Search Results - "Thomas, Andrew W."

Reducing GABAA α5 receptor-mediated inhibition rescues functional and neuromorphological deficits in a mouse model of down syndrome by Martínez-Cué, Carmen, Martínez, Paula, Rueda, Noemí, Vidal, Rebeca, García, Susana, Vidal, Verónica, Corrales, Andrea, Montero, Juan A, Pazos, Ángel, Flórez, Jesús, Gasser, Rodolfo, Thomas, Andrew W, Honer, Michael, Knoflach, Frédéric, Trejo, Jose Luis, Wettstein, Joseph G, Hernández, Maria-Clemencia

“…Down syndrome (DS) is associated with neurological complications, including cognitive deficits that lead to impairment in intellectual functioning. Increased…”
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Basmisanil, a highly selective GABAA-α5 negative allosteric modulator: preclinical pharmacology and demonstration of functional target engagement in man by Hipp, Joerg F., Knoflach, Frederic, Comley, Robert, Ballard, Theresa M., Honer, Michael, Trube, Gerhard, Gasser, Rodolfo, Prinssen, Eric, Wallace, Tanya L., Rothfuss, Andreas, Knust, Henner, Lennon-Chrimes, Sian, Derks, Michael, Bentley, Darren, Squassante, Lisa, Nave, Stephane, Nöldeke, Jana, Wandel, Christoph, Thomas, Andrew W., Hernandez, Maria-Clemencia

“…GABA A -α5 subunit-containing receptors have been shown to play a key modulatory role in cognition and represent a promising drug target for cognitive…”
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The Ability of Exercise-Associated Oxidative Stress to Trigger Redox-Sensitive Signalling Responses by Webb, Richard, Hughes, Michael G, Thomas, Andrew W, Morris, Keith

“…In this review, we discuss exercise as an oxidative stressor, and elucidate the mechanisms and downstream consequences of exercise-induced oxidative stress…”
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Discovery of Small Molecule Therapeutics for Treatment of Chronic HBV Infection by Feng, Song, Gao, Lu, Han, Xingchun, Hu, Taishan, Hu, Yimin, Liu, Haixia, Thomas, Andrew W, Yan, Zhipeng, Yang, Song, Young, John A. T, Yun, Hongying, Zhu, Wei, Shen, Hong C

“…The chronic infection of hepatitis B virus (HBV) inflicts 250 million people worldwide representing a major public health threat. A significant subpopulation…”
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Organic synthesis provides opportunities to transform drug discovery by Blakemore, David C., Castro, Luis, Churcher, Ian, Rees, David C., Thomas, Andrew W., Wilson, David M., Wood, Anthony

“…Despite decades of ground-breaking research in academia, organic synthesis is still a rate-limiting factor in drug-discovery projects. Here we present some…”
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Interleukin-6 and associated cytokine responses to an acute bout of high-intensity interval exercise: the effect of exercise intensity and volume by Cullen, Tom, Thomas, Andrew W, Webb, Richard, Hughes, Michael G

“…Acute increases in interleukin (IL)-6 following prolonged exercise are associated with the induction of a transient anti-inflammatory state (e.g., increases in…”
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M2 macrophages exhibit higher sensitivity to oxLDL-induced lipotoxicity than other monocyte/macrophage subtypes by Isa, Suleiman A, Ruffino, José S, Ahluwalia, Maninder, Thomas, Andrew W, Morris, Keith, Webb, Richard

“…In obesity, phenotypic switches occur in macrophage populations such that the predominantly M2-polarised anti-inflammatory state seen in lean individuals…”
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Modern Synthetic Methods for Copper-Mediated C(aryl)O, C(aryl)N, and C(aryl)S Bond Formation by Ley, Steven V., Thomas, Andrew W.

“…The copper‐mediated C(aryl)N, C(aryl)O, and C(aryl)S bond formation is an important transformation and has been developed to include a wide range of…”
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Discovery of the imidazo[1,5-α][1,2,4].triazolo[1,5-d][1,4]benzodiazepine scaffold as a novel, potent and selective GABAA α5 inverse agonist series by ACHERMANN, Guido, BALLARD, Theresa M, KOBLET, Andreas, KNUST, Henner, KURT, Anke, MARTIN, James R, MASCIADRI, Raffaello, PORTER, Richard H. P, STADLER, Heinz, THOMAS, Andrew W, TRUBE, Gerhard, WICHMANN, Jürgen, BLASCO, Francesca, BROUTIN, Pierre-Emmanuel, BÜTTELMANN, Bernd, FISCHER, Holger, GRAF, Martin, HERNANDEZ, Maria-Clemencia, HILTY, Peter, KNOFLACH, Frédéric

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sIL-6R Is Related to Weekly Training Mileage and Psychological Well-being in Athletes by Cullen, Tom, Thomas, Andrew W, Webb, Richard, Phillips, Thom, Hughes, Michael G

“…Interleukin 6 (IL-6) has been ascribed both positive and negative roles in the context of exercise and training. The dichotomous nature of IL-6 signaling seems…”
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Synthesis, structure and reactivity of some chiral benzylthio alcohols, 1,3-oxathiolanes and their S-oxides by Aitken, R. Alan, Lightfoot, Philip, Thomas, Andrew W.

