Search Results - "Thomas, Alan"

Depression and dementia: Cause, consequence or coincidence? by Bennett, Sophia, Thomas, Alan J

“…Abstract The relationship between depression and dementia is complex and still not well understood. A number of different views exist regarding how the two…”
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Vascular dementia by O'Brien, John T, Prof, Thomas, Alan, Prof

“…Summary Vascular dementia is one of the most common causes of dementia after Alzheimer's disease, causing around 15% of cases. However, unlike Alzheimer's…”
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TDP‐43 pathology in Alzheimer's disease, dementia with Lewy bodies and ageing by McAleese, Kirsty E., Walker, Lauren, Erskine, Daniel, Thomas, Alan J., McKeith, Ian G., Attems, Johannes

“…Intracellular inclusions consisting of TAR DNA binding protein‐43 (TDP‐43 pathology) are present in up to 57% of Alzheimer's disease (AD) cases and follow a…”
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Peripheral inflammation in prodromal Alzheimer’s and Lewy body dementias by King, Eleanor, O’Brien, John Tiernan, Donaghy, Paul, Morris, Christopher, Barnett, Nicola, Olsen, Kirsty, Martin-Ruiz, Carmen, Taylor, John-Paul, Thomas, Alan J

“…ObjectivesThere is growing evidence for the role of systemic inflammation in Alzheimer’s disease (AD) and other neurodegenerative diseases; however the…”
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New evidence on the management of Lewy body dementia by Taylor, John-Paul, McKeith, Ian G, Burn, David J, Boeve, Brad F, Weintraub, Daniel, Bamford, Claire, Allan, Louise M, Thomas, Alan J, O'Brien, John T

“…Dementia with Lewy bodies and Parkinson's disease dementia, jointly known as Lewy body dementia, are common neurodegenerative conditions. Patients with Lewy…”
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A systematic review comparing clinical features in early age at onset and late age at onset late-life depression by Grayson, Louise, Thomas, Alan

“…Abstract Background Although evidence suggests that there are neurobiological differences between unipolar depression in younger versus older adults,…”
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The RON2-AMA1 interaction is a critical step in moving junction-dependent invasion by apicomplexan parasites by Lamarque, Mauld, Besteiro, Sébastien, Papoin, Julien, Roques, Magali, Vulliez-Le Normand, Brigitte, Morlon-Guyot, Juliette, Dubremetz, Jean-François, Fauquenoy, Sylvain, Tomavo, Stanislas, Faber, Bart W, Kocken, Clemens H, Thomas, Alan W, Boulanger, Martin J, Bentley, Graham A, Lebrun, Maryse

“…Obligate intracellular Apicomplexa parasites share a unique invasion mechanism involving a tight interaction between the host cell and the parasite surfaces…”
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Dysfunctional brain dynamics and their origin in Lewy body dementia by Schumacher, Julia, Peraza, Luis R, Firbank, Michael, Thomas, Alan J, Kaiser, Marcus, Gallagher, Peter, O'Brien, John T, Blamire, Andrew M, Taylor, John-Paul

“…Lewy body dementia includes dementia with Lewy bodies and Parkinson's disease dementia and is characterized by transient clinical symptoms such as fluctuating…”
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The Impact of Environment on Gait Assessment: Considerations from Real-World Gait Analysis in Dementia Subtypes by Mc Ardle, Ríona, Del Din, Silvia, Donaghy, Paul, Galna, Brook, Thomas, Alan J, Rochester, Lynn

“…Laboratory-based gait assessments are indicative of clinical outcomes (e.g., disease identification). Real-world gait may be more sensitive to clinical…”
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Amyloid PET Imaging in Lewy Body Disorders by Donaghy, Paul, M.Res, Thomas, Alan J., Ph.D, O'Brien, John T., D.M

“…Lewy body (LB) disorders, including Parkinson disease (PD), Parkinson disease dementia (PDD), and dementia with Lewy bodies (DLB), are the second most common…”
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Neuropathologically mixed Alzheimer’s and Lewy body disease: burden of pathological protein aggregates differs between clinical phenotypes by Walker, Lauren, McAleese, Kirsty E., Thomas, Alan J., Johnson, Mary, Martin-Ruiz, Carmen, Parker, Craig, Colloby, Sean J., Jellinger, Kurt, Attems, Johannes

“…Multiple different pathological protein aggregates are frequently seen in human postmortem brains and hence mixed pathology is common. Mixed dementia on the…”
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Dementia with Lewy bodies: an update and outlook by Outeiro, Tiago Fleming, Koss, David J, Erskine, Daniel, Walker, Lauren, Kurzawa-Akanbi, Marzena, Burn, David, Donaghy, Paul, Morris, Christopher, Taylor, John-Paul, Thomas, Alan, Attems, Johannes, McKeith, Ian

