Search Results - "Thomae, David"

The phosphodiesterase 10 positron emission tomography tracer, [18F]MNI-659, as a novel biomarker for early Huntington disease by Russell, David S, Barret, Olivier, Jennings, Danna L, Friedman, Joseph H, Tamagnan, Gilles D, Thomae, David, Alagille, David, Morley, Thomas J, Papin, Caroline, Papapetropoulos, Spyridon, Waterhouse, Rikki N, Seibyl, John P, Marek, Kenneth L

“…In Huntington disease (HD) striatal neuron loss precedes and predicts motor signs or symptoms. Current imaging biomarkers lack adequate sensitivity for…”
Get more information

MR-based spatial normalization improves [18F]MNI-659 PET regional quantification and detectability of disease effect in the Q175 mouse model of Huntington's disease by Bertoglio, Daniele, Verhaeghe, Jeroen, Kosten, Lauren, Thomae, David, Van der Linden, Annemie, Stroobants, Sigrid, Wityak, John, Dominguez, Celia, Mrzljak, Ladislav, Staelens, Steven

“…The positron emission tomography (PET) tracer [18F]MNI-659, selective for phosphodiesterase 10A (PDE10A), is a promising tool to assess an early biomarker for…”
Get full text

Noninvasive Relative Quantification of [ 11 C]ABP688 PET Imaging in Mice Versus an Input Function Measured Over an Arteriovenous Shunt by Verhaeghe, Jeroen, Bertoglio, Daniele, Kosten, Lauren, Thomae, David, Verhoye, Marleen, Van Der Linden, Annemie, Wyffels, Leonie, Stroobants, Sigrid, Wityak, John, Dominguez, Celia, Mrzljak, Ladislav, Staelens, Steven

“…Impairment of the metabotropic glutamate receptor 5 (mGluR5) has been implicated with various neurologic disorders. Although mGluR5 density can be quantified…”
Get full text

Synthesis of substituted [1,3]thiazolo[4,5- b]pyridines and [1,3]thiazolo[4,5- d][1,2,3]triazines by Thomae, David, Perspicace, Enrico, Hesse, Stéphanie, Kirsch, Gilbert, Seck, Pierre

“…In this work, we described an easy preparation of substituted 4-amino-5-cyano-1,3-thiazoles. These compounds have been used as starting materials to obtain two…”
Get full text

Extending the Scope of the Aza-Fischer Synthesis of 4- and 6-Azaindoles by Thomae, David, Jeanty, Matthieu, Coste, Jérome, Guillaumet, Gérald, Suzenet, Franck

“…Fischer indole cyclization has recently been described as an efficient approach to the synthesis of azaindoles bearing electron‐donating groups. We now show…”
Get full text

One-pot synthesis of new 2,4,5-trisubstituted 1,3-thiazoles and 1,3-selenazoles by Thomae, David, Perspicace, Enrico, Xu, Zhanjie, Henryon, Dorothée, Schneider, Serge, Hesse, Stéphanie, Kirsch, Gilbert, Seck, Pierre

“…In this work, we describe the synthesis of new 2,4,5-trisubstituted-1,3-thiazoles and 1,3-selenazole achieved by an easy one-pot four-step procedure. Expected…”
Get full text

Evaluation of [18F]Fluorothymidine as a Biomarker for Early Therapy Response in a Mouse Model of Colorectal Cancer by Rapic, Sara, Vangestel, Christel, Verhaeghe, Jeroen, Thomae, David, Pauwels, Patrick, Van den Wyngaert, Tim, Staelens, Steven, Stroobants, Sigrid

“…Purpose In oncology, positron emission tomography imaging using dedicated tracers as biomarkers may assist in early evaluation of therapy efficacy. Using…”
Get full text

Synthesis of new selenophene and thiazole analogues of the Tacrine series by Seck, Pierre, Thomae, David, Perspicace, Enrico, Hesse, Stéphanie, Kirsch, Gilbert

Get full text

Longitudinal Characterization of mGluR5 Using ^sup 11^C-ABP688 PET Imaging in the Q175 Mouse Model of Huntington Disease by Bertoglio, Daniele, Kosten, Lauren, Verhaeghe, Jeroen, Thomae, David, Wyffels, Leonie, Stroobants, Sigrid, Wityak, John, Dominguez, Celia, Mrzljak, Ladislav, Staelens, Steven

“…Metabotropic glutamate receptor 5 (mGluR5) represents a potential therapeutic target for Huntington disease. Using 11C-ABP688…”
Get full text

Longitudinal Characterization of mGluR5 Using 11 C-ABP688 PET Imaging in the Q175 Mouse Model of Huntington Disease by Bertoglio, Daniele, Kosten, Lauren, Verhaeghe, Jeroen, Thomae, David, Wyffels, Leonie, Stroobants, Sigrid, Wityak, John, Dominguez, Celia, Mrzljak, Ladislav, Staelens, Steven

Get full text

Keeping the peace of the realm by David Thomae

“…Review(s) of: Keeping the peace of the realm, by Samuel White, Lexisnexis, 2021,XXIV + 138 PP ISBN 9780409354379 (HARDCOVER), ISBN 9780409354386 (EPUB)…”
Get full text

