Search Results - "Thomas, Gareth J"

Pan-cancer deconvolution of tumour composition using DNA methylation by Chakravarthy, Ankur, Furness, Andrew, Joshi, Kroopa, Ghorani, Ehsan, Ford, Kirsty, Ward, Matthew J., King, Emma V., Lechner, Matt, Marafioti, Teresa, Quezada, Sergio A., Thomas, Gareth J., Feber, Andrew, Fenton, Tim R.

“…The nature and extent of immune cell infiltration into solid tumours are key determinants of therapeutic response. Here, using a DNA methylation-based approach…”
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mTOR regulates MAPKAPK2 translation to control the senescence-associated secretory phenotype by Herranz, Nicolás, Gallage, Suchira, Mellone, Massimiliano, Wuestefeld, Torsten, Klotz, Sabrina, Hanley, Christopher J., Raguz, Selina, Acosta, Juan Carlos, Innes, Andrew J., Banito, Ana, Georgilis, Athena, Montoya, Alex, Wolter, Katharina, Dharmalingam, Gopuraja, Faull, Peter, Carroll, Thomas, Martínez-Barbera, Juan Pedro, Cutillas, Pedro, Reisinger, Florian, Heikenwalder, Mathias, Miller, Richard A., Withers, Dominic, Zender, Lars, Thomas, Gareth J., Gil, Jesús

“…Senescent cells secrete a combination of factors collectively known as the senescence-associated secretory phenotype (SASP). The SASP reinforces senescence and…”
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PTBP1-Mediated Alternative Splicing Regulates the Inflammatory Secretome and the Pro-tumorigenic Effects of Senescent Cells by Georgilis, Athena, Klotz, Sabrina, Hanley, Christopher J., Herranz, Nicolas, Weirich, Benedikt, Morancho, Beatriz, Leote, Ana Carolina, D'Artista, Luana, Gallage, Suchira, Seehawer, Marco, Carroll, Thomas, Dharmalingam, Gopuraja, Wee, Keng Boon, Mellone, Marco, Pombo, Joaquim, Heide, Danijela, Guccione, Ernesto, Arribas, Joaquín, Barbosa-Morais, Nuno L., Heikenwalder, Mathias, Thomas, Gareth J., Zender, Lars, Gil, Jesús

“…Oncogene-induced senescence is a potent tumor-suppressive response. Paradoxically, senescence also induces an inflammatory secretome that promotes…”
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Implications of Tuberculosis Reactivation after Immune Checkpoint Inhibition by Elkington, Paul T, Bateman, Adrian C, Thomas, Gareth J, Ottensmeier, Christian H

“…Antituberculosis treatment was initiated, which led to clinical improvement, normalization of liver function tests, and regression of the lung lesion. [...]the…”
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Targeting the Myofibroblastic Cancer-Associated Fibroblast Phenotype Through Inhibition of NOX4 by Hanley, Christopher J, Mellone, Massimiliano, Ford, Kirsty, Thirdborough, Steve M, Mellows, Toby, Frampton, Steven J, Smith, David M, Harden, Elena, Szyndralewiez, Cedric, Bullock, Marc, Noble, Fergus, Moutasim, Karwan A, King, Emma V, Vijayanand, Pandurangan, Mirnezami, Alex H, Underwood, Timothy J, Ottensmeier, Christian H, Thomas, Gareth J

“…Cancer-associated fibroblasts (CAFs) are tumor-promoting and correlate with poor survival in many cancers, which has led to their emergence as potential…”
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Characterising cancer-associated fibroblast heterogeneity in non-small cell lung cancer: a systematic review and meta-analysis by Irvine, Andrew F., Waise, Sara, Green, Edward W., Stuart, Beth, Thomas, Gareth J.

