Search Results - "Thomas, J.F"

A Bio-Acoustic Levitational (BAL) Assembly Method for Engineering of Multilayered, 3D Brain-Like Constructs, Using Human Embryonic Stem Cell Derived Neuro-Progenitors by Bouyer, Charlène, Chen, Pu, Güven, Sinan, Demirtaş, Tuğrul Tolga, Nieland, Thomas J. F., Padilla, Frédéric, Demirci, Utkan

“…A bio‐acoustic levitational assembly method for engineering of multilayered, 3D brainlike constructs is presented. Acoustic radiation forces are used to…”
Get full text

An epigenetic blockade of cognitive functions in the neurodegenerating brain by Gräff, Johannes, Rei, Damien, Guan, Ji-Song, Wang, Wen-Yuan, Seo, Jinsoo, Hennig, Krista M., Nieland, Thomas J. F., Fass, Daniel M., Kao, Patricia F., Kahn, Martin, Su, Susan C., Samiei, Alireza, Joseph, Nadine, Haggarty, Stephen J., Delalle, Ivana, Tsai, Li-Huei

“…Histone deacetylase 2 is shown to suppress genes involved in cognitive function epigenetically, potentially opening the door to treatments for Alzheimer’s and…”
Get full text

Innovations in 3D Tissue Models of Human Brain Physiology and Diseases by Lovett, Michael L., Nieland, Thomas J. F., Dingle, Yu‐Ting L., Kaplan, David L.

“…3D laboratory tissue cultures have emerged as an alternative to traditional 2D culture systems that do not recapitulate native cell behavior. The discrepancy…”
Get full text

Lysosomal exocytosis of HSP70 stimulates monocytic BMP6 expression in Sjögren's syndrome by Mo, Ying-Qian, Nakamura, Hiroyuki, Tanaka, Tsutomu, Odani, Toshio, Perez, Paola, Ji, Youngmi, French, Benjamin N, Pranzatelli, Thomas Jf, Michael, Drew G, Yin, Hongen, Chow, Susan S, Khalaj, Maryam, Afione, Sandra A, Zheng, Changyu, Oliveira, Fabiola Reis, Motta, Ana Carolina F, Ribeiro-Silva, Alfredo, Rocha, Eduardo M, Nguyen, Cuong Q, Noguchi, Masayuki, Atsumi, Tatsuya, Warner, Blake M, Chiorini, John A

“…BMP6 is a central cytokine in the induction of Sjögren's syndrome-associated (SS-associated) secretory hypofunction. However, the upstream initiation leading…”
Get full text

A Long‐Living Bioengineered Neural Tissue Platform to Study Neurodegeneration by Rouleau, Nicolas, Cantley, William L., Liaudanskaya, Volha, Berk, Alexander, Du, Chuang, Rusk, William, Peirent, Emily, Koester, Cole, Nieland, Thomas J. F., Kaplan, David L.

“…The prevalence of dementia and other neurodegenerative diseases continues to rise as age demographics in the population shift, inspiring the development of…”
Get full text

In vitro and in vivo evaluation of clinically-approved ionizable cationic lipids shows divergent results between mRNA transfection and vaccine efficacy by Escalona-Rayo, Oscar, Zeng, Ye, Knol, Renzo A., Kock, Thomas J.F., Aschmann, Dennis, Slütter, Bram, Kros, Alexander

“…Ionizable cationic lipids (ICLs) play an essential role in the effectiveness of lipid nanoparticles (LNPs) for delivery of mRNA therapeutics and vaccines;…”
Get full text

High-Throughput Genetic Screen for Synaptogenic Factors: Identification of LRP6 as Critical for Excitatory Synapse Development by Sharma, Kamal, Choi, Se-Young, Zhang, Yong, Nieland, Thomas J.F., Long, Shunyou, Li, Min, Huganir, Richard L.

“…Genetic screens in invertebrates have discovered many synaptogenic genes and pathways. However, similar genetic studies have not been possible in mammals. We…”
Get full text

Modeling Controlled Cortical Impact Injury in 3D Brain‐Like Tissue Cultures by Liaudanskaya, Volha, Chung, Joon Yong, Mizzoni, Craig, Rouleau, Nicolas, Berk, Alexander N., Wu, Limin, Turner, Julia A., Georgakoudi, Irene, Whalen, Michael J., Nieland, Thomas J. F., Kaplan, David L.

“…Traumatic brain injury (TBI) survivors suffer long term from mental illness, neurodegeneration, and neuroinflammation. Studies of 3D tissue models have…”
Get full text

Functional Characterization of Three-Dimensional Cortical Cultures for In Vitro Modeling of Brain Networks by Dingle, Yu-Ting L., Liaudanskaya, Volha, Finnegan, Liam T., Berlind, Kyler C., Mizzoni, Craig, Georgakoudi, Irene, Nieland, Thomas J.F., Kaplan, David L.