“…A series of amino acid-derived chiral benzylthio alcohols have been prepared and characterized. A chiral mercapto alcohol derived from S-leucine has been used…”
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Inhibition of alcohol self-administration by positive allosteric modulators of the GABAB receptor in rats: lack of tolerance and potentiation of baclofen by Maccioni, Paola, Vargiolu, Daniela, Thomas, Andrew W., Malherbe, Pari, Mugnaini, Claudia, Corelli, Federico, Leite-Morris, Kimberly A., Gessa, Gian Luigi, Colombo, Giancarlo

“…Rationale Treatment with positive allosteric modulators (PAMs) of the GABA B receptor (GABA B PAMs) inhibits several alcohol-motivated behaviors in rodents,…”
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Transposition of DEH, a Broad-Host-Range Transposon Flanked by ISPpu12, in Pseudomonas putida Is Associated with Genomic Rearrangements and Dehalogenase Gene Silencing by Weightman, Andrew J, Topping, Andrew W, Hill, Katja E, Lee, Li Ling, Sakai, Kenji, Slater, J Howard, Thomas, Andrew W

“…Article Usage Stats Services JB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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The positive allosteric modulator of the GABA(B) receptor, rac-BHFF, suppresses alcohol self-administration by Maccioni, Paola, Thomas, Andrew W, Carai, Mauro A M, Gessa, Gian Luigi, Malherbe, Pari, Colombo, Giancarlo

“…The present study was designed to extend to the newly synthesized rac-BHFF [(R,S)-5,7-di-tert-butyl-3-hydroxy-3-trifluoromethyl-3H-benzofuran-2-one] the…”
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Reduction of alcohol intake by the positive allosteric modulator of the GABA(B) receptor, rac-BHFF, in alcohol-preferring rats by Loi, Barbara, Maccioni, Paola, Lobina, Carla, Carai, Mauro A M, Gessa, Gian Luigi, Thomas, Andrew W, Malherbe, Pari, Colombo, Giancarlo

“…Previous research has demonstrated that treatment with the positive allosteric modulator (PAM) of the GABA(B) receptor (GABA(B) PAM), rac-BHFF, suppressed…”
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Positive Allosteric Modulation of GABAB Receptors Ameliorates Sensorimotor Gating in Rodent Models by Frau, Roberto, Bini, Valentina, Pillolla, Giuliano, Malherbe, Pari, Pardu, Alessandra, Thomas, Andrew W., Devoto, Paola, Bortolato, Marco

“…Summary Background Converging evidence points to the involvement of γ‐amino‐butyric acid B receptors (GABABRs) in the regulation of information processing. We…”
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Reduction of alcohol intake by the positive allosteric modulator of the GABAB receptor, rac -BHFF, in alcohol-preferring rats by Loi, Barbara, Maccioni, Paola, Lobina, Carla, Carai, Mauro A.M, Gessa, Gian Luigi, Thomas, Andrew W, Malherbe, Pari, Colombo, Giancarlo

“…Abstract Previous research has demonstrated that treatment with the positive allosteric modulator (PAM) of the GABAB receptor (GABAB PAM), rac -BHFF,…”
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The discovery and unique pharmacological profile of RO4938581 and RO4882224 as potent and selective GABAA α5 inverse agonists for the treatment of cognitive dysfunction by Knust, Henner, Achermann, Guido, Ballard, Theresa, Buettelmann, Bernd, Gasser, Rodolfo, Fischer, Holger, Hernandez, Maria-Clemencia, Knoflach, Frédéric, Koblet, Andreas, Stadler, Heinz, Thomas, Andrew W., Trube, Gerhard, Waldmeier, Pius

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The positive allosteric modulator of the GABAB receptor, rac -BHFF, suppresses alcohol self-administration by Maccioni, Paola, Thomas, Andrew W, Carai, Mauro A.M, Gessa, Gian Luigi, Malherbe, Pari, Colombo, Giancarlo

“…Abstract The present study was designed to extend to the newly synthesized rac -BHFF [( R , S )-5,7-di- tert -butyl-3-hydroxy-3-trifluoromethyl-3 H…”
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A concise route to triazolobenzodiazepine derivatives via a one-Pot alkyne-Azide cycloaddition reaction by Thomas, Andrew W

“…A new and efficient one-pot synthesis of [1,2,3]triazolo[1,5- a][1,4] benzodiazepin-6(4 H)-ones is described starting from readily available anthranilic acids…”
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