Search Results - "Thomas, Della"

Exploring the new horizons of drug repurposing: A vital tool for turning hard work into smart work by Kumar, Rajesh, Harilal, Seetha, Gupta, Sheeba Varghese, Jose, Jobin, Thomas Parambi, Della Grace, Uddin, Md. Sahab, Shah, Muhammad Ajmal, Mathew, Bijo

“…Drug discovery and development are long and financially taxing processes. On an average it takes 12–15 years and costs 1.2 billion USD for successful drug…”
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Magnetic nanoparticles for hyperthermia in cancer treatment: an emerging tool by Jose, Jobin, Kumar, Rajesh, Harilal, Seetha, Mathew, Githa Elizabeth, Parambi, Della Grace Thomas, Prabhu, Ankitha, Uddin, Md. Sahab, Aleya, Lotfi, Kim, Hoon, Mathew, Bijo

“…Cancer remains as the major cause of death worldwide. The main reason why available therapies fail is that a vicious cycle in established which initiates…”
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Potent and highly selective dual‐targeting monoamine oxidase‐B inhibitors: Fluorinated chalcones of morpholine versus imidazole by Mathew, Bijo, Baek, Seung C., Thomas Parambi, Della G., Lee, Jae P., Mathew, Githa E., Jayanthi, Sivaraman, Vinod, Devaraji, Rapheal, Clariya, Devikrishna, Vinod, Kondarath, Shahin Shad, Uddin, Md. Sahab, Kim, Hoon

“…Two series of fluorinated chalcones containing morpholine and imidazole‐based compounds (f1–f8) were synthesized and evaluated for recombinant human monoamine…”
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FDA-approved drugs containing dimethylamine pharmacophore: a review of the last 50 years by Bindra, Sandeep, Bose, Kuntal, Thekkantavida, Amrutha Chandran, Grace Thomas Parambi, Della, Alsahli, Tariq G, Pant, Manu, Pappachen, Leena K, Kim, Hoon, Mathew, Bijo

“…Dimethylamine (DMA) derivatives represent a promising class of compounds with significant potential in the field of medicinal chemistry. DMA derivatives…”
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A New Potent and Selective Monoamine Oxidase‐B Inhibitor with Extended Conjugation in a Chalcone Framework: 1‐[4‐(Morpholin‐4‐yl)phenyl]‐5‐phenylpenta‐2,4‐dien‐1‐one by Maliyakkal, Naseer, Eom, Bo Hyun, Heo, Jeong Hyun, Abdullah Almoyad, Mohammad Ali, Thomas Parambi, Della Grace, Gambacorta, Nicola, Nicolotti, Orazio, Beeran, Asmy Appadath, Kim, Hoon, Mathew, Bijo

“…The general blueprint for the design of monoamine oxidase‐B (MAO‐B) inhibitors has been based on two phenyl or heteronuclei linked via a spacer of appropriate…”
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The Role of Mitochondrial Genes in Neurodegenerative Disorders by Kumar, Rajesh, Harilal, Seetha, Parambi, Della Grace Thomas, Kanthlal, S K, Rahman, Md Atiar, Alexiou, Athanasios, Batiha, Gaber El-Saber, Mathew, Bijo

“…Mitochondrial disorders are clinically heterogeneous, resulting from nuclear gene and mitochondrialmutations that disturb the mitochondrial functions and…”
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Selected aryl thiosemicarbazones as a new class of multi-targeted monoamine oxidase inhibitors by Mathew, Bijo, Baek, Seung Cheol, Grace Thomas Parambi, Della, Pil Lee, Jae, Joy, Monu, Annie Rilda, P R, Randev, Rugma V, Nithyamol, P, Vijayan, Vijitha, Inasu, Sini T, Mathew, Githa Elizabeth, Lohidakshan, Krishnakumar K, Kumar Krishnan, Girish, Kim, Hoon

“…A series of 13 phenyl substituted thiosemicarbazones ( ) were synthesized and evaluated for their inhibitory potential towards human recombinant monoamine…”
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Design, Synthesis and Biological Evaluation of New HDAC1 and HDAC2 Inhibitors Endowed with Ligustrazine as a Novel Cap Moiety by Al-Sanea, Mohammad M, Gotina, Lizaveta, Mohamed, Mamdouh Fa, Grace Thomas Parambi, Della, Gomaa, Hesham A M, Mathew, Bijo, Youssif, Bahaa G M, Alharbi, Khalid Saad, Elsayed, Zainab M, Abdelgawad, Mohamed A, Eldehna, Wagdy M

“…Histone deacetylases (HDACs) represent one of the most validated cancer targets. The inhibition of HDACs has been proven to be a successful strategy for the…”
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Advancements in nanotherapeutics for Alzheimer’s disease: current perspectives by Harilal, Seetha, Jose, Jobin, Parambi, Della Grace Thomas, Kumar, Rajesh, Mathew, Githa Elizabeth, Uddin, Md. Sahab, Kim, Hoon, Mathew, Bijo

“…Objectives Considerable progress has been made in the treatment of Alzheimer’s disease (AD), but all available strategies focus on alleviating symptoms rather…”
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Multiple renal calculi due to hypercalcaemia induced by over-the-counter vitamin D intoxication by Manappallil, Robin George, Shylendran, Sudhin, Kakkattil, Aryasree, Thomas, Archana Della

“…Renal stone disease is a common and painful condition. Even though it is rarely fatal, patients describe it as the worst pain in their life. While dietary…”
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Gene Therapy Approach with an Emphasis on Growth Factors: Theoretical and Clinical Outcomes in Neurodegenerative Diseases by Parambi, Della Grace Thomas, Alharbi, Khalid Saad, Kumar, Rajesh, Harilal, Seetha, Batiha, Gaber El-Saber, Cruz-Martins, Natália, Magdy, Omnia, Musa, Arafa, Panda, Dibya Sundar, Mathew, Bijo

“…The etiology of many neurological diseases affecting the central nervous system (CNS) is unknown and still needs more effective and specific therapeutic…”
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A literature review on pharmacological aspects, docking studies, and synthetic approaches of quinazoline and quinazolinone derivatives by Ghoneim, Mohammed M., Abdelgawad, Mohamed A., Elkanzi, Nadia A. A., Parambi, Della Grace Thomas, Alsalahat, Izzeddin, Farouk, Amr, Bakr, Rania B.