“…Dementia with Lewy bodies (DLB) is an age-associated neurodegenerative disorder producing progressive cognitive decline that interferes with normal life and…”
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Parietal white matter lesions in Alzheimer’s disease are associated with cortical neurodegenerative pathology, but not with small vessel disease by McAleese, Kirsty E., Walker, Lauren, Graham, Sophie, Moya, Elisa L. J., Johnson, Mary, Erskine, Daniel, Colloby, Sean J., Dey, Madhurima, Martin-Ruiz, Carmen, Taylor, John-Paul, Thomas, Alan J., McKeith, Ian G., De Carli, Charles, Attems, Johannes

“…Cerebral white matter lesions (WML) encompass axonal loss and demyelination, and the pathogenesis is assumed to be small vessel disease (SVD)-related ischemia…”
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Selectively biorefining astaxanthin and triacylglycerol co-products from microalgae with supercritical carbon dioxide extraction by Kwan, Thomas Alan, Kwan, Sarah Elizabeth, Peccia, Jordan, Zimmerman, Julie Beth

“…[Display omitted] •Solvatochromic measurements show tunable scCO2 clustering of solutes.•Pressure changes and solute matrix can enhance/diminish solubility in…”
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Research criteria for the diagnosis of prodromal dementia with Lewy bodies by McKeith, Ian G., Ferman, Tanis J., Thomas, Alan J., Blanc, Frédéric, Boeve, Bradley F., Fujishiro, Hiroshige, Kantarci, Kejal, Muscio, Cristina, O'Brien, John T., Postuma, Ronald B., Aarsland, Dag, Ballard, Clive, Bonanni, Laura, Donaghy, Paul, Emre, Murat, Galvin, James E., Galasko, Douglas, Goldman, Jennifer G., Gomperts, Stephen N., Honig, Lawrence S., Ikeda, Manabu, Leverenz, James B., Lewis, Simon J.G., Marder, Karen S., Masellis, Mario, Salmon, David P., Taylor, John Paul, Tsuang, Debby W., Walker, Zuzana, Tiraboschi, Pietro

“…The prodromal phase of dementia with Lewy bodies (DLB) includes (1) mild cognitive impairment (MCI), (2) delirium-onset, and (3) psychiatric-onset…”
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Recalibrating the epigenetic clock: implications for assessing biological age in the human cortex by Shireby, Gemma L, Davies, Jonathan P, Francis, Paul T, Burrage, Joe, Walker, Emma M, Neilson, Grant W A, Dahir, Aisha, Thomas, Alan J, Love, Seth, Smith, Rebecca G, Lunnon, Katie, Kumari, Meena, Schalkwyk, Leonard C, Morgan, Kevin, Brookes, Keeley, Hannon, Eilis, Mill, Jonathan

“…Human DNA methylation data have been used to develop biomarkers of ageing, referred to as 'epigenetic clocks', which have been widely used to identify…”
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Inflammation in dementia with Lewy bodies by Amin, Jay, Erskine, Daniel, Donaghy, Paul C., Surendranathan, Ajenthan, Swann, Peter, Kunicki, Amy P., Boche, Delphine, Holmes, Clive, McKeith, Ian G., O'Brien, John T., Teeling, Jessica L., Thomas, Alan J.

“…Dementia with Lewy bodies (DLB) is the second most common neurodegenerative cause of dementia, behind Alzheimer's disease (AD). The profile of inflammation in…”
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Recent progress in battery electric vehicle noise, vibration, and harshness by Hua, Xia, Thomas, Alan, Shultis, Kurt

“…As battery electric vehicle (BEV) market share grows so must our understanding of the noise, vibration, and harshness (NVH) phenomenon found inside the BEVs…”
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Pharmacological Management of Lewy Body Dementia: A Systematic Review and Meta-Analysis by Stinton, Chris, McKeith, Ian, Taylor, John-Paul, Lafortune, Louise, Mioshi, Eneida, Mak, Elijah, Cambridge, Victoria, Mason, James, Thomas, Alan, O’Brien, John T.

“…Objective:The authors examined research on effects, costs, and patient and caregiver views of pharmacological management strategies for Lewy body…”
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Concomitant neurodegenerative pathologies contribute to the transition from mild cognitive impairment to dementia by McAleese, Kirsty E., Colloby, Sean J., Thomas, Alan J., Al‐Sarraj, Safa, Ansorge, Olaf, Neal, James, Roncaroli, Federico, Love, Seth, Francis, Paul T., Attems, Johannes

“…Introduction The aged brain frequently exhibits multiple pathologies, rather than a single hallmark pathology (pure pathology [PurP]), ranging from…”
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