Search Results - "Thomas, G. A. O."

Natural history of Crohn's disease in a population-based cohort from Cardiff (1986-2003): a study of changes in medical treatment and surgical resection rates by Ramadas, A V, Gunesh, S, Thomas, G A O, Williams, G T, Hawthorne, A B

“…Benefits of immunosuppressive therapy in Crohn's disease have been demonstrated in controlled trials; however, it is unclear whether these drugs alter the…”
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The incidence of Crohn’s disease in Cardiff over the last 75 years: an update for 1996–2005 by GUNESH, S., THOMAS, G. A. O., WILLIAMS, G. T., ROBERTS, A., HAWTHORNE, A. B.

“…Summary Background The incidence of Crohn's disease rose rapidly in industralized countries over the past 50 years, but it is unclear whether the incidence is…”
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Naloxone treatment for irritable bowel syndrome — a randomized controlled trial with an oral formulation by Hawkes, N. D., Rhodes, J., Evans, B. K., Rhodes, P., Hawthorne, A. B., Thomas, G. A. O.

“…SUMMARY Background : Opioids change gut motility and secretion, causing delayed intestinal transit and constipation. Endorphins play a role in the constipation…”
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Non-hepatic hyperammonaemia: an important, potentially reversible cause of encephalopathy by Hawkes, N D, Thomas, G A O, Jurewicz, A, Williams, O M, Hillier, C E M, McQueen, I N F, Shortland, G

“…The clinical syndrome of encephalopathy is most often encountered in the context of decompensated liver disease and the diagnosis is usually clear cut…”
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Nicotine enemas for treatment of ulcerative colitis: a study of the pharmacokinetics and adverse events associated with three doses of nicotine by Ingram, J. R., Routledge, P., Rhodes, J., Marshall, R. W., Buss, D. C., Evans, B. K., Feyerabend, C., Thomas, G. A. O.

“…Summary Background : Transdermal nicotine is of value in active ulcerative colitis but causes adverse events because of systemic absorption. Nicotine enemas…”
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Controlled trial of antituberculous chemotherapy in Crohn’s disease: a five year follow up study by Thomas, G A O, Swift, G L, Green, J T, Newcombe, R G, Braniff-Mathews, C, Rhodes, J, Wilkinson, S, Strohmeyer, G, Kreuzpainter, G

“…Background—It has been suggested thatMycobacterium paratuberculosis is the cause of Crohn’s disease. In a previous report the immediate effect of two years…”
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Nicotine Enemas for Active Crohn's Colitis : An Open Pilot Study by Thomas, G. A. O., Evans, B. K., Rhodes, J., Ingram, J. R.

“…Background. Smoking has a detrimental effect in Crohn's disease (CD), but this may be due to factors in smoking other than nicotine. Given that transdermal…”
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Nicotine enemas for active ulcerative colitis—a pilot study by GREEN, J. T., THOMAS, G. A. O., RHODES, J., WILLIAMS, G. T., EVANS, B. K., RUSSELL, M. A. H., FEYERABEND, C., RHODES, P., SANDBORN, W. J.

“…Background Since transdermal nicotine is of value in the treatment of active ulcerative colitis but is often associated with side‐effects, an alternative in…”
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Nitric oxide mediates a therapeutic effect of nicotine in ulcerative colitis by Green, J. T., Richardson, C., Marshall, R. W., Rhodes, J., Mckirdy, H. C., Thomas, G. A. O., Williams, G. T.

“…Background: Ulcerative colitis is a condition of nonsmokers in which nicotine is of therapeutic benefit. Aims: To examine the in vitro effect of nicotine on…”
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Clinical status of ulcerative colitis in patients who smoke by Green, J.T, Rhodes, J, Ragunath, K, Thomas, G.A.O, Williams, G.T, Mani, V, Feyerabend, C, Russell, M.A.H

“…Objectives: Ulcerative colitis (UC) is largely a disease of nonsmokers. There are few patients who are current smokers, but we have identified a group and…”
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Enteric‐release glyceryl trinitrate in active Crohn’s disease: a randomized, double‐blind, placebo‐controlled trial by Hawkes, N. D., Richardson, C., Ch'Ng, C. L., Green, J. T., Evans, B. K., Williams, J., Rhodes, P., Rhodes, J., Swift, G. L., Thomas, G. A. O., Hawthorne, A. B., Kingham, J. G. C., Mayberry, J. F.

“…Background: Mucosal ischaemia may contribute to the pathogenesis of Crohn’s disease. Microvascular abnormalities have been found in colonic resection…”
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Squamous carcinoma in an oesophageal foregut cyst by JACOB, R, HAWKES, N. D, DALLIMORE, N, BUTCHART, E. G, THOMAS, G. A. O, MAUGHAN, T. S

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Effect of smoking and transdermal nicotine on colonic nicotinic acetylcholine receptors in ulcerative colitis by Richardson, C.E., Morgan, J.M., Jasani, B., Green, J.T., Rhodes, J., Williams, G.T., Lindstrom, J., Wonnacott, S., Peel, S., Thomas, G.A.O.

“…Background: Ulcerative colitis (UC) is a disease largely of non‐smokers, in which nicotine is of therapeutic value. The mode of action is unknown, but may…”
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Comparative study of enema retention and preference in ulcerative colitis by Ingram, J R, Rhodes, J, Evans, B K, Newcombe, R G, Thomas, G A O

“…Background: Therapeutic enemas are often used to treat active colitis but their retention may be limited because of urgency to defecate. Some preparations may…”
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Effect of an enteric‐release formulation of naloxone on intestinal transit in volunteers taking codeine by Hawkes, N. D., Richardson, C., Evans, B. K., Rhodes, J., Lewis, S. J., Thomas, G. A. O.

“…Introduction: Constipation is a common side‐effect of opioid therapy; in addition to their analgesic effect, opioids reduce intestinal secretion and motility…”
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Generalised oedema, lethargy, personality disturbance, and recurring nightmares in a young girl by Hawkes, N D, Mutimer, D, Thomas, G A O

“…A 17 year old girl presented with a six week history of loose, yellow motions, marked leg swelling, increased shortness of breath, lethargy, and decreased…”
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An oral formulation of nicotine for release and absorption in the colon: its development and pharmacokinetics by GREEN, J. T, EVANS, B. K, RHODES, J, THOMAS, G. A. O, RANSHAW, C, FEYERABEND, C, RUSSELL, M. A. H

“…Aims Ulcerative colitis is predominantly a disease of nonsmokers and transdermal nicotine has therapeutic value in active disease; however side‐effects are…”
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Unexplained weight loss and a palpable abdominal mass in a middle aged woman by Hawkes, N D, Thomas, G A O

“…A barium meal examination showed an 8 cm, non-distensible narrowing in the upper oesophagus but a follow up endoscopy was normal. Because of ongoing weight…”
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Thickness of adherent mucus gel on colonic mucosa in humans and its relevance to colitis by Pullan, R D, Thomas, G A, Rhodes, M, Newcombe, R G, Williams, G T, Allen, A, Rhodes, J

“…The thickness of adherent mucus gel on the surface of colonic mucosa was measured in surgically resected specimens from 46 'control' patients most of whom had…”
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Inflammatory bowel disease and smoking—A review by Thomas, Gareth A.O., Rhodes, John, Green, John T.

“…The relationship between smoking and inflammatory bowel disease is a curious but well-established one. It is negatively associated with ulcerative colitis but…”
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