“…Three-dimensional (3D) in vitro cultures recapitulate key features of the brain including morphology, cell-cell and cell-extracellular matrix interactions,…”
Get full text

Exoplasmic cysteine Cys384 of the HDL receptor SR-BI is critical for its sensitivity to a small-molecule inhibitor and normal lipid transport activity by Yu, Miao, Romer, Katherine A, Nieland, Thomas J.F, Xu, Shangzhe, Saenz-Vash, Veronica, Penman, Marsha, Yesilaltay, Ayce, Carr, Steven A, Krieger, Monty

“…The HDL receptor, scavenger receptor, class B, type I (SR-BI), is a homooligomeric cell surface glycoprotein that controls HDL structure and metabolism by…”
Get full text

124 Lessons Learned: Developing an Education Format for Disseminating Clinical Pearls Gleaned from Adverse Event Review by Thomas, J.F, Martin, D, Scanlan-Hanson, L, Snow, K, Nestler, D

Get full text

Integrated functional neuronal network analysis of 3D silk-collagen scaffold-based mouse cortical culture by Dingle, Yu-Ting L., Bonzanni, Mattia, Liaudanskaya, Volha, Nieland, Thomas J.F., Kaplan, David L.

“…Bioengineered 3D tunable neuronal constructs are a versatile platform for studying neuronal network functions, offering numerous advantages over existing…”
Get full text

135 How Accurate is “My Gut Feeling?”: Comparing the Accuracy of System 1 versus System 2 Decisionmaking for the Acuity Prediction of Patients Presenting to an Emergency Department by Walston, J.M, Thomas, J.F, Wiswell, J.L, Anderson, J.R, Bellolio, M.F, Hess, E.P, Cabrera, D

Get full text

Cross-inhibition of SR-BI- and ABCA1-mediated cholesterol transport by the small molecules BLT-4 and glyburide by Nieland, Thomas J F, Chroni, Angeliki, Fitzgerald, Michael L, Maliga, Zoltan, Zannis, Vassilis I, Kirchhausen, Tomas, Krieger, Monty

“…Scavenger receptor class B type I (SR-BI) and ABCA1 are structurally dissimilar cell surface proteins that play key roles in HDL metabolism. SR-BI is a…”
Get full text

Forecasting the future burden of opioids for osteoarthritis by Ackerman, I.N., Zomer, E., Gilmartin-Thomas, J.F.-M., Liew, D.

“…To quantify the current national burden of opioids for osteoarthritis (OA) pain in Australia in terms of number of dispensed opioid prescriptions and…”
Get full text

Influence of HDL-cholesterol-elevating drugs on the in vitro activity of the HDL receptor SR-BI by Nieland, Thomas J.F., Shaw, Jared T., Jaipuri, Firoz A., Maliga, Zoltan, Duffner, Jay L., Koehler, Angela N., Krieger, Monty

“…Treatment of atherosclerotic disease often focuses on reducing plasma LDL-cholesterol or increasing plasma HDL-cholesterol. We examined in vitro the effects on…”
Get full text

HDAC2 negatively regulates memory formation and synaptic plasticity by Guan, Ji-Song, Haggarty, Stephen J., Giacometti, Emanuela, Dannenberg, Jan-Hermen, Joseph, Nadine, Gao, Jun, Nieland, Thomas J. F., Zhou, Ying, Wang, Xinyu, Mazitschek, Ralph, Bradner, James E., DePinho, Ronald A., Jaenisch, Rudolf, Tsai, Li-Huei

“…Chromatin modifications, especially histone-tail acetylation, have been implicated in memory formation. Increased histone-tail acetylation induced by…”
Get full text

Global warming triggers coral reef bleaching tipping point: This article belongs to Ambio's 50th Anniversary Collection. Theme: Climate change impacts by Goreau, Thomas J. F., Hayes, Raymond L.

Get full text

3D biocomposite culture enhances differentiation of dopamine-like neurons from SH-SY5Y cells: A model for studying Parkinson's disease phenotypes by Fiore, Nicholas J., Tamer-Mahoney, Jackson D., Beheshti, Afshin, Nieland, Thomas J.F., Kaplan, David L.

“…Studies of underlying neurodegenerative processes in Parkinson's Disease (PD) have traditionally utilized cell cultures grown on two-dimensional (2D) surfaces…”
Get full text

Thermal Expansion of Metal–Organic Framework Crystal–Glass Composites by Ashling, Christopher W., Lampronti, Giulio I., Southern, Thomas J. F., Evans, Rachel C., Bennett, Thomas D.

“…Metal–organic framework crystal–glass composites (MOF CGCs) are a class of materials comprising a crystalline framework embedded within a MOF glass matrix…”
Get full text