“…Quinazoline and quinazolinone derivatives piqued medicinal chemistry interest in developing novel drug candidates owing to their pharmacological potential…”
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Ameliorative effect of ethoxylated chalcone-based MAO-B inhibitor on behavioural predictors of haloperidol-induced Parkinsonism in mice: evidence of its antioxidative role against Parkinson’s diseases by Maliyakkal, Naseer, Saleem, Uzma, Anwar, Fareeha, Shah, Muhammad Ajmal, Ahmad, Bashir, Umer, Filzah, Almoyad, Mohammad Ali Abdullah, Parambi, Della Grace Thomas, Beeran, Asmy Appadath, Nath, Lekshmi R, Aleya, Lotfi, Mathew, Bijo

“…Parkinson’s disease is a progressive neurodegenerative disorder that affects mostly elderly people above the age of 60. Previously, we have reported that the…”
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Halogenated class of oximes as a new class of monoamine oxidase-B inhibitors for the treatment of Parkinson’s disease: Synthesis, biochemistry, and molecular dynamics study by Thomas Parambi, Della Grace, Oh, Jong Min, Kumar, Sunil, Sudevan, Sachithra Thazhathuveedu, Hendawy, Omnia Magdy, Abdelgawad, Mohamed A., Musa, Arafa, Al-Sanea, Mohammad M., Ahmad, Iqrar, Patel, Harun, Kim, Hoon, Mathew, Bijo

“…Oximes are the promising structural scaffold for inhibiting monoamine oxidase (MAO)-B. Eight chalcone-based oxime derivatives were synthesized by…”
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A Comprehensive Review of The Molecular Dynamic Study Of Chalcones, Coumarins and Chromones as Selective MAO‐B Inhibitors [2015‐Till Date] by Rachel Thomas, Riya, Chandran, Namitha, Thomas Parambi, Della Grace, Kumar, Sunil, Alsahli, Tariq G., Verma, Shivani, Al‐Sehemi, Abdullah G., Mathew, Bijo

“…Molecular dynamics (MD) simulation is an in silico method used in the biomolecular level of research to study how the protein interacts with the target with…”
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Recent Progress in Synthetic and Natural Catechol‑O‑methyltransferase Inhibitors for Neurological Disorders by Bindra, Sandeep, Datta, Ananya, Yasin, Haya Khader Ahmad, Thomas, Riya Rachel, Verma, Shailesh, Patel, Ankita, Parambi, Della Grace Thomas, Mali, Suraj N., Rangarajan, T. M., Mathew, Bijo

“…Catechol-O-methyltransferase (COMT) inhibitors have played a crucial role in the development of potent and selective drugs for the treatment of Parkinson’s…”
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Studies on the interaction between HSA and new halogenated metformin derivatives: influence of lipophilic groups in the binding ability by Chaves, Otávio Augusto, Mathew, Bijo, Parambi, Della Grace Thomas, C. S. de Oliveira, Cosme Henrique, Cesarin-Sobrinho, Dari, Lakshminarayanan, Balasubramanian, Najeeb, Sadiya, Nafna, E. K., Marathakam, Akash, Uddin, Md. Sahab, Joy, Monu, Carlos Netto-Ferreira, José

“…In the type II diabetes mellitus, Metformin hydrochloride is recommended as a common FAD approved drug. Synthesis of novel metformin series has been widely…”
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Conjugated Dienones from Differently Substituted Cinnamaldehyde as Highly Potent Monoamine Oxidase‑B Inhibitors: Synthesis, Biochemistry, and Computational Chemistry by Mathew, Bijo, Oh, Jong Min, Abdelgawad, Mohamed A, Khames, Ahmed, Ghoneim, Mohammed M, Kumar, Sunil, Nath, Lekshmi R, Sudevan, Sachithra Thazhathuveedu, Parambi, Della Grace Thomas, Agoni, Clement, Soliman, Mahmoud E. S, Kim, Hoon

“…Fifteen multiconjugated dienones (MK1–MK15) were synthesized and evaluated to determine their inhibitory activities against monoamine oxidases (MAOs) A and B…”
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Screening and Molecular Docking of Bioactive Metabolites of the Red Sea Sponge Callyspongia siphonella as Potential Antimicrobial Agents by Musa, Arafa, Abdelgawad, Mohamed A, Shaker, Mohamed E, El-Ghorab, Ahmed H, Parambi, Della Grace Thomas, Hamed, Ahmed A, Sayed, Ahmed M, Hassan, Hossam M, Aboseada, Mahmoud A

“…Marine sponges create a wide range of bioactive secondary metabolites, as documented throughout the year. Several bioactive secondary metabolites were isolated…”
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Nanosecond laser induced breakdown spectroscopy for biofouling analysis and classification of fouling constituents by Thomas, Della, Surendran, S., Vasa, N.J.

“…Marine biofouling refers to the undesirable growth and adhesion of marine organisms such as barnacles, macroalgae and microbial slimes on immersed structures…”
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