Search Results - "Thomas, Andrew P."

AZD4547: An Orally Bioavailable, Potent, and Selective Inhibitor of the Fibroblast Growth Factor Receptor Tyrosine Kinase Family by GAVINE, Paul R, MOONEY, Lorraine, NIGEL BROOKS, A, KLINOWSKA, Teresa, KILGOUR, Elaine, THOMAS, Andrew P, AL-KADHIMI, Katherine, BECK, Sarah, ROONEY, Claire, COLEMAN, Tanya, BAKER, Dawn, MELLOR, Martine J

“…The fibroblast growth factor (FGF) signaling axis is increasingly implicated in tumorigenesis and chemoresistance. Several small-molecule FGF receptor (FGFR)…”
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The G2019S variant of leucine-rich repeat kinase 2 (LRRK2) alters endolysosomal trafficking by impairing the function of the GTPase RAB8A by Rivero-Ríos, Pilar, Romo-Lozano, María, Madero-Pérez, Jesús, Thomas, Andrew P., Biosa, Alice, Greggio, Elisa, Hilfiker, Sabine

“…Mutations in the gene encoding for leucine-rich repeat kinase 2 (LRRK2) are a common cause of hereditary Parkinson’s disease. LRRK2 regulates various…”
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Selective CRAF Inhibition Elicits Transactivation by Morgan, Charles W, Dale, Ian L, Thomas, Andrew P, Hunt, James, Chin, Jason W

“…Discovering molecules that regulate closely related protein isoforms is challenging, and in many cases the consequences of isoform-specific pharmacological…”
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Acidocalcisomes of Trypanosoma brucei have an inositol 1,4,5-trisphosphate receptor that is required for growth and infectivity by Huang, Guozhong, Bartlett, Paula J., Thomas, Andrew P., Moreno, Silvia N. J., Docampo, Roberto

“…Acidocalcisomes are acidic calcium stores rich in polyphosphate and found in a diverse range of organisms. The mechanism of Ca ²⁺ release from these organelles…”
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Amino acids activate mTOR complex 1 via Ca2+/CaM signaling to hVps34 by Gulati, Pawan, Gaspers, Lawrence D, Dann, Stephen G, Joaquin, Manel, Nobukuni, Takahiro, Natt, Francois, Kozma, Sara C, Thomas, Andrew P, Thomas, George

“…Excess levels of circulating amino acids (AAs) play a causal role in specific human pathologies, including obesity and type 2 diabetes. Moreover, obesity and…”
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Reliable encoding of stimulus intensities within random sequences of intracellular Ca2+ spikes by Thurley, Kevin, Tovey, Stephen C, Moenke, Gregor, Prince, Victoria L, Meena, Abha, Thomas, Andrew P, Skupin, Alexander, Taylor, Colin W, Falcke, Martin

“…Ca(2+) is a ubiquitous intracellular messenger that regulates diverse cellular activities. Extracellular stimuli often evoke sequences of intracellular Ca(2+)…”
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Impact of Matrix Gel Variations on Primary Culture of Microvascular Endothelial Cell Function by Burboa, Pía C., Corrêa‐Velloso, Juliana C., Arriagada, Cecilia, Thomas, Andrew P., Durán, Walter N., Lillo, Mauricio A.

“…Objective The endothelium regulates crucial aspects of vascular function, including hemostasis, vasomotor tone, proliferation, immune cell adhesion, and…”
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Melatonin and IP3-induced Ca2+ Release from Intracellular Stores in the Malaria Parasite Plasmodium falciparum within Infected Red Blood Cells by Alves, Eduardo, Bartlett, Paula J., Garcia, Celia R.S., Thomas, Andrew P.

“…IP3-dependent Ca2+ signaling controls a myriad of cellular processes in higher eukaryotes and similar signaling pathways are evolutionarily conserved in…”
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InsP3 Signaling in Apicomplexan Parasites by Garcia, Celia R S, Alves, Eduardo, Pereira, Pedro H S, Bartlett, Paula J, Thomas, Andrew P, Mikoshiba, Katsuhiko, Plattner, Helmut, Sibley, L David

“…Phosphoinositides (PIs) and their derivatives are essential cellular components that form the building blocks for cell membranes and regulate numerous cell…”
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Differential Regulation of Multiple Steps in Inositol 1,4,5-Trisphosphate Signaling by Protein Kinase C Shapes Hormone-stimulated Ca2+ Oscillations by Bartlett, Paula J., Metzger, Walson, Gaspers, Lawrence D., Thomas, Andrew P.

