Reproducibility of differential renal function in four week old piglets
PURPOSE Congenital obstructive renal disease often requires a decision very early in the patients’ life on whether or not surgery is required. Here the renogram provides important information for the correct decision in this process. In our investigations of experimental unilateral ureteropelvic jun...
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| Published in: | Journal of pediatric urology Vol. 3; p. S65 |
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| Main Author: | |
| Format: | Journal Article |
| Language: | English |
| Published: |
Elsevier Ltd
2007
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| Subjects: | |
| Online Access: | Get full text |
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| Summary: | PURPOSE Congenital obstructive renal disease often requires a decision very early in the patients’ life on whether or not surgery is required. Here the renogram provides important information for the correct decision in this process. In our investigations of experimental unilateral ureteropelvic junction obstruction we have used both99m Tc-DTPA and99m Tc-DMSA in young pigs. This study was designed to describe the day to day variations in such investigations. MATERIAL AND METHODS Six normal animals each underwent 3 examinations with99m Tc-DTPA and99m Tc-DMSA, respectively, on alternating consecutive days. From all renograms differential renal function (DRF) was calculated using different types of background subtraction. Further, DRF from the99m Tc-DTPA renograms were calculated using both the area under the curve (AUC) and the Rutland-Patlak equation. The data was analysed to asses the variation and their possible origin from biological day-to-day differences. Day-to-day variations in the results of each type of background subtraction were analysed using the coefficient of variation (CV). RESULTS The results did not indicate that biological difference is a source of variation, The DRF calculated from the99m Tc-DMSA studies showed little variation with a CV of 3.92% in the worst case. The99m Tc-DTPA studies showed large variation. The AUC technique with the best background subtraction showed the narrowest variation with a CV of 14.96%. The Rutland-Patlak technique with its’ best background subtraction showed a slight improvement with a CV of 10.89%. CONCLUSIONS The study demonstrates that DRF calculated from99m Tc-DMSA studies have limited variability and results are highly reproducible. The DRF calculated from99m Tc-DTPA renograms failed to show acceptable reproducibility when analysed using both AUC and the Rutland-Patlak correction. |
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| ISSN: | 1477-5131 1873-4898 |
| DOI: | 10.1016/j.jpurol.2007.01.113 |