Search Results - "Thoenen, Hans"

Neurotrophins: from enthusiastic expectations through sobering experiences to rational therapeutic approaches by Thoenen, Hans, Sendtner, Michael

“…Despite high enthusiasm, early attempts to develop clinical treatments based on animal research with neurotrophins were not successful. Here we survey clinical…”
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Neurotrophins and Neuronal Plasticity by Thoenen, Hans

“…There is increasing evidence that neurotrophins (NTs) are involved in processes of neuronal plasticity besides their well-established actions in regulating the…”
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Induction of Long-Term Potentiation and Depression Is Reflected by Corresponding Changes in Secretion of Endogenous Brain-Derived Neurotrophic Factor by Aicardi, Giorgio, Argilli, Emanuela, Cappello, Silvia, Santi, Spartaco, Riccio, Massimo, Thoenen, Hans, Canossa, Marco

“…Neurotrophins play an important role in modulating activity-dependent neuronal plasticity. In particular, threshold levels of brain-derived neurotrophic factor…”
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Neurotrophin Release by Neurotrophins: Implications for Activity-Dependent Neuronal Plasticity by Canossa, Marco, Griesbeck, Oliver, Berninger, Benedikt, Campana, Gabriele, Kolbeck, Roland, Thoenen, Hans

“…Neurotrophins, secreted in an activity-dependent manner, are thought to be involved in the activity-dependent refinement of synaptic connections. Here we…”
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Ataxia and Altered Dendritic Calcium Signaling in Mice Carrying a Targeted Null Mutation of the Calbindin D28k Gene by Airaksinen, Matti S., Eilers, Jens, Garaschuk, Olga, Thoenen, Hans, Konnerth, Arthur, Meyer, Michael

“…Intracellular calcium-binding proteins are abundantly expressed in many neuronal populations. Previous evidence suggests that calcium-binding proteins can…”
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GABAergic Stimulation Regulates the Phenotype of Hippocampal Interneurons through the Regulation of Brain-Derived Neurotrophic Factor by Marty, Serge, Berninger, Benedikt, Carroll, Patrick, Thoenen, Hans

“…γ-Aminobutyric acid (GABA) switches from enhancing to repressing brain-derived neurotrophic factor (BDNF) mRNA synthesis during the maturation of hippocampal…”
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Neurotrophin-6 is a new member of the nerve growth factor family by Götz, Rudolf, Köster, Reinhard, Winkler, Christoph, Raulf, Friedrich, Lottspeich, Friedrich, Schartl, Manfred, Thoenen, Hans

“…During vertebrate development, many neurons depend for survival and differentiation on their target cells. The best documented mediator of such a retrograde…”
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Ciliary neurotrophic factor prevents the degeneration of motor neurons after axotomy by Sendtner, Michael, Kreutzberg, Georg W, Thoenen, Hans

“…The period of natural cell death in the development of rodent motor neurons is followed by a period of sensitivity to axonal injury. In the rat this early…”
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Autocrine-paracrine regulation of hippocampal neuron survival by IGF-1 and the neurotrophins BDNF, NT-3 and NT-4 by Lindholm, D, Carroll, P, Tzimagiorgis, G, Thoenen, H

“…In contrast to sympathetic and sensory neurons in the peripheral nervous system, the neurotrophic requirements for neurons in the central nervous system (CNS)…”
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Brain-derived neurotrophic factor is a survival factor for cultured rat cerebellar granule neurons and protects them against glutamate-induced neurotoxicity by Lindholm, D, Dechant, G, Heisenberg, C P, Thoenen, H

“…We have studied the effects of different neurotrophins on the survival and proliferation of rat cerebellar granule cells in culture. These neurons express trkB…”
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Endogenous Ciliary Neurotrophic Factor Is a Lesion Factor for Axotomized Motoneurons in Adult Mice by Sendtner, Michael, Gotz, Rudolf, Holtmann, Bettina, Thoenen, Hans

“…Ciliary neurotrophic factor (CNTF) is an abundant cytosolic molecule in myelinating Schwann cells of adult rodents. In newborn animals in which CNTF is not yet…”
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Molecular cloning and expression of brain-derived neurotrophic factor by Leibrock, Joachim, Lottspeich, Friedrich, Hohn, Andreas, Hofer, Magdalena, Hengerer, Bastian, Masiakowski, Piotr, Thoenen, Hans, Barde, Yves-Alain

“…During the development of the vertebrate nervous system, many neurons depend for survival on interactions with their target cells. Specific proteins are…”
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Positive feedback between acetylcholine and the neurotrophins nerve growth factor and brain-derived neurotrophic factor in the rat hippocampus by Knipper, M, da Penha Berzaghi, M, Blöchl, A, Breer, H, Thoenen, H, Lindholm, D

“…In the rat hippocampus, nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) are synthesized by neurons in an activity-dependent manner…”
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GABAergic stimulation switches from enhancing to repressing BDNF expression in rat hippocampal neurons during maturation in vitro by Berninger, B, Marty, S, Zafra, F, da Penha Berzaghi, M, Thoenen, H, Lindholm, D

“…gamma-Aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the adult mammalian central nervous system. However, GABA depolarizes immature rat…”
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Specific Subtypes of Cutaneous Mechanoreceptors Require Neurotrophin-3 Following Peripheral Target Innervation by Airaksinen, Matti S, Koltzenburg, Martin, Lewin, Gary R, Masu, Yasuo, Helbig, Christian, Wolf, Eckhard, Brem, Gottfried, Toyka, Klaus V, Thoenen, Hans, Meyer, Michael

“…Neurotrophin-3 (NT-3) is required for the development of most sensory neurons of the dorsal root ganglia. Using electrophysiological techniques in mice with…”
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The induction of LTP increases BDNF and NGF mRNA but decreases NT-3 mRNA in the dentate gyrus by Castrén, E, Pitkänen, M, Sirviö, J, Parsadanian, A, Lindholm, D, Thoenen, H, Riekkinen, P J

“…We have investigated the expression of the mRNAs for brain-derived neurotrophic factor (BDNF), nerve growth factor (NGF), neurotrophin-3 (NT-3) and…”
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Neurotrophins and activity-dependent plasticity by Thoenen, H

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Timing and site of nerve growth factor synthesis in developing skin in relation to innervation and expression of the receptor by Davies, Alun M, Bandtlow, Christine, Heumann, Rolf, Korsching, Sigrun, Rohrer, Hermann, Thoenen, Hans

“…We show that nerve growth factor (NGF) synthesis in developing skin begins with sensory innervation and that sensory neurons do not express NGF receptors until…”
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Neurotrophic Factors by Thoenen, Hans, Edgar, David

“…In addition to nerve growth factor (NGF), many proteins present in soluble tissue extracts and in the extracellular matrix influence the survival and…”
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TrkA tyrosine residues involved in NGF-induced neurite outgrowth of PC12 cells by Inagaki, N, Thoenen, H, Lindholm, D

“…The proto-oncogene product gp140prototrk (TrkA) is the receptor tyrosine kinase that mediates nerve growth factor-induced neuronal survival and…”
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