Search Results - "Thomae, B A"

Human catechol O-methyltransferase genetic variation: gene resequencing and functional characterization of variant allozymes by SHIELD, A. J, THOMAE, B. A, ECKLOFF, B. W, WIEBEN, E. D, WEINSHILBOUM, R. M

“…Catechol O-methyltransferase (COMT) plays an important role in the metabolism of catecholamines, catecholestrogens and catechol drugs. A common COMT G472A…”
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Genetic diversity and function in the human cytosolic sulfotransferases by Hildebrandt, M A T, Carrington, D P, Thomae, B A, Eckloff, B W, Schaid, D J, Yee, V C, Weinshilboum, R M, Wieben, E D

“…Amino-acid substitutions, which result from common nonsynonymous (NS) polymorphisms, may dramatically alter the function of the encoded protein. Gaining…”
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Human sulfotransferase SULT2A1 pharmacogenetics: genotype-to-phenotype studies by THOMAE, B. A, ECKLOFF, B. W, FREIMUTH, R. R, WIEBEN, E. D, WEINSHILBOUM, R. M

“…SULT2A1 catalyzes the sulfate conjugation of dehydroepiandrosterone (DHEA) as well as other steroids. As a step toward pharmacogenetic studies, we have…”
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The Risk of Pretransplant Blood Transfusion for Primary Graft Dysfunction After Lung Transplant by Kaihou, Taisuke, Toyoda, Takahide, Cerier, Emily, Yagi, Yuriko, Manerikar, Adwaiy, Thomae, Benjamin Louis, Kandula, Viswajit, Bharat, Ankit, Kurihara, Chitaru

“…Primary graft dysfunction (PGD) is the leading cause of short- and long-term mortality associated with lung transplantation. The impact of pretransplantation…”
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Human Arsenic Methyltransferase (AS3MT) Pharmacogenetics: GENE RESEQUENCING AND FUNCTIONAL GENOMICS STUDIES by Wood, Thomas C, Salavagionne, Oreste E, Mukherjee, Baidehi, Wang, Liewei, Klumpp, Annette F, Thomae, Bianca A, Eckloff, Bruce W, Schaid, Daniel J, Wieben, Eric D, Weinshilboum, Richard M

“…Arsenic contaminates ground water worldwide. Methylation is an important reaction in the biotransformation of arsenic. We set out to study the pharmacogenetics…”
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Human phenylethanolamine N-methyltransferase (PNMT) pharmacogenetics: gene resequencing and functional genomic studies by Ji, Y., Salavaggione, O. E., Adjei, A. A., Thomae, B. A., Eckloff, B., Wieben, E. D., Weinshilboum, R. M.

“…PNMT (EC 2.1.1.28) catalyzes the N‐methylation of norepinephrine to form epinephrine. We set out to resequence the human PNMT gene, including all exons and…”
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Human estrogen sulfotransferase (SULT1E1) pharmacogenomics: gene resequencing and functional genomics by Adjei, Araba A, Thomae, Bianca A, Prondzinski, Janel L, Eckloff, Bruce W, Wieben, Eric D, Weinshilboum, Richard M

“…Estrogens are used as drugs and estrogen exposure is a risk factor for hormone‐dependent diseases such as breast cancer. Sulfate conjugation is an important…”
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Human catecholamine sulfotransferase (SULT1A3) pharmacogenetics: functional genetic polymorphism by Thomae, Bianca A., Rifki, Oktay F., Theobald, Michelle A., Eckloff, Bruce W., Wieben, Eric D., Weinshilboum, Richard M.

“…Sulfotransferase (SULT) 1A3 catalyzes the sulfate conjugation of catecholamines and structurally related drugs. As a step toward studies of the possible…”
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Cat red blood cell thiopurine S-methyltransferase: companion animal pharmacogenetics by Salavaggione, Oreste E, Yang, Chen, Kidd, Linda B, Thomae, Bianca A, Pankratz, V Shane, Trepanier, Lauren A, Weinshilboum, Richard M

“…A common genetic polymorphism for thiopurine S-methyltransferase (TPMT) is a major factor responsible for individual variation in the toxicity and therapeutic…”
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Pharmacogenetics of human 3′-phosphoadenosine 5′-phosphosulfate synthetase 1 (PAPSS1): gene resequencing, sequence variation, and functional genomics by Xu, Zhen-Hua, Thomae, Bianca A., Eckloff, Bruce W., Wieben, Eric D., Weinshilboum, Richard M.

“…3′-Phosphoadenosine 5′-phosphosulfate (PAPS) is the high-energy “sulfate donor” for reactions catalyzed by sulfotransferase (SULT) enzymes. The strict…”
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