Search Results - "Thomas, David W."

An investigation into the robustness of a double-ended wideband impedance-based fault location technique by Jahanger, Hayder K., Thomas, David W. P., Sumner, Mark

“…The double-ended impedance-based fault location technique (DEFLT) uses the wideband frequency content of the transient generated by the fault to determine the…”
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Alginate oligosaccharides inhibit fungal cell growth and potentiate the activity of antifungals against Candida and Aspergillus spp by Tøndervik, Anne, Sletta, Håvard, Klinkenberg, Geir, Emanuel, Charlotte, Powell, Lydia C, Pritchard, Manon F, Khan, Saira, Craine, Kieron M, Onsøyen, Edvar, Rye, Phil D, Wright, Chris, Thomas, David W, Hill, Katja E

“…The oligosaccharide OligoG, an alginate derived from seaweed, has been shown to have anti-bacterial and anti-biofilm properties and potentiates the activity of…”
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Antimicrobial tolerance and the significance of persister cells in recalcitrant chronic wound biofilms by Percival, Steven L., Hill, Katja E., Malic, Sladjana, Thomas, David W., Williams, David W.

“…ABSTRACT The application of antimicrobials in the management of wounds is a complex procedure requiring appropriate clinical decision making, judgment and a…”
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Overcoming Drug Resistance with Alginate Oligosaccharides Able To Potentiate the Action of Selected Antibiotics by KHAN, Saira, TØNDERVIK, Anne, THOMAS, David W, SLETTA, Havard, KLINKENBERG, Geir, EMANUEL, Charlotte, ONSØYEN, Edvar, MYRVOLD, Rolf, HOWE, Robin A, WALSH, Timothy R, HILL, Katja E

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Modeling Electromagnetic Emissions From Printed Circuit Boards in Closed Environments Using Equivalent Dipoles by Xin Tong, Thomas, David W P, Nothofer, Angela, Sewell, Phillip, Christopoulos, Christos

“…In this paper, a method for representing electromagnetic emissions from a printed circuit board (PCB) using an equivalent dipole model deduced from near-field…”
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A physicochemical assessment of the thermal stability of dextrin–colistin conjugates by Chiron, Emilie, Varache, Mathieu, Stokniene, Joana, Thomas, David W., Ferguson, Elaine L.

“…Attachment of polysaccharide carriers is increasingly being used to achieve precision delivery and improved effectiveness of protein and peptide drugs…”
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Alginate oligosaccharides enhance diffusion and activity of colistin in a mucin-rich environment by Stokniene, Joana, Varache, Mathieu, Rye, Philip D., Hill, Katja E., Thomas, David W., Ferguson, Elaine L.

“…In a number of chronic respiratory diseases e.g. cystic fibrosis (CF) and chronic obstructive pulmonary disease (COPD), the production of viscous mucin reduces…”
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Alginate oligosaccharides enhance the antifungal activity of nystatin against candidal biofilms by Powell, Lydia C, Adams, Jennifer Y M, Quoraishi, Sadik, Py, Charlène, Oger, Anaϊs, Gazze, Salvatore A, Francis, Lewis W, von Ruhland, Christopher, Owens, David, Rye, Philip D, Hill, Katja E, Pritchard, Manon F, Thomas, David W

“…The increasing prevalence of invasive fungal infections in immuno-compromised patients is a considerable cause of morbidity and mortality. With the rapid…”
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Hyaluronan Facilitates Transforming Growth Factor-β1-mediated Fibroblast Proliferation by Meran, Soma, Thomas, David W., Stephens, Phillip, Enoch, Stuart, Martin, John, Steadman, Robert, Phillips, Aled O.

“…This study aims to understand the role of the matrix polysaccharide hyaluronan (HA) in influencing fibroblast proliferation and thereby affecting wound healing…”
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Bi-Functional Alginate Oligosaccharide-Polymyxin Conjugates for Improved Treatment of Multidrug-Resistant Gram-Negative Bacterial Infections by Stokniene, Joana, Powell, Lydia C, Aarstad, Olav A, Aachmann, Finn L, Rye, Philip D, Hill, Katja E, Thomas, David W, Ferguson, Elaine L

“…The recent emergence of resistance to colistin, an antibiotic of last resort with dose-limiting toxicity, has highlighted the need for alternative approaches…”
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Anti-pseudomonad Activity of Manuka Honey and Antibiotics in a Specialized ex vivo Model Simulating Cystic Fibrosis Lung Infection by Roberts, Aled E L, Powell, Lydia C, Pritchard, Manon F, Thomas, David W, Jenkins, Rowena E

“…causes problematic chronic lung infections in those suffering from cystic fibrosis. This is due to its antimicrobial resistance mechanisms and its ability to…”
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A phase-space approach for propagating field-field correlation functions by Gradoni, Gabriele, Creagh, Stephen C, Tanner, Gregor, Smartt, Christopher, Thomas, David W P

“…We show that radiation from complex and inherently random but correlated wave sources can be modelled efficiently by using an approach based on the Wigner…”
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Clinical development success rates for investigational drugs by Hay, Michael, Thomas, David W, Craighead, John L, Economides, Celia, Rosenthal, Jesse

“…The most comprehensive survey of clinical success rates across the drug industry to date shows productivity may be even lower than previous estimates…”
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Development and Characterisation of a Human Chronic Skin Wound Cell Line-Towards an Alternative for Animal Experimentation by Caley, Matthew, Wall, Ivan B, Peake, Matthew, Kipling, David, Giles, Peter, Thomas, David W, Stephens, Phil

“…: Chronic skin wounds are a growing financial burden for healthcare providers, causing discomfort/immobility to patients. Whilst animal chronic wound models…”
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Defining in vitro topical antimicrobial and antibiofilm activity of epoxy-tigliane structures against oral pathogens by Xue, Wenya, Pritchard, Manon F, Khan, Saira, Powell, Lydia C, Stokniene, Joana, Wu, Jingxiang, Claydon, Nicholas, Reddell, Paul, Thomas, David W, Hill, Katja E

“…Peri-implantitis has become an inexorable clinical challenge in implantology. Topical immunomodulatory epoxy-tiglianes (EBCs), derived from the Queensland…”
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Quantifying the effects of antibiotic treatment on the extracellular polymer network of antimicrobial resistant and sensitive biofilms using multiple particle tracking by Powell, Lydia C., Abdulkarim, Muthanna, Stokniene, Joana, Yang, Qiu E., Walsh, Timothy R., Hill, Katja E., Gumbleton, Mark, Thomas, David W.

“…Novel therapeutics designed to target the polymeric matrix of biofilms requires innovative techniques to accurately assess their efficacy. Here, multiple…”
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Identification of a transcriptional signature for the wound healing continuum by Peake, Matthew A., Caley, Mathew, Giles, Peter J., Wall, Ivan, Enoch, Stuart, Davies, Lindsay C., Kipling, David, Thomas, David W., Stephens, Phil

“…There is a spectrum/continuum of adult human wound healing outcomes ranging from the enhanced (nearly scarless) healing observed in oral mucosa to scarring…”
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Structure–Activity Relationships of Low Molecular Weight Alginate Oligosaccharide Therapy against Pseudomonas aeruginosa by Pritchard, Manon F., Powell, Lydia C., Adams, Jennifer Y. M., Menzies, Georgina, Khan, Saira, Tøndervik, Anne, Sletta, Håvard, Aarstad, Olav, Skjåk-Bræk, Gudmund, McKenna, Stephen, Buurma, Niklaas J., Farnell, Damian J. J., Rye, Philip D., Hill, Katja E., Thomas, David W.

“…Low molecular weight alginate oligosaccharides have been shown to exhibit anti-microbial activity against a range of multi-drug resistant bacteria, including…”
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Controlled release of dextrin-conjugated growth factors to support growth and differentiation of neural stem cells by Ferguson, Elaine L., Naseer, Sameza, Powell, Lydia C., Hardwicke, Joseph, Young, Fraser I., Zhu, Bangfu, Liu, Qian, Song, Bing, Thomas, David W.

“…An essential aspect of stem cell in vitro culture and in vivo therapy is achieving sustained levels of growth factors to support stem cell survival and…”
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A prospective study of the microbiology of chronic venous leg ulcers to reevaluate the clinical predictive value of tissue biopsies and swabs by Davies, Charlotte E., Hill, Katja E., Newcombe, Robert G., Stephens, Phil, Wilson, Melanie J., Harding, Keith G., Thomas, David W.

“…ABSTRACT This study determined whether comprehensive microbiological analysis offered real predictive value in terms of healing outcome, and assessed the…”
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