Search Results - "Thomas, B L"

On the evolution of cellular senescence by Kowald, Axel, Passos, João F., Kirkwood, Thomas B. L.

“…The idea that senescent cells are causally involved in aging has gained strong support from findings that the removal of such cells alleviates many age‐related…”
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Deciphering death: a commentary on Gompertz (1825) ‘On the nature of the function expressive of the law of human mortality, and on a new mode of determining the value of life contingencies’ by Kirkwood, Thomas B. L.

“…In 1825, the actuary Benjamin Gompertz read a paper, ‘On the nature of the function expressive of the law of human mortality, and on a new mode of determining…”
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Age-related frailty and its association with biological markers of ageing by Mitnitski, Arnold, Collerton, Joanna, Martin-Ruiz, Carmen, Jagger, Carol, von Zglinicki, Thomas, Rockwood, Kenneth, Kirkwood, Thomas B L

“…The relationship between age-related frailty and the underlying processes that drive changes in health is currently unclear. Considered individually, most…”
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Mitochondrial dysfunction accounts for the stochastic heterogeneity in telomere-dependent senescence by Passos, João F, Saretzki, Gabriele, Ahmed, Shaheda, Nelson, Glyn, Richter, Torsten, Peters, Heiko, Wappler, Ilka, Birket, Matthew J, Harold, Graham, Schaeuble, Karin, Birch-Machin, Mark A, Kirkwood, Thomas B L, von Zglinicki, Thomas

“…Aging is an inherently stochastic process, and its hallmark is heterogeneity between organisms, cell types, and clonal populations, even in identical…”
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A systematic look at an old problem by Kirkwood, Thomas B. L

“…As life expectancy increases, a systems-biology approach is needed to ensure that we have a healthy old age. Research Horizons A new series begins this week…”
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Grip Strength Decline and Its Determinants in the Very Old: Longitudinal Findings from the Newcastle 85+ Study by Granic, Antoneta, Davies, Karen, Jagger, Carol, Kirkwood, Thomas B L, Syddall, Holly E, Sayer, Avan A

“…Weak grip strength (GS) is a key component of sarcopenia and frailty and a powerful predictor of mortality, morbidity and disability. Despite increasing…”
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Local treatments for metastases of renal cell carcinoma: a systematic review by Dabestani, Saeed, MD, Marconi, Lorenzo, MD, Hofmann, Fabian, MD, Stewart, Fiona, MSc, Lam, Thomas B L, MD, Canfield, Steven E, MD, Staehler, Michael, MD, Powles, Thomas, Prof, Ljungberg, Börje, Prof, Bex, Axel, Dr

“…Summary Local treatment of metastases such as metastasectomy or radiotherapy remains controversial in the treatment of metastatic renal cell carcinoma. To…”
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Systematic Review of Perioperative and Quality-of-life Outcomes Following Surgical Management of Localised Renal Cancer by MacLennan, Steven, Imamura, Mari, Lapitan, Marie C, Omar, Muhammad Imran, Lam, Thomas B.L, Hilvano-Cabungcal, Ana M, Royle, Pam, Stewart, Fiona, MacLennan, Graeme, MacLennan, Sara J, Dahm, Philipp, Canfield, Steven E, McClinton, Sam, Griffiths, T.R. Leyshon, Ljungberg, Börje, N’Dow, James

“…Abstract Context For the treatment of localised renal cell carcinoma (RCC), uncertainties remain over the perioperative and quality-of-life (QoL) outcomes for…”
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Frailty and the role of inflammation, immunosenescence and cellular ageing in the very old: Cross-sectional findings from the Newcastle 85+ Study by Collerton, Joanna, Martin-Ruiz, Carmen, Davies, Karen, Hilkens, Catharien M., Isaacs, John, Kolenda, Claire, Parker, Craig, Dunn, Michael, Catt, Michael, Jagger, Carol, von Zglinicki, Thomas, Kirkwood, Thomas B.L.