“…Cancer-associated fibroblasts (CAFs) are a key component of the tumour microenvironment with evidence suggesting they represent a heterogeneous population…”
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Human tissue models in cancer research: looking beyond the mouse by Jackson, Samuel J, Thomas, Gareth J

“…Mouse models, including patient-derived xenograft mice, are widely used to address questions in cancer research. However, there are documented flaws in these…”
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Cancer-associated fibroblasts predict poor outcome and promote periostin-dependent invasion in oesophageal adenocarcinoma by Underwood, Timothy J, Hayden, Annette L, Derouet, Mathieu, Garcia, Edwin, Noble, Fergus, White, Michael J, Thirdborough, Steve, Mead, Abbie, Clemons, Nicholas, Mellone, Massimiliano, Uzoho, Chudy, Primrose, John N, Blaydes, Jeremy P, Thomas, Gareth J

“…Interactions between cancer cells and cancer‐associated fibroblasts (CAFs) play an important role in tumour development and progression. In this study we…”
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Single-cell analysis reveals prognostic fibroblast subpopulations linked to molecular and immunological subtypes of lung cancer by Hanley, Christopher J., Waise, Sara, Ellis, Matthew J., Lopez, Maria A., Pun, Wai Y., Taylor, Julian, Parker, Rachel, Kimbley, Lucy M., Chee, Serena J., Shaw, Emily C., West, Jonathan, Alzetani, Aiman, Woo, Edwin, Ottensmeier, Christian H., Rose-Zerilli, Matthew J. J., Thomas, Gareth J.

“…Fibroblasts are poorly characterised cells that variably impact tumour progression. Here, we use single cell RNA-sequencing, multiplexed immunohistochemistry…”
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Anti-PD-1 immunotherapy leads to tuberculosis reactivation via dysregulation of TNF-α by Tezera, Liku B, Bielecka, Magdalena K, Ogongo, Paul, Walker, Naomi F, Ellis, Matthew, Garay-Baquero, Diana J, Thomas, Kristian, Reichmann, Michaela T, Johnston, David A, Wilkinson, Katalin Andrea, Ahmed, Mohamed, Jogai, Sanjay, Jayasinghe, Suwan N, Wilkinson, Robert J, Mansour, Salah, Thomas, Gareth J, Ottensmeier, Christian H, Leslie, Alasdair, Elkington, Paul T

“…Previously, we developed a 3-dimensional cell culture model of human tuberculosis (TB) and demonstrated its potential to interrogate the host-pathogen…”
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A subset of myofibroblastic cancer-associated fibroblasts regulate collagen fiber elongation, which is prognostic in multiple cancers by Hanley, Christopher J, Noble, Fergus, Ward, Matthew, Bullock, Marc, Drifka, Cole, Mellone, Massimiliano, Manousopoulou, Antigoni, Johnston, Harvey E, Hayden, Annette, Thirdborough, Steve, Liu, Yuming, Smith, David M, Mellows, Toby, Kao, W John, Garbis, Spiros D, Mirnezami, Alex, Underwood, Tim J, Eliceiri, Kevin W, Thomas, Gareth J

“…Collagen structure has been shown to influence tumor cell invasion, metastasis and clinical outcome in breast cancer. However, it remains unclear how it…”
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Targeting Head and Neck Cancer by Vaccination by Wang, Chuan, Dickie, James, Sutavani, Ruhcha V, Pointer, Catherine, Thomas, Gareth J, Savelyeva, Natalia

“…Head and neck cancer (HNC) is a heterogeneous group of squamous cell cancers that affect the oral cavity, pharynx, and larynx. Worldwide, it is the sixth most…”
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Stromal features are predictive of disease mortality in oral cancer patients by Marsh, Daniel, Suchak, Krishna, Moutasim, Karwan A, Vallath, Sabarinath, Hopper, Colin, Jerjes, Waseem, Upile, Tahwinder, Kalavrezos, Nicholas, Violette, Shelia M, Weinreb, Paul H, Chester, Kerry A, Chana, Jagdeep S, Marshall, John F, Hart, Ian R, Hackshaw, Allan K, Piper, Kim, Thomas, Gareth J

“…Worldwide, approximately 405 000 cases of oral cancer (OSCC) are diagnosed each year, with a rising incidence in many countries. Despite advances in surgery…”
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Cancer-Associated Fibroblasts in Oral Cancer: A Current Perspective on Function and Potential for Therapeutic Targeting by Bienkowska, Kamila J, Hanley, Christopher J, Thomas, Gareth J

