Search Results - "Thomas, C. P."

Miltefosine: a review of its pharmacology and therapeutic efficacy in the treatment of leishmaniasis by DORLO, Thomas P. C, BALASEGARAM, Manica, BEIJNEN, Jos H, DE VRIES, Peter J

“…Miltefosine is an alkylphosphocholine drug with demonstrated activity against various parasite species and cancer cells as well as some pathogenic bacteria and…”
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Increasing Failure of Miltefosine in the Treatment of Kala-azar in Nepal and the Potential Role of Parasite Drug Resistance, Reinfection, or Noncompliance by Rijal, Suman, Ostyn, Bart, Uranw, Surendra, Rai, Keshav, Bhattarai, Narayan Raj, Dorlo, Thomas P. C., Beijnen, Jos H., Vanaerschot, Manu, Decuypere, Saskia, Dhakal, Subodh S., Lal Das, Murari, Karki, Prahlad, Singh, Rupa, Boelaert, Marleen, Dujardin, Jean-Claude

“…Background. Miltefosine (MIL), the only oral drug for visceral leishmaniasis (VL), is currently the first-line therapy in the VL elimination program of the…”
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Harnessing Escherichia coli for Bio-Based Production of Formate under Pressurized H2 and CO2 Gases by Roger, Magali, Reed, Thomas C. P, Sargent, Frank

“…Escherichia coli is a Gram-negative bacterium that is a workhorse for biotechnology. The organism naturally performs a mixed-acid fermentation under anaerobic…”
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Systematic Review of Host-Mediated Activity of Miltefosine in Leishmaniasis through Immunomodulation by Palić, Semra, Bhairosing, Patrick, Beijnen, Jos H, Dorlo, Thomas P C

“…Host immune responses are pivotal for the successful treatment of the leishmaniases, a spectrum of infections caused by parasites. Previous studies speculated…”
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Extra-Gastrointestinal Manifestations of Inflammatory Bowel Disease May Be Less Common Than Previously Reported by Card, Timothy R., Langan, Sinéad M., Chu, Thomas P. C.

“…Background and Aims Extra-intestinal manifestations are well recognized in inflammatory bowel disease (IBD). To what extent the commonly recognized…”
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Cassini Observes the Active South Pole of Enceladus by Porco, C. C, Helfenstein, P, Thomas, P. C, Ingersoll, A. P, Wisdom, J, West, R, Neukum, G, Denk, T, Wagner, R, Roatsch, T, Kieffer, S, Turtle, E, McEwen, A, Johnson, T. V, Rathbun, J, Veverka, J, Wilson, D, Perry, J, Spitale, J, Brahic, A, Burns, J. A, DelGenio, A. D, Dones, L, Murray, C. D, Squyres, S

“…Cassini has identified a geologically active province at the south pole of Saturn's moon Enceladus. In images acquired by the Imaging Science Subsystem (ISS),…”
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Efficacy and Safety of AmBisome in Combination with Sodium Stibogluconate or Miltefosine and Miltefosine Monotherapy for African Visceral Leishmaniasis: Phase II Randomized Trial by Wasunna, Monique, Njenga, Simon, Balasegaram, Manica, Alexander, Neal, Omollo, Raymond, Edwards, Tansy, Dorlo, Thomas P C, Musa, Brima, Ali, Mohammed Hassan Sharaf, Elamin, Mohammed Yasein, Kirigi, George, Juma, Rashid, Kip, Anke E, Schoone, Gerard J, Hailu, Asrat, Olobo, Joseph, Ellis, Sally, Kimutai, Robert, Wells, Susan, Khalil, Eltahir Awad Gasim, Strub Wourgaft, Nathalie, Alves, Fabiana, Musa, Ahmed

“…SSG&PM over 17 days is recommended as first line treatment for visceral leishmaniasis in eastern Africa, but is painful and requires hospitalization…”
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Failure of miltefosine treatment for visceral leishmaniasis in children and men in South-East Asia by Ostyn, Bart, Hasker, Epco, Dorlo, Thomas P C, Rijal, Suman, Sundar, Shyam, Dujardin, Jean-Claude, Boelaert, Marleen

“…High frequency of relapse in miltefosine-treated visceral leishmaniasis (VL) patients in India and Nepal followed up for twelve months. To identify…”
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Optimal Dosing of Miltefosine in Children and Adults with Visceral Leishmaniasis by DORLO, Thomas P. C, HUITEMA, Alwin D. R, BEIJNEN, Jos H, DE VRIES, Peter J

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Population Pharmacokinetics of Fludarabine in Children and Adults during Conditioning Prior to Allogeneic Hematopoietic Cell Transplantation by Langenhorst, Jurgen B., Dorlo, Thomas P. C., van Maarseveen, Erik M., Nierkens, Stefan, Kuball, Jürgen, Boelens, Jaap Jan, van Kesteren, Charlotte, Huitema, Alwin D. R.