“…How Ca2+ oscillations are generated and fine-tuned to yield versatile downstream responses remains to be elucidated. In hepatocytes, G protein-coupled…”
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Hormone-Induced Calcium Oscillations Depend on Cross-Coupling with Inositol 1,4,5-Trisphosphate Oscillations by Gaspers, Lawrence D., Bartlett, Paula J., Politi, Antonio, Burnett, Paul, Metzger, Walson, Johnston, Jane, Joseph, Suresh K., Höfer, Thomas, Thomas, Andrew P.

“…Receptor-mediated oscillations in cytosolic Ca2+ concentration ([Ca2+]i) could originate either directly from an autonomous Ca2+ feedback oscillator at the…”
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Ca²⁺ oscillation frequency decoding in cardiac cell hypertrophy: Role of calcineurin/NFAT as Ca²⁺ signal integrators by Colella, Matilde, Grisan, Francesca, Robert, Valerie, Turner, Jay D, Thomas, Andrew P, Pozzan, Tullio

“…The role of Ca²⁺ signaling in triggering hypertrophy was investigated in neonatal rat cardiomyocytes in vitro. We show that an increase in cell size and…”
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Models of IP3 and Ca2+ oscillations: frequency encoding and identification of underlying feedbacks by Politi, Antonio, Gaspers, Lawrence D, Thomas, Andrew P, Höfer, Thomas

“…Hormones that act through the calcium-releasing messenger, inositol 1,4,5-trisphosphate (IP3), cause intracellular calcium oscillations, which have been…”
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IP3-Dependent Ca2+ Oscillations Switch into a Dual Oscillator Mechanism in the Presence of PLC-Linked Hormones by Bartlett, Paula J., Cloete, Ielyaas, Sneyd, James, Thomas, Andrew P.

“…Ca2+ oscillations that depend on inositol-1,4,5-trisphosphate (IP3) have been ascribed to biphasic Ca2+ regulation of the IP3 receptor (IP3R) or feedback…”
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Uncoupling Protein-2 Modulates Myocardial Excitation–Contraction Coupling by Turner, Jay D, Gaspers, Lawrence D, Wang, Guoqiang, Thomas, Andrew P

“…RATIONALE:Uncoupling protein (UCP)2 is a mitochondrial inner membrane protein that is expressed in mammalian myocardium under normal conditions and upregulated…”
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Protein–Ligand Crystal Structures Can Guide the Design of Selective Inhibitors of the FGFR Tyrosine Kinase by Norman, Richard A, Schott, Anne-Kathrin, Andrews, David M, Breed, Jason, Foote, Kevin M, Garner, Andrew P, Ogg, Derek, Orme, Jonathon P, Pink, Jennifer H, Roberts, Karen, Rudge, David A, Thomas, Andrew P, Leach, Andrew G

“…The design of compounds that selectively inhibit a single kinase is a significant challenge, particularly for compounds that bind to the ATP site. We describe…”
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Receptor-specific Ca2+ oscillation patterns mediated by differential regulation of P2Y purinergic receptors in rat hepatocytes by Corrêa-Velloso, Juliana C., Bartlett, Paula J., Brumer, Robert, Gaspers, Lawrence D., Ulrich, Henning, Thomas, Andrew P.

“…Extracellular agonists linked to inositol-1,4,5-trisphosphate (IP3) formation elicit cytosolic Ca2+ oscillations in many cell types, but despite a common…”
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Purinergic signaling in liver disease: calcium signaling and induction of inflammation by Ulrich, Henning, Glaser, Talita, Thomas, Andrew P

“…Purinergic signaling regulates many metabolic functions and is implicated in liver physiology and pathophysiology. Liver functionality is modulated by…”
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Glucagon-like peptide-1 mobilizes intracellular Ca2+ and stimulates mitochondrial ATP synthesis in pancreatic MIN6 beta-cells by Tsuboi, Takashi, da Silva Xavier, Gabriela, Holz, George G, Jouaville, Laurence S, Thomas, Andrew P, Rutter, Guy A

“…Glucagon-like peptide-1 (GLP-1) is a potent regulator of glucose-stimulated insulin secretion whose mechanisms of action are only partly understood. In the…”
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Ca2+Marks: Miniature Calcium Signals in Single Mitochondria Driven by Ryanodine Receptors by Pacher, Pál, Thomas, Andrew P., Hajnóczky, György

“…Propagation of cytosolic [Ca2+] ([Ca2+]c) signals to the mitochondria is believed to be supported by a local communication between Ca2+release channels and…”
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