Search Results - "Thomae, Tami L"
-
1
Resistance to 2,3,7,8-Tetrachlorodibenzo-p-dioxin Toxicity and Abnormal Liver Development in Mice Carrying a Mutation in the Nuclear Localization Sequence of the Aryl Hydrocarbon Receptor
Published in The Journal of biological chemistry (16-05-2003)“…The Ah receptor (AHR) mediates the metabolic adaptation to a number of planar aromatic chemicals. Essential steps in this adaptive mechanism include AHR…”
Get full text
Journal Article -
2
Liver deformation in Ahr-null mice: evidence for aberrant hepatic perfusion in early development
Published in Molecular pharmacology (01-05-2006)“…Mice harboring mutations in the Ahr locus display a patent ductus venosus and smaller livers throughout life. We tested the hypothesis that these hepatic…”
Get more information
Journal Article -
3
A Maternal Ahr Null Genotype Sensitizes Embryos to Chemical Teratogenesis
Published in The Journal of biological chemistry (16-07-2004)“…The aryl hydrocarbon receptor (encoded by the Ahr locus) is a ligand-activated transcription factor that mediates the toxicology and teratology of…”
Get full text
Journal Article -
4
The teratogenic sensitivity to 2,3,7,8-tetrachlorodibenzo-p-dioxin is modified by a locus on mouse chromosome 3
Published in Molecular pharmacology (01-03-2006)“…In an effort to understand how genetics can influence individual sensitivity to environmentally induced disease, we performed a linkage analysis to identify…”
Get more information
Journal Article -
5
Transforming Growth Factor-β3 Restores Fusion in Palatal Shelves Exposed to 2,3,7,8-Tetrachlorodibenzo-p-dioxin
Published in The Journal of biological chemistry (01-04-2005)“…The pollutant, 2,3,7,8-tetrachlorodibenzo-p-dioxin (“dioxin”), has been implicated in the etiology of a wide variety of human birth defects. In an effort to…”
Get full text
Journal Article -
6
DW-MRI as a Predictive Biomarker of Radiosensitization of GBM through Targeted Inhibition of Checkpoint Kinases
Published in Translational oncology (01-04-2013)“…Abstract PURPOSE: The inherent treatment resistance of glioblastoma (GBM) can involve multiple mechanisms including checkpoint kinase (Chk1/2)-mediated…”
Get full text
Journal Article -
7
Transforming Growth Factor- beta 3 Restores Fusion in Palatal Shelves Exposed to 2,3,7,8-Tetrachlorodibenzo-p-dioxin
Published in The Journal of biological chemistry (01-04-2005)“…The pollutant, 2,3,7,8-tetrachlorodibenzo-p-dioxin ("dioxin"), has been implicated in the etiology of a wide variety of human birth defects. In an effort to…”
Get full text
Journal Article -
8
Transforming growth factor-beta3 restores fusion in palatal shelves exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin
Published in The Journal of biological chemistry (01-04-2005)“…The pollutant, 2,3,7,8-tetrachlorodibenzo-p-dioxin ("dioxin"), has been implicated in the etiology of a wide variety of human birth defects. In an effort to…”
Get full text
Journal Article -
9
Transforming Growth Factor-β3 Restores Fusion in Palatal Shelves Exposed to 2,3,7,8-Tetrachlorodibenzo-p-dioxin
Published in The Journal of biological chemistry (01-04-2005)“…The pollutant, 2,3,7,8-tetrachlorodibenzo- p -dioxin (âdioxinâ), has been implicated in the etiology of a wide variety of human birth defects. In an effort…”
Get full text
Journal Article -
10
DW-MRI as a Predictive Biomarker of Radiosensitization of GBM through Targeted Inhibition of Checkpoint Kinases1
Published in Translational oncology (01-04-2013)“…PURPOSE: The inherent treatment resistance of glioblastoma (GBM) can involve multiple mechanisms including checkpoint kinase (Chk1/2)-mediated increased DNA…”
Get full text
Journal Article -
11
Biochemical, physiological and genetic modifiers of dioxin induced teratogenesis
Get full text
Dissertation -
12
Biochemical, physiological and genetic modifiers of dioxin induced teratogenesis
Published 01-01-2004“…The toxic effects of environmental pollutants such as 2,3,7,8-tetrachlorodibenzo- p-dioxin (dioxin or TCDD) are believed to be mediated largely through the…”
Get full text
Dissertation