Search Results - "Thole, Hubert"

Lysine 268 adjacent to transmembrane helix 5 of hamster P‐glycoprotein is the major photobinding site of iodomycin in CHO B30 cells by Demmer, Annette, Thole, Hubert, Raida, Manfred, Tümmler, Burkhard, Sonnino, Sandro

“…P‐glycoprotein (Pgp) detoxifies cells by exporting hundreds of chemically dissimilar hydrophobic and amphipathic compounds and is implicated in multidrug…”
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Human Hydroxysteroid (17-β) Dehydrogenase 1 Expression Enhances Estrogen Sensitivity of MCF-7 Breast Cancer Cell Xenografts by Husen, Bettina, Huhtinen, Kaisa, Saloniemi, Taija, Messinger, Josef, Thole, Hubert H, Poutanen, Matti

“…Hydroxysteroid (17-β) dehydrogenase 1 (HSD17B1) catalyzes the conversion between estrone (E1) and estradiol (E2). The reaction is reversible in vitro, but the…”
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Expression analysis of the genes involved in estradiol and progesterone action in human ovarian endometriosis by Šmuc, Tina, Pucelj, Martina Ribi, Šinkovec, Jasna, Husen, Bettina, Thole, Hubert, Ri ner, Tea Lanišnik

“…Endometriosis is defined as the presence of endometrial glands and stroma within extrauterine sites, and it is well known that endometriosis is an…”
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Species used for drug testing reveal different inhibition susceptibility for 17beta-hydroxysteroid dehydrogenase type 1 by Möller, Gabriele, Husen, Bettina, Kowalik, Dorota, Hirvelä, Leena, Plewczynski, Dariusz, Rychlewski, Leszek, Messinger, Josef, Thole, Hubert, Adamski, Jerzy

“…Steroid-related cancers can be treated by inhibitors of steroid metabolism. In searching for new inhibitors of human 17beta-hydroxysteroid dehydrogenase type 1…”
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Expression and regulation of estrogen-converting enzymes in ectopic human endometrial tissue by Fechner, Sabine, Ph.D, Husen, Bettina, Ph.D, Thole, Hubert, M.D, Schmidt, Markus, M.D, Gashaw, Isabella, Ph.D, Kimmig, Rainer, M.D, Winterhager, Elke, Ph.D, Grümmer, Ruth, Ph.D

“…Objective To investigate the regulation of estrogen-converting enzymes in human ectopic endometrial tissue. Design Animal study. Setting Academic medical…”
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Purification and characterisation of a jacalin-related, coleoptile specific lectin from Hordeum vulgare by Grunwald, Ingo, Heinig, Ines, Thole, Hubert H, Neumann, Dieter, Kahmann, Uwe, Kloppstech, Klaus, Gau, Achim E

“…A plant lectin was isolated from barley (Hordeum vulgare) coleoptiles using acidic extraction and different chromatographic methods. Sequencing of more than…”
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Caspase-Dependent Regulation and Subcellular Redistribution of the Transcriptional Modulator YY1 during Apoptosis by Krippner-Heidenreich, Anja, Walsemann, Gesa, Beyrouthy, Maroun J., Speckgens, Stefanie, Kraft, Regine, Thole, Hubert, Talanian, Robert V., Hurt, Myra M., Lüscher, Bernhard

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Dydrogesterone (Duphaston®) and its 20-dihydro-derivative as selective estrogen enzyme modulators in human breast cancer cell lines. Effect on sulfatase and on 17β-hydroxysteroid dehydrogenase (17β-HSD) activity by CHETRITE, Gérard Samuel, THOLE, Hubert H, PHILIPPE, Jean-Claude, PASQUALINI, Jorge Raul

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Phosphatidylcholine metabolism of rat trachea in relation to lung parenchyma and surfactant by Rau, Gunnar A, Dombrowsky, Heike, Gebert, Andreas, Thole, Hubert H, von der Hardt, Horst, Freihorst, Joachim, Bernhard, Wolfgang

“…Departments of 1 Pediatric Pulmonology and Neonatology and 3 Applied and Functional Anatomy, Hannover Medical School, 30625 Hannover; 4 Solvay Pharmaceuticals…”
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Photocross-linking of the Homing Endonuclease PI-SceI to Its Recognition Sequence by Pingoud, V, Thole, H, Christ, F, Grindl, W, Wende, W, Pingoud, A

“…PI- Sce I is an intein-encoded protein that belongs to the LAGLIDADG family of homing endonucleases. According to the crystal structure and mutational studies,…”
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Localization of the Iodomycin Binding Site in Hamster P-glycoprotein by Demmer, Annette, Thole, Hubert, Kubesch, Peter, Brandt, Tanja, Raida, Manfred, Fislage, Rainer, Tümmler, Burkhard