Decreased levels of active uPA and KLK 8 assessed by [ 111 In] MICA ‐401 binding correlate with the seizure burden in an animal model of temporal lobe epilepsy by Missault, Stephan, Peeters, Lore, Amhaoul, Halima, Thomae, David, Van Eetveldt, Annemie, Favier, Barbara, Thakur, Anagha, Van Soom, Jeroen, Pitkänen, Asla, Augustyns, Koen, Joossens, Jurgen, Staelens, Steven, Dedeurwaerdere, Stefanie

Get full text

Decreased levels of active uPA and KLK8 assessed by [111In]MICA‐401 binding correlate with the seizure burden in an animal model of temporal lobe epilepsy by Missault, Stephan, Peeters, Lore, Amhaoul, Halima, Thomae, David, Van Eetveldt, Annemie, Favier, Barbara, Thakur, Anagha, Van Soom, Jeroen, Pitkänen, Asla, Augustyns, Koen, Joossens, Jurgen, Staelens, Steven, Dedeurwaerdere, Stefanie

“…Summary Objective Urokinase‐type plasminogen activator (uPA) and kallikrein‐related peptidase 8 (KLK8) are serine proteases that contribute to extracellular…”
Get full text

In vivo evaluation of (18)F-labeled TCO for pre-targeted PET imaging in the brain by Wyffels, Leonie, Thomae, David, Waldron, Ann-Marie, Fissers, Jens, Dedeurwaerdere, Stefanie, Van der Veken, Pieter, Joossens, Jurgen, Stroobants, Sigrid, Augustyns, Koen, Staelens, Steven

“…The tetrazine-trans-cylooctene cycloaddition using radiolabeled tetrazine or radiolabeled trans-cyclooctene (TCO) has been reported to be a very fast,…”
Get full text

Multiprobe molecular imaging of an NMDA receptor hypofunction rat model for glutamatergic dysfunction by Kosten, Lauren, Verhaeghe, Jeroen, Verkerk, Robert, Thomae, David, De Picker, Livia, wyffels, Leonie, Van Eetveldt, Annemie, Dedeurwaerdere, Stefanie, Stroobants, Sigrid, Staelens, Steven

“…Abstract There are many indications of a connection between abnormal glutamate transmission through N-methyl- d -aspartate (NMDA) receptor hypofunction and the…”
Get full text

One-pot synthesis of new tetrasubstituted thiophenes and selenophenes by Thomae, David, Perspicace, Enrico, Henryon, Dorothée, Xu, Zhanjie, Schneider, Serge, Hesse, Stéphanie, Kirsch, Gilbert, Seck, Pierre

“…In this work, we described the synthesis of new tetrasubstituted thiophenes and selenophenes achieved by an easy one-pot four-step procedure. Expected…”
Get full text

Preclinical evaluation of [ 111 In]MICA-401, an activity-based probe for SPECT imaging of in vivo uPA activity by Vangestel, Christel, Thomae, David, Van Soom, Jeroen, Ides, Johan, Wyffels, Leonie, Pauwels, Patrick, Stroobants, Sigrid, Van der Veken, Pieter, Magdolen, Viktor, Joossens, Jurgen, Augustyns, Koen, Staelens, Steven

“…Urokinase-type plasminogen activator (uPA) and its inhibitor PAI-1 are key players in cancer invasion and metastasis. Both uPA and PAI-1 have been described as…”
Get more information

Evaluation of [18F]BR420 and [18F]BR351 as radiotracers for MMP‐9 imaging in colorectal cancer by Vazquez, Naiara, Missault, Stephan, Vangestel, Christel, Deleye, Steven, Thomae, David, Van der Veken, Pieter, Augustyns, Koen, Staelens, Steven, Dedeurwaerdere, Stefanie, wyffels, Leonie

“…MMP‐9 is a zinc‐dependent endopeptidase that is involved in the proteolytic degradation of the extracellular matrix and plays an important role in cancer…”
Get full text

In Vivo Assessment and Dosimetry of 2 Novel PDE10A PET Radiotracers in Humans: ^sup 18^F-MNI-659 and ^sup 18^F-MNI-654 by Barret, Olivier, Thomae, David, Tavares, Adriana, Alagille, David, Papin, Caroline, Waterhouse, Rikki, McCarthy, Timothy, Jennings, Danna, Marek, Ken, Russell, David, Seibyl, John, Tamagnan, Gilles

“…Phosphodiesterase (PDE) 10A is an enzyme involved in the regulation of cyclic adenosine monophosphate and cyclic guanosine monophosphate and is highly…”
Get full text

In Vivo Assessment and Dosimetry of 2 Novel PDE10A PET Radiotracers in Humans: sigma up 18 Theta -MNI-659 and sigma up 18 Theta -MNI-654 by Barret, Olivier, Thomae, David, Tavares, Adriana, Alagille, David, Papin, Caroline, Waterhouse, Rikki, McCarthy, Timothy, Jennings, Danna, Marek, Ken, Russell, David, Seibyl, John, Tamagnan, Gilles

“…Phosphodiesterase (PDE) 10A is an enzyme involved in the regulation of cyclic adenosine monophosphate and cyclic guanosine monophosphate and is highly…”
Get full text