Search Results - "Thomas, Gavin H."
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1
Global Distribution and Conservation of Evolutionary Distinctness in Birds
Published in Current biology (05-05-2014)“…Integrated, efficient, and global prioritization approaches are necessary to manage the ongoing loss of species and their associated function. “Evolutionary…”
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2
Sialic acid acquisition in bacteria-one substrate, many transporters
Published in Biochemical Society transactions (15-06-2016)“…The sialic acids are a family of 9-carbon sugar acids found predominantly on the cell-surface glycans of humans and other animals within the Deuterostomes and…”
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3
A cautionary note on the use of Ornstein Uhlenbeck models in macroevolutionary studies
Published in Biological journal of the Linnean Society (01-05-2016)“…Phylogenetic comparative methods are increasingly used to give new insights into the dynamics of trait evolution in deep time. For continuous traits the core…”
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4
Comprehensive identification of RNA–protein interactions in any organism using orthogonal organic phase separation (OOPS)
Published in Nature biotechnology (01-02-2019)“…Existing high-throughput methods to identify RNA-binding proteins (RBPs) are based on capture of polyadenylated RNAs and cannot recover proteins that interact…”
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5
Mega-evolutionary dynamics of the adaptive radiation of birds
Published in Nature (London) (16-02-2017)“…A study of more than 2,000 bird species shows that diversity in bill shape expands towards extreme morphologies early in avian evolution in a series of major…”
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6
Water Networks Can Determine the Affinity of Ligand Binding to Proteins
Published in Journal of the American Chemical Society (09-10-2019)“…Solvent organization is a key but underexploited contributor to the thermodynamics of protein–ligand recognition, with implications for ligand discovery, drug…”
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7
The substrate-binding protein in bacterial ABC transporters: dissecting roles in the evolution of substrate specificity
Published in Biochemical Society transactions (01-10-2015)“…ATP-binding cassette (ABC) transporters, although being ubiquitous in biology, often feature a subunit that is limited primarily to bacteria and archaea. This…”
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8
Sexual selection predicts the rate and direction of colour divergence in a large avian radiation
Published in Nature communications (16-04-2019)“…Sexual selection is proposed to be a powerful driver of phenotypic evolution in animal systems. At macroevolutionary scales, sexual selection can theoretically…”
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9
Using pose estimation to identify regions and points on natural history specimens
Published in PLoS computational biology (01-02-2023)“…A key challenge in mobilising growing numbers of digitised biological specimens for scientific research is finding high-throughput methods to extract…”
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10
Sialic acid utilization by bacterial pathogens
Published in Microbiology (Society for General Microbiology) (01-09-2007)“…1 Department of Biology (Area 10), University of York, PO Box 373, York YO10 5YW, UK 2 Molecular Infectious Diseases Group, University of Oxford Department of…”
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11
Heterogeneous relationships between rates of speciation and body size evolution across vertebrate clades
Published in Nature ecology & evolution (01-01-2021)“…Several theories predict that rates of phenotypic evolution should be related to the rate at which new lineages arise. However, drawing general conclusions…”
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12
Cross-validation of distance measurements in proteins by PELDOR/DEER and single-molecule FRET
Published in Nature communications (29-07-2022)“…Pulsed electron-electron double resonance spectroscopy (PELDOR/DEER) and single-molecule Förster resonance energy transfer spectroscopy (smFRET) are frequently…”
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13
Conformational coupling of the sialic acid TRAP transporter HiSiaQM with its substrate binding protein HiSiaP
Published in Nature communications (08-01-2024)“…The tripartite ATP-independent periplasmic (TRAP) transporters use an extra cytoplasmic substrate binding protein (SBP) to transport a wide variety of…”
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14
Ecology and allometry predict the evolution of avian developmental durations
Published in Nature communications (14-05-2020)“…The duration of the developmental period represents a fundamental axis of life-history variation, yet broad insights regarding the drivers of this diversity…”
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15
Tripartite ATP-Independent Periplasmic (TRAP) Transporters and Tripartite Tricarboxylate Transporters (TTT): From Uptake to Pathogenicity
Published in Frontiers in cellular and infection microbiology (12-02-2018)“…The ability to efficiently scavenge nutrients in the host is essential for the viability of any pathogen. All catabolic pathways must begin with the transport…”
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Interrogation of RNA-protein interaction dynamics in bacterial growth
Published in Molecular systems biology (02-05-2024)“…Characterising RNA–protein interaction dynamics is fundamental to understand how bacteria respond to their environment. In this study, we have analysed the…”
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17
Phylogenetic distributions of British birds of conservation concern
Published in Proceedings of the Royal Society. B, Biological sciences (22-09-2008)“…Recent studies suggest that species' life histories and ecology can be used to forecast future extinction risk. Threatened species often share similar traits…”
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18
Structural and mechanistic analysis of a tripartite ATP-independent periplasmic TRAP transporter
Published in Nature communications (04-08-2022)“…Tripartite ATP-independent periplasmic (TRAP) transporters are found widely in bacteria and archaea and consist of three structural domains, a soluble…”
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19
A simple polytomy resolver for dated phylogenies
Published in Methods in ecology and evolution (01-10-2011)“…Summary 1. Unresolved nodes in phylogenetic trees (polytomies) have long been recognized for their influences on specific phylogenetic metrics such as…”
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Land-Sparing Agriculture Best Protects Avian Phylogenetic Diversity
Published in Current biology (21-09-2015)“…The conversion of natural habitats to farmland is a major driver of the global extinction crisis [1, 2]. Two strategies are promoted to mitigate the impacts of…”
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