, Leitinger, Norbert, Owens, Gary K

“…Atherosclerosis is a vascular disease characterized by lipid deposition and inflammation within the arterial wall. Oxidized phospholipids (oxPLs), such as…”
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Outcomes of a tertiary-based innovative approach to engage primary care providers in provision of hepatitis C treatment in community settings by Pourmarzi, Davoud, Thompson, Hayley, Thomas, James A, Hall, Lisa, Smirnov, Andrew, FitzGerald, Gerard, Rahman, Tony

“…Australia is committed to eliminating the hepatitis C virus (HCV) by 2030. Despite regulations in Australia that enable the prescription of subsidised direct…”
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Human Immunodeficiency Virus Type 1 cDNAs Produced in the Presence of APOBEC3G Exhibit Defects in Plus-Strand DNA Transfer and Integration by MBISA, Jean L, BARR, Rebekah, ENGELMAN, Alan, PATHAK, Vinay K, THOMAS, James A, VANDEGRAAFF, Nick, DORWEILER, Irene J, SVAROVSKAIA, Evguenia S, BROWN, William L, MANSKY, Louis M, GORELICK, Robert J, HARRIS, Reuben S

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Efficiency of Human Immunodeficiency Virus Type 1 Postentry Infection Processes: Evidence against Disproportionate Numbers of Defective Virions by THOMAS, James A, OTT, David E, GORELICK, Robert J

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Expanding the diagnostic toolkit in chronic cholestasis by Smith, Nicholas, Borowsky, Jennifer, Thomas, James A.

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The interdomain linker region of HIV-1 capsid protein is a critical determinant of proper core assembly and stability by Jiang, Jiyang, Ablan, Sherimay D, Derebail, Suchitra, Hercík, Kamil, Soheilian, Ferri, Thomas, James A, Tang, Shixing, Hewlett, Indira, Nagashima, Kunio, Gorelick, Robert J, Freed, Eric O, Levin, Judith G

“…Abstract The HIV-1 capsid protein consists of two independently folded domains connected by a flexible peptide linker (residues 146–150), the function of which…”
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Cellular mosaicism for X-linked polymorphisms and IRAK1 expression presents a distinct phenotype and improves survival following sepsis by Chandra, Rachna, Federici, Stephanie, Németh, Zoltán H., Csóka, Balázs, Thomas, James A., Donnelly, Robert, Spolarics, Zoltán

“…X chromosome cellular mosaicism for IRAK1 expression in mice increases circulating B cell numbers and preconditions for improved sepsis outcome. ChrX cellular…”
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FADD Negatively Regulates Lipopolysaccharide Signaling by Impairing Interleukin-1 Receptor-Associated Kinase 1-MyD88 Interaction by Zhande, Rachel, Dauphinee, Shauna M., Thomas, James A., Yamamoto, Masahiro, Akira, Shizuo, Karsan, Aly

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Real-time PCR analysis of HIV-1 replication post-entry events by Mbisa, Jean L, Delviks-Frankenberry, Krista A, Thomas, James A, Gorelick, Robert J, Pathak, Vinay K

“…The reverse transcriptase enzyme plays an essential role in the HIV-1 life cycle by converting a single-stranded viral RNA genome into a double-stranded viral…”
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Innate immunity mediates myocardial preconditioning through Toll-like receptor 2 and TIRAP-dependent signaling pathways by Dong, Jian-Wen, Vallejo, Jesus G, Tzeng, Huei-Ping, Thomas, James A, Mann, Douglas L

“…Recent studies have implicated Toll-like receptor 2 (TLR2) and TLR4 signaling in delimiting liver and brain injury following ischemia-reperfusion (I/R). To…”
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PDGF-DD, a novel mediator of smooth muscle cell phenotypic modulation, is upregulated in endothelial cells exposed to atherosclerosis-prone flow patterns by Thomas, James A, Deaton, Rebecca A, Hastings, Nicole E, Shang, Yueting, Moehle, Christopher W, Eriksson, Ulf, Topouzis, Stavros, Wamhoff, Brian R, Blackman, Brett R, Owens, Gary K

“…Platelet-derived growth factor (PDGF)-BB is a well-known smooth muscle (SM) cell (SMC) phenotypic modulator that signals by binding to PDGF alphaalpha-,…”
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