Search Results - "Thomas, Alan J."

Peripheral inflammation in prodromal Alzheimer’s and Lewy body dementias by King, Eleanor, O’Brien, John Tiernan, Donaghy, Paul, Morris, Christopher, Barnett, Nicola, Olsen, Kirsty, Martin-Ruiz, Carmen, Taylor, John-Paul, Thomas, Alan J

“…ObjectivesThere is growing evidence for the role of systemic inflammation in Alzheimer’s disease (AD) and other neurodegenerative diseases; however the…”
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The Impact of Environment on Gait Assessment: Considerations from Real-World Gait Analysis in Dementia Subtypes by Mc Ardle, Ríona, Del Din, Silvia, Donaghy, Paul, Galna, Brook, Thomas, Alan J, Rochester, Lynn

“…Laboratory-based gait assessments are indicative of clinical outcomes (e.g., disease identification). Real-world gait may be more sensitive to clinical…”
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Neuropathologically mixed Alzheimer’s and Lewy body disease: burden of pathological protein aggregates differs between clinical phenotypes by Walker, Lauren, McAleese, Kirsty E., Thomas, Alan J., Johnson, Mary, Martin-Ruiz, Carmen, Parker, Craig, Colloby, Sean J., Jellinger, Kurt, Attems, Johannes

“…Multiple different pathological protein aggregates are frequently seen in human postmortem brains and hence mixed pathology is common. Mixed dementia on the…”
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Amyloid PET Imaging in Lewy Body Disorders by Donaghy, Paul, M.Res, Thomas, Alan J., Ph.D, O'Brien, John T., D.M

“…Lewy body (LB) disorders, including Parkinson disease (PD), Parkinson disease dementia (PDD), and dementia with Lewy bodies (DLB), are the second most common…”
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Inflammation in dementia with Lewy bodies by Amin, Jay, Erskine, Daniel, Donaghy, Paul C., Surendranathan, Ajenthan, Swann, Peter, Kunicki, Amy P., Boche, Delphine, Holmes, Clive, McKeith, Ian G., O'Brien, John T., Teeling, Jessica L., Thomas, Alan J.

“…Dementia with Lewy bodies (DLB) is the second most common neurodegenerative cause of dementia, behind Alzheimer's disease (AD). The profile of inflammation in…”
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A meta-analysis of epigenome-wide association studies in Alzheimer’s disease highlights novel differentially methylated loci across cortex by Smith, Rebecca G., Pishva, Ehsan, Shireby, Gemma, Smith, Adam R., Roubroeks, Janou A. Y., Hannon, Eilis, Wheildon, Gregory, Mastroeni, Diego, Gasparoni, Gilles, Riemenschneider, Matthias, Giese, Armin, Sharp, Andrew J., Schalkwyk, Leonard, Haroutunian, Vahram, Viechtbauer, Wolfgang, van den Hove, Daniel L. A., Weedon, Michael, Brokaw, Danielle, Francis, Paul T., Thomas, Alan J., Love, Seth, Morgan, Kevin, Walter, Jörn, Coleman, Paul D., Bennett, David A., De Jager, Philip L., Mill, Jonathan, Lunnon, Katie

“…Epigenome-wide association studies of Alzheimer’s disease have highlighted neuropathology-associated DNA methylation differences, although existing studies…”
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Degeneration of dopaminergic circuitry influences depressive symptoms in Lewy body disorders by Patterson, Lina, Rushton, Steven P., Attems, Johannes, Thomas, Alan J., Morris, Christopher M.

“…Aims Depression is commonly observed even in prodromal stages of Lewy body disorders (LBD), and is associated with cognitive impairment and a faster rate of…”
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Neuropathology of depression in Alzheimer's disease: current knowledge and the potential for new treatments by Khundakar, Ahmad A, Thomas, Alan J

“…Depression is among the most common behavioral and psychological symptoms of dementia, and leads to more rapid decline and higher mortality. Treatment for…”
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Dynamic functional connectivity changes in dementia with Lewy bodies and Alzheimer's disease by Schumacher, Julia, Peraza, Luis R, Firbank, Michael, Thomas, Alan J, Kaiser, Marcus, Gallagher, Peter, O'Brien, John T, Blamire, Andrew M, Taylor, John-Paul

“…We studied the dynamic functional connectivity profile of dementia with Lewy bodies (DLB) and Alzheimer's disease (AD) compared to controls, how it differs…”
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Clinical prevalence of Lewy body dementia by Kane, Joseph P M, Surendranathan, Ajenthan, Bentley, Allison, Barker, Sally A H, Taylor, John-Paul, Thomas, Alan J, Allan, Louise M, McNally, Richard J, James, Peter W, McKeith, Ian G, Burn, David J, O'Brien, John T

“…The prevalence of dementia with Lewy bodies (DLB) and dementia in Parkinson's disease (PDD) in routine clinical practice is unclear. Prevalence rates observed…”
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Computational meta-analysis of statistical parametric maps in major depression by Arnone, Danilo, Job, Dominic, Selvaraj, Sudhakar, Abe, Osamu, Amico, Francesco, Cheng, Yuqi, Colloby, Sean J., O'Brien, John T., Frodl, Thomas, Gotlib, Ian H., Ham, Byung-Joo, Kim, M Justin, Koolschijn, P Cédric MP, Périco, Cintia A.-M., Salvadore, Giacomo, Thomas, Alan J., Van Tol, Marie-José, van der Wee, Nic J.A., Veltman, Dick J., Wagner, Gerd, McIntosh, Andrew M.