“…Background Fludarabine is often used as an important drug in reduced toxicity conditioning regimens prior to hematopoietic cell transplantation (HCT). As no…”
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Safety and efficacy of paromomycin/miltefosine/liposomal amphotericin B combinations for the treatment of post-kala-azar dermal leishmaniasis in Sudan: A phase II, open label, randomized, parallel arm study by Younis, Brima Musa, Mudawi Musa, Ahmed, Monnerat, Séverine, Abdelrahim Saeed, Mohammed, Awad Gasim Khalil, Eltahir, Elbashir Ahmed, Anas, Ahmed Ali, Mujahid, Noureldin, Ali, Muthoni Ouattara, Gina, Nyakaya, Godfrey M, Teshome, Samuel, Omollo, Truphosa, Ochieng, Michael, Egondi, Thaddaeus, Mmbone, Mildred, Chu, Wan-Yu, Dorlo, Thomas P C, Zijlstra, Eduard E, Wasunna, Monique, Alvar, Jorge, Alves, Fabiana

“…Treatment for post-kala-azar dermal leishmaniasis (PKDL) in Sudan is currently recommended only for patients with persistent or severe disease, mainly because…”
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Systematic review of biomarkers to monitor therapeutic response in leishmaniasis by Kip, Anke E, Balasegaram, Manica, Beijnen, Jos H, Schellens, Jan H M, de Vries, Peter J, Dorlo, Thomas P C

“…Recently, there has been a renewed interest in the development of new drugs for the treatment of leishmaniasis. This has spurred the need for pharmacodynamic…”
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Failure of Miltefosine in Visceral Leishmaniasis Is Associated With Low Drug Exposure by Dorlo, Thomas P. C., Rijal, Suman, Ostyn, Bart, de Vries, Peter J., Singh, Rupa, Bhattarai, Narayan, Uranw, Surendra, Dujardin, Jean-Claude, Boelaert, Marleen, Beijnen, Jos H., Huitema, Alwin D. R.

“…Background. Recent reports indicated high miltefosine treatment failure rates for visceral leishmaniasis (VL) on the Indian subcontinent. To further explore…”
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Leishmania blood parasite dynamics during and after treatment of visceral leishmaniasis in Eastern Africa: A pharmacokinetic-pharmacodynamic model by Verrest, Luka, Monnerat, Séverine, Musa, Ahmed M, Mbui, Jane, Khalil, Eltahir A G, Olobo, Joseph, Wasunna, Monique, Chu, Wan-Yu, Huitema, Alwin D R, Schallig, Henk D F H, Alves, Fabiana, Dorlo, Thomas P C

“…With the current treatment options for visceral leishmaniasis (VL), recrudescence of the parasite is seen in a proportion of patients. Understanding parasite…”
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Functional differences between neurochemically defined populations of inhibitory interneurons in the rat spinal dorsal horn by Polgár, Erika, Sardella, Thomas C.P., Tiong, Sheena Y.X., Locke, Samantha, Watanabe, Masahiko, Todd, Andrew J.

“…Neurochemically defined populations of inhibitory interneurons in the superficial dorsal horn of the spinal cord differ in their receptor expression pattern…”
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Pharmacokinetics of Miltefosine in Children and Adults with Cutaneous Leishmaniasis by Castro, María Del Mar, Gomez, Maria Adelaida, Kip, Anke E, Cossio, Alexandra, Ortiz, Eduardo, Navas, Adriana, Dorlo, Thomas P C, Saravia, Nancy Gore

“…An open-label pharmacokinetics (PK) clinical trial was conducted to comparatively assess the PK and explore the pharmacodynamics (PD) of miltefosine in…”
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Geophysical implications of the long-wavelength topography of the Saturnian satellites by Nimmo, F., Bills, B. G., Thomas, P. C.

“…We use limb profiles to quantify the long‐wavelength topography of the Saturnian satellites. The degree 2 shapes of Mimas, Enceladus, and Tethys are not…”
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Bioanalytical methods for pharmacokinetic studies of antileishmanial drugs by Roseboom, Ignace C., Rosing, Hilde, Beijnen, Jos H., Dorlo, Thomas P. C.

“…Bioanalytical method development and validation for the quantification of antileishmanial drugs are pivotal to support clinical trials and provide the data…”
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Pharmacokinetic Targets for Therapeutic Drug Monitoring of Small Molecule Kinase Inhibitors in Pediatric Oncology by Janssen, Julie M., Dorlo, Thomas P. C., Steeghs, Neeltje, Beijnen, Jos H., Hanff, Lidwien M., Eijkelenburg, Natasha K. A., Lugt, Jasper, Zwaan, C. Michel, Huitema, Alwin D. R.

“…In recent years new targeted small molecule kinase inhibitors have become available for pediatric patients with cancer. Relationships between drug exposure and…”
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Population Pharmacokinetics of Artemether, Dihydroartemisinin, and Lumefantrine in Rwandese Pregnant Women Treated for Uncomplicated Plasmodium falciparum Malaria by Lohy Das, Jesmin, Rulisa, Stephen, de Vries, Peter J, Mens, Petra F, Kaligirwa, Nadine, Agaba, Steven, Tarning, Joel, Karlsson, Mats O, Dorlo, Thomas P C

“…The artemisinin-based combination therapy artemether-lumefantrine is commonly used in pregnant malaria patients. However, the effect of pregnancy-related…”
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