“…► We confirm the importance of inflammation in frailty in a very old population. ► Limited evidence was found for role of immunosenescence in frailty in the…”
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A comparison of subjective and objective measures of physical activity from the Newcastle 85+ study by Innerd, Paul, Catt, Michael, Collerton, Joanna, Davies, Karen, Trenell, Michael, Kirkwood, Thomas B L, Jagger, Carol

“…Little is known about physical activity (PA) in the very old, the fastest growing age group in the population. We aimed to examine the convergent validity of…”
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Transcription could be the key to the selection advantage of mitochondrial deletion mutants in aging by Kowald, Axel, Kirkwood, Thomas B.L.

“…The mitochondrial theory of aging is widely popular but confronted by several apparent inconsistencies. On the one hand, mitochondrial energy production is of…”
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Systematic Review of Oncological Outcomes Following Surgical Management of Localised Renal Cancer by MacLennan, Steven, Imamura, Mari, Lapitan, Marie C, Omar, Muhammad Imran, Lam, Thomas B.L, Hilvano-Cabungcal, Ana M, Royle, Pam, Stewart, Fiona, MacLennan, Graeme, MacLennan, Sara J, Canfield, Steven E, McClinton, Sam, Griffiths, T.R. Leyshon, Ljungberg, Börje, N'Dow, James

“…Abstract Context Renal cell carcinoma (RCC) accounts for 2–3% of adult malignancies. There remain uncertainties over the oncological outcomes for the surgical…”
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Systematic Review of Surgical Management of Nonmetastatic Renal Cell Carcinoma with Vena Caval Thrombus by Lardas, Michael, Stewart, Fiona, Scrimgeour, Duncan, Hofmann, Fabian, Marconi, Lorenzo, Dabestani, Saeed, Bex, Axel, Volpe, Alessandro, Canfield, Steven E, Staehler, Michael, Hora, Milan, Powles, Thomas, Merseburger, Axel S, Kuczyk, Markus A, Bensalah, Karim, Mulders, Peter F.A, Ljungberg, Börje, Lam, Thomas B.L

“…Abstract Context Overall, 4–10% of patients with renal cell carcinoma (RCC) present with venous tumour thrombus. It is uncertain which surgical technique is…”
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Systems biology of ageing and longevity by Kirkwood, Thomas B. L.

“…Ageing is intrinsically complex, being driven by multiple causal mechanisms. Each mechanism tends to be partially supported by data indicating that it has a…”
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On the Programmed/Non-Programmed Nature of Ageing within the Life History by Kirkwood, Thomas B.L., Melov, Simon

“…Understanding why and how senescence evolved is of great importance in investigating the multiple, complex mechanisms that influence the course of ageing in…”
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Prevalence and incidence of sarcopenia in the very old: findings from the Newcastle 85+ Study by Dodds, Richard Matthew, Granic, Antoneta, Davies, Karen, Kirkwood, Thomas B. L., Jagger, Carol, Sayer, Avan Aihie

“…Introduction Recognition that an older person has sarcopenia is important because this condition is linked to a range of adverse outcomes. Sarcopenia becomes…”
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Mitochondrial mutations and aging: random drift is insufficient to explain the accumulation of mitochondrial deletion mutants in short‐lived animals by Kowald, Axel, Kirkwood, Thomas B. L.

“…Summary Mitochondrial DNA deletions accumulate over the life course in post‐mitotic cells of many species and may contribute to aging. Often a single mutant…”
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Types of indwelling urethral catheters for short-term catheterisation in hospitalised adults by Lam, Thomas B L, Omar, Muhammad Imran, Fisher, Euan, Gillies, Katie, MacLennan, Sara

“…Urinary tract infection (UTI) is the most common hospital-acquired infection. The major associated cause is indwelling urethral catheters. Several measures…”
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New horizons in the compression of functional decline by Gore, Peter G, Kingston, Andrew, Johnson, Garth R, Kirkwood, Thomas B L, Jagger, Carol

“…Abstract Population ageing, which has come about through the combination of increases in life expectancy, larger post-war cohorts reaching older age and…”
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Dynamic modelling of pathways to cellular senescence reveals strategies for targeted interventions by Dalle Pezze, Piero, Nelson, Glyn, Otten, Elsje G, Korolchuk, Viktor I, Kirkwood, Thomas B L, von Zglinicki, Thomas, Shanley, Daryl P

“…Cellular senescence, a state of irreversible cell cycle arrest, is thought to help protect an organism from cancer, yet also contributes to ageing. The changes…”
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