“…P-glycoprotein, the overexpression of which is a major cause for the failure of cancer chemotherapy in man, recognizes and transports a broad range of…”
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IdiA, a 34 kDa protein in the cyanobacteria Synechococcus sp. strains PCC 6301 and PCC 7942, is required for growth under iron and manganese limitations by Michel, Klaus-Peter, Thole, Hubert H, Pistorius, Elfriede K

“…Biologie VIII: Zellphysiologie, Universität Bielefeld, 33501 Bielefeld, Germany Max-Planck-Institut für experimentelle Endokrinologie, 30603 Hannover, Germany…”
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The HDQVH-motif in domain E of the estradiol receptor α is responsible for zinc-binding and zinc-induced hormone release by Humeny, Andreas, Bökenkamp, Dirk, Thole, Hubert H

“…The estradiol receptor α and proteolytic fragments thereof which contain the entire ligand-binding domain E, bind 65Zn with high affinity. Four putative…”
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Disturbed estrogen and progesterone action in ovarian endometriosis by Šmuc, Tina, Hevir, Neli, Ribič-Pucelj, Martina, Husen, Bettina, Thole, Hubert, Rižner, Tea Lanišnik

“…Endometriosis is a very common disease in pre-menopausal women, where defective metabolism of steroid hormones plays an important role in its development and…”
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Sodium transport and bone mineral density in hypercalciuria with thiazide treatment by REUSZ, G. S, DOBOS, M, VASARHELYI, B, SALLAY, P, SZABO, A, HORVATH, C, BYRD, D. J, THOLE, H. H, TULASSAY, T

“…Erythrocyte sodium-potassium (Na+/K+)-ATPase and sodium-lithium (Na+/Li+) countertransport activities were measured in 18 children (aged 9.6 years, range 6-16…”
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Design, Synthesis, and Biological Evaluation of (Hydroxyphenyl)naphthalene and -quinoline Derivatives: Potent and Selective Nonsteroidal Inhibitors of 17β-Hydroxysteroid Dehydrogenase Type 1 (17β-HSD1) for the Treatment of Estrogen-Dependent Diseases by Frotscher, Martin, Ziegler, Erika, Marchais-Oberwinkler, Sandrine, Kruchten, Patricia, Neugebauer, Alexander, Fetzer, Ludivine, Scherer, Christiane, Müller-Vieira, Ursula, Messinger, Josef, Thole, Hubert, Hartmann, Rolf W

“…Human 17β-hydroxysteroid dehydrogenase type 1 (17β-HSD1) catalyzes the reduction of the weak estrogen estrone (E1) to the highly potent estradiol (E2). This…”
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Synthesis and investigation of the anticancer effects of estrone-16-oxime ethers in vitro by Berényi, Ágnes, Minorics, Renáta, Iványi, Zoltán, Ocsovszki, Imre, Ducza, Eszter, Thole, Hubert, Messinger, Josef, Wölfling, János, Mótyán, Gergő, Mernyák, Erzsébet, Frank, Éva, Schneider, Gyula, Zupkó, István

“…► Antiproliferative screen of 63 newly synthetized estrone-16-oxime ethers. ► Disturbance of cell cycle and apoptosis induction. ► Action mediated via proteins…”
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Substituted 6-Phenyl-2-naphthols. Potent and Selective Nonsteroidal Inhibitors of 17β-Hydroxysteroid Dehydrogenase Type 1 (17β-HSD1): Design, Synthesis, Biological Evaluation, and Pharmacokinetics by Marchais-Oberwinkler, Sandrine, Kruchten, Patricia, Frotscher, Martin, Ziegler, Erika, Neugebauer, Alexander, Bhoga, Umadevi, Bey, Emmanuel, Müller-Vieira, Ursula, Messinger, Josef, Thole, Hubert, Hartmann, Rolf W

“…17β-Estradiol (E2) is implicated in the genesis and the development of estrogen-dependent diseases. Its concentration is mainly regulated by 17β-hydroxysteroid…”
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Estrone C15 derivatives—A new class of 17β-hydroxysteroid dehydrogenase type 1 inhibitors by Messinger, Josef, Husen, Bettina, Koskimies, Pasi, Hirvelä, Leena, Kallio, Lila, Saarenketo, Pauli, Thole, Hubert

“…Lowering local estradiol concentration by inhibition of the estradiol-synthesizing enzyme 17β-hydroxysteroid dehydrogenase type 1 (17beta-HSD1) has been…”
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In vivo mouse model for analysis of hydroxysteroid (17β) dehydrogenase 1 inhibitors by Lamminen, Tarja, Saloniemi, Taija, Huhtinen, Kaisa, Koskimies, Pasi, Messinger, Josef, Husen, Bettina, Thole, Hubert, Poutanen, Matti

“…Hydroxysteroid (17β) dehydrogenase 1 (HSD17B1) catalyzes the reaction between the low active 17-ketosteroids and the highly active 17beta-hydroxysteroids. In…”
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