“…Objective Several neuroimaging meta‐analyses have summarized structural brain changes in major depression using coordinate‐based methods. These methods might…”
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Epigenome-wide association study of human frontal cortex identifies differential methylation in Lewy body pathology by Pihlstrøm, Lasse, Shireby, Gemma, Geut, Hanneke, Henriksen, Sandra Pilar, Rozemuller, Annemieke J. M., Tunold, Jon-Anders, Hannon, Eilis, Francis, Paul, Thomas, Alan J., Love, Seth, Mill, Jonathan, van de Berg, Wilma D. J., Toft, Mathias

“…Parkinson’s disease (PD) and dementia with Lewy bodies (DLB) are closely related progressive disorders with no available disease-modifying therapy,…”
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Using Digital Technology to Quantify Habitual Physical Activity in Community Dwellers With Cognitive Impairment: Systematic Review by Mc Ardle, Ríona, Jabbar, Khalid Abdul, Del Din, Silvia, Thomas, Alan J, Robinson, Louise, Kerse, Ngaire, Rochester, Lynn, Callisaya, Michele

“…Participating in habitual physical activity (HPA) can support people with dementia and mild cognitive impairment (MCI) to maintain functional independence…”
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Prevalence, distribution, and severity of cerebral amyloid angiopathy differ between Lewy body diseases and Alzheimer's disease by Walker, Lauren, Simpson, Harry, Thomas, Alan J, Attems, Johannes

“…Dementia with Lewy bodies (DLB), Parkinson's disease dementia (PDD), and Parkinson's disease (PD) collectively known as Lewy body diseases (LBDs) are…”
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Extravascular fibrinogen in the white matter of Alzheimer’s disease and normal aged brains: implications for fibrinogen as a biomarker for Alzheimer’s disease by McAleese, Kirsty E., Graham, Sophie, Dey, Madhurima, Walker, Lauren, Erskine, Daniel, Johnson, Mary, Johnston, Eleanor, Thomas, Alan J., McKeith, Ian G., DeCarli, Charles, Attems, Johannes

“…The blood–brain barrier (BBB) regulates cerebrovascular permeability and leakage of blood‐derived fibrinogen. Dysfunction of the BBB has been associated with…”
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Free water imaging of the cholinergic system in dementia with Lewy bodies and Alzheimer's disease by Schumacher, Julia, Ray, Nicola J, Hamilton, Calum A, Bergamino, Maurizio, Donaghy, Paul C, Firbank, Michael, Watson, Rosie, Roberts, Gemma, Allan, Louise, Barnett, Nicola, O'Brien, John T, Thomas, Alan J, Taylor, John-Paul

“…Degeneration of cortical cholinergic projections from the nucleus basalis of Meynert (NBM) is characteristic of dementia with Lewy bodies (DLB) and Alzheimer's…”
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EEG alpha reactivity and cholinergic system integrity in Lewy body dementia and Alzheimer's disease by Schumacher, Julia, Thomas, Alan J, Peraza, Luis R, Firbank, Michael, Cromarty, Ruth, Hamilton, Calum A, Donaghy, Paul C, O'Brien, John T, Taylor, John-Paul

“…Lewy body dementia (LBD), which includes dementia with Lewy bodies (DLB) and Parkinson's disease dementia (PDD), is characterised by marked deficits within the…”
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Examining carer stress in dementia: the role of subtype diagnosis and neuropsychiatric symptoms by Lee, David R, McKeith, Ian, Mosimann, Urs, Ghosh-Nodyal, Arunima, Thomas, Alan J

“…Introduction Caring for people with dementia incurs significant stress for carers. Stress has been related to the duration of caring role, the number of weekly…”
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Neural correlates of attention-executive dysfunction in lewy body dementia and Alzheimer's disease by Firbank, Michael, Kobeleva, Xenia, Cherry, George, Killen, Alison, Gallagher, Peter, Burn, David J., Thomas, Alan J., O'Brien, John T., Taylor, John-Paul

“…Attentional and executive dysfunction contribute to cognitive impairment in both Lewy body dementia and Alzheimer's disease. Using functional MRI, we examined…”
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Improving the identification of dementia with Lewy bodies in the context of an Alzheimer's-type dementia by Thomas, Alan J, Mahin-Babaei, Fariba, Saidi, Mohammad, Lett, Debbie, Taylor, John Paul, Walker, Lauren, Attems, Johannes

“…Dementia due to Alzheimer's disease (AD) and dementia with Lewy bodies (DLB) are the two most common neurodegenerative causes of dementia. They commonly occur…”
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