“…The role of the tumour microenvironement (TME) in cancer progression and resistance to therapies is now widely recognized. The most prominent non-immune cell…”
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Integrated analysis of cervical squamous cell carcinoma cohorts from three continents reveals conserved subtypes of prognostic significance by Chakravarthy, Ankur, Reddin, Ian, Henderson, Stephen, Dong, Cindy, Kirkwood, Nerissa, Jeyakumar, Maxmilan, Rodriguez, Daniela Rothschild, Martinez, Natalia Gonzalez, McDermott, Jacqueline, Su, Xiaoping, Egawa, Nagayasau, Fjeldbo, Christina S., Skingen, Vilde Eide, Lyng, Heidi, Halle, Mari Kyllesø, Krakstad, Camilla, Soleiman, Afschin, Sprung, Susanne, Lechner, Matt, Ellis, Peter J. I., Wass, Mark, Michaelis, Martin, Fiegl, Heidi, Salvesen, Helga, Thomas, Gareth J., Doorbar, John, Chester, Kerry, Feber, Andrew, Fenton, Tim R.

“…Human papillomavirus (HPV)-associated cervical cancer is a leading cause of cancer deaths in women. Here we present an integrated multi-omic analysis of 643…”
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YAP drives cutaneous squamous cell carcinoma formation and progression by Vincent-Mistiaen, Zoé, Elbediwy, Ahmed, Vanyai, Hannah, Cotton, Jennifer, Stamp, Gordon, Nye, Emma, Spencer-Dene, Bradley, Thomas, Gareth J, Mao, Junhao, Thompson, Barry

“…Squamous cell carcinoma (SCC) can progress to malignant metastatic cancer, including an aggressive subtype known as spindle cell carcinoma (spSCC). spSCC…”
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The Nrf2 transcription factor contributes to resistance to cisplatin in bladder cancer by Hayden, Annette, Ph.D, Douglas, James, M.D, Sommerlad, Matthew, M.D, Andrews, Lawrence, Ph.D, Gould, Katherine, B.Sc, Hussain, Syed, M.D., Ph.D, Thomas, Gareth J., M.D., Ph.D, Packham, Graham, Ph.D, Crabb, Simon J., M.D., Ph.D

“…Abstract Objectives Cisplatin is the key systemic chemotherapeutic agent used for bladder cancer, but chemoresistance is a major clinical problem. The…”
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JAML immunotherapy targets recently activated tumor-infiltrating CD8+ T cells by Eschweiler, Simon, Wang, Alice, Ramírez-Suástegui, Ciro, von Witzleben, Adrian, Li, Yingcong, Chee, Serena J., Simon, Hayley, Mondal, Monalisa, Ellis, Matthew, Thomas, Gareth J., Chandra, Vivek, Ottensmeier, Christian H., Vijayanand, Pandurangan

“…Junctional adhesion molecule-like protein (JAML) serves as a co-stimulatory molecule in γδ T cells. While it has recently been described as a cancer…”
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Treatment of actinic keratosis through inhibition of cyclooxygenase‐2: Potential mechanism of action of diclofenac sodium 3% in hyaluronic acid 2.5 by Thomas, Gareth J., Herranz, Pedro, Cruz, Susana Balta, Parodi, Aurora

“…Cyclooxygenase‐2 (COX‐2) and its metabolic product prostaglandin E2 (PGE2) are induced in response to growth factors, inflammatory cytokines, tumor promoters,…”
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The ZEB2‐dependent EMT transcriptional programme drives therapy resistance by activating nucleotide excision repair genes ERCC1 and ERCC4 in colorectal cancer by Sreekumar, Rahul, Al‐Saihati, Hajir, Emaduddin, Muhammad, Moutasim, Karwan, Mellone, Massimiliano, Patel, Ashish, Kilic, Seval, Cetin, Metin, Erdemir, Sule, Navio, Marta Salgado, Lopez, Maria Antonette, Curtis, Nathan, Yagci, Tamer, Primrose, John N., Price, Brendan D., Berx, Geert, Thomas, Gareth J., Tulchinsky, Eugene, Mirnezami, Alex, Sayan, A. Emre

“…Resistance to adjuvant chemotherapy is a major clinical problem in the treatment of colorectal cancer (CRC). The aim of this study was to elucidate the